New oral pill HPP737 takes on psoriasis in Head-to-Head trial

NCT ID NCT07712731

Completed Disease control Sponsor: Newsoara Biopharma Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This Phase 3 trial tests whether an experimental oral drug, HPP737, can reduce psoriasis severity in adults with moderate-to-severe plaque psoriasis. Participants take HPP737 or an active control drug daily for 16 weeks. Researchers measure skin clearance using standard scores like PASI and sPGA to compare effectiveness and monitor safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental oral drug called HPP737
What this could lead to: If successful, HPP737 could offer a new oral treatment option for people with moderate-to-severe plaque psoriasis.
What could go wrong: This is a Phase 3 trial, but results may not show superiority over existing treatments. Side effects and long-term safety are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIASIS

Contacts and locations

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Locations

Affiliated Central Hospital of Shenyang Medical College

Shengyang, China
Affiliated Hospital of Chengde Medical College

Chengde, China
Affiliated Hospital of Guilin Medical University

Guilin, China
Affiliated Hospital of Jiangsu University

Wuxi, China
Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine

Tianjin, China
Affiliated Hospital of Xuzhou Medical University

Xuzhou, China
Affiliated Hospital of Zunyi Medical University

Zunyi, China
Beijing Friendship Hospital, Capital Medical University

Beijing, China
Beijing Tongren Hospital, Capital Medical University

Beijing, China
Beijing Tsinghua Changgung Hospital

Beijing, China
Cangzhou People's Hospital

Cangzhou, China
Changde First People's Hospital

Changde, China
Changzhi Second People's Hospital

Changzhi, China
Chengdu Second People's Hospital

Chengdu, China
Dalian Dermatology Hospital

Dalian, China
Dermatology Hospital, Shandong First Medical University

Jinan, China
Dermatology Hospital, Southern Medical University

Guangzhou, China
First Affiliated Hospital of Chongqing Medical University

Chongqing, China
First Affiliated Hospital of Ningbo University

Ningbo, China
First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China
First Hospital of Shanxi Medical University

Taiyuan, China
General Hospital of Ningxia Medical University

Yinchuan, China
Guangzhou First People's Hospital

Guangzhou, China
Hainan Fifth People's Hospital

Haikou, China
Hangzhou First People's Hospital

Hangzhou, China
Hospital of Dermatology, Chinese Academy of Medical Sciences

Nanjing, China
Huashan Hospital, Fudan University

Shanghai, China
Inner Mongolia Baogang Hospital

Baotou, China
Jiangxi Provincial Dermatology Hospital

Nanchang, China
Jinan Central Hospital

Jinan, China
Jingzhou Central Hospital

Jingmen, China
Lianyungang First People's Hospital

Lianyungang, China
Liaocheng People's Hospital

Liaocheng, China
Liaoning Provincial People's Hospital

Shenyang, China
Meihekou Central Hospital

Tonghua, China
Peking University People's Hospital

Beijing, China
Qingdao Traditional Chinese Medicine Hospital (Hai Ci Hospital)

Qingdao, China
Qujing First People's Hospital

Qujing, China
Second Affiliated Hospital of Chongqing Medical University

Chongqing, China
Second Affiliated Hospital of Nanchang University

Nanchang, China
Second Affiliated Hospital of Wannan Medical College

Wuhu, China
Shandong Provincial Hospital

Jinan, China
Shanghai Skin Disease Hospital

Shanghai, China
Shenyang Hospital of Integrated Traditional Chinese and Western Medicine

Shenyang, China
Shenzhen Second People's Hospital

Shenzhen, China
Shiyan People's Hospital

Shiyan, China
Sichuan Provincial People's Hospital

Chengdu, China
Suining Central Hospital

Suining, China
The First Affiliated Hospital of Kunming Medical University

Kunming, China
The First Hospital of Hebei Medical University

Shijiazhuang, China
The Second Affiliated Hospital of Harbin Medical University

Harbin, China
The Second Hospital of Jilin University

Changchun, China
Third Xiangya Hospital of Central South University

Changsha, China
Wuhan First Hospital

Wuhan, China
Wuxi Second People's Hospital

Wuxi, China
Xingtai People's Hospital

Xingtai, China
Yancheng First People's Hospital

Yancheng, China
Zhejiang Provincial People's Hospital

Hangzhou, China
Zhongyi Northeast International Hospital Co., Ltd.

Shengyang, China
Zhujiang Hospital of Southern Medical University

Guangzhou, China

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