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Could a ketogenic diet reshape metabolism and thyroid health in women?

NCT ID NCT07775326

Disease control Sponsor: The Jerzy Kukuczka Academy of Physical Education in Katowice Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 25, 2026 · Updated 3 times

Summary

This trial tests whether a 12-week ketogenic diet—low in carbs and high in fat—can influence thyroid function and glucose-insulin metabolism in premenopausal women aged 30-50. Participants across different body weight categories will follow individualized meal plans, with blood tests measuring thyroid hormones, insulin, glucose, and other markers before and after the diet. The goal is to see if this eating pattern might improve metabolic health and thyroid activity in this population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ketogenic diet
What this could lead to
If successful, this could show that a ketogenic diet helps improve insulin sensitivity and thyroid function in premenopausal women, potentially offering a dietary strategy for weight and metabolic management.
What could go wrong
The trial is relatively short (12 weeks) and focuses on biomarkers, not long-term health outcomes. Individual responses may vary, and the diet may be hard to sustain or cause side effects like nutrient deficiencies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Mar 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Premenopausal status * No use of a specific diet, calorie-restricted diet, or food-elimination regimen during the preceding 12 months * Willingness to follow the prescribed ketogenic diet for 12 weeks * Provision of written informed consent Exclusion Criteria: * Postmenopausal status * Pregnancy or breastfeeding * Previously diagnosed thyroid disease * Thyroid hormone replacement therapy * Use of antithyroid medication * Use of other pharmacological treatments known to substantially affect thyroid function * Use of dietary supplements known to substantially affect glucose or lipid metabolism before enrollment * Use of pharmacological treatment for insulin resistance * Use of pharmacological treatment for dyslipidemia

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Conditions

The condition(s) this trial relates to.

Insulin Resistance obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin resistance Ketogenic diet Obesity & overweight Thyroid function

Contacts and locations

Locations

  • Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice

    Katowice, 40-065, Poland

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