Could a higher oxytocin dose reduce C-Sections in obese women?

NCT ID NCT04760496

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving a higher dose of oxytocin (a drug that strengthens contractions) could lower the rate of C-sections in obese women having their first baby. Over 400 women took part, receiving either a standard or a higher dose during labour. The goal was to see if the higher dose helps labour progress better and reduces the need for surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Oxytocin
What this could lead to: If successful, this could lead to a simple change in oxytocin dosing to reduce C-sections in obese women during labour.
What could go wrong: This is a completed Phase 4 trial, but results may not apply to all hospitals or populations. Higher oxytocin doses also carry risks like excessive contractions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESE OXYTOCIN PRIMIPAROUS WOMEN

Contacts and locations

Locations

CHU d'Angers

Angers, France
CHU de Bordeaux (Pellegrin)

Bordeaux, France
CHU de Montpellier

Montpellier, France
CHU de Nimes

Nîmes, France
CHU de Poissy St Germain

Poissy, France
CHU de Saint Etienne

Saint-Etienne, France
CHU de Strasbourg (Centre Médico Chirurgical et Obstétrical)

Schiltigheim, France
CHU de Strasbourg (Hôpital de Hautepierre)

Strasbourg, France
Hôpital Bicêtre

Le Kremlin-Bicêtre, 94270, France
Hôpital Béclère

Clamart, France
Hôpital Cochin Port Royal

Paris, France
Hôpital Tenon

Paris, France

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