A Once-a-Week shot could transform hemophilia Care—Even for those with inhibitors

NCT ID NCT03938792

Completed Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial is testing an investigational drug called PF-06741086, given as a once-weekly injection under the skin, to see if it can reduce the number of bleeding episodes in people with severe hemophilia A or moderately severe to severe hemophilia B. The study includes both people who have inhibitors (antibodies that block standard factor replacement therapy) and those who do not. The goal is to compare this new approach to standard treatment and see if it offers better bleeding control, more convenience, and fewer bleeds.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-06741086, an investigational drug given as a weekly injection under the skin
What this could lead to: If successful, this could offer a more convenient and effective way to prevent bleeding episodes in people with hemophilia, including those who have developed inhibitors to standard treatments.
What could go wrong: This is a phase 3 trial, but it's still experimental. It may not work for everyone, and there are risks of side effects like injection site reactions, allergic reactions, or blood clotting issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hemophilia A hemophilia B Hemorrhage severe hemophilia A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMOPHILIA A HEMOPHILIA B

Contacts and locations

Locations

Acibadem Adana Hospital

Adana, 01130, Turkey (Türkiye)
Akdeniz University Medical Faculty

Antalya, 07060, Turkey (Türkiye)
Beijing Children's Hospital, Capital Medical University

Beijing, 100045, China
Centro Multidisciplinario para el Desarrollo Especializado de la Inv. Clínica en Yucatán, S.C.P.

Mérida, Yucatán, 97130, Mexico
ChangHua Christian Hospital

Changhua, Changhua County, 500, Taiwan
Charlotte Maxeke Johannesburg Academic Hospital

Johannesburg, Gauteng, 2193, South Africa
Christian Medical College

Vellore, Tamil Nadu, 632004, India
Clinical Center Kragujevac

Kragujevac, 34000, Serbia
Clinical Center Nis

Niš, 18000, Serbia
Clinical Center of Serbia

Belgrade, 11000, Serbia
Dr. Behcet Uz Child Diseases Surgery Education and Research Hospital

Izmir, 35210, Turkey (Türkiye)
Ege University Medical Faculty

Izmir, 35040, Turkey (Türkiye)
Erciyes University Medical Faculty

Kayseri, 38039, Turkey (Türkiye)
FGBOU VO "Samara State Medical University" of MoH of Russia

Samara, 443079, Russia
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Milan, 20122, Italy
Gazi University Health Research and Practice Center Gazi Hospital

Ankara, 06500, Turkey (Türkiye)
Gaziantep University Sahinbey Research and Training Hospital

Gaziantep, 27310, Turkey (Türkiye)
Hacettepe University Medical Faculty

Ankara, 06230, Turkey (Türkiye)
Hiroshima University Hospital

Hiroshima, 734-8551, Japan
Hospital Universitario "Dr Jose Eleuterio Gonzalez"

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario A Coruna

A Coruña, 15006, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain
Hospital Universitario Vall d´Hebron

Barcelona, 08035, Spain
Hospital Universitario de Salamanca

Salamanca, 37007, Spain
Hôpital Necker Enfants Malades

Paris, 75015, France
Institute for Mother and Child healthcare "Dr Vukan Cupic"

Belgrade, 11000, Serbia
Institute of Hematology, Chinese Academy of Medical Sciences

Tianjin, Tianjin Municipality, 300020, China
Istanbul University Oncology Institute

Istanbul, 34093, Turkey (Türkiye)
Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, 306113, China
Karadeniz Technical University Medical Faculty

Trabzon, 61080, Turkey (Türkiye)
King Abdulaziz University Hospital

Jeddah, 21589, Saudi Arabia
King Faisal Specialist Hospital & Research Center

Riyadh, Saudi Arabia
Klinicki bolnicki centar Zagreb

Zagreb, 10000, Croatia
Kyung Hee University Hospital At Gangdong

Seoul, 05278, South Korea
Kyungpook National University Hospital

Daegu, 41944, South Korea
McMaster Children's Hospital

Hamilton, Ontario, L8S 4K1, Canada
McMaster University

Hamilton, Ontario, L8S 4K1, Canada
McMaster University Medical Centre - Hamilton Health Sciences

Hamilton, Ontario, L8N 3Z5, Canada
Nagoya University Hospital - Transfusion Medicine

Nagoya, Aichi-ken, 466-8560, Japan
Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, 510515, China
National Specialized Hospital for the Active Treatment of Hematological Diseases - EAD, Sofia

Sofia, 1756, Bulgaria
Nirmal Hospital Pvt, Ltd

Surat, Gujarat, 395002, India
Northwell Health HTC

New Hyde Park, New York, 11040, United States
Ondokuz Mayıs University Medical Faculty

Samsun, 55280, Turkey (Türkiye)
Prince of Wales Hospital

Hong Kong, Hong Kong
Queen Mary Hospital

Hong Kong, Hong Kong
Sahyadri Clinical Research and Development Center

Pune, Maharashtra, 411004, India
Sahyadri Super Speciality Hospital

Pune, Maharashtra, 411004, India
Saitama Medical University Hospital

Iruma-gun, Saitama, 350-0495, Japan
Sapporo Tokushukai Hospital

Sapporo, Hokkaido, 004-0041, Japan
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Sultan Qaboos University Hospital

Muscat, 123, Oman
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
The Affiliated Hospital of Guizhou Medical University

Guiyang, Guizhou, 550004, China
The Hospital For Sick Children

Toronto, Ontario, M5G 1X8, Canada
UMHAT "Prof.Dr. Stoyan Kirkovich"

Stara Zagora, 6003, Bulgaria
USF Health Morsani Center For Advanced Healthcare

Tampa, Florida, 33612, United States
University of Iowa

Iowa City, Iowa, 52242, United States
Università degli Studi di Perugia, Azienda Ospedaliera di Perugia, Ospedale Santa Maria della

Perugia, 06156, Italy
Università degli Studi di Roma "Sapienza"-Policlinico Umberto I

Roma, RM, 00161, Italy
Washington Institute for Coagulation

Seattle, Washington, 98101, United States

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