Can ketamine or magnesium ease pain after breast surgery?

NCT ID NCT04275661

Completed Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding ketamine or magnesium sulfate to a standard numbing medicine (levobupivacaine) can improve pain control after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons via a nerve block. The main goal was to see if these additions reduce the need for morphine in the first two days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine and magnesium sulfate
What this could lead to: If successful, this could point toward better pain control after breast cancer surgery, reducing the need for strong opioids like morphine.
What could go wrong: This is a small, early-phase trial with only 60 participants. Results may not apply to all patients, and the added drugs could cause side effects like sedation or nausea.

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Conditions

The condition(s) this trial relates to.

agnosia breast cancer breast neoplasm pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA BREAST CANCER

Contacts and locations

Locations

south Egypt Cancer Institute Assiut University

Asyut, Egypt

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