Blue dye under the microscope: could a routine cataract tool damage corneal cells?
NCT ID NCT07735000
First seen Jul 29, 2026 · Last updated Jul 31, 2026 · Updated 2 times
Summary
This trial tests whether trypan blue, a dye sometimes used to stain the lens capsule during cataract surgery, affects the number of corneal endothelial cells — the inner layer of the cornea that keeps it clear. Sixty adults aged 45 to 75 with age-related cataracts will be randomly assigned to receive either standard cataract surgery or surgery with the dye. The main goal is to compare corneal cell counts after surgery to see if the dye causes extra cell loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- trypan blue dye injected into the eye during cataract surgery
- What this could lead to
- If the dye is found to be safe for corneal cells, it could confirm its continued use in routine cataract surgery.
- What could go wrong
- This is a small, early-stage trial with only 60 participants, so results may not apply to all patients. The dye could potentially cause more cell loss than standard surgery.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Ophthalmology, Hayatabad Medical Complex, Peshawar, Pakistan
Peshawar, KPK, 25000, Pakistan
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