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Oxygen Face-Off: High-Flow nose tubes vs. BiPAP masks for safer intubation in obese patients

NCT ID NCT03106441

Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Obese patients with a BMI over 35 face higher risks when they need a breathing tube for surgery. This trial compares two ways to give extra oxygen beforehand: high-flow oxygen through a nose tube (Optiflow) and BiPAP through a face mask. Researchers will measure oxygen levels at the end of tube placement and track any complications. The goal is to see which method better prepares these patients for intubation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-flow nasal cannula oxygen therapy (Optiflow) versus BiPAP facial mask ventilation
What this could lead to
If high-flow nasal oxygen works better, it could become a standard way to prepare obese patients for breathing tube placement, possibly reducing low-oxygen episodes during surgery.
What could go wrong
This is a single-centre study of 100 patients, so results may not apply to all hospitals or patient groups. Both methods are already used in practice, and the difference in oxygen levels may turn out to be small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Jun 2017

Finished

Apr 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Obese patient with BMI \> 35kg/m2 * Age between 18 and 80 years * Requiring a crash induction sequence for oro-tracheal intubation. Exclusion Criteria: * Pulse oxymetry \< 90% in ambient air * Haemodynamic instability * Burned patient * Indication of intubation vigil in spontaneous ventilation * Patients with a documented Cormack IV exposition before inclusion * Protected adult * Pregnancy * Lack of consent * Patient already enrolled in an other randomized study looking forward improving preoxygenation quality. * Lack of French social protection

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Conditions

The condition(s) this trial relates to.

morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Severe obesity design as bmi > 35KG/M2

Contacts and locations

Locations

  • Nantes University Hospital, Hôtel Dieu, Medical intensive care unit

    Nantes, 44093, France