Can we predict kidney damage in young diabetics before it starts?
NCT ID NCT05530356
First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time
Summary
This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease. The findings could help identify who is at risk and guide future prevention efforts.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Diagnostic agents (aminohippurate, iohexol, dextran) and imaging procedures (MRI, PET, kidney biopsy)
- What this could lead to
- If successful, this could reveal how kidney damage progresses in young people with type 2 diabetes, pointing to earlier detection and prevention strategies.
- What could go wrong
- This is an observational follow-up, not a treatment trial, so it won't directly test a therapy. The small sample and exploratory nature may limit how broadly the findings apply.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
-
57 people
The number who actually took part.
- Started
-
Sep 2022
- Finished
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Jun 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Population to be enrolled will be comprised of obese youth with and without T2D and lean controls who were previously enrolled in the Renal-HEIR (#16-1752) study.
- Ages
-
12 to 26 years
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Obese youth with and without Type 2 Diabetes + lean controls who were previously enrolled in the Renal HEIR Study * Participants who will undergo a PET Scan: ≥ 18 years Exclusion Criteria: * Anemia * Seafood, iodine, or penicillin allergy * Pregnancy * MRI Scanning contraindications (claustrophobia, implantable devices, \>550 lbs) * History of bleeding or clotting disorders, thrombocytopenia, warfarin and/or heparin use * Taking sulfonamides, procaine, thiazolsulfone or probenecid
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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