When to add Weight-Loss pills? new study tests timing for teens

NCT ID NCT04007393

Completed Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 150 teens aged 12-17 with severe obesity to find the best time to add a weight-loss pill (phentermine) if lifestyle changes alone weren't enough. Participants first tried lifestyle therapy for 12 or 24 weeks, then those who didn't lose enough weight started the medication. The goal was to see how much their body mass index (BMI) changed over 48 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Phentermine
What this could lead to: If successful, this could show doctors the best way to combine lifestyle changes with medication to help teens with severe obesity lose weight more effectively.
What could go wrong: This is a small, early-phase study (Phase 2) with only 150 teens. The results may not apply to all teens, and phentermine can have side effects like increased heart rate or insomnia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADOLESCENT OBESITY

Contacts and locations

Locations

University of Minnesota

Minneapolis, Minnesota, 55414, United States

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