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Can Weight-Loss surgery patients skip the opioids?

NCT ID NCT04240626

Symptom relief Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers at UC Davis are comparing two pain-control plans for women having weight-loss surgery. One group receives standard opioid-based care, while the other gets a mix of non-narcotic medicines with opioids available only if needed. The trial measures pain scores and how much opioid medication each group uses in the days and weeks after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A combination of gabapentin, hydromorphone, bupivacaine, and oxycodone used for pain control after bariatric surgery
What this could lead to
If the non-narcotic approach works, it could give patients having weight-loss surgery a way to manage pain with fewer opioids.
What could go wrong
This is a small Phase 4 study at one medical center, so the results may not apply to all patients or other hospitals. Some participants may still need opioid rescue medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

60 people

The number who actually took part.

Started

Jan 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women who undergo index weight loss procedures at UC Davis Medical Center * Women with a BMI =\>30 * Age from 35-65 * American Society of Anesthesiology (ASA) score of 3 or less * No previous history of prior abdominal/foregut surgery Exclusion Criteria: * Not having an index weight los surgery for obesity * Do not meet the NIH Standards for weight loss surgery * Additional planned or unplanned procedures during the index surgical procedure such as Cholecystectomy or extensive lysis of adhesions (\>30 minutes) * BMI \< 30 * Men * Women considering or currently planning on gender altering/modification * ASA score of 4 or higher * Patients less than 35 years of age or older than 65 years of age at the time of surgical consent * A history of open abdominal surgery including umbilical, ventral, or splengalic hernia repair with or without mesh implantation, transplant or vascular surgery or any foregut procedures including hiatal hernia repair or anti-reflux surgery * Arthritis, Fibromyalgia, chronic pain syndrome * Other conditions requiring daily use of oral pain medications * Prisoners * Allergy to Gabapentin

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Conditions

The condition(s) this trial relates to.

agnosia morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bariatric surgery candidate Obesity, morbid Surgery

Contacts and locations

Locations

  • UC Davis Health

    Sacramento, California, 95817, United States

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