BOTOX for a sharper jawline? phase 3 trial tests Muscle-Weakening shots
NCT ID NCT06399718
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 study tested whether BOTOX injections can safely reduce the appearance of a widened lower face caused by prominent masseter (chewing) muscles. About 207 adults with moderate-to-severe muscle prominence received either BOTOX or a placebo in both sides of the jaw. The study measured changes in muscle size and participant satisfaction over several months, with an option for repeat treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- onabotulinumtoxinA (BOTOX)
- What this could lead to
- If it works, this could offer a non-surgical option to slim the lower face by relaxing the chewing muscles.
- What could go wrong
- This is a cosmetic treatment, not a cure for a disease. Results may be modest, temporary, and side effects like injection-site reactions or asymmetry are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aesthetic Center at Woodholme /ID# 248481
Baltimore, Maryland, 21208-6391, United States
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Austin Institute for Clinical Research at SBA Dermatology /ID# 248228
Houston, Texas, 77056-4129, United States
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DeNova Research /ID# 248237
Chicago, Illinois, 60610, United States
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DelRicht Research /ID# 250313
Baton Rouge, Louisiana, 70809, United States
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DermResearch Inc. /ID# 248227
Austin, Texas, 78759, United States
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Etre Cosmetic Dermatology and Laser Center /ID# 248229
New Orleans, Louisiana, 70130-4353, United States
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Kavali Plastic Surgery and Skin Renewal Center /ID# 248480
Atlanta, Georgia, 30328, United States
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Laser & Skin Surgery Center of New York /ID# 248479
New York, New York, 10016-4974, United States
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Luxurgery /ID# 248236
New York, New York, 10021, United States
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Michigan Center for Research Corporation /ID# 249145
Clinton Township, Michigan, 48038, United States
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Pacific Clinical Innovations /ID# 248231
Vista, California, 92083-6030, United States
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Private Practice - Dr. Steven G. Yoelin /ID# 268046
Newport Beach, California, 92663, United States
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Sherber + RAD /ID# 248894
Washington D.C., District of Columbia, 20005-5002, United States
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Sherman Aesthetic Center /ID# 248482
Nashville, Tennessee, 37205-2205, United States
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Skin Research Institute LLC /ID# 248230
Coral Gables, Florida, 33146-1837, United States
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Skin Specialists /ID# 248233
Omaha, Nebraska, 68144, United States
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Steven Fagien MD Aesthetic Eyelid Plastic Surgery /ID# 248478
Boca Raton, Florida, 33431-6465, United States
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The Practice of Brian S. Biesman MD PLLC /ID# 248226
Nashville, Tennessee, 37203, United States
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Westlake Dermatology & Cosmetic Surgery - Westlake /ID# 249875
Austin, Texas, 78746-4720, United States
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Westside Aesthetics /ID# 248232
Los Angeles, California, 90025-1708, United States
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