Hereditary disease

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This study tested a gene transfer treatment for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and affects movement, breathing, and other functions. Fourteen people aged 3 and older received a single injection of the treatment into the fluid around the …

This Phase 3 trial tests whether TAS-205, an oral drug, can improve movement and safety in people with Duchenne muscular dystrophy. It includes 104 participants, both those who can walk and those who cannot. The study compares TAS-205 to a placebo over 52 weeks.

This study tests whether aerobic exercise in simulated altitude (normobaric hypoxia) can improve body composition and metabolism in people with MASLD, a type of fatty liver disease. Twenty sedentary adults with MASLD will walk on a treadmill for 8 weeks, either in mild altitude o…

This study looks at the Bonebridge BCI 602, a bone conduction implant designed to help people with certain types of hearing loss. The trial will measure how well the device improves hearing and speech understanding one year after implantation, compared to not using it. It also tr…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This pilot study is testing whether a dietary supplement made from the tinder fungus can safely ease gut symptoms in adults with mild-to-moderate ulcerative colitis or Crohn's disease. Participants will drink the supplement and be monitored for changes in symptoms, inflammation m…

This trial asks whether taking magnesium oxide for three months before the fertility drug letrozole can improve ovulation rates in women with insulin-resistant polycystic ovary syndrome (PCOS). About 60 subfertile women aged 18–35 will either receive magnesium oxide followed by l…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This trial is testing an investigational drug called PF-06741086, given as a once-weekly injection under the skin, to see if it can reduce the number of bleeding episodes in people with severe hemophilia A or moderately severe to severe hemophilia B. The study includes both peopl…

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This trial tests a program called PD_Pal, where a specially trained nurse helps people with Parkinson's and their family caregivers create a personalized care plan. The plan covers current care, future needs, and end-of-life preferences, aiming to ensure that care matches what th…

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This study tests whether pulsed electromagnetic field therapy (PEMT) can improve swallowing function in people with cervicogenic dysphagia, a swallowing disorder caused by neck problems. Forty adults aged 50-60 with this condition will receive either real or placebo PEMT, along w…

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This early-stage trial is testing an experimental drug called APX005M in 32 children with brain tumors that have come back or are hard to treat, including a type of brain stem glioma. The drug works by activating the immune system to attack cancer cells. The main goals are to fin…

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This study tested a new type of artificial lens, called the AT ELANA 841P, for people having cataract surgery. 284 adults with cataracts in both eyes received either the new lens or a standard lens. Researchers measured how well patients could see at different distances and check…

This small safety trial tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area linked to Parkinson's motor symptoms. Seven people with advanced Parkinson's took part to see if the procedure is safe and might improve movement. The go…

This phase 2 trial tests a treatment called Lete-Cel, which uses a patient's own immune cells that have been specially trained to attack cancer cells. It is for people with advanced synovial sarcoma or myxoid/round cell liposarcoma whose tumors have a specific marker (NY-ESO-1) a…

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This study is testing whether upadacitinib, an oral medication, can safely and effectively manage Crohn's disease over the long term. Participants who completed a previous year-long study will continue taking the drug and be monitored for up to a year. The goal is to see if the d…

This study tested a gel called SGX302, which is activated by visible light, on 15 people with mild-to-moderate plaque psoriasis. The goal was to see if it could clear or nearly clear skin lesions over 18 weeks. The treatment is applied to the skin and then exposed to light, aimin…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This study tests whether doing a gum graft at the same time as placing a dental implant works as well as the traditional two-step approach. The goal is to increase the width of keratinized gum tissue around implants, which helps prevent inflammation and implant failure. Twenty-tw…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This trial is testing whether a piece of the patient's own eye tissue, called Tenon's capsule, can help close large or recurrent macular holes—tears in the center of the retina that can blur or distort vision. During standard vitrectomy surgery, the tissue is harvested and placed…

This trial tests whether eating oat-based porridge daily, alongside standard prenatal calcium and vitamin D supplements, can improve calcium and vitamin D levels in pregnant women with mild to moderate hypocalcemia. Researchers will measure blood levels at weeks 8 and 33 of pregn…

This trial is testing whether a higher dose of the fertility drug letrozole (10 mg) works better than the standard lower dose (5 mg) for stimulating ovulation in infertile women with polycystic ovary syndrome (PCOS). About 86 women aged 18-35 with PCOS will take one of the two do…

This trial investigates whether the method of inserting orthodontic miniscrews (self-drilling vs. self-tapping), along with patient sex and jaw location, influences the risk of complications like inflammation, pain, root damage, or screw failure. The study involves adults aged 20…

This trial follows women with polycystic ovary syndrome (PCOS) who take metformin, a standard diabetes medication, for six months. Researchers track changes in insulin resistance, iron levels, erythropoietin, cholesterol, and blood counts at three and six months. The goal is to s…

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This early-phase trial tests the safety and tolerability of a new drug called GRT6019 in 24 healthy men. Participants receive multiple doses over 4 weeks and are monitored for side effects and how the drug moves through the body. The goal is to see if GRT6019 is safe enough to st…

This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participa…

This early-stage trial tests a new drug called SG301, given as an injection under the skin every two weeks, for systemic lupus erythematosus (SLE). The study first gives a single dose to healthy volunteers to check safety, then gives multiple doses to people with lupus. The main …

This study tests a gene therapy (PF-06838435) for people with severe hemophilia B, a bleeding disorder. The therapy uses a harmless virus to deliver a working gene for clotting factor IX. Researchers are following 21 participants long-term to see if it is safe and reduces bleedin…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare genetic mutations not currently approved for this treatment. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin …

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This study looked at whether a custom-made hip spacer can help people with infected hip replacements. 25 patients had their infected hip implant removed and replaced with a temporary custom spacer, followed by antibiotics. After the infection cleared, they received a new permanen…

This trial tests whether eating dairy products can improve how the body uses insulin in overweight and obese adults with prediabetes. Participants will be randomly assigned to eat either limited dairy (1 serving or less per day), reduced-fat dairy, or regular-fat dairy for 12 wee…

This early-stage study tests the safety and how the body handles a new drug called VX-828, alone or combined with other CF medicines. It involves about 165 healthy adults and people with cystic fibrosis. The goal is to see if VX-828 is safe enough for further testing.

This trial compares two psychological treatments for obsessive-compulsive disorder (OCD): metacognitive therapy, which focuses on changing unhelpful thinking patterns, and exposure and response prevention, the current standard behavioral therapy. The study aims to see if metacogn…

This study tested a new daily medicine called ESK-001 in 862 adults with moderate to severe plaque psoriasis. The goal was to see if it reduces psoriasis severity and is safe, comparing it to a placebo and an existing drug (apremilast). Participants took the medicine for 24 weeks…

This study tested whether a new daily pill, ESK-001, can safely reduce psoriasis severity in adults with moderate to severe plaque psoriasis. Over 900 participants took either ESK-001, a placebo (dummy pill), or an approved psoriasis drug (apremilast) for 24 weeks. Researchers me…

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This phase 2 trial is testing an experimental drug called TransCon CNP in children with achondroplasia, a common form of dwarfism. The study aims to see if a once-weekly injection under the skin can safely improve growth, measured by height velocity over a year. Participants will…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This registry follows thousands of adults who undergo laparoscopic surgery for gastroesophageal reflux disease (GERD) or hiatal hernia. It compares two common procedures: fundoplication, which wraps part of the stomach around the esophagus to reinforce the valve, and the LINX dev…

This study tested a new oral medication called iptacopan in 34 adults with a rare disease called atypical hemolytic uremic syndrome (aHUS), which causes blood clots, low platelets, and kidney damage. The goal was to see if the drug could improve blood counts and kidney function w…

This trial tests whether a once-daily application of ARQ-151 cream 0.3% is safe and well-tolerated in children aged 2 to 5 with plaque psoriasis. Over four weeks, researchers measure how much of the drug enters the bloodstream and watch for any side effects or skin reactions. The…

This study tests whether wearing a continuous glucose monitor (CGM) alongside lifestyle changes can improve insulin sensitivity in teens aged 10-17 with prediabetes. Fifteen overweight or obese participants will use the Dexcom G7 device to see real-time glucose data, aiming to bo…

This study asks whether adding a medically supervised ketogenic diet to occupational therapy can help children aged 4 to 7 with ARX gene mutations and drug-resistant epilepsy. Twenty children will take part: half follow the ketogenic diet while the other half do not, and both gro…

This trial tests whether an experimental biosimilar called 9MW0311 works as well as the established drug Prolia (both containing denosumab) in postmenopausal women with osteoporosis who are at high risk for fractures. Participants receive either 9MW0311 or Prolia as an injection …

This clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different…

This study tests whether a specially designed mobile app can help women with Polycystic Ovary Syndrome (PCOS) improve their eating and exercise habits. About 92 women will either use the app or receive a pamphlet with advice. The goal is to see if the app leads to better weight m…

This early-phase trial tested a gene therapy for cystinosis, a rare genetic disorder that causes cystine crystals to build up in cells, damaging organs. Researchers took blood stem cells from 6 patients, added a working copy of the faulty gene, and infused the corrected cells bac…

This study looks at whether a procedure called endoscopic cardia banding plication (ECBP) can help people who still have severe heartburn and reflux after having a sleeve gastrectomy for obesity. The procedure narrows the opening between the stomach and esophagus using bands, wit…

This trial is testing whether a prebiotic supplement called 2'-FL, found in human milk, can safely ease gut symptoms in young people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Participants, aged 11 to 25, are in remission and already …

This phase 3 trial is testing a drug called setmelanotide in people with obesity linked to certain gene variants (POMC, PCSK1, LEPR, NCOA1, or SH2B1). About 296 participants, aged 6 to 65, will receive either the drug or a placebo to see if it helps reduce body weight. The study …

This trial is testing whether daily injections of recombinant human growth hormone can improve growth in children with achondroplasia, a genetic condition that causes short stature. The study will include children aged 2 to 10 who have not previously been treated with growth horm…

This phase 3 trial is testing whether a hydrocortisone acetate suppository, given once or twice daily, can safely and effectively treat ulcerative proctitis, a form of ulcerative colitis limited to the rectum. About 200 adults with active disease will receive either the active su…

This large Phase 3 trial tested an experimental oral drug called enlicitide decanoate (MK-0616) in nearly 3,000 adults with high cholesterol, including those with a genetic form. The goal was to see if the drug safely lowers 'bad' LDL cholesterol more than a placebo over 24 weeks…

This study tests whether a laser-guided system can mark the correct position for a toric intraocular lens more accurately than the traditional manual ink method during cataract surgery. The trial involves 30 patients with corneal astigmatism who are having femtosecond laser-assis…

This trial tests whether a standardized respiratory physiotherapy program, delivered in primary care over six months, can improve quality of life and key health measures in adults aged 40 to 74 with mild COPD. Participants are randomly assigned to either the physiotherapy program…

This trial tests whether a standardized ashwagandha (Withania somnifera) extract, combined with vitamin D and folate, can improve depression, stress, sleep, and metabolic health in women with polycystic ovary syndrome (PCOS). Participants will take either the ashwagandha blend or…

This study in Zambia evaluates whether dedicated 'viremic clinics'—where people with HIV who have high viral loads receive extra support from a team of healthcare providers—can improve viral suppression. The trial includes 548 participants aged 15 and older who have been on first…

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This trial tests whether a freezing balloon, called cryoballoon ablation, can safely and effectively remove non-cancerous but potentially precancerous growths (adenomas) in the duodenum, the first part of the small intestine. The study includes people with sporadic adenomas or th…

This trial tests whether a zero-profile anchored cage, used in anterior cervical discectomy and fusion, can improve outcomes for people with cervical degenerative disc disease. The study will enroll 30 adults aged 18-70 who have not had prior cervical spine surgery and whose symp…

This early-phase study tested whether adding fenofibrate to standard treatment (ursodeoxycholic acid) helps people newly diagnosed with primary biliary cholangitis, a chronic liver disease. Thirty adults participated to see if the combination could normalize liver enzyme levels a…

This early-stage trial is evaluating the safety and tolerability of an experimental drug called KP405, which is being developed as a potential treatment for Parkinson's disease. The study will first give single and then multiple doses to healthy volunteers, and later include peop…

This trial tests whether a single yogurt drink made from vegetable proteins rich in leucine, cysteine, and arginine can improve blood vessel function and reduce inflammation in older adults with cardiometabolic risk. Participants, aged 65 and older, will consume either the vegeta…

This study follows about 600 adults with Crohn's disease who are receiving ustekinumab (Stelara) as part of their routine care. The goal is to see how many achieve steroid-free remission after one year, using a standard symptom score. By including patients from both large researc…

This Phase III trial is testing an investigational biologic called LZM012 in adults with moderate-to-severe plaque psoriasis. The drug targets two inflammatory proteins, IL-17A and IL-17F, to potentially reduce skin symptoms. Participants will receive LZM012 injections, and resea…

This study tested whether community health workers can help Black postpartum patients who had preeclampsia or other pregnancy complications. 61 participants were split into two groups: one received usual care, the other also got support from a community health worker. The goal wa…

This early-stage trial tests the safety and tolerability of two experimental injectable drugs (capsid inhibitors) in 85 healthy adults. Participants receive a single dose or multiple doses of the drug or a placebo. The goal is to see if these drugs are safe enough to study furthe…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This study tested a drug called leuprorelin to control central precocious puberty, a condition where children start puberty too early. About 80 children received an injection every 12 weeks for 6 months. The goal was to suppress hormones that drive early puberty, helping children…

This study tests a drug called certolizumab pegol (Cimzia) in children aged 6 to 17 with moderate to severe plaque psoriasis. The goal is to see how the drug moves through the body and whether it is safe. Some children will get the drug, others a placebo. The study is active but …

This study tests whether a home eye-scanning device can improve care for people with wet age-related macular degeneration (AMD) who are switching to the medication faricimab. Participants will scan their own retinas at home several times a week, and the images will be sent to the…

This study tests whether a DASH diet—a plan rich in fruits, vegetables, and low-fat dairy—can help menopausal women with metabolic syndrome lose weight and improve health markers like blood pressure, cholesterol, and blood sugar. Researchers will also check if certain gene variat…

This study tests whether brivaracetam, taken as an oral solution, can stop absence seizures in people aged 2 to 25 with childhood or juvenile absence epilepsy. Participants receive either the drug or a placebo, and seizure freedom is checked using a 24-hour EEG after 14 days. The…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This trial tests whether the type of physical activity—resistance, endurance, or a mix—combined with a low-calorie diet can reduce belly fat and cardiovascular risk in people with metabolic syndrome. Adults aged 50-70 with metabolic syndrome are randomly assigned to one of three …

This clinical trial is testing whether two experimental oral medications, AD-224A and AD-224B, can safely lower blood pressure in people with essential hypertension (high blood pressure with no known cause). About 254 participants will take one of the drugs or a placebo once dail…

This study is testing the long-term safety of dasiglucagon, a drug given as a continuous injection under the skin, in children with congenital hyperinsulinism (a condition causing dangerously low blood sugar). The trial includes 42 children who completed earlier studies. Research…

This trial tests whether injecting platelet-rich plasma (PRP) — a concentrate made from a person's own blood — into the penile plaque can reduce curvature and ease symptoms in men with Peyronie's disease. Half the participants receive PRP injections and half receive a placebo (sa…

This Phase 3 trial tests whether an experimental oral drug, HPP737, can reduce psoriasis severity in adults with moderate-to-severe plaque psoriasis. Participants take HPP737 or an active control drug daily for 16 weeks. Researchers measure skin clearance using standard scores li…

This Phase 3 trial tests whether an oral drug called HPP737 can safely improve moderate-to-severe plaque psoriasis in adults. Participants take HPP737 or a placebo daily for 16 weeks, with doctors measuring skin clearance using standard scores like PASI. The study aims to see if …

This trial asks whether animated video lessons can help people with asthma or COPD manage their condition at home better than traditional paper brochures. Participants receive a home-based pulmonary rehabilitation program in either format, and researchers compare how well each gr…

This study tested two doses of bimekizumab, a drug that targets inflammation, in 41 adolescents aged 12 to 17 with moderate to severe plaque psoriasis. The main goals were to measure how the drug behaves in the body and to check its safety. Researchers also looked at how well it …

This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either pol…

This trial tests whether an oral drug called HPP737 can safely improve moderate-to-severe plaque psoriasis in adults. Participants take either HPP737 or a placebo daily for 85 days. Researchers measure skin improvement using standard scoring tools and track any side effects. The …

This study tested different treatments for autonomic dysfunction, including POTS, in 381 adults with Long COVID. It compared non-drug approaches and medications to see which best eased symptoms like rapid heart rate and dizziness. The goal was to find effective ways to manage the…

This clinical trial is testing whether an experimental eye injection called ONS-5010 (bevacizumab) can help preserve vision in people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study will compare ONS-5010 to an existing treatment, ranibiz…

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if reducing the amount of chemotherapy could still control the cancer while causing less damage to the immune system. Participants rec…

This study tests whether a high-dose probiotic (De Simone formulation) can lower bile acid levels in stool and improve diarrhea in people with bile acid malabsorption. Twenty-four adults will take the probiotic or a placebo for about three weeks. Researchers will measure changes …

This study follows adolescents and young adults (ages 12–21) with sickle cell disease who take hydroxyurea, a medication that helps prevent pain crises and other complications. The researchers are testing whether a mobile app called HU-Go can help these patients build a consisten…

This pilot trial tests whether a smartphone app called MED-Go can help adolescents and young adults with sickle cell disease take their daily hydroxyurea more consistently. Participants aged 12 to 21 will use the app for 12 weeks, and researchers will measure how often they log t…

This trial compares two common techniques for fusing bones in the neck after removing a damaged disc: using a piece of the patient's own hip bone versus a synthetic cage. The study includes adults aged 20-60 with a single-level disc problem in the lower neck. Researchers will che…

This trial tests whether ferric maltol, an oral iron supplement, can safely raise hemoglobin levels in adults with inflammatory bowel disease (IBD) who have iron deficiency anemia and have not responded to or cannot tolerate standard ferrous iron pills. Participants take either f…

This study tests whether adding a cinnamon-enriched cookie to standard treatment can improve cholesterol levels and liver function in adults aged 45-55 with high cholesterol. Participants eat one cookie daily alongside their usual therapy, and researchers track weight, BMI, lipid…

This trial investigates whether drinking pomegranate juice for 12 weeks can reduce gut inflammation in people with Crohn's disease or ulcerative colitis who are in remission. Participants will drink either pomegranate juice or a placebo beverage twice daily, and researchers will …

This trial tests whether taking a daily supplement of cornelian cherry fruit for six months can improve markers of heart, blood vessel, eye, and bone health in people with metabolic syndrome. Participants will receive either the cherry supplement or a placebo, and researchers wil…

This trial tests whether time-restricted eating (TRE) — limiting all food intake to an 8-10 hour daily window — can improve blood sugar control and metabolic health in people with metabolic syndrome or prediabetes. Participants are randomly assigned to either standard nutritional…

This trial tests whether a nasal spray containing bevacizumab, a drug typically used for cancer, can reduce frequent nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). The study enrolls 20 adults who have at least 10 nosebleeds per month. The goal is to see if…

This trial is investigating whether a targeted drug called CMC-544 (inotuzumab ozogamicin), given alone or later combined with rituximab, can control acute lymphoblastic leukemia (ALL) that has returned or not responded to standard treatment. The study enrolls adults and older ch…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial tests whether a home monitoring tool — combining daily lung function measurements and symptom surveys — can help doctors better manage cystic fibrosis patients who are waiting for a lung transplant. The tool sends data to the clinic, which may trigger earlier adjustmen…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This trial tests an experimental drug, BI 1291583, in adults with bronchiectasis who produce sputum and have a history of flare-ups. Participants are randomly assigned to one of three doses of the drug or a placebo, taken once daily for at least 24 weeks. The study measures how l…

This study explores whether romiplostim, a drug that stimulates platelet production, can safely and effectively help platelet recovery in children with thalassemia who receive a half-matched stem cell transplant. Researchers will track how quickly platelet levels rise, how many p…

This study tests whether a week of intensive therapy involving horses can improve motor skills, posture, and breathing in children with spinal muscular atrophy (SMA). Children with SMA types I, II, or III will receive either horse-assisted physiotherapy or standard individual phy…

This phase 2 trial is testing whether the chemotherapy drug temozolomide can shrink tumors in people with a rare type of gastrointestinal stromal tumor (GIST) that has a mutation in the SDH gene. Standard GIST treatments do not work for this subtype. Participants take temozolomid…

This observational study tests whether hetrombopag, a platelet-boosting drug, can safely speed platelet recovery in children with thalassemia who receive a half-matched (haploidentical) stem cell transplant. Thirty children aged 2 to 17 will be followed for 28 days after transpla…

This phase 2 trial tests whether a Chinese medicine formula called Inflammatory Skin Disease Formula (ISDF) can reduce the severity of plaque psoriasis, a common inflammatory skin condition. Adults with mild to moderate psoriasis will take either ISDF granules or a placebo twice …

This trial tests whether a single drop of timolol maleate, given just before Nd:YAG laser capsulotomy, can prevent a short-term rise in eye pressure. The study includes adults who developed clouding of the lens capsule months after cataract surgery. Half receive the timolol drop;…

This trial compares two common methods for placing a totally implantable vascular access device (TIVAD), a port used for chemotherapy and other treatments in cancer patients. Researchers are randomly assigning patients to have the port inserted via either the internal jugular vei…

This trial tests whether taking estradiol (a form of estrogen) for about 10 days before starting ovarian stimulation can help women with polycystic ovary syndrome (PCOS) have more synchronized follicle growth and better IVF outcomes. Sixty women with PCOS undergoing ICSI are rand…

This trial investigates whether injecting bleomycin directly into low-flow vascular malformations (abnormal clusters of blood or lymph vessels) in the head and neck can shrink them. Twenty participants will receive up to four sessions of the drug under local anesthesia. The main …

This trial tests whether a pharmacist, at the time of hospital admission, can review a patient's prescribed inhaler for insurance coverage and clinical appropriateness. The goal is to see if this simple check helps patients get the most cost-effective inhaler and reduces the chan…

This trial tests an experimental drug called HRS-5965 in people with primary IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug can reduce protein leakage in the urine, a sign of kidney damage. About 123 adults with confirmed IgA nep…

This trial tests a new replacement heart valve, the Neovasc Tiara, that is delivered through a small tube (catheter) inserted into the chest. It is designed for people with severe mitral regurgitation—a leaky heart valve—who are too high-risk for traditional open-heart surgery. T…

This trial investigates whether two common osteoporosis medications, denosumab and alendronate, can reduce liver fat and scarring in postmenopausal women who also have nonalcoholic fatty liver disease (NAFLD). The study will compare changes in liver fat and stiffness over 12 mont…

This trial investigates whether one month of daily vitamin E, folic acid, or both can improve hormone profiles and reduce symptoms like excess hair growth in women with polycystic ovary syndrome (PCOS). Researchers will measure changes in key reproductive hormones and a protein c…

This trial investigates whether an injection of ranibizumab, a drug that blocks abnormal blood vessel growth, can effectively treat aggressive posterior retinopathy of prematurity (AP-ROP) in premature infants. AP-ROP is a fast-progressing eye condition that can lead to retinal d…

Osteoporosis weakens bones and raises fracture risk, but the best exercise for building bone is unclear. This trial tests two supervised strength-training programs in adults aged 50 and older with low bone density. One group lifts at a moderate intensity (70% of their max), the o…

This study tests a custom helmet fitted with temperature and pressure sensors to monitor how long and how well it is worn by infants being treated for flat head syndrome (plagiocephaly or brachycephaly). The goal is to see if the sensors can accurately track wear time and detect …

This trial tests a new type of intraocular lens, the CT LUCIA 621P, designed to improve vision after cataract surgery. The lens has a special shape that may correct vision more precisely than standard lenses. Researchers will measure how well people see at distance and intermedia…

This phase 2 trial tests a personalized approach for people with newly diagnosed, advanced classical Hodgkin lymphoma. After two cycles of standard chemotherapy, patients are grouped based on a PET scan. Those with a moderate response receive the immunotherapy drug sintilimab plu…

This trial investigates how well a new multifocal intraocular lens, the AT ELANA, improves vision in people having cataract or refractive lens exchange surgery. About 69 participants will receive the lens in both eyes and be followed for 12 months to measure visual sharpness and …

This trial investigates whether people with knee osteoarthritis who also have a bowleg deformity (tibia vara) experience different pain relief after a partial knee replacement compared to those without the deformity. The study will measure medial knee pain using a standard pain s…

This phase 2 trial tests whether an experimental oral drug called TLL018 can improve skin clearance in adults with moderate-to-severe plaque psoriasis. Participants receive one of two doses of TLL018 or a placebo for 12 weeks. The main goal is to see if at least 75% of skin plaqu…

This study tests whether a specific diet, called the IBD-AID, can improve symptoms of inflammatory bowel disease (IBD) by changing the bacteria in the gut. Participants aged 15 and older with IBD will follow the diet for 8 weeks, with guidance from study staff and cooking classes…

This study examines how wearing Ortho-K contact lenses overnight changes the optical quality of the cornea in children and young adults aged 8 to 21 with mild to moderate nearsightedness and astigmatism. Participants wear the lenses for 8–10 hours each night, and researchers meas…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) to standard osteoporosis treatment can improve bone density in postmenopausal women. Participants are women aged 55 and older with osteoporosis who also have high cholesterol. The trial compares standard t…

This study investigates whether taking vitamin E supplements, at 200 mg or 400 mg per day, can reduce calcium oxalate crystals in people with kidney stones. Participants continue their usual medications while adding vitamin E. The goal is to see if this antioxidant can help manag…

This trial compares two surgical methods for repairing distal hypospadias, a birth defect where the urethral opening is on the underside of the penis. One technique is called glandular urethral disassembly (GUD), and the other is the tubularized incised plate (TIP) method. The st…

This study tests whether a personalized balance and strengthening exercise program can reduce falls in people with Parkinson's disease. Thirty-two participants are randomly assigned to start the program either right away or after a three-month delay. The program involves group se…

This trial investigates whether deep brain stimulation of the subthalamic nucleus can improve quality of life for people aged 70 and older with Parkinson's disease. Participants are randomly assigned to receive the stimulation or standard care. The study measures changes in motor…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This trial tests whether 3D-printed crowns work better than standard stainless-steel crowns for restoring damaged first permanent molars in children. The study will compare how well each crown holds up, its effect on gum health, and how satisfied children and parents are with the…

This study tests bempedoic acid, a cholesterol-lowering tablet, in children aged 6 to 17 with heterozygous familial hypercholesterolemia (HeFH), an inherited condition causing very high cholesterol. Researchers measure how the drug moves through the body and how well it lowers ch…

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This study compares two visual field tests used to monitor glaucoma: the current standard Humphrey Visual Field Analyzer and the newer iCare COMPASS. About 28 people with glaucoma or related eye conditions will take both tests in the same visit, with the order alternating between…

This study tests whether tissue taken during routine carpal tunnel release surgery can help diagnose amyloidosis, a condition where abnormal proteins build up in organs. People with bilateral carpal tunnel syndrome and certain risk factors—like age, heart issues, or family histor…

This study tests whether intestinal ultrasound can accurately detect pouchitis—inflammation of the internal pouch created after ulcerative colitis surgery. Adults who have had this surgery will receive an ultrasound, and the results will be compared to the standard pouchoscopy wi…

This study tests whether a modified action camera can take clear images inside the nose, compared to the standard large camera system. Forty adults with tearing or sinus issues will have both types of images taken during their routine exam. Doctors will rate the image quality to …

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This trial explores whether a standardized breakfast and a continuous glucose monitor can replace the traditional glucose drink test for diagnosing diabetes and prediabetes in people with Dunnigan's lipodystrophy, a rare genetic condition that causes severe insulin resistance. Th…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This study tests whether a 7-day adhesive ECG patch (MEMO Patch) can detect more heart rhythm abnormalities than a conventional 24-hour Holter monitor in adults who experience palpitations or dizziness. Participants wear both devices at the same time for the first day, then conti…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study is developing and testing a simple endoscopic classification to predict whether patients still have pathologic acid reflux after anti-reflux surgery (Nissen or Toupet fundoplication). Researchers are evaluating three key features seen during endoscopy—valve position, v…

This trial tests whether adding a low-dose propofol infusion during general anesthesia can prevent post-operative nausea and vomiting (PONV) in adults with a history of PONV or motion sickness. Participants receive either a hybrid approach (propofol plus sevoflurane) or propofol …

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications tha…

This trial tests whether a higher dose of nepafenac eye drops is better than a lower dose at preventing macular edema—a swelling of the central retina—after cataract surgery. Adults aged 18 to 60 scheduled for cataract surgery will receive either a 0.3% solution once daily or a 0…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tests whether taking a daily vitamin D supplement (4000 IU) can lower the chance of preeclampsia returning in pregnant women who have had it before. Researchers will randomly assign 146 women to receive either vitamin D or a placebo from enrollment until 36 weeks of pr…

This study tests a new type of lens implant (extended depth of focus IOL) for people with age-related cataracts. The lens is designed to provide clear vision at multiple distances, potentially reducing the need for glasses after surgery. About 220 adults will be randomly assigned…

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study tests whether a virtual reality (VR) mindfulness app can reduce anxiety before surgery and acute pain after surgery. Adults scheduled for surgery will use the VR headset for up to 25 minutes, and researchers will measure changes in anxiety and pain scores, as well as u…

This trial compares two exercise programs—stabilization exercises and corrective exercises—to see which better reduces pain, improves breathing, and corrects posture in office workers with upper cross syndrome. About 50 adults aged 24–40 who work long hours at computers will be r…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This study compared two types of ultrasound-guided nerve blocks (caudal block and dorsal penile block) to control pain after hypospadias repair in 62 boys aged 1-6 years. The main goal was to see how long it took before children needed extra pain medicine. The results could help …

This study tested short, digital exercises (called micro-interventions) designed to reduce distress and improve well-being in breast cancer survivors. 120 women who had been diagnosed with early-stage breast cancer in the past 5 years and had mild-to-moderate anxiety or depressio…

This study tests whether a low dose of oral ketamine can safely help with anxiety in people with pancreatic cancer. Twenty participants will receive both ketamine and a placebo at different times to compare effects. The main goal is to see if such a study is even possible, not to…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This study tested whether a computerized training program that targets emotional reactions can help relieve obsessive thoughts and compulsive behaviors in people with OCD. Five adults with OCD completed 14 training sessions over three weeks. The goal was to see if this approach c…

This trial tests whether giving trigger point injections—small amounts of numbing medication into tender neck muscles—shortly after anterior cervical surgery can reduce pain and the need for opioid painkillers. Patients undergoing elective anterior neck surgery are randomly assig…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This trial tests whether a specialized amino acid supplement designed for people with Parkinson's disease can improve nutrition without interfering with their dopamine medication. Researchers will compare this supplement to a store-bought whey protein supplement and an inactive p…

This study tests whether a single injection of nanofat—made from a person's own fat—can improve the appearance of atrophic scars caused by burns or trauma. Each participant has two similar scars: one gets the nanofat injection plus silicone gel, and the other gets only silicone g…

This study compares two non-invasive treatments—high-power laser and pulsed electromagnetic therapy—for reducing pain and improving nerve function in people with lumbar radiculopathy (sciatica from a herniated disc). Sixty participants aged 55-68 will receive one of the therapies…

This trial tests whether adding DIR/Floortime™—a play-based, relationship-focused therapy—to standard care can improve emotional development and everyday skills in children aged 4-12 with mild to moderate intellectual developmental disorder. Over 10 weeks, some children receive t…

This completed Phase 3 study tested whether BOTOX injections can safely reduce the appearance of a widened lower face caused by prominent masseter (chewing) muscles. About 207 adults with moderate-to-severe muscle prominence received either BOTOX or a placebo in both sides of the…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This trial tests whether watching a 30-40 minute augmented-reality animation that shows a child's journey through surgery can reduce anxiety in children aged 3-12 before adenotonsillectomy. Half the children will watch the animation before surgery, while the other half receives s…

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This study evaluates a new dermocosmetic cream containing 15% azelaic acid in people with mild-to-moderate acne. Researchers will observe how well the cream reduces acne lesions and improves skin discoloration, and how well it is tolerated, compared to standard treatments like or…

This pilot study explores whether adding improv comedy to standard cognitive behavioral therapy (CBT) can help adults with obsessive-compulsive disorder (OCD). Participants will take part in therapist-led group sessions that combine exposure and response prevention (ERP) with imp…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (tTIS) to see if it can improve motor symptoms in people with Parkinson's disease. 90 participants will be randomly assigned to receive either real stimulation targeting specifi…

This study tests two different home exercise programs designed to prevent falls in people with Parkinson's disease. Thirty participants will do one of the programs for six weeks, and researchers will measure changes in balance, walking, and fear of falling. The goal is to find ou…

This study tests a drug called bezisterim (NE3107) in 60 people with early Parkinson's disease who have not yet started standard treatment. The goal is to see if it can improve movement symptoms like stiffness and slowness. Participants take the drug or a placebo twice daily for …

This trial tests a 12-week smartphone-based program called PACT, which combines acceptance and commitment training with positive parenting advice, for parents of children with special health care needs. The goal is to see if it can improve parents' mental well-being, psychologica…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This trial tests whether two different kinesio taping techniques, combined with exercise, can reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. Participants will receive one of the taping methods or serve as a control, with measurements…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This study looks at whether auto-captioning glasses are easy and helpful for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses for 12 weeks and report their experience through surveys and interviews. The goal is to see if th…

This study explores whether listening to music after a cesarean section can help first-time mothers feel less pain and anxiety, and improve their breastfeeding success. Participants will be divided into groups, with one group listening to music and the other receiving standard ca…

This small study tested a non-invasive device called Transcranial Pulse Stimulation (TPS) in 14 people with Parkinson's disease. TPS uses sound wave pulses to stimulate the brain. Participants received 12 sessions over four weeks. Researchers checked if TPS safely improved moveme…

This trial tests whether adding breathing exercises to standard physiotherapy improves lung function, pain, and quality of life in people with thoracic discopathy, a condition affecting the upper spine. Forty participants will be randomly assigned to receive either 15 sessions of…

This trial tests whether using a virtual reality headset can reduce pain, improve comfort, and ease psychological symptoms in boys aged 6-12 after hypospadias surgery. Half the children will play a car racing game in VR for 15 minutes shortly after surgery, while the other half r…

This pilot study is testing whether a low-cost, portable driving simulator can help retrain driving skills in people who have had a stroke or who live with Parkinson's disease or multiple sclerosis. Participants will be randomly assigned to train on either the portable simulator …

This study tested a short, skills-based anxiety treatment for veterans in primary care. 177 veterans with anxiety symptoms were randomly assigned to either the new treatment or usual care. The goal was to see if the brief therapy reduces anxiety and improves daily functioning bet…

This trial tests a topical serum containing 0.5% salicylic acid in adults with acne-prone skin. Over eight weeks, participants apply the serum as directed and report changes in acne symptoms, skin texture, tone, and more. The study uses questionnaires and expert photo grading to …

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study in Japan looked at 32 children (ages 2 to under 18) with hereditary angioedema who received Firazyr injections for acute attacks. Researchers tracked side effects and how quickly symptoms resolved over 3 months. The goal was to gather real-world safety and effectivenes…

This study tested a robotic device called iotaSOFT that helps surgeons insert cochlear implants into the ears of children with hearing loss. Twenty children aged 9 months to 12 years took part. The goal was to see if the robot is safe and works well. Researchers tracked any probl…

This trial compares three approaches for people dealing with hair fall and premature graying: a polyherbal hair oil, a minoxidil 5% hair serum, and a combination of both. About 99 healthy adults aged 18 to 55 with noticeable hair fall will apply their assigned product to the scal…

This study tests a new liquid drug called HBI-002, which contains carbon monoxide, in 9 people with sickle cell disease aged 14 to 55. Participants take the drug daily for 14 days to see if it is safe and helps with symptoms. The goal is to find a better way to manage this painfu…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This small pilot study tests a smart shoe called NUSHU that provides gentle vibrations to see if it can help people with Parkinson's disease walk faster. Sixteen participants will complete two short walking tests—one with the vibration on and one without—to compare their speed, s…

This study tests whether a mobile app can help people with gastroesophageal reflux disease (GERD) reduce symptom recurrence and improve sleep quality and quality of life. Participants with confirmed GERD will be randomly assigned to either use the app—which provides education, li…

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This study tests whether pain neuroscience education (PNE) can improve symptoms in people with mild to moderate carpal tunnel syndrome. Participants will receive PNE along with standard home exercises and a wrist splint. The goal is to see if understanding pain better leads to le…

This trial tests whether NOBO, a deodorant spray made from a yeast fermentation product (a postbiotic), can reduce underarm odor in healthy adults aged 18 to 70. Each participant applies NOBO to one armpit and a placebo to the other, then rates the odor themselves. The goal is to…

This study tested a drug called sebetralstat in 36 children aged 2 to 11 with hereditary angioedema (HAE) types I or II, a condition that causes sudden, painful swelling. The goal was to see if the drug is safe and how well it works to relieve attacks. The trial was open-label, m…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This trial tests whether ultrasound therapy, nerve gliding exercises, or a combination of both can reduce pain and improve hand function in people with mild-to-moderate carpal tunnel syndrome. Participants will be randomly assigned to one of three groups: ultrasound alone, nerve …

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This trial tests whether a mindfulness-based neurofeedback program can help racial and ethnic minority college students reduce performance anxiety and improve academic performance. Participants practice mindfulness meditation while a device monitors their brain activity and provi…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study tested whether acupressure—a technique using gentle pressure on specific points on the body—can reduce anxiety, embarrassment, and fear in people undergoing a bladder function test called urodynamics. Sixty-eight adults were randomly assigned to receive either acupress…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the real surgery. About 260 adults scheduled for cataract surgery will either use VR glasses to experience the sights and…

This study tests whether wearing virtual reality glasses during a cystoscopy—a procedure to look inside the bladder—can reduce pain and anxiety. Half of the participants will use VR while the other half receives standard care. The trial aims to see if VR can make the experience m…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the actual surgery. Sixty adults scheduled for cataract surgery will either watch the VR video or receive standard care. …

This study tests whether wearing virtual reality goggles that show calming nature scenes with music can reduce pain, anxiety, and changes in heart rate and blood pressure during urodynamics, a procedure that checks how well the bladder works. Half of the participants will wear th…

This trial tests a computer-based tool called PAINRelieveIt for adults with sickle cell disease, a condition that causes intense pain episodes. The tool has three parts: one helps patients report their pain, another educates them about pain management, and a third helps doctors c…

This study tested whether a rehabilitation program that combines physical balance exercises with mental tasks (like counting or decision-making) improves balance more than standard physical therapy alone in people with Parkinson's disease. Sixty participants with early-to-moderat…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This study tested a facial moisturizer in 47 people with mild to moderate acne over 4 weeks. Researchers checked skin dryness, redness, and overall appearance, and participants reported how their skin felt. The goal was to see if the moisturizer is gentle and helpful for acne-pro…

This study tests whether a four-week mindfulness program can reduce symptoms of depression, anxiety, and stress in college students in Guangzhou, China. Participants are randomly assigned to either the mindfulness training or a health education control group. The study also looks…

This trial tests whether adding kinesio taping to a standard exercise program helps people with carpal tunnel syndrome more than exercise alone. Carpal tunnel syndrome happens when the median nerve is compressed at the wrist, causing pain, numbness, and weakness. Participants wil…

This trial tests whether injecting a local anesthetic called bupivacaine under the chest muscle during breast reduction surgery can lower pain and reduce the need for narcotic painkillers afterward. About 52 female patients aged 13 to 25 will be randomly assigned to receive eithe…

This study explores whether an AI-powered chatbot can deliver personalized sleep coaching to Black/African American adults aged 18-25 who have poor sleep and at least one cardiometabolic risk factor. The chatbot uses principles of cognitive-behavioral therapy for insomnia (CBT-I)…

This trial compares two types of lasers—fractional carbon dioxide and long-pulsed Nd:YAG—to see which works better for keratosis pilaris, the rough bumps often called 'chicken skin.' People aged 13 and older with keratosis pilaris on both upper arms will receive each laser on a d…

This trial tests whether watching an entertaining video through virtual reality glasses or on a tablet can reduce pain, anxiety, and fear in children aged 7 to 12 during intravenous (IV) cannulation in an emergency department. Children are randomly assigned to one of three groups…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This trial investigates whether structured tango therapy can improve motor function, balance, and quality of life in people with mild to moderate Parkinson's disease. Participants are assigned to tango sessions, a standard motor reconditioning program, or a control group. Over th…

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This study investigates how easy or hard it is for adults with inflammatory bowel disease (IBD) to follow three different eating plans: intermittent fasting, the Mediterranean diet, and the low FODMAP diet. Researchers will interview participants to understand what helps or hinde…

This study looks at how satisfied people are with their vision six months after having WaveLight Plus LASIK surgery to correct nearsightedness. It also measures vision sharpness and how the surgery affects daily life. Sixty participants will fill out questionnaires and have their…

This trial tests whether injecting botulinum toxin into the fingers can improve blood flow and temperature in people with Raynaud's phenomenon that has not responded to standard treatments. Participants are randomly assigned to receive a placebo, a low dose, or a higher dose of t…

This trial compares Botox injections with ibuprofen pills to see which better eases jaw muscle pain and improves quality of life in people with sleep bruxism (teeth grinding). Forty adults with jaw pain are randomly assigned to receive either Botox injections into the masseter an…

This trial tests whether stem cells from children's shed baby teeth can replace the standard hip bone graft for repairing a cleft in the upper jaw. Twenty children aged 7 to 12 with cleft lip and palate will receive either the stem cell graft or a traditional bone graft from thei…

This phase 2a trial tests whether an experimental oral drug called PORT-77 can lower levels of protoporphyrin IX (PPIX) in the blood of adults with erythropoietic protoporphyria (EPP). People with EPP experience severe pain and skin reactions after even brief sun exposure. The st…

This trial tests whether distraction techniques—like drawing, reading a story, watching a cartoon, or using a toy nebulizer and mask—can lower fear and anxiety in children aged 3 to 6 during inhalation therapy for respiratory infections. Children are randomly assigned to one of t…

This trial tests whether a 4-week progressive muscle relaxation (PMR) program can reduce psychological stress and improve bowling speed and accuracy in male cricket medium-fast bowlers aged 18-25. Participants are assigned to either PMR sessions before warm-ups or standard traini…

This trial investigates whether transcranial magnetic stimulation (TMS) can help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Participants first receive standard TMS to the motor cortex; those who don't imp…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial investigates whether a 20-minute virtual reality nature scene or the Benson Relaxation Technique can lower anxiety and increase happiness in adults who have recently had bariatric surgery. Participants are randomly assigned to one of two groups or a control group, and …

This trial tests whether moving specific wrist bones (scaphoid, lunate, triquetrum) one by one relieves carpal tunnel symptoms better than moving the whole wrist. Adults aged 30–60 with at least two months of mild-to-moderate carpal tunnel syndrome are randomly assigned to one of…

This early trial is testing whether drinking a wild blueberry powder mix every day for 8 weeks can improve walking, balance, and other movements in people with Parkinson's disease. Twenty-four adults aged 50–89 with mild to moderate Parkinson's will receive either the blueberry d…

This study tests whether a device called oscillatory positive expiratory pressure (OPEP) therapy can reduce cough symptoms and improve lung mechanics in people with COPD. Participants use the device at home twice daily for four weeks. Researchers compare lung function and symptom…

This study tests two online programs for people with mild to moderate anxiety or depression who are not already in therapy. One program focuses on five daily behaviors linked to better mood, while the other uses a forgiveness process to address relationship issues. Participants c…

This trial tests whether JASPER, a play-based behavioral intervention, can improve social communication and play skills in infants (12–36 months) with tuberous sclerosis complex (TSC). Caregivers learn strategies during daily and weekly sessions to support their child's developme…

This trial tests whether wavefront-guided LASIK, set to create monovision in one eye for near vision and the other for distance, can improve vision and reduce the need for reading glasses in people with presbyopia. About 219 participants aged 40 and older with mild to moderate ne…

This trial compares two rehabilitation approaches for people with Parkinson's disease: whole-body vibration therapy and proprioceptive neuromuscular facilitation (PNF) patterns combined with rhythmic-based training. The goal is to see which method better improves balance, walking…

This phase 3 trial is testing an experimental drug called linerixibat against a placebo in about 238 adults with primary biliary cholangitis (PBC) who suffer from moderate to severe itching. The goal is to see if linerixibat can reduce itch severity and improve quality of life ov…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This trial tests whether a four-week home-based strengthening program can improve how calf muscles handle energy in people with Parkinson's disease. Using magnetic resonance spectroscopy, researchers will measure muscle metabolism before and after the program. The study includes …

This trial tests a school-based counselling program called Knowledge Insight Tools (KIT), which is based on cognitive behavioural therapy (CBT). It is designed for secondary school students aged 11-18 who are struggling with anxiety and low mood. Participants first go through a w…

This study tests PAfitME™, a telehealth program that uses personalized motion exergames to help young adult cancer survivors (ages 18–39) improve their physical function. The program is tailored to each person's fitness level, fatigue, and pain. Researchers will see if it is feas…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tests whether playing a recording of a mother's heartbeat, breathing, and chest vibrations to her newborn during phototherapy for jaundice can reduce maternal anxiety and stress. Forty mothers and their full-term newborns will take part, with half receiving the heartbe…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study looked at how fat-carrying particles called lipoproteins work in healthy people and those with high cholesterol or other lipid disorders. Researchers injected tiny, safe amounts of radioactive lipoproteins to track them in the body. The goal was to better understand ho…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study is building an international registry of people with GNE myopathy, an ultra-rare muscle disease that causes progressive weakness and often leads to wheelchair use. Participants will complete online questionnaires about their symptoms, medical history, quality of life, …

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study is observing 66 pregnant women at high risk for preeclampsia to see if changes in their platelets (blood cells involved in clotting) can predict pregnancy complications. Researchers will collect blood samples before and after starting daily low-dose aspirin. The goal i…

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This study investigates whether using a lower, more natural eye pressure during cataract surgery reduces trauma to the cornea compared to traditional high-pressure methods. The Active Sentry device helps maintain stable pressure by sensing changes in the eye. Researchers will mea…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study looks at whether adults aged 70 and older with multiple chronic conditions (but no heart disease) can safely stop taking statins. Researchers are comparing those who continue statins to those who stop, tracking deaths and major heart events over 2-4 years. The goal is …

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study asks whether pioglitazone, a widely used diabetes medication, might reduce bone density in people with type 2 diabetes. Researchers will compare bone mineral density and bone turnover markers in adults aged 30-55 who take pioglitazone versus those who do not. The goal …

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This trial asks whether the barbell back squat or the barbell hip thrust is better for building glute muscle and strength. About 39 young, untrained adults will train twice a week for nine weeks with one of the two exercises. Researchers will measure muscle size with MRI and stre…

This study aims to understand how ultra-processed foods affect energy metabolism compared to unprocessed foods. Healthy adults aged 18-60 will stay at a research center for four weeks, eating different diets each week. Researchers will measure how much they eat, their metabolic r…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study looked at whether certain blood markers of inflammation and vitamin B12 levels are linked to carpal tunnel syndrome. Researchers compared 70 people with and without the condition. The goal was to see if these markers could help explain why some cases are more severe.

This study collects information from about 889 people with inherited retinal diseases (IRDs) to understand how vision changes over time. Participants have their eyesight and visual field tested regularly. The goal is to learn more about the natural course of these rare eye condit…

This trial investigates whether the shape of the gum flap lifted during wisdom tooth removal affects blood flow to the nearby tooth and gum tissue. Participants are healthy adults aged 18 to 40 with one impacted lower wisdom tooth. They are assigned to one of two flap designs: a …

This study is testing whether an artificial intelligence system can more accurately classify small bowel Crohn's disease and predict how patients will fare over the next year. Researchers will analyze existing CT or MRI scans from 437 patients, combining imaging features with cli…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study looks at how IgA nephropathy, a kidney disease, is actually treated in the United States. By analyzing medical records from thousands of patients, researchers aim to understand which therapies are used, in what order, and for how long. The goal is to see how current tr…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looks at how children over age 3 with pyridoxine-dependent epilepsy, a rare genetic condition, develop cognitively over time. Researchers will use a standardized questionnaire called Vineland II to measure adaptive behaviors like communication and daily living skills. …

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This trial asks whether a single tablet combining three HIV medications (ACC017, emtricitabine, and tenofovir alafenamide) is absorbed by the body just as well as taking the same drugs separately. Healthy adult volunteers will receive both versions in a random order under fasting…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study tests a gene therapy technique in the lab using skin cells from people with Huntington's disease. The goal is to see if the therapy can correct the genetic mistake that causes the disease. If it works in these cells, it could be a step toward a future treatment.

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study aims to understand why some parents of children with sickle cell disorder (SCD) may not engage with health services during the first year after diagnosis, and to co-design strategies with parents and health professionals to improve support accessibility. The research i…

This study compares three different methods for prescribing eyeglasses in people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The goal is to see if the best method depends on the shape of the cornea, as measured by corneal topography. Res…

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study looks back at the medical records of over 1,000 people hospitalized with inflammatory bowel disease (IBD) in China. The goal is to understand the features, treatments, and outcomes of patients whose IBD does not respond well to standard therapies. By analyzing real-wor…

This study looked at what happens in the blood of people with sickle cell disease during painful attacks. Researchers compared blood samples taken during a pain crisis to samples taken when participants were feeling well. The goal was to learn more about the role of inflammation …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study observes 1006 adults with ulcerative colitis or Crohn's disease in Brazil who are taking or have taken vedolizumab. Researchers will look at how long patients stay on the drug and what other treatments they used before. No new treatment is given—this is just a review o…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study investigates whether brain signals can be recorded at home in people with essential tremor who have a deep brain stimulation (DBS) device. The goal is to see if these recordings are clear enough to understand how the brain responds to stimulation during rest and moveme…

This study looks at how smoking and gum disease (periodontitis) affect certain proteins and genetic markers in the body. Researchers will compare these markers in smokers and non-smokers with and without gum disease, before and after a standard deep-cleaning treatment. The goal i…

This trial investigates whether gluten consumption affects digestive comfort, quality of life, and physical performance in non-celiac athletes who train intensively. Participants, who are healthy and free of digestive diseases, will be randomly assigned to a gluten-containing or …

This study investigates whether measurements from eye imaging devices can predict the tilt (misalignment) of an artificial lens implanted during cataract surgery. Researchers will use OCT and Scheimpflug cameras to measure the eye before and after surgery in about 110 adults. The…

This study aims to find out whether bright light or meal timing is the main signal that resets the body's internal clock. Researchers will expose 48 healthy adults aged 18-30 to different combinations of light and meal schedules in a controlled setting. They will measure changes …

This study is testing whether a specific gene variant (MC4R rs17782313) and metabolic health status influence how men with obesity respond to a 12-week exercise and diet program. Forty men aged 18 to 59 with obesity will be classified as having metabolically healthy or unhealthy …

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This observational study explores whether data from everyday smartwatches and smartphones can be used to remotely assess the health-related quality of life of people with Parkinson's disease. Researchers will develop an algorithm, called the Q-index, based on passively collected …

This study checks how well a small, wearable heart monitor (Zio monitor) works when worn for up to 30 days. About 150 adults will wear the device to see how long it stays on, how much usable heart data it records, and if it causes any skin irritation. The goal is to make sure the…

This study aims to understand how inflammation and the dominance of mutant blood cells drive VEXAS syndrome, a rare and severe autoinflammatory disease. Researchers will analyze blood and bone marrow samples from VEXAS patients and healthy controls to identify key mechanisms and …

This study follows 103 adults with a genetic eye condition called retinitis pigmentosa caused by EYS mutations. Researchers will track changes in vision and eye structure over 4 years. The goal is to better understand how the disease progresses so that future clinical trials can …

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study followed 50 adults with a C9ORF72 gene mutation that can cause ALS or frontotemporal dementia. Over three years, researchers measured changes in strength, thinking, memory, and behavior using brain scans, spinal fluid tests, and other assessments. The goal was to under…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study investigates how Parkinson's disease affects exercise capacity and muscle oxygenation. Researchers will compare Parkinson's patients with healthy adults on tests of walking, arm movement, and muscle oxygen use. The goal is to better understand the physical limitations …

This trial compares three orthodontic techniques for pulling the upper front teeth backward in adults with Class II malocclusion. All methods use small temporary screws for anchorage, but they differ in bracket design and archwire setup. The goal is to see which approach causes t…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study compares three ways of delivering genetic counseling to adults with inherited heart conditions. Some participants get counseling before testing, others get it after, with or without a required phone call. The goal is to see which approach is most efficient and empoweri…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study looked at people with neurofibromatosis type 1 (NF1) to better understand how harmless tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Ten participants had MRI, PET scans, and tumor biopsies. Researchers tested whether a special PET scan (FLT PET…

This study looked at whether a simple test measuring how fast eyes recover in the dark can help track early to middle dry age-related macular degeneration (AMD). Researchers followed 217 adults aged 50 and older, with or without AMD, for up to 5 years. The goal was to see if chan…

This study looks back at medical records of people with two rare genetic conditions—ENPP1 deficiency and the early-onset form of ABCC6 deficiency—to map how these diseases progress over time. By collecting information on symptoms, imaging, and growth, researchers hope to better u…

This study follows boys with Duchenne muscular dystrophy who have small mutations in their genes, a group that is less understood than others. Over one year, researchers will use muscle MRI, genetic tests, and motor and respiratory assessments to see how the disease progresses. T…

This study looks for genetic changes linked to progressive familial intrahepatic cholestasis (PFIC) in adults with unexplained bile flow problems. Researchers will collect health information and blood samples from 150 participants across Spain during a single visit. The goal is t…

This study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This study follows 40 people with Friedreich's ataxia, a hereditary neurological condition that affects movement and speech, to see how their oral communication changes over one year. Researchers will assess speech clarity, voice quality, and hearing using speech therapy evaluati…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This trial tests whether trypan blue, a dye sometimes used to stain the lens capsule during cataract surgery, affects the number of corneal endothelial cells — the inner layer of the cornea that keeps it clear. Sixty adults aged 45 to 75 with age-related cataracts will be randoml…

This study investigates whether Parkinson's disease patients who carry a mutation in the GBA gene are more likely to experience cognitive decline after deep brain stimulation (DBS) surgery. Researchers will compare thinking and memory test results in 150 patients with and without…

This study tests whether a teaching approach called ARCS (Attention, Relevance, Confidence, Satisfaction) can improve nursing students' ability to perform cardiovascular physical exams. One hundred second-year nursing students will receive either standard training or standard tra…

This study tests whether a special camera called the OcuMet Beacon can detect stressed cells in the retina of people with geographic atrophy, an advanced form of age-related macular degeneration. Researchers want to see if the patterns of stress match areas of damage seen on stan…

This study follows people with cystic fibrosis who are taking a highly effective medication called elexacaftor/tezacaftor/ivacaftor (ETI). Participants use a mobile app to report their daily symptoms, medication use, and any changes in their health over 12 months. The goal is to …

Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine that can bleed, causing strokes, seizures, and headaches. This study follows people with an inherited form of CCM to identify factors—such as genetics, gut microbiome, and blood …

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This trial tests whether giving children aged 8–10 a daily supplement of lutein and zeaxanthin — nutrients found in leafy greens and eggs — can improve their attention, memory, and academic achievement over a school year. Half the children receive the supplement, while the other …

This study uses ultrasound to measure the hips of healthy newborns between 32 and 46 weeks gestational age. The goal is to create a growth chart showing normal hip measurements, which could help doctors better diagnose developmental dysplasia of the hip (DDH) in infants. Research…

This project creates a central repository of medical records, genetic test results, and patient-reported information from people with Duchenne or Becker muscular dystrophy, as well as carriers. Anyone aged 4 weeks or older with a confirmed diagnosis can join. The goal is to provi…

This pilot study tests whether a multi-ingredient whey supplement can reduce fructose malabsorption in healthy adults after hiking under heat stress. Eight participants will consume fructose and have their breath hydrogen measured as a marker of malabsorption, both before and aft…

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

Osteoporosis is a common complication after spinal cord injury, raising the risk of broken bones. This study surveys 94 adults with chronic traumatic spinal cord injury to measure their awareness of osteoporosis and identify factors — such as education level or healthcare visits …

Sickle cell disease can affect brain development even in very young children. This study uses eye-tracking—a simple, non-invasive method—to measure attention and processing speed in infants aged 6 to 24 months. The goal is to identify those at highest risk for cognitive challenge…

This study aims to discover new genes and mutations that cause isolated forms of amelogenesis imperfecta and dentinogenesis imperfecta—inherited conditions that affect tooth enamel and dentin. Researchers are using whole exome sequencing on participants who have these tooth disor…

This study investigates how specific fat molecules called diacylglycerols and sphingolipids inside muscle cells influence insulin resistance. Researchers will measure these lipids in different parts of muscle cells before and after weight loss or exercise in people with obesity, …