BOTOX may slim the jaw without surgery
NCT ID NCT06137287
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This study tests whether BOTOX injections can reduce the prominence of the masseter muscle, the chewing muscle that can make the lower face look wide or square. About 250 Japanese adults with marked or very marked masseter muscle prominence will receive either BOTOX or a placebo injected into both jaw muscles. The trial measures changes in jaw appearance and checks for side effects over about one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BOTOX (onabotulinumtoxinA)
- What this could lead to
- If successful, this could offer a non-surgical option to slim the lower face for people bothered by a square jaw shape.
- What could go wrong
- This is an early-phase study with a placebo group, so the real benefit over placebo is not yet known. Side effects may include injection-site reactions or asymmetry.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Azabu beauty clinic /ID# 254519
Minato, Tokyo, 106-0032, Japan
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Chiharu Dermatology Clinic Urawa /ID# 254778
Saitama, 333-0055, Japan
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Dermatology and Ophthalmology Kume Clinic /ID# 254632
Sakai-shi, Osaka, 593-8324, Japan
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Ginza Skin Clinic /ID# 254666
Chuo-ku, Tokyo, 104-0061, Japan
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Greenwood Skin Clinic Tachikawa /ID# 254830
Tachikawa-shi, Tokyo, 190-0023, Japan
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Ikebukuronishiguchi Fukurou Dermatology Clinic /ID# 254639
Toshima-ku, Tokyo, 171-0021, Japan
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Jiyugaoka Clinic /ID# 256666
Meguro-ku, Tokyo, 152-0023, Japan
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Jun Clinic /Id# 254870
Nagano, 380-0826, Japan
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Jyosui Dermatology Clinic /ID# 254300
Fukuoka, Fukuoka, 810-0022, Japan
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Kitasato University Kitasato Institute Hospital /ID# 255369
Minato-ku, Tokyo, 108-8642, Japan
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Kotoni Tower Skin And Cosmetic Surgery Clinic /ID# 260668
Sapporo, Hokkaido, 063-0812, Japan
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Roppongi Imaizumi Skin Clinic /ID# 254573
Minato-ku, Tokyo, 106-0032, Japan
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Skin Clinic Fujieda /ID# 254214
Fujieda-shi, Shizuoka, 426-0067, Japan
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Tokai University Hospital /ID# 254204
Isehara, Kanagawa, 259-1193, Japan
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Tokyo Asbo Clinic /ID# 257728
Chuo-ku, Tokyo, 104-0031, Japan
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Tokyo Center Clinic /ID# 254775
Chuo-ku, Tokyo, 103-0027, Japan
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Touyama Plastic Surgery Clinic /ID# 254831
Naha, Okinawa, 900-0015, Japan
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Yoshikawa Skin Ecru Clinic /ID# 256505
Kyoto, Kyoto, 604-8035, Japan
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