Overnutrition

This study investigates whether a daily fiber supplement called inulin, extracted from Thai Jerusalem artichoke, can change the gut bacteria and reduce body fat in obese children aged 7 to 15. Over six months, one group receives inulin, another gets a placebo, and a third group r…

This study tests whether combining lifestyle counseling with weight-loss medication helps teens aged 12–17 with severe obesity lose weight. About 120 participants will receive counseling and medication for a year. The goal is to find a practical, effective treatment that is easie…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tested whether the drug RDX-002 can lower high blood fat levels in people who recently stopped taking weight-loss medications like semaglutide or tirzepatide. Sixty-eight adults who had lost at least 10% of their body weight on those drugs took either RDX-002 or a plac…

This study looked at whether getting more sleep or keeping a regular bedtime could improve how the body handles sugar and insulin in overweight adults who usually sleep less than 7 hours a night. Eighteen African American men and women aged 21-50 were asked to either extend their…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests whether the drug lisdexamfetamine (Vyvanse), usually used for ADHD, can help children aged 6 to 12 with severe obesity lose weight. About 44 children will receive either the drug or a placebo, plus lifestyle therapy, for 24 weeks. The main goal is to see if their…

This study tests whether adding a canine health-literacy module to an existing family lifestyle program helps overweight teens and their parents become more active. The program includes lessons on dog care, behavior, and exercise, along with activity trackers and surveys. Partici…

This study investigates whether cryolipolysis, a non-invasive fat freezing technique, can lower inflammatory markers in obese postmenopausal women. Participants are women aged 50-60 with a BMI of 30-40. The treatment is applied to the lower belly for 30 minutes, and researchers m…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study investigates whether adding whole-body electrical muscle stimulation (WB-EMS) to a calorie-restricted diet improves body composition and metabolic health in women with obesity. Participants follow an 8-week diet plan, with half also receiving twice-weekly 20-minute WB-…

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. One group received weekly group sessions on diet and activity, while the other got extra health information and classes. Researchers tracked weight ga…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This study tested a 12-week program for Hispanic mothers with overweight or obesity and their 3-5 year old children. The program included weekly classes on nutrition, exercise, and coping skills, plus exercise sessions. Researchers measured changes in weight, body fat, and health…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested a new injectable drug called ASC30 in 115 adults with obesity. The goal was to check its safety, how the body processes it, and its effect on weight. Participants received either the drug or a placebo, and researchers monitored side effects and weight changes ov…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This phase 2 study tested a new drug called eloralintide (LY3841136) for weight management in 263 adults with obesity or overweight. Participants received either the drug or a placebo for about 64 weeks. The main goal was to see how much weight they lost after 48 weeks. Results w…

This study tested whether a low glycemic index (GI) diet helps overweight Chinese teenagers lose weight and improve health. 285 adolescents followed either a low-GI or regular Chinese diet for 12 months. Researchers measured changes in body mass index, body fat, and heart-related…

This study tests whether a dietary supplement called Satisens®, made from lemon verbena, hibiscus, saffron, and carob extract, can help reduce emotional eating and cravings for sweets in healthy adults who are overweight or obese. Participants take two capsules daily for a set pe…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This trial investigates whether adding hypnosis sessions to standard dietary monitoring can help people lose weight after bariatric surgery has not worked. About 25% of patients do not achieve lasting weight loss from surgery alone. The study enrolls 60 adults aged 18-65 with obe…

This study tested whether eating probiotic-enriched pasta daily for 4 weeks could improve metabolic health and reduce inflammation in overweight and obese adults. Forty healthy men and women with a BMI between 25 and 35 ate either probiotic pasta or regular pasta. Researchers mea…

This completed Phase 1 trial tested how the experimental drug maridebart cafraglutide (AMG 133) is absorbed when given as two different injections. 348 adults with overweight or obesity received a single dose. The main goal was to measure drug levels in the blood, not weight loss…

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis treatment (ixekizumab) helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 250 adults will receive either ixekizumab alone or both drugs together for…

This study looks at whether using a continuous glucose monitor (CGM) alongside standard nutrition and activity advice can improve metabolic health in young people aged 11 and older who have prediabetes and are overweight. Participants wear the CGM intermittently to see how daily …

This study tests a new, non-surgical weight loss method called endoscopic Gastric Mucosal Ablation (GMA). It uses a thin tube and heat to treat the stomach lining, aiming to help people with obesity lose weight. The study involves 15 participants and will follow them for up to 12…

This study tested a new, non-surgical weight loss technique called Gastric Mucosal Ablation (GMA) in 13 people with class III obesity. The procedure uses a device to carefully burn the stomach lining, aiming to mimic the hormonal effects of weight-loss surgery. The main goal was …

This small pilot study tested the safety of a swallowable intra-gastric balloon (IGBalloon) for weight loss in 5 people with obesity. Participants swallowed up to 5 balloons over 8 weeks, with regular check-ups including blood tests and endoscopies. The study also looked at weigh…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to…

This study looked at whether a supervised exercise program, started 3 months after bariatric surgery, helps improve body composition, muscle strength, and insulin resistance. 61 adults with severe obesity took part. Participants were randomly assigned to either an exercise group …

This study tested a culturally adapted online program for families with overweight or obese children aged 7-9 in Vietnam. The program aimed to improve parents' confidence and healthy role modeling, and children's eating habits, physical activity, and body measurements. Sixty fami…

This study looked at whether giving protein supplements after sleeve gastrectomy surgery helps patients keep their muscle mass while losing weight. 90 obese adults who had the surgery took part. Researchers measured changes in lean body mass and other health markers over 5 weeks.

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This study tested a 16-week weight-loss program using the drug tirzepatide before elective hernia surgery in 91 adults with obesity. Participants lost an average of 13.8% of their body weight, and all reached the target weight needed for surgery. Compared to a similar group who h…

This completed study tested a remote, self-guided lifestyle program for 696 veterans with obesity and obstructive sleep apnea. Participants watched videos, completed handouts, and tracked their eating and activity, with optional coaching. The goal was to see if this low-cost appr…

This study tested whether a school-based gardening, nutrition, and cooking program could help low-income Hispanic children eat more vegetables and maintain a healthy weight. Over 3,000 students in 16 Texas elementary schools took part, with some schools getting the program and ot…

This Phase 3 study tested a new drug called IBI362 (mazdutide) against the well-known semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. Participants received weekly injections for 32 weeks, with some continuing for an extra 24 weeks. The main goal was to s…

This study tested whether a diet focused on low-energy-density foods (like fruits, vegetables, and broth-based soups) helps people maintain weight loss better than simply counting calories. 345 adults with obesity were followed for 22 months. Researchers measured changes in weigh…

This study tested a new medicine called HS-20094 to help overweight and obese adults lose weight. About 600 people took either the drug or a placebo for up to 48 weeks. The main goals were to see how much weight they lost and how many lost at least 5% of their starting weight.

This phase 3 trial tests whether a daily oral drug called orforglipron can help people with obesity or overweight maintain weight loss they achieved with injectable tirzepatide or semaglutide. About 376 participants who completed a prior weight-loss study will receive orforglipro…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This Phase 2 study tested an investigational drug called HS-20094 in 200 overweight or obese adults. Participants received either the drug or a placebo injection over several weeks. The main goal was to see how much weight they lost and whether the drug was safe.

This study tested whether a telemedicine program for children with obesity works better than standard in-person care. 100 children aged 10-18 were split into two groups: one received most of their care through video calls, and the other had monthly in-person visits. The main goal…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This completed Phase 2 trial tested whether a daily injection of ROSE-010, a GLP-1 analogue, can reduce appetite and food intake in 40 overweight or obese women. Participants received either a low or high dose of ROSE-010 or a placebo, and researchers measured how much they ate a…

This study compared two weight loss surgeries for people with severe obesity: SASI and SAPI. Researchers looked at costs, weight loss, and safety in 68 adults aged 18-65. The goal was to see which surgery is more affordable and effective for long-term weight control.

This study tested whether two experimental drugs, AZD9550 and AZD6234, given together as weekly shots, help people with obesity or overweight lose more weight than a placebo or either drug alone. 377 adults aged 18-75 with a BMI of 27 or higher and at least one weight-related hea…

This study tested two mobile apps for parents of children aged 2 to 5. One app focused on nutrition, physical activity, and sleep; the other on reading. Researchers wanted to see if the apps could help parents encourage healthier habits and lower obesity risk. Over 200 parents in…

This study tested a new drug called MET097, given as a weekly injection, to help adults with obesity or overweight lose weight. 239 participants received either MET097 or a placebo for 28 weeks. The main goal was to see how much weight people lost compared to those on placebo. Re…

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This study looked at whether a 6-month program combining exercise and healthy eating could improve the health of 36 obese office workers (BMI over 30). Participants were assigned to the program or a control group. The goal was to see changes in body fat, blood pressure, cholester…

This Phase 2 study tested a once-daily pill called RGT001-075 in 267 adults who are obese or overweight with weight-related health problems like high blood pressure or sleep apnea. The goal was to see if the drug helps with weight loss and is safe. Participants took either the dr…

This completed Phase 2 study tested different doses of CX11 tablets against a placebo in 250 overweight or obese adults. Participants took the pill once daily with meals for 36 weeks, followed by a 2-week safety check. The main goal was to see how much weight people lost and whet…

This study tested a new daily pill called DA-302168S in 250 overweight or obese adults. The pill works like a natural hormone to control appetite. Researchers measured weight loss and side effects over 16 weeks. The goal is to see if this pill is a safe and effective option for w…

This study tested whether a combination of two weight-loss drugs, phentermine and topiramate, could help 100 teens with severe obesity keep weight off after losing it through a meal replacement program. The goal was to see if the medication could counteract the body's natural ten…

This early-stage trial tested a new weekly injection called MET233 in 144 otherwise healthy adults with overweight or obesity. The main goal was to check safety and how the drug moves through the body. Researchers also looked at different dosing schedules over several weeks. Sinc…

This study tested an oral drug called LY3502970 in 72 healthy overweight and obese adults to see if it is safe and how the body processes it. Participants took the drug by mouth, and researchers monitored side effects and drug levels in the blood over up to 42 days. The goal was …

This study tested a lifestyle program to help pregnant women with obesity maintain their weight and lose body fat during pregnancy. About 100 women in early pregnancy took part, receiving either the program or standard care. The goal was to see if the program could improve mother…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in …

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This Phase 2 study tested an injectable drug called HRS9531 in 61 overweight or obese adults to see if it helps with weight loss over 36 weeks. Participants received either the drug or a placebo, and researchers measured changes in body weight. The goal is to find a new treatment…

This study tested a new magnetic device (MagDI System) that creates a connection between two parts of the small intestine without staples or stitches. The goal was to help adults with obesity and type 2 diabetes lose weight and control blood sugar. Twenty-seven participants recei…

This study tested if limiting when you eat (time-restricted eating) helps families lose weight. 36 pairs of one parent and one child (ages 3-9) with obesity were assigned to either eat only within a 10-12 hour window each day or to follow standard diet advice. The program lasted …

This study tested a 6-month peer-led weight loss program called TOPS (Take Off Pounds Sensibly) in 116 older African American women with obesity. Participants attended dietitian-facilitated classes, while a waitlist group received the program later. The goal was to see if this co…

This early-phase trial tested a new drug called XW003 in 48 Chinese teenagers with obesity. The main goal was to check safety and how the body processes the drug, while also tracking weight changes. Participants received either the drug or a placebo injection. Results will help d…

This study tested whether giving small weekly cash incentives (up to $300 total) for tracking what you eat and losing weight helps adults with obesity shed pounds. Over 700 participants were followed for 18 months. The goal was to see if these rewards lead to at least 5% weight l…

This study tested a mental strategy called WOOP (Wish, Outcome, Obstacle, Plan) to help veterans with obesity lose weight. Over 400 veterans were split into two groups: one got the VA's standard weight program (MOVE!) plus WOOP, the other got MOVE! alone. The goal was to see if a…

This study tested a new surgical technique called FundoRing, where the surgeon wraps the unused part of the stomach around the new stomach pouch during gastric bypass. The goal is to improve weight loss and reduce bile reflux compared to the standard bypass. One thousand adults w…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study tested whether exercising with augmented reality (AR) glasses for 12 weeks could improve metabolic health and body measurements in 20 obese adolescents aged 10-19. Half the teens used AR glasses during moderate exercise three times a week, while the other half served a…

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This study tested four simple 'nudge' strategies to see if they could get college students to pick sugar-free drinks over sugary ones. Over 1,600 students were shown drink menus with different nudges, like showing sugar content or health warnings. The goal was to see if these gen…

This study tested the Bright Bodies program, a family-based lifestyle intervention for children ages 7-13 with obesity. The program includes nutrition education, behavior modification, and exercise sessions. Researchers measured changes in BMI and other health outcomes across thr…

This study looked at whether aerobic exercise can change body composition—like body fat, muscle, water, and bone mass—in overweight and obese boys aged 8 to 12. A total of 80 boys participated, and their body measurements were taken using a special scale. The goal was to see if e…

This study tested a once-daily medication called LY3549492 to help adults with obesity or overweight lose weight. About 288 participants took either the drug or a placebo for around one year. The main goal was to see how much weight they lost and how safe the treatment was.

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This small study tested a new procedure that uses a special device to stitch the stomach from the inside, aiming to help people with obesity lose weight. Only 3 people took part, and the main goals were to see if the procedure is safe and leads to weight loss over 3 to 12 months.…

This study looked at whether three different low-calorie diets could improve blood sugar and body composition in 120 shift workers who are overweight and have prediabetes or type 2 diabetes. Each diet had a different amount and timing of protein. The goal was to see which approac…

This study tested whether adding a weekly semaglutide injection to a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar in people with type 2 diabetes who are overweight. About 573 adults took part for roughly 11 months. The goal was…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested whether training older high school students as peer mentors could help younger teens become more physically active. Over 500 students from Appalachian high schools took part, comparing a peer-mentored program to a teacher-led one. The goal was to see if the ment…

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This study tested whether eating a fermented pea-and-legume product for three weeks could improve gut health and reduce inflammation in people with metabolic syndrome. 56 adults with a large waist and at least one other risk factor (like high blood sugar or cholesterol) took part…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study tested a daily oral semaglutide tablet (50 mg) for weight loss in 667 adults with overweight or obesity. Participants took the pill or a placebo for 68 weeks, along with diet and exercise advice. The main goals were to measure percentage weight loss and how many people…

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study tested a new weekly injection called UBT251 in 205 overweight or obese adults to see if it helps with weight loss. Participants received different doses of the drug or a placebo for 24 weeks. The main goal was to measure the percentage change in body weight, with addit…

This study explored whether using a mobile app and a Fitbit Inspire 3 tracker can help adults with metabolic syndrome become more physically active. One hundred participants were split into two groups: one used the digital tools plus usual care, the other received usual care alon…

This study looked at whether adding a second drug (mibavademab) to the weight-loss medication tirzepatide helps adults with obesity lose more weight than tirzepatide alone. About 392 participants with a BMI between 30 and 40 took part. The goal was to measure changes in body weig…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study looked at 150 teens aged 12-17 with severe obesity to find the best time to add a weight-loss pill (phentermine) if lifestyle changes alone weren't enough. Participants first tried lifestyle therapy for 12 or 24 weeks, then those who didn't lose enough weight started t…

This study looked at whether a low-carb, high-fat ketogenic diet with fewer calories can reduce inflammation and improve blood sugar control in prediabetic obese adults aged 18 to 40. Ninety participants were split into three groups: a keto diet, a normal diet with fewer calories…

This study looked at whether eating different amounts of pecans every day for 28 days can improve cholesterol and other heart health markers in adults who are overweight or have high cholesterol. 108 participants were split into groups that ate pecans providing 6%, 13%, or 20% of…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether giving Hispanic teenagers a Fitbit and sending them text messages could help them be more active and sleep better. The goal was to reduce their risk of type 2 diabetes. 43 teens aged 14-16 with obesity took part. The study measured how many teens joined,…

This study looked at whether adding small amounts of cottonseed oil to the diet can improve cholesterol and other heart disease risk factors. 95 adults at increased risk for heart disease drank shakes and ate snacks with different amounts of cottonseed oil for 28 days. Researcher…

This study tested whether adding the drug semaglutide to lifestyle counseling helps young adults (ages 18-28) with obesity who previously did not lose enough weight through diet and exercise alone. About 246 participants were split into groups based on their past response to life…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with overweight or obesity lose weight. About 300 adults took part, receiving either CagriSema or a dummy shot once a week for around 1½ years. The main goal…

This study tested whether adding a crural repair and gastropexy to standard sleeve gastrectomy reduces acid reflux in people with severe obesity. Fifty patients were randomly assigned to either the standard surgery or the enhanced version. After one year, the group with the extra…

This study tested a new medicine called survodutide for weight loss in 274 Japanese adults with obesity and related health problems like diabetes or high blood pressure. Participants received weekly injections of survodutide or a placebo for about 1.5 years, along with diet and e…

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much weight people lost and if at least 5% of body …

This study tests a medicine called survodutide in adults with overweight or obesity and a liver condition called NASH. Participants receive weekly injections of survodutide or a placebo for about a year, along with diet and exercise advice. The goal is to see if the drug reduces …

This study tested a new drug called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. About 85 adults took either the drug or a placebo for 44 weeks, along with diet and exercise. The main goal was to check safety and side effects, while also measuri…

This completed Phase 3 trial tested a high 7.2 mg weekly dose of semaglutide (a drug already used for diabetes and weight loss) in 512 adults with obesity and type 2 diabetes. Participants received either the high dose, a lower dose, or a placebo, along with lifestyle counseling.…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose more weight and improve their metabolism. A total of 110 people aged 25-35 with a BMI of 24 or higher took part. The results will help guide better dieta…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested a new drug called Mazdutide to help adults with obesity or overweight lose weight. 179 participants took either the drug or a placebo for about 62 weeks. The main goal was to see how much weight they lost after 32 weeks, with a focus on safety and effectiveness.

This completed Phase 3 trial tested a high dose (7.2 mg weekly) of semaglutide, a drug already used for weight loss, in 1407 adults with obesity. Participants received the drug or a placebo, plus lifestyle advice. The main goal was to measure weight loss from start to 72 weeks. R…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested a new drug called enicepatide (CT-388) given as a weekly injection for 48 weeks. It involved 469 adults with obesity or overweight who also had at least one weight-related health problem like high blood pressure or prediabetes. The goal was to see how much weigh…

This study tested a new medicine called NNC0519-0130, given as a weekly injection, to see if it helps people with excess body weight lose weight. About 354 adults with overweight or obesity received different doses of the drug, a placebo, or an existing weight-loss drug for up to…

This early-stage trial tested a new injectable drug called CPX101 in 72 healthy volunteers and overweight or obese patients. The main goal was to check safety and how the body processes the drug, with a preliminary look at weight loss. The study is complete, but results are not y…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study tested a program called HealthyWE in 60 older adults in Camden, New Jersey, to help them manage their weight and reduce pain. The program included training on healthy eating, staying active, and mental wellness. Researchers measured changes in body mass index and pain …

This study tested a modified adjustable stomach balloon (Spatz4) in 20 adults with a BMI of 27 or higher who had struggled to lose weight with diet and exercise alone. The balloon is placed in the stomach and can be adjusted at week 16 to change its volume. The main goal was to s…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested a new drug called CPX101 in 240 overweight or obese adults without diabetes. Participants received different doses of CPX101 or a placebo by injection for 24 weeks. The goal was to see if the drug helps with weight loss and to check its safety.

This study tested a mobile health lifestyle program for 200 overweight or obese pregnant women in China. Participants used a WeChat account and a Huawei wristband to track diet, exercise, and weight, and received personalized feedback. The goal was to see if this approach could h…

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-12) manage their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly group coaching. The main goa…

This study compared three commercial weight management programs to see which helps adults with overweight or obesity lose the most weight in 12 weeks. 459 participants were randomly assigned to one of the programs. The main goal was to measure weight change and percentage of body…

This completed study looked at 226 adults who had lost at least 15% of their body weight while taking GLP-1 medications like Wegovy or Ozempic. Participants stopped their GLP-1 drug and were given either bupropion-naltrexone or bupropion-naltrexone-metformin, plus behavioral supp…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps overweight adults lose weight and improve their gut bacteria. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, cholesterol, and …

This study tested a new weekly injection (HD1916) similar to semaglutide for weight loss in 462 obese adults without diabetes. Participants received the drug for 44 weeks, and researchers measured how much weight they lost and any side effects. The goal was to see if this treatme…

This study tested whether a daily cocoa flavonol supplement could improve body composition, metabolism, and inflammation in 104 obese teenagers aged 10 to 16. Participants took either the supplement or a placebo for 12 weeks, alongside standard diet and exercise advice. The goal …

This study compared two behavioral weight-loss programs in 321 adults with obesity and elevated blood pressure. One program taught maintenance skills before weight loss, while the other focused on losing weight first. Participants were followed for three years to see who could lo…

This study tested a device that uses self-forming magnets to create new connections in the gut. It was done in 28 adults with severe obesity who had already had weight-loss surgery but did not lose enough weight. The goal was to see if the device is safe and works as intended. Th…

This completed Phase 2 study tested an experimental pill called HRS9531 in 166 adults with obesity. Participants took either the drug or a placebo daily for 26 weeks. The main goal was to see how much weight they lost compared to those on placebo.

This completed Phase 1 trial tested a new drug called NNC0519-0130 in 134 overweight or obese adults. The goal was to see if different ways of increasing the dose could reduce side effects. Participants received weekly or twice-weekly injections for about 24 weeks. The study focu…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This completed study tested whether a high-intensity medical weight loss program, supported by a digital platform and continuous glucose monitors, could help people with type 2 diabetes lose weight and achieve remission. 64 participants were enrolled and compared to a group recei…

This study tested whether a probiotic called Lactobacillus gasseri could help overweight women manage their weight and balance sex hormones. Over 12 weeks, 110 women took either the probiotic or a placebo. Researchers measured changes in estrogen levels and body fat. The goal was…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This early-stage study tested a new medicine, NNC0519-0130, in 20 overweight or obese Chinese men. The goal was to see how the drug moves through the body and if it is safe. Participants received either the drug or a placebo for about 28 weeks. This is not a cure, but aims to hel…

This study tested whether a new medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of the two drugs alone, or a pl…

This study tested whether personalized health planning delivered in shared medical appointments could help adults with obesity lose weight. Eleven motivated patients aged 30 to 60 with a BMI between 35 and 50 took part. The approach combined individual health plans with group sup…

This study tested whether the drug tirzepatide, given once weekly, can help people with obesity or overweight maintain weight loss they achieved during a prior diet period. About 441 participants took either tirzepatide or a placebo for 60 weeks. The goal was to see if the drug c…

This study tested whether personalized diet advice based on a person's gut bacteria could improve food choices and gut health in 50 adults with obesity in Colombia. Participants either got tailored diet recommendations or standard advice for 12 weeks. Researchers measured changes…

This study tested whether weighing yourself daily with a wireless scale can help adults with obesity manage their weight. About 400 people from primary care clinics took part. They were asked to weigh themselves each day and see their weight trend on the scale's display. The goal…

This study looked at a procedure called endoscopic sleeve gastroplasty, which reduces stomach size using a flexible tube through the mouth. 75 adults with obesity who had trouble losing weight with diet and exercise alone took part. The goal was to see how much weight they lost a…

This study tested a new weekly injection called petrelintide to help people with obesity or overweight (plus related health issues) lose weight. About 493 participants received either the drug or a placebo, along with diet and exercise advice, for 28 weeks. The main goal was to s…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This completed study gave 580 Native American adults and children in Osage Nation weekly boxes of fresh fruits and vegetables along with healthy recipes and cooking classes. The goal was to see if this program could improve diet, lower blood pressure, and reduce health risks like…

This study tested a computer-based tool that helps doctors follow guidelines for managing overweight and obesity in children. The tool was used in primary care clinics across three health systems, involving over 58,000 patients. Researchers measured changes in children's BMI and …

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study looked at whether eating fermented plant-based foods (like certain vegetables and grains) can improve health in people with metabolic syndrome—a condition that raises risk for heart disease and diabetes. About 89 adults with signs of metabolic syndrome ate either ferme…

This study tested whether using ideal body weight (instead of total body weight) to calculate heparin doses during heart-lung bypass reduces excessive bleeding in obese patients. Sixty obese adults scheduled for heart surgery were randomly assigned to receive heparin based on eit…

This study tested a 100-day weight management program in 140 overweight adults. The program included meal replacements, protein and fiber supplements, probiotics, diet plans, exercise, and counseling. Researchers measured weight loss and health changes to see if the program is sa…

This study tested whether adding a diabetes drug (polyethylene glycol loxenatide) to a hormone-releasing IUD (LNG-IUS) helps women with a precancerous uterine condition called endometrial atypical hyperplasia. The 30 participants were all obese and wanted to preserve their fertil…

This study tested a workplace weight loss program for employees of a hospital who were obese (BMI 27 or higher). Over 500 participants used the So99 app to track healthy eating and exercise as part of a team competition. The goal was to see if the app helped people lose weight an…

This study tested a new medicine called survodutide (BI 456906) to help people with obesity or overweight lose weight. Over 700 adults without type 2 diabetes received either the drug or a placebo injection once a week for about a year and a half, along with diet and exercise adv…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tests a summer garden program called 'Summer Harvest Adventure' for children aged 8 to 11 from low-resource communities. The program teaches nutrition and healthy habits through gardening and cooking activities. Researchers will measure changes in fruit and vegetable i…

This study tested whether encouraging water instead of sugary drinks in childcare centers helps prevent obesity in young children. Over 1,000 preschool-age children and their families took part. The program included better access to healthy drinks at daycare, plus education and c…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study tested whether offering free summer day camps with physical activity, enrichment, and meals could reduce unhealthy weight gain in 651 first- to third-graders from low-income households. The camps removed cost barriers that often lead to sedentary time and poor diet dur…

This study tested a 1-year online program designed to help adults aged 40-70 who are at risk for heart disease become more physically active. Participants either received a fitness tracker plus online coaching and goal-setting sessions, or just a fitness tracker with standard act…

This study tested whether giving extra health coaching to new parents—especially fathers—could help prevent rapid weight gain in babies and reduce obesity risk. Researchers enrolled 657 parents from Massachusetts General Hospital and randomly assigned them to either receive coach…

This completed study tested a program called HomeStyles-2, which aims to help parents of children aged 6 to 11 create healthier home environments. The program focuses on improving diet, physical activity, and sleep habits to prevent obesity. Over 450 families participated, with s…

This pilot study tested whether adding health literacy lessons to an obesity prevention program helps teenagers eat healthier and be more active. 36 adolescents aged 13-16 took part. The program taught them how to find, understand, and use health information to make better choice…

This study tested a program that helps families build healthier habits to prevent obesity in children. It involved 48 fourth-graders and their mothers. The program focused on nutrition and physical activity to lower body mass index (BMI) and reduce obesity risk factors.

This completed study tested a school-based program to prevent obesity in over 1,100 preschool children in South Texas. The program included nutrition education and physical activity encouragement. Researchers measured changes in BMI, fruit and vegetable intake, and fitness levels…

This study tested a 12-week diet and lifestyle program called the SWW Method in 85 women aged 35-75. The program included intermittent fasting, a high-protein diet, and other healthy habits. Researchers measured changes in blood sugar, weight, and other markers to see if it could…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus providing bottled water at home, can lower obesity risk in Hispanic mothers and their infants. Over 200 mother-infant pairs were randomly assigned to one of three groups: …

This study looks at whether giving a nerve block (TAP block) early during laparoscopic sleeve gastrectomy reduces pain more than giving it later. About 200 adults having this weight-loss surgery will receive the same numbing medicine, but at different times. Researchers will comp…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study tests whether time-restricted eating (fasting for 16 hours each day) can improve memory, thinking, and overall well-being in overweight adults aged 65 and older who are worried about their memory. Over 24 weeks, participants either follow the fasting plan or join a hea…

This study is testing a mobile app that gives weekly suggestions to help people with binge eating and obesity. The goal is to see which suggestions work best and in what order. About 300 adults who binge eat regularly and have a BMI of 30 or higher are taking part. The app tracks…

This study compares two types of stitches used during robotic gastric bypass surgery for weight loss. About 150 adults with severe obesity will be randomly assigned to receive either a special barbed suture or a standard one. The main goal is to see which stitch is faster to use …

This study looked at whether a 10-week tai chi or multimodal exercise program could improve balance in overweight and obese women. 75 women participated, and researchers measured balance using several tests like standing on one leg and walking quickly. The goal was to find better…

This study tested whether a dietary supplement with plant extracts can boost natural appetite-regulating hormones in people with overweight or obesity. Forty adults took either the supplement or a placebo daily for 12 weeks. Researchers measured hormone levels and asked about hun…

This study tested whether taking 1,000 mg of glycine daily for six months could improve memory and thinking in older adults. Fifty-nine participants took the supplement, and researchers measured changes in a brain health marker and cognitive test scores. The goal was to see if th…

This study tested whether a special lung-opening maneuver during anesthesia can reduce breathing problems and oxygen needs after weight-loss surgery. Researchers studied 230 obese patients undergoing bariatric surgery. Half received the extra lung-opening procedure, while the oth…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested whether a 12-week home-based circuit training program could improve blood vessel function and metabolism in adults with obesity. Twenty-nine participants were randomly assigned to either the exercise group or a control group that continued their usual activities…

This study tested a self-help tool called EMBER to see if it helps veterans with obesity engage in VA weight management programs. 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers tracked whether participants used weight management servi…

This study tested a digital health program (Adhera Caring Digital Program®) combined with standard medication for 40 families of children aged 13-18 with obesity. The goal was to see if the program improved treatment satisfaction, adherence, and mood over one year. Participants u…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can help overweight and obese adults lose weight and reduce food cravings. Fifty participants received either real rTMS, fake rTMS, or no treatment over 5 weeks. The goal was to see if stimulating a spe…

This study tested whether a dietary supplement called NatureU Burn, made from African mango seed extract and inulin, can increase feelings of fullness after a sugary drink. Fourteen healthy adults took either glucose alone or glucose plus the supplement, then rated their fullness…

This study looked at whether taking Korean ginseng extract daily for eight weeks could reduce fatigue and improve exercise performance in healthy adults aged 20 to 50. Sixty participants were randomly assigned to receive either the ginseng extract or a placebo. The researchers me…

This study tested whether using a lower amount of fresh gas during anesthesia (low-flow) could reduce lung collapse (atelectasis) after laparoscopic weight-loss surgery. Sixty adults were randomly assigned to receive either low-flow or normal-flow anesthesia. The researchers meas…

This study tested two methods to strengthen the staple line during weight-loss sleeve surgery: using medical glue (cyanoacrylate) or a piece of the patient's own belly tissue (omentum). Seventy adults aged 18-65 with obesity took part. The goal was to see which method better prev…

This study looked at whether taking soluble dietary fiber supplements can improve sperm quality in men with obesity. 74 men took either fiber or a placebo for a period. The goal was to see if fiber could help with sperm movement, shape, and count, which are often poor in men with…

This study tested a dietary supplement called WM Formula in 20 adults with high body fat. The supplement aims to increase GLP-1, a hormone that helps control blood sugar and appetite. Participants took the supplement or a placebo and had blood tests over several hours. The study …

This study looked at whether changing how often women eat (meal frequency) can improve their confidence and reduce stress while dieting. It involved 72 women aged 25-55 who had a history of losing and regaining weight (weight cycling) and were overweight or obese. The goal was to…

This study tested whether adding a patient coach helps older adults with obesity follow their weight and health plan. 19 participants worked with a coach to address barriers to diet and physical therapy goals. The study measured how many attended appointments, achieved goals, and…

This study tested whether the herb Salacia chinensis, known to slow sugar absorption, can help control appetite and blood sugar in overweight or obese adults. Fifty-one participants took either a low or high dose of the herb or a placebo with a meal. Researchers measured appetite…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

This study looked at 290 people having laparoscopic sleeve gastrectomy (a weight-loss surgery) to see which method of reinforcing the staple line works better to prevent leaks. One method uses titanium clips, the other uses suturing and omentopexy (tacking the omentum over the st…

This study tested whether a diet packed with fiber, but lower in calories and sugar, helps control blood sugar after meals and keeps people feeling full. Twenty-four overweight or obese adults ate either the high-fiber diet or a typical Western diet for a short period. Researcher…

This study tested a new video laryngeal mask airway (SaCoVLM™) in 57 morbidly obese patients undergoing bariatric surgery. The device helped doctors place a breathing tube on the first try in most cases. The goal was to see if it is safe and effective for this group of patients.…

This study tested whether following a very low calorie diet before bariatric surgery helps patients lose more weight and feel more satisfied. 85 adults who were eligible for surgery took part. Researchers compared the very low calorie diet to standard dietary advice.

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested a weight management program called MOVE!+UP, designed specifically for veterans with PTSD who are overweight or obese. The program adds extra support to standard PTSD care to help overcome barriers like stress and unhealthy habits. Researchers compared it to the…

This early-stage study tested a new injection called HRS-4729 in 102 healthy adults who were overweight or obese. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effec…

This study tested a 6-week group program combining nutrition education with psychological sessions based on Well-Being Therapy in 50 adults with obesity. The goal was to see if improving mental health could lead to healthier, more sustainable eating and weight loss. Participants …

This study looked at whether standing on a vibrating platform while doing foot exercises could improve ankle strength, balance, and body awareness in overweight and obese young adults. Twenty-six people took part in supervised sessions three times a week for eight weeks. The resu…

This study compared two ways to find the right spot for spinal anesthesia in 100 obese women having C-sections. One group used ultrasound to guide the needle, the other used traditional touch-based landmarks. The goal was to see which method leads to a successful first attempt, r…

This study tested whether using a nerve block at one or two spots on the back (erector spinae plane block) provides better pain relief after laparoscopic weight-loss surgery. Sixty obese adults were randomly assigned to receive either a one-level or two-level block along with gen…

This completed study tested whether semaglutide, a drug used for type 2 diabetes and weight loss, could improve sleep apnea in 15 people with diabetes or obesity. Researchers measured breathing pauses during sleep (AHI) after 1 and 4 weeks of treatment. The goal was to see if the…

This study aimed to find the right dose of a spinal anesthesia drug (bupivacaine) for women with a BMI over 50 undergoing a planned C-section. Researchers tested different doses in 45 women to see which dose worked best without needing extra pain relief. The goal is to improve sa…

This study tested two anesthesia approaches for gastric sleeve surgery in 96 patients. One group received standard opioids, while the other also got ketamine. Researchers measured how much opioid pain medicine patients needed after surgery and their pain levels. The goal was to s…

This study looked at whether a 7-month low-carb, high-fat (ketogenic) diet could improve symptoms and quality of life in 121 women with lipedema, a chronic fat tissue disorder causing painful leg swelling. Participants followed the diet and were monitored for changes in leg size,…

This study tested whether the sleep medication suvorexant (Belsomra) can reduce insomnia severity and improve metabolic health in midlife women who have both insomnia and signs of metabolic syndrome. Thirty-one healthy women aged 40-65 who were perimenopausal or postmenopausal to…

This study looked at whether adding TECAR therapy or shock wave therapy to standard treatment (complex decongestive therapy) could better reduce leg swelling in severely obese women with lymphedema. Forty-five women took part, receiving one of three treatments over four weeks. Re…

This study compared two types of pain blocks—MTP and ESPB—for people having laparoscopic sleeve gastrectomy (weight loss surgery). 52 adults with a BMI of 35 or higher took part. The goal was to see which block better reduces pain after surgery using a standard pain scale.

This study looked at whether a 10-week Zumba dance program could reduce body fat and improve flexibility in healthy 8-year-old children. 115 kids took part in 40-minute sessions, three times a week. Researchers measured body fat and flexibility before and after the program, and a…

This study tested whether a short educational video watched before bariatric surgery could lower patients' fear and improve their recovery. Fifty-one adults having weight-loss surgery were randomly assigned to either watch the video or receive standard care. Researchers measured …

This study tested a new hand position called the 'hook technique' to see if it helps doctors give oxygen more effectively to obese patients (BMI 30-40) using one hand. 375 adults took part, and the researchers measured chest rise, oxygen levels, and other signs of good breathing.…

This study looked at whether eating 3 low-calorie meals a day is better than 5 small meals for blood sugar control and weight loss in people with type 2 diabetes who are overweight or obese. Fifty adults aged 40-70 followed one of the two meal plans for 11 weeks. Researchers meas…

This study looked at whether doing Pilates two or three days per week makes a difference in how well women with overweight or obesity can move, balance, and feel day-to-day. Fifty-one women were randomly assigned to either 12 weeks of Pilates three times a week or 18 weeks of Pil…

This study looked at whether adding special breathing training to aerobic exercise helps people with obesity. 45 adults aged 25-60 with a BMI between 30-40 took part. The goal was to see if this combination improves body composition, heart health, breathing, and exercise ability.

This study tested whether special food supplement capsules that release nutrients in the lower gut can increase appetite-regulating hormones and reduce food intake. Twenty adults with obesity took either the active supplement or a placebo on two separate days. The supplement incr…

This pilot study tested whether a remote digital exercise program (Vitala app) is feasible and helpful for adults with obesity and poorly controlled asthma. Twenty participants received a tailored exercise prescription and were encouraged to complete 150 minutes of activity per w…

This study tested if it's safe for people with obesity to go home the same day after a specific type of gastric bypass surgery (FundoRing method) instead of staying overnight. 200 adults were randomly assigned to either same-day or one-day discharge. Researchers tracked complicat…

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study tested if using warm saline (body temperature) to rinse the stomach staple line during laparoscopic sleeve gastrectomy could reduce early bleeding after surgery. 200 adults having weight-loss surgery were randomly assigned to receive either warm or room-temperature sal…

This study looked at whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers tested three specific skills: awareness, acceptance, and values clarity, to see …

This completed study looked at how lean and obese individuals respond to thirst and water deprivation. Researchers gave 75 healthy men a high-salt infusion and a 24-hour water fast, measuring their thirst, hormone levels, and water intake. The goal was to understand if body fat a…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This study tests whether a device called the oxygen reserve index (ORi) can warn doctors earlier than standard pulse oximetry when an older patient's oxygen level starts to drop during surgery. Researchers are comparing obese and non-obese patients aged 65 and older to see if ORi…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 participated. The goal was to understand why some people are more resistant to gai…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This completed pilot study examined how fat tissue dysfunction contributes to type 2 diabetes risk in overweight men from South Asian, Black African/Caribbean, and White European backgrounds. Researchers used MRI scans and blood tests to measure fat distribution, inflammation, an…

This study looked at how being in different temperatures (from about 61°F to 88°F) affects how many calories healthy adults burn. Researchers also checked for brown fat activity, a type of fat that burns energy to keep you warm. 104 healthy men and women stayed in a hospital unit…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This Phase 1 study in 40 overweight or obese adults examined how a new drug called HRS-7535 interacts with four common medications: acetaminophen (pain reliever), digoxin (heart medication), rosuvastatin (cholesterol drug), and omeprazole (acid reflux treatment). Participants too…

This completed pilot study tested a 6-week web-based program called Mind Your Heart in 37 adults who were university employees. The program combined DASH diet education with mindful eating training to improve eating habits and health measures like blood pressure and cholesterol. …

This study used ultrasound to measure the optic nerve sheath (the lining around the eye nerve) in 56 adults having laparoscopic bariatric surgery. The goal was to see how brain pressure changes during surgery due to gas inflation and body positioning. No drug or treatment was tes…

This study looked at whether a time-restricted eating plan (fasting for 16 hours, 2-3 days a week) is feasible and acceptable for older adults aged 65-80 who have mild cognitive impairment and obesity. 33 participants completed the 12-week program, working with a psychologist to …

This study looked at how different types of anesthesia affect thinking and memory after surgery in 90 obese patients. Some received sevoflurane gas at low or normal flow, others received intravenous anesthesia. Researchers tested their mental function before surgery, 30 minutes a…

This study looked at whether replacing non-dairy foods with two servings a day of full-fat or low-fat fermented dairy (like yogurt and cheese) could improve insulin sensitivity and other heart health markers. 110 overweight adults with high triglycerides took part. The goal was t…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study looks at how upper body versus lower body combined strength and endurance training affects two key proteins in overweight and obese men: myostatin, which regulates muscle growth, and hormone-sensitive lipase, which helps break down fat. Thirty-six men were split into t…

This study looks at how eating organically or conventionally grown fruits and vegetables affects the bacteria in your gut and your overall health. Researchers will compare two groups: healthy adults and those with metabolic syndrome (a condition linked to obesity and high blood s…

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study tested whether taking tadalafil (Cialis) daily for 12 weeks can change how fat tissue works in obese adults. Researchers used MRI scans and fat samples to measure fat metabolism and gene activity. The goal was to understand if the drug could make fat behave more like c…

This study looked at 40 adults who had sleeve gastrectomy surgery for obesity. Researchers measured blood levels of fractalkine, a protein involved in inflammation, before and three months after surgery. The goal was to see how fractalkine levels change and whether those changes …

This study looks at whether gastric bypass surgery can protect the kidneys of people who are severely obese and have chronic kidney disease. Researchers measured kidney function before and one year after surgery in 14 patients. The goal is to see if the surgery improves the balan…

This study looked at why many families leave pediatric weight management programs early. Researchers used data from over 1,200 children and their parents to build a tool that predicts dropout. The goal is to help programs keep families engaged and improve long-term health outcome…

This study explored how Ramadan intermittent fasting changes gut bacteria and intestinal barrier function in healthy adults. Researchers followed 79 participants from Italy and Lebanon before, during, and after the fasting month. They collected blood and stool samples to measure …

This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers …

This study tested whether a pre-filled syringe and a pre-filled pen deliver the same amount of survodutide into the body. Fifty-six healthy or overweight adults received a single dose of each version in random order. Researchers measured drug levels in the blood to see if the two…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study examined the link between obesity and iron deficiency anemia in 165 nonpregnant Indonesian women aged 19-29. Participants took daily iron-folic acid supplements for 90 days. Researchers compared iron levels between overweight/obese and normal-weight women to see if wei…

This study followed 53 adults with overweight or obesity who were already receiving standard lifestyle-based weight loss care at a clinic. Researchers measured changes in body weight, fat mass, blood sugar, cholesterol, and other health markers before and after weight loss. The g…

This study looked at 60 obese adults scheduled for weight-loss surgery. Doctors used an ultrasound before surgery to measure how much food or liquid was still in the stomach, even after fasting. The goal was to see if a higher body mass index (BMI) or longer fasting time was link…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study looked at how Enneagram personality types are connected to body weight, eating behaviors, emotional eating, and overall well-being in 210 adults. Participants completed questionnaires about their personality, eating habits, and mental health. The goal was to better und…

This study looked at whether placing patients in a specific position (head up, feet down) before starting laparoscopic weight-loss surgery could reduce pressure on the brain. Researchers measured the optic nerve sheath diameter, an indicator of brain pressure, in 90 patients. The…

This study looked at how the upper part of the gut (foregut) senses nutrients and controls metabolism in 27 lean and obese adults. Researchers measured hormone and sugar levels after feeding through a tube to understand if faulty gut signals contribute to obesity. The goal was to…

This study tested a special belt that uses electrical currents to measure lung function in 30 obese patients during laparoscopic surgery. The goal was to see if the belt could set the breathing machine pressure better than standard methods. The results may help improve breathing …

This study collects and stores medical data from adults who had robotic bariatric surgery between 2018 and 2019. The goal is to build a database that helps doctors understand how well this type of surgery works for weight loss and related health issues. By analyzing real-world ou…

This study looked at 90 adults who had bariatric surgery to see if changing the variety of foods they ate affected their food cravings, calorie intake, and weight loss over 12 months. Researchers tracked participants' diets to understand patterns that might help improve long-term…

This study looked at how often people eat and whether it affects weight loss. Researchers followed 30 overweight adults aged 18 to 65. They tracked eating habits, calories, and weight to better understand the link between meal timing and losing weight.

This study looked at whether eating foods with fewer calories per bite (low energy density) helps people lose weight. Sixty adults with overweight or obesity followed a 12-week lifestyle program. Researchers tracked what they ate, how full they felt, and weight changes to find th…

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake mea…

This study looked at how three different types of dietary advice affect what families eat and their overall health. It involved 45 families with an overweight parent and a child aged 6-12 who was at a healthy weight. Researchers measured changes in diet, body measurements, and pa…

This study looked at whether a single dose of apple cider vinegar, taken with a meal, changes levels of a substance linked to oxidative stress in the blood of adults with obesity. 46 healthy obese adults were randomly assigned to either receive apple cider vinegar with a standard…

This study looked at 53 obese patients having laparoscopic sleeve gastrectomy (weight-loss surgery) to compare two ways of helping them breathe during the operation. One group received standard ventilation support, while the other got a stronger support with higher pressure and e…

This study looked at how diet affects gum health in 200 adults with obesity but no other health conditions. Researchers calculated each person's dietary inflammation score and measured gum health and inflammation markers in blood and gum fluid. The goal was to see if a pro-inflam…

This study looked at how certain gut hormones change after eating a standard meal in 80 adults aged 40-60 with different body weights. Researchers measured hormones like GLP-1 and GIP, which help control appetite and blood sugar. The goal was to understand how these hormone respo…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This study looked at how levels of ghrelin, a hormone that controls hunger, change after eating a standardized meal in 80 adults aged 40-60 with different body weights. Participants drank a nutritional supplement, and their blood was tested over several hours. The goal was to und…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study looked at whether obesity increases the body's production of oxalate, a substance that can lead to kidney stones. 58 adults without a history of kidney stones ate a special low-oxalate diet for 4 days and provided urine samples. Researchers measured oxalate levels to s…

This study used MRI to examine how the brain and gut communicate after eating different types of drinks in people with obesity and healthy weight. Researchers gave participants a high-fat drink or a carbohydrate drink and scanned their brains and stomachs. The goal was to develop…

This completed study followed 687 people who had bariatric surgery (gastric bypass or sleeve gastrectomy) in Norwegian public hospitals between 2010 and 2015. Researchers aimed to see how long weight loss lasts and whether related health problems like diabetes, high blood pressur…

This study tested three digital diet-tracking apps (Nutritics-Libro, MyFood24, and Intake24) in 64 adults with obesity who were about to start GLP-1 medications like Wegovy. Participants used each app for three days over three weeks. The goal was to see which app patients and doc…

This completed study from Purdue University looked at whether GLP-1 receptor agonists (like Ozempic or Wegovy) change how people taste, smell, and crave food. Researchers compared 90 adults with obesity who were either not taking the drug, or had been taking it for about 1 month …

This study tested whether tirzepatide, a weight-loss drug, could change certain markers in the blood, breast tissue, and mammograms that are linked to breast cancer risk. It included 25 women with obesity and other breast cancer risk factors. The goal was to see if the drug might…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This study looked at whether exercising right before a meal changes how much teenagers eat. Researchers tested 54 teens with normal weight or obesity, having them exercise at different times or rest. They measured appetite, taste and smell responses, and daily habits like sleep a…

This study tested a technique to help doctors insert a breathing tube in very obese patients having weight-loss surgery. The method uses a laryngeal mask airway as a temporary helper to keep oxygen flowing while the doctor prepares for the main tube. Thirty-six patients took part…

This study looked at whether saliva can be used to measure endocannabinoids—natural chemicals linked to appetite and weight—instead of taking blood. Researchers compared 12 obese and 12 normal-weight adults after fasting. The goal was to see if saliva levels differ between the gr…

This study looked at whether stress hormones (glucocorticoids) released after eating contribute to fat gain in overweight people. Twenty-three overweight men were given either a drug combination that blocks these hormones or a placebo while overeating for a week. Researchers meas…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at 216 women aged 18-45 to see if weight affects bladder symptoms, hygiene habits, and body awareness. Researchers compared normal-weight women to those who are overweight or obese using questionnaires. The goal was to understand how these factors relate and to …

This study measured levels of a hormone called pregnenolone and related compounds in the blood of 25 men—some with obesity and some at a healthy weight. Researchers wanted to see if a breakdown in the body's natural feedback loop might lead to overactivity of the endocannabinoid …

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This study tested whether using a special breath test (indirect calorimetry) can help doctors give the right amount of nutrition to critically ill patients with obesity who are on breathing machines. The study involved 60 adults from intensive care units in Australia and New Zeal…

This completed Phase 1 study looked at how orforglipron, an experimental drug, changes the way the body processes several common medications (digoxin, simvastatin, rosuvastatin, acetaminophen, and midazolam) in 50 healthy overweight or obese adults. The goal was to measure drug l…

This completed Phase 1 study in 34 adults with overweight or obesity examined whether CagriSema (a combination of cagrilintide and semaglutide) changes how the body processes atorvastatin (a cholesterol drug) and warfarin (a blood thinner). Participants took single doses of atorv…

This study looked at whether adding moderate aerobic exercise during Ramadan fasting helps overweight adults lose more fat and improve heart health compared to fasting alone. Twenty-eight participants were split into two groups: one only fasted, the other fasted and exercised fiv…

This study tested whether adding omentopexy — stitching the omentum to the stomach — during sleeve gastrectomy changes stomach shape and emptying. Thirty-six adults having weight-loss surgery were randomly assigned to get the extra stitch or not. Researchers measured stomach angl…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at how eating a high-fat diet for 5 days affects inflammation in older adults (ages 50-79) with normal weight or obesity. Researchers measured blood markers and gut bacteria to see if a high-fat diet causes more inflammation than a low-fat diet. The goal was to …

This study tested whether a protein from amaranth (a plant) could change the gut bacteria in children with overweight or obesity. 56 children took part, and researchers measured their gut bacteria and blood markers. The goal was to learn more, not to treat or cure the condition.

This study looked at whether cycling in a cool room versus a warm room changes how much fat overweight women lose. Thirty women rode a stationary bike three times a week for three months. Researchers measured body fat, waist size, and blood markers to see if temperature makes a d…

This pilot study tested three simple ways to encourage blood sugar screening in 102 overweight or obese adults without known diabetes: a text message, a patient portal message, or a mailed letter. The goal was to see which method was most acceptable and effective at getting peopl…

This study looked at how a peanut-based meal affects inflammation and appetite in 17 older adults who were overweight. Participants ate either a high-saturated-fat meal or a peanut meal rich in healthy unsaturated fats. Researchers measured blood markers of inflammation and hunge…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Vietnam. The program included monthly lessons, videos, and support to improve eating habits and physical activity. Researchers compared these children to a control group to see i…

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study tested whether a 6-month high-intensity functional training program is feasible and helpful for overweight or obese adults with long-term mobility disabilities. Twenty-five participants did exercise sessions three times a week. The goal was to see if the program could …

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This study looked at 78 people with severe obesity who had sleeve gastrectomy surgery. Researchers wanted to see if the balance of two hormones, adiponectin and leptin, in the blood could predict how much weight they would lose. The goal is to help doctors decide who will benefit…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This completed trial compared two types of opioid-free anesthesia—total intravenous (TIVA) versus inhaled gas—in 280 adults undergoing laparoscopic bariatric surgery. The main goal was to see which method reduces postoperative nausea and vomiting in the first 24 hours. Researcher…

This study looked at 80 people with severe obesity who had sleeve gastrectomy surgery. Researchers measured a blood protein called resistin before surgery to see if it could predict how much harmful internal belly fat patients would lose. The goal is to find a simple blood test t…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study looked at how babies suck on bottle nipples with different hole sizes. Researchers wanted to see if mothers who lost weight before pregnancy had babies with different sucking patterns. Ten mothers and their infants took part. The goal was to learn more about infant fee…

This study tested whether health data can be collected remotely from adults with overweight or obesity using a smartphone app and connected devices like a watch and scale. 146 participants took part for 24 weeks without any study medicine. The goal was to learn how to run future …

This study tested a new computer algorithm that uses data from wearable sensors and food diaries to predict a person's real-time risk of developing prediabetes. 77 overweight or obese adults wore glucose monitors and fitness trackers for 4 months. The goal was to collect data to …

This study looked at whether a ketone supplement drink can change appetite-related hormones in adults with and without obesity. Twenty-six people took part, each receiving the ketone drink on one visit and a placebo on another. Researchers measured hunger and fullness hormones be…

This study looked at whether body contouring surgery (like tummy tucks) after weight loss surgery helps people keep the weight off and affects metabolism. Researchers measured weight and certain blood markers in 60 adults before and after body contouring. The goal was to see if r…

This completed online trial tested whether adding Nutri-Score labels (A to E, like a nutrition grade) to delivery app menus helps people choose healthier meals. 870 adults who regularly use food delivery apps made hypothetical meal choices in a simulated app. The study compared t…

This completed observational study from Karolinska Institutet looked at 312 children and teens with obesity who used a digital treatment tool called Evira at home. Researchers checked their medical records to see if any developed signs of disordered eating or were diagnosed with …

This study looked at 90 children and teens (ages 7-18) taking antipsychotic medication to see how it affects their hormones, growth, and metabolism. Researchers measured prolactin levels and checked for links to sex hormones, metabolic health, and puberty development. The goal wa…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study looked at whether 3 weeks of alternate-day fasting (eating normally one day, fasting the next) changes how the heart uses fuel compared to a typical Western diet. Sixteen overweight adults aged 55-70 with insulin resistance underwent PET scans and lab tests after each …

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This study looked at 720 Indian teenagers aged 14-16 to understand how their weight (normal, overweight, or underweight) relates to their mental strength, eating habits, physical activity, and overall quality of life. Researchers surveyed students and their parents in Kolkata sch…

This study tested whether sodium phenylbutyrate can lower levels of branched chain amino acids (BCAAs) in the blood of obese and prediabetic men. High BCAAs are linked to insulin resistance and type 2 diabetes. Researchers also looked at how the drug affects blood sugar, insulin …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutritional counseling and physical activity. The program included three diet workshops and weekly exercise sessions. Researchers an…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at how salt affects blood pressure in Black adults. Researchers wanted to see if changes in blood pressure from eating more or less salt were linked to signs seen on medical scans. 19 people took part, and the goal was to learn more, not to test a new treatment.

This study looked at how physical activity relates to quality of life and mental health in 38 adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track sitting, standing, and movement. The goal was to see if simply monitoring activity coul…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study looked at how weight loss from a calorie-restricted diet affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet. The goal was…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindfulness program, both, or neither. The goal was…

This study tested whether a specially designed storybook could improve nutrition habits in 70 healthy children aged 5-6. Researchers measured snack choices (fruit vs. cookies) before and after the storybook program. The goal was to see if storytelling can encourage healthier eati…

This completed study collected neck tissue, blood, and urine from 34 adults having neck surgery. The samples are stored in a central bank for researchers to study obesity and diabetes. The goal is to help scientists learn more about these conditions and find new ways to predict, …

This study looked at how a 12-week exercise program affects body composition and metabolism in women who had sleeve gastrectomy surgery at least 3 months earlier. Twenty women participated, doing either aerobic exercise alone or a mix of aerobic and strength training. The goal wa…

This study examined 160 children aged 8 to 10 who were overweight or obese and had signs of smartphone addiction. Researchers measured their sleep habits and body mass index to see if these factors were connected. The goal was to understand the relationship, not to test a treatme…

This study looked at whether exercising in the afternoon versus the morning makes a difference in blood sugar levels for people with pre-diabetes. Fifteen overweight adults aged 40-75 completed a 12-week high-intensity interval training program. The main goal was to see if aftern…

This study aims to understand why some people gain or lose weight more easily than others. Researchers will measure how the body's energy use changes during overeating and dieting in 83 healthy adults. Participants will stay in the hospital for 10 weeks, undergoing tests like met…

This study looked at whether a special weight-based dose of the antiviral drug acyclovir works properly in people with obesity. Researchers enrolled 13 hospitalized patients (10 obese and 3 non-obese) who were already receiving acyclovir as part of their care. They took blood sam…

This completed study looked at how different lying positions affect air and blood flow in the lungs of 40 healthy volunteers—half with obesity and half without. Using a non-invasive imaging tool called electrical impedance tomography (EIT), researchers measured how well ventilati…

This completed study looked at how well doctors can detect serious and non-serious side effects of the weight-loss drug Saxenda (liraglutide) in 27 Mexican patients with obesity. The main goal was to track cases of pancreatitis and other possible drug reactions. Patients took Sax…

This study looked at 76 children aged 8-10 from rural areas to understand why some stay at a healthy weight despite being surrounded by obesity risks. Researchers measured brain activity, eating habits, and body fat to see how kids learn from food cues. The goal is to find factor…

This study tested new paper and electronic checklists that help people describe the foods in their home. The goal was to see if these tools are accurate and easy to use for English and Spanish speakers. 439 adults who do most of the grocery shopping for their home took part. The …

This study looked at how a 20% calorie-restricted diet changes metabolism in obese men of two age groups: 30-40 and 60-70 years old. Researchers measured fat breakdown at rest and during exercise, along with genetic markers in muscle and fat tissue. The goal was to understand if …

This study looked at how common weight-related health problems are in people of different weights in India, Pakistan, Philippines, and Vietnam. Researchers tracked 1,170 adults for about 2 years without giving any treatment. The goal was to understand which weight groups have mor…

This study looked at 44 adults with obesity to see if symptoms of hyperventilation (like rapid breathing and shortness of breath) are linked to physical performance. Participants completed walking, balance, and strength tests, and reported their breathing symptoms. The goal is to…

This early-stage study tested a single injection of petrelintide, a potential weight-management drug, in 48 adults with a BMI of 27 or higher. Researchers wanted to see if using different concentrations of the drug changed how the body processes it or affected safety. Participant…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the link between p…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 30 days could improve gut bacteria, weight, and heart health in 47 healthy adults aged 18-60. Participants were randomly assigned to receive the supplement or a placebo. The goal was to gather i…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study looked at how the drug topiramate works in teenagers with severe obesity. Researchers wanted to understand why some teens lose weight while others don't, by measuring drug levels in the blood. The goal is to eventually personalize dosing for better results.

This study looked at 470 adults aged 18-75 with type 2 diabetes and metabolic syndrome to identify their Traditional Chinese Medicine (TCM) patterns. Researchers used a standard questionnaire and four TCM diagnostic methods to classify each person's syndrome. The goal was to bett…

This study tested whether sending automated health tips via the LINE messaging app could help parents of obese children engage with weight management programs. Over 500 parents in Taipei were split into two groups: one got messages right away, the other after a delay. The study f…

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This study looked at how two common drugs—rifampin and itraconazole—change the way the body processes VCT220, a new medicine being developed for obesity. Thirty-two healthy adults took VCT220 alone and then with each of these drugs to see if their levels in the blood changed. The…

This completed study looked at 128 adults with obesity to understand how blood sugar levels, gut bacteria, and brain iron deposits are connected to thinking skills. Some participants followed a diet or had bariatric surgery, but the goal was to observe changes over one year, not …

This study checked how a new experimental drug for obesity, VCT220, interacts with three common medications (repaglinide for diabetes, rosuvastatin for cholesterol, and digoxin for heart conditions). Twenty-four healthy overweight adults took VCT220 alone and then with the other …

This study tested whether a substance called Lac-Phe, which the body makes during exercise, can reduce appetite and lower blood sugar in healthy overweight or obese adults. Twenty-three participants received either Lac-Phe or a salt solution on separate days, then ate a meal and …

This completed study looked at 61 adults to see if physical fitness, body composition, and diet are linked to gum disease severity. Researchers reviewed dental records and lifestyle questionnaires from a previous study. No new treatments were tested; the goal was simply to unders…

This study looked at what happens to the body when people with obesity stop following restrictive diets like calorie cutting or intermittent fasting. Researchers measured changes in mitochondria (the cell's energy factories) and gut bacteria in 84 adults over 24 weeks. The goal i…

This study looked at how a single dose of the drug VCT220 behaves in people with moderate kidney problems compared to those with healthy kidneys. Researchers measured drug levels in the blood and checked for side effects. The goal is to find the right dose for people with kidney …

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction…

This study tested whether a medical body composition scale (mBCA 555) could pick up early changes in body fat, muscle, and water balance in 41 overweight adults using L112 lipid-binding products. The goal was to find signs of progress that appear before the scale shows weight los…

This study used smartphone surveys and Fitbit trackers to figure out what causes people to slip up on their diet and exercise goals during a weight loss program. About 119 adults with overweight or obesity participated in a remote behavioral weight loss program. The goal is to us…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This completed study examined how diet influences inflammation and metabolism in 393 healthy and obese adults. Researchers measured immune cells, hormones, and other markers after participants ate a high-fat meal. The goal was to better understand the complex interactions between…

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured change…

This study looked at whether two different doses of dietary supplements (DIM and Perilla oil) delivered to the lower gut can reduce appetite and food intake in adults with obesity. Sixteen participants fasted, took capsules, and had blood tests and hunger ratings over 8 hours. Th…

This study looked at why obese people with asthma often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis to examine airway changes in 49 obese adults with asthma. The goal was to better understand the…

This completed trial compared pediatric and adult colonoscopes in 244 obese patients (BMI >30) undergoing screening colonoscopy. The goal was to see which scope reaches the cecum faster and more reliably without needing to switch devices. Results could help doctors choose the bes…

This study tested a web-based tool called WeDosify that helps doctors manage dosing of the weight-loss drug semaglutide for adults with overweight or obesity. Twenty participants who had recently started semaglutide used the tool over three months. The main goal was to see how ma…

This study looked at whether the environment where you exercise makes a difference. Fifty overweight women aged 60 and older walked for 10 weeks either in the scenic Yangshuo countryside or in a nursing home. Researchers measured changes in weight, body fat, mood, sleep, and stre…

This study looked at the genes of 2,500 people who had weight loss surgery (bariatric surgery). The goal was to find out if certain genes are linked to how well the surgery works and if those genes are more common in some ethnic groups. No new treatment was tested; instead, resea…

This study looked at over 21,000 people in Switzerland who had gastric bypass surgery for severe obesity. It compared two ways of connecting the stomach to the small intestine: using a linear stapler or a circular stapler. The goal was to see which method leads to fewer complicat…

This study looked at whether giving an antibiotic (piperacillin-tazobactam) as a longer infusion helps people with obesity reach the right drug levels in their blood. It included 45 hospitalized adults with a BMI of 30 or higher. The main goal was to see if a larger study is poss…

This study compared two types of gastric bypass surgery in 40 adults with obesity and type 2 diabetes. Researchers measured changes in gut hormones like GLP-1 to see which surgery better improves insulin resistance and diabetes. The goal was to understand how each surgery affects…

This completed Phase 1 trial looked at whether multiple doses of Survodutide, a weight-loss drug, change how the body absorbs and processes three common drugs: bupropion (an antidepressant), caffeine, and midazolam (a sedative). Thirty-four otherwise healthy adults with overweigh…

This study looked at whether using a face mask to help obese patients breathe during a short pause in anesthesia makes intubation safer. Over 700 patients with a BMI of 35 or higher took part. The goal was to see which method leads to fewer complications like low oxygen levels or…

This study looked at how stress influences eating and physical activity in African-American, Hispanic, and white teen girls aged 13-17. Researchers measured food intake after stress and non-stress sessions, along with BMI and activity levels. The goal was to understand why obesit…

This study tested whether a genetic score could predict how well adults with metabolic syndrome respond to a calorie-cutting diet. 115 Mexican adults followed a reduced-calorie diet for a period, and researchers measured changes in waist size, blood sugar, cholesterol, and blood …