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BOTOX may slim the jaw without surgery

NCT ID NCT06137287

Symptom relief Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests whether BOTOX injections can reduce the prominence of the masseter muscle, the chewing muscle that can make the lower face look wide or square. About 250 Japanese adults with marked or very marked masseter muscle prominence will receive either BOTOX or a placebo injected into both jaw muscles. The trial measures changes in jaw appearance and checks for side effects over about one year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BOTOX (onabotulinumtoxinA)
What this could lead to
If successful, this could offer a non-surgical option to slim the lower face for people bothered by a square jaw shape.
What could go wrong
This is an early-phase study with a placebo group, so the real benefit over placebo is not yet known. Side effects may include injection-site reactions or asymmetry.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

259 people

The number who actually took part.

Started

Nov 2023

Finished

Jul 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult Japanese individuals. * Participant with marked or very marked masseter muscle prominence (MMP). Exclusion Criteria: * Asymmetry of left and right sides of the face that could prevent identical Masseter Muscle Prominence Scale (MMPS) or MMPS-P grading on both sides of the face, as determined by the investigator. * History of permanent soft tissue fillers in the jawline.

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Conditions

The condition(s) this trial relates to.

masticatory muscles, hypertrophy of

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Masseter muscle prominence

Contacts and locations

Locations

  • Azabu beauty clinic /ID# 254519

    Minato, Tokyo, 106-0032, Japan

  • Chiharu Dermatology Clinic Urawa /ID# 254778

    Saitama, 333-0055, Japan

  • Dermatology and Ophthalmology Kume Clinic /ID# 254632

    Sakai-shi, Osaka, 593-8324, Japan

  • Ginza Skin Clinic /ID# 254666

    Chuo-ku, Tokyo, 104-0061, Japan

  • Greenwood Skin Clinic Tachikawa /ID# 254830

    Tachikawa-shi, Tokyo, 190-0023, Japan

  • Ikebukuronishiguchi Fukurou Dermatology Clinic /ID# 254639

    Toshima-ku, Tokyo, 171-0021, Japan

  • Jiyugaoka Clinic /ID# 256666

    Meguro-ku, Tokyo, 152-0023, Japan

  • Jun Clinic /Id# 254870

    Nagano, 380-0826, Japan

  • Jyosui Dermatology Clinic /ID# 254300

    Fukuoka, Fukuoka, 810-0022, Japan

  • Kitasato University Kitasato Institute Hospital /ID# 255369

    Minato-ku, Tokyo, 108-8642, Japan

  • Kotoni Tower Skin And Cosmetic Surgery Clinic /ID# 260668

    Sapporo, Hokkaido, 063-0812, Japan

  • Roppongi Imaizumi Skin Clinic /ID# 254573

    Minato-ku, Tokyo, 106-0032, Japan

  • Skin Clinic Fujieda /ID# 254214

    Fujieda-shi, Shizuoka, 426-0067, Japan

  • Tokai University Hospital /ID# 254204

    Isehara, Kanagawa, 259-1193, Japan

  • Tokyo Asbo Clinic /ID# 257728

    Chuo-ku, Tokyo, 104-0031, Japan

  • Tokyo Center Clinic /ID# 254775

    Chuo-ku, Tokyo, 103-0027, Japan

  • Touyama Plastic Surgery Clinic /ID# 254831

    Naha, Okinawa, 900-0015, Japan

  • Yoshikawa Skin Ecru Clinic /ID# 256505

    Kyoto, Kyoto, 604-8035, Japan

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