Lower respiratory tract disorder

This phase 2 trial tests whether a vaccine made from immune cell-derived exosomes can slow cancer growth in people with advanced non-small cell lung cancer who have responded to initial chemotherapy. Participants receive low-dose cyclophosphamide followed by weekly injections of …

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This trial is testing whether giving the immunotherapy drug atezolizumab before surgery can help people with early-stage non-small cell lung cancer. The study includes adults with stage IB to IIIA (non-N2) disease who are eligible for surgery. Participants receive one dose of ate…

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger …

This trial tests whether high-flow nasal oxygenation (HFNO) keeps breathing and oxygen levels steadier than standard low-flow nasal oxygenation (LFNO) in patients undergoing sedated vitrectomy, a type of eye surgery. Participants are normal-weight adults with different anesthesia…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase trial tested the drug everolimus (RAD001) alongside radiation therapy in 26 people with advanced non-small cell lung cancer that could not be surgically removed. The goal was to find a safe dose and check for side effects. Participants received everolimus weekly …

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This phase 2 study tested a combination of three drugs in 46 people with a specific type of lung cancer (EGFR-mutated) that had spread to the lining of the brain and spinal cord (meningeal metastasis). The treatment included a high-dose targeted pill (furmonertinib), an intraveno…

This study looks at whether using a breathing machine (non-invasive ventilation) at home, with remote monitoring, can help people with advanced COPD avoid hospital visits. It tracks how often patients need unplanned hospital care and whether the monitoring data can predict proble…

This study tested a new way of giving radiation therapy combined with immunotherapy for people with advanced non-small cell lung cancer that does not have certain genetic mutations. The goal was to see if mixing high-dose and low-dose radiation could help the immune system fight …

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This phase II trial is testing whether the immunotherapy drug tislelizumab can help control locally advanced non-small cell lung cancer when given after radiation therapy or sequential chemoradiation. The study enrolls people with stage III lung cancer who cannot tolerate the sta…

This early-phase study tests a new oral drug, furmonertinib, in 30 people with advanced non-small cell lung cancer that has a specific EGFR exon 20 insertion mutation. Some participants have already tried other treatments, while others are newly diagnosed. The goal is to see if t…

This study tests whether the steroid hydrocortisone, added to usual care, can help ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone against a placebo in 180 adults. The goal is to see if the drug reduces early death or worsening of bre…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This trial tests whether giving an inhaled steroid (budesonide) to newborns with meconium aspiration syndrome can speed up their recovery. Meconium aspiration happens when a baby breathes in a mixture of meconium and amniotic fluid during birth, causing lung inflammation and brea…

This trial tests whether using a blood test that measures procalcitonin—a marker of bacterial infection—can safely guide decisions about antibiotics in people hospitalized for a COPD flare-up. Participants are randomly assigned to either usual care or procalcitonin-guided treatme…

This study tests whether wet cupping therapy, an ancient practice of drawing blood through small skin incisions, can help adults with asthma. Researchers will compare lung function, asthma control, fatigue, and quality of life between a group receiving two cupping sessions and a …

This trial tests whether adding the beta-blocker metoprolol to standard care can reduce a combined risk of death, COPD flare-ups, and heart-related hospitalizations in people with COPD who do not have known heart disease. About 1,700 adults with COPD will receive either metoprolo…

This Phase 2 trial tests whether adding chemotherapy (carboplatin and pemetrexed) to the targeted drug osimertinib works better than osimertinib alone for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The study enrolls 80 patients w…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-stage trial is testing whether an immunotherapy drug called tislelizumab can be given as a simple injection under the skin instead of through an IV drip for people with advanced non-small cell lung cancer. The study will compare how well the body absorbs the drug in bo…

This early-stage trial is testing an experimental drug called AMG 355, given alone or together with the immunotherapy Keytruda, in 77 adults with advanced solid tumors (like lung, colon, stomach, or melanoma) that have not responded to standard treatments. The main goals are to c…

This study looked at whether adding special breathing muscle training to a swimming program could improve asthma control in children with mild asthma. Thirty children aged 8-11 took part in a 4-week swimming program, with half also doing breathing exercises twice daily. Researche…

This early-stage trial is testing an experimental inhaled medication called TQC3721 in people with moderate to severe chronic obstructive pulmonary disease (COPD). The study aims to see how safe and tolerable the drug is, how it moves through the body, and what effects it has on …

This early-phase study tested a new drug called BAY 2862789 in 45 people with advanced solid tumors, including non-small cell lung cancer. The drug works by activating immune cells to fight cancer. The main goals were to check safety, find the best dose, and see how the drug move…

This early-phase trial is testing whether adding an experimental drug called alisertib to the standard treatment osimertinib can help people with stage IV EGFR-mutant lung cancer. The study aims to find the safest dose of alisertib when given with osimertinib and to see how the c…

This trial tests whether an automated oxygen delivery system, called FreeO2, can help patients with pneumonia recover faster and leave the hospital sooner. The device automatically adjusts oxygen flow based on continuous monitoring of blood oxygen levels, aiming to keep patients …

This trial tests whether continuous pulse oximetry with wireless alerts to clinicians can reduce serious breathing complications (respiratory depression) after surgery. Patients on two surgical wards will be monitored continuously instead of every four hours. The goal is to see i…

This trial tests whether a breath-activated dry powder inhaler (NEXThaler) delivers the same asthma control as a traditional pressurized inhaler (pMDI), both containing the same combination of medications (beclometasone and formoterol). Adults with well-controlled asthma will use…

This trial compares two widely used combination inhalers—Foster (beclomethasone plus formoterol) and Seretide (fluticasone plus salmeterol)—in people with chronic obstructive pulmonary disease (COPD). The goal is to see if Foster works better at improving lung function right afte…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This pilot study investigates whether an 8-week ketogenic diet—high in fat and very low in carbs—can improve lung function, reduce inflammation, and boost exercise capacity in men aged 40–75 with mild-to-moderate COPD. Participants are randomly assigned to either the ketogenic di…

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this …

This trial tests whether implanting small valves in the airways—a procedure called lung volume reduction—can improve heart and skeletal muscle function in people with severe chronic obstructive pulmonary disease (COPD). Participants will undergo the procedure and be followed for …

This early-stage trial is testing an experimental drug called AEB1102 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The main goal is to find the highest dose that is safe and to understand the drug's…

This trial is testing a new radiation technique called CT-STAR for people with early-stage non-small cell lung cancer located near the center of the chest, where treatment is tricky. The approach uses a machine that takes CT images during each session and adapts the radiation pla…

This trial tests whether a standardized respiratory physiotherapy program, delivered in primary care over six months, can improve quality of life and key health measures in adults aged 40 to 74 with mild COPD. Participants are randomly assigned to either the physiotherapy program…

This trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy can help people with advanced non-small cell lung cancer whose tumors have a specific EGFR mutation and have stopped responding to TKI targeted therapy. About 440 participants will be…

This study tested an inhaled drug called ARO-MMP7 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to check safety and how the body handles the drug. About 105 participants took p…

This trial is testing whether adding the traditional herbal remedy Bojungikki-tang to the immunotherapy drug pembrolizumab can help people with advanced non-small cell lung cancer. The study includes adults with stage IV disease whose tumors are PD-L1 positive and who have no EGF…

This trial examines whether using a quick nasal swab to check for MRSA bacteria can help doctors decide how long to treat pneumonia patients with the antibiotic vancomycin. The study compares the duration of therapy and costs before and after implementing this screening test. Par…

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, wh…

This trial tests whether a 6-week program of high-intensity interval training using an arm ergometer can improve oxygen consumption, muscle oxygenation, and physical activity in people with interstitial lung disease. Participants will be randomly assigned to receive the supervise…

This trial is testing a new inhaler that combines two asthma medications—fluticasone propionate and albuterol sulfate—in a single device with an electronic module. The study involves children aged 4 to 11 with stable asthma. The goal is to measure how much of the medication gets …

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This trial compares the antibiotic faropenem to a standard combination of co-amoxiclav and clarithromycin in adults with community-acquired bacterial pneumonia. Participants are randomly assigned to one of two treatment groups for seven days, then followed for four weeks. The stu…

This trial asks whether animated video lessons can help people with asthma or COPD manage their condition at home better than traditional paper brochures. Participants receive a home-based pulmonary rehabilitation program in either format, and researchers compare how well each gr…

This trial tests whether a single dose of risedronate, a bone-strengthening drug, given before stereotactic body radiation therapy (SBRT) for peripheral lung tumors can prevent the rapid bone loss that radiation can cause in nearby ribs. Adults with lung tumors within 2 cm of the…

This study tests whether adding thymosin alpha 1 to standard chemoradiation and immunotherapy helps patients with advanced non-small cell lung cancer complete a full year of immunotherapy. About 114 adults will participate. The goal is to see if this approach improves survival an…

This early-stage trial is testing an experimental stem cell therapy called VUM02 in people with idiopathic pulmonary fibrosis (IPF), a condition that causes progressive lung scarring and breathing difficulty. The study aims to see if the treatment is safe and tolerable, and wheth…

This trial is testing whether adding an experimental drug called HBI-8000 to the immunotherapy nivolumab can safely control advanced melanoma, kidney cancer, and non-small cell lung cancer. The study enrolls adults whose cancers have not responded to prior treatments. Researchers…

This early-phase trial is testing an experimental drug called SPYK04 in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look for early signs that SPYK…

This study tested a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell) that had stopped responding to standard targeted pills. The trial enrolled 95 adults and gave them two different combinations of immunotherapy (atezolizum…

This trial tests whether treating gum disease can reduce bacteria that cause lung infections in people with bronchiectasis. Participants with both conditions will receive either basic cleaning, deep cleaning, or deep cleaning plus light therapy. Researchers will measure bacteria …

This phase 2 trial tests whether adding lenvatinib to a standard chemotherapy-plus-immunotherapy regimen can shrink tumors in people with advanced non-squamous non-small cell lung cancer that has a specific EGFR mutation. Participants will receive lenvatinib capsules daily along …

This trial tests an experimental drug, BI 1291583, in adults with bronchiectasis who produce sputum and have a history of flare-ups. Participants are randomly assigned to one of three doses of the drug or a placebo, taken once daily for at least 24 weeks. The study measures how l…

This trial tests whether a two-day course of intravenous dexamethasone works as well as a standard five-day course of methylprednisolone for children having a severe asthma attack. Children aged 2 to 18 with a severe exacerbation are randomly assigned to one of the two treatments…

This trial compares a home-based exercise program, guided by a workbook and weekly phone calls, to supervised center-based rehabilitation for people recovering from a long ICU stay. The goal is to see if the home program can improve muscle strength, endurance, and daily function …

This trial tests whether a pharmacist, at the time of hospital admission, can review a patient's prescribed inhaler for insurance coverage and clinical appropriateness. The goal is to see if this simple check helps patients get the most cost-effective inhaler and reduces the chan…

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…

This phase 3 trial tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can improve outcomes for people with stage II-III non-small cell lung cancer. Participants receive either toripalimab plus chemotherapy or a placebo plus chemotherap…

This trial investigates whether custom-made stents, designed using 3D computer modeling and printing, can safely treat complex airway narrowing that standard stents cannot fit. Ten adults with symptomatic, anatomically complex airway stenosis will receive a personalized stent and…

This trial tests whether children aged 6 to 17 with asthma can manage their condition remotely using an artificial intelligence tool called the Asthma-Guidance and Prediction System, combined with a home monitoring device (AsthmaTuner). The goal is to see if this approach improve…

This phase II trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 50 participants will receive the combination treatment, and …

This phase 3 trial tested a new triple-combination inhaler (beclometasone, formoterol, and glycopyrrolate) against a standard two-drug inhaler in 1,368 adults with severe COPD. The study measured changes in lung function and breathlessness over 52 weeks. The goal was to see if th…

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This study tests whether injecting a diluted hydrogen peroxide solution or steroids into the chest can break up scar tissue and free a trapped lung, compared to a standard surgical scraping procedure (thoracoscopy). The trial enrolls adults aged 18-62 with a lung infection that h…

This trial investigates an experimental oral drug, LY3143921 hydrate, which blocks a protein called Cdc7 that cancer cells need to divide. It is being tested in adults with advanced solid tumours, including colorectal, ovarian, lung, and pancreatic cancers, that have not responde…

This phase 3 trial tested whether a triple-combination inhaler (CHF 5993) works better than a standard dual inhaler (Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 700 adults aged 40 and older with a history of smoking took part. The main goal was t…

This study tests an experimental drug called lebrikizumab in people whose asthma remains uncontrolled despite daily use of inhaled steroids and a second controller medication. Participants receive either lebrikizumab or a placebo injection every 4 weeks for a year, while continui…

This trial investigates whether combining stereotactic body radiotherapy (SBRT), a precise form of radiation, with the immunotherapy drug nivolumab is safe and tolerable for people with early-stage non-small cell lung cancer. Participants receive SBRT followed by nivolumab infusi…

This study tests whether adding whole-body vibration to standard pulmonary rehabilitation can improve lung function, exercise capacity, and quality of life in adults aged 40–80 with fibrotic interstitial lung disease. Participants are randomly assigned to either rehab alone or re…

This phase 3 trial tests whether lebrikizumab, an injectable drug that blocks a protein involved in asthma inflammation, can improve lung function in adults with mild to moderate asthma. Participants receive either lebrikizumab injections, a placebo, or an open-label montelukast …

This trial tests an experimental drug called enfortumab vedotin, which is designed to seek out and destroy cancer cells that have a specific protein called Nectin-4 on their surface. The study includes people with metastatic urothelial cancer (a type of bladder cancer) and other …

This study looks at whether giving targeted drugs called ROS1 inhibitors before surgery can help people with a rare form of lung cancer. The drugs, entrectinib or crizotinib, are designed to attack cancer cells with a specific genetic change. Researchers will check how much the t…

This study tests whether a new drug called RPH-075, a biosimilar of pembrolizumab (Keytruda), works as well as the original in people with skin melanoma, lung cancer, or head and neck cancer. Participants receive a single dose of either RPH-075 or Keytruda, and researchers compar…

This trial tests whether using a lower oxygen saturation threshold (88%) versus the standard (92%) to decide when to give supplemental oxygen helps children aged 6 weeks to 12 years recover faster from respiratory distress. Participants are randomly assigned to one of two groups,…

This phase 2 trial tests a needle-free epinephrine nasal spray (ARS-1) for managing asthma symptoms. People with persistent asthma receive a single dose of ARS-1, albuterol, or placebo in random order. The study measures how well the spray improves lung function compared to stand…

This phase 2 trial tests the experimental drug LDK378 in adults with advanced non-small cell lung cancer that has a specific genetic change called a ROS1 rearrangement. Participants must have already received at least one platinum-based chemotherapy and their cancer must have pro…

This study looks at how allergy shots (subcutaneous allergen immunotherapy) affect immune markers in adults with allergic asthma. Researchers will measure changes in eosinophil cationic protein and sputum eosinophils over six months, along with asthma symptom scores. The goal is …

This study tests whether adding delpazolid to standard treatment can reduce bacterial levels in people with hard-to-treat Mycobacterium abscessus lung infections. Participants take delpazolid tablets daily for 12 weeks, with the option to continue up to one year if there is clini…

This early-stage trial tests an inhaled drug called CMR316 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The study's main goal is to check the drug's safety and how the body processes it. Participants r…

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which …

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This phase 3 trial tests whether tezepelumab, an injectable drug, can reverse airway wall thickening (remodeling) in adults with asthma. Participants, aged 18 to 85 with moderate-to-severe asthma, will receive either tezepelumab or a placebo for about a year. Researchers will use…

This trial investigates whether adding the immunotherapy drug atezolizumab (Tecentriq) to standard chemotherapy (carboplatin and etoposide) helps people with a rare and aggressive lung cancer called large cell neuroendocrine carcinoma (LCNEC). The study enrolls adults with advanc…

This phase II trial tests whether adding canakinumab, an anti-inflammatory drug, to standard chemoradiation and immunotherapy (durvalumab) helps control locally advanced non-small cell lung cancer. About 41 participants will receive the combination to see if it improves progressi…

This study tested whether adding a personalized dendritic cell vaccine to the immunotherapy drug atezolizumab could help people with extensive-stage small cell lung cancer stay stable longer after initial chemotherapy. Twenty participants received standard chemo plus atezolizumab…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tests whether giving doctors a personalized infographic showing a COPD patient's predicted lung function decline over 15 years can increase smoking cessation counseling and medication prescriptions. The tool uses individual patient data like age, sex, and lung function…

This study investigates whether eccentric cycling—where the pedals resist the rider's effort, similar to walking downhill—can improve exercise capacity in people with heart or lung conditions. Unlike normal cycling, eccentric cycling demands less oxygen, which may allow patients …

This study tests whether virtual or in-person care transition programs are better at helping people with COPD avoid emergency room visits and hospital readmissions within 30 days of discharge. The trial enrolls hospital sites across the U.S., not individual patients, and compares…

This study investigates whether 4DCT scans—which capture how a tumor moves when a person breathes—can be used to design radiation plans that avoid high-functioning healthy lung tissue. People with non-small cell lung cancer who are scheduled for radiation therapy may join. The go…

This study compares two widely used asthma inhalers—Advair and Symbicort—to see if they have different effects on airway constriction. Researchers use a methacholine challenge test to measure how sensitive the airways are after four weeks of treatment. The study includes 20 adult…

This study tests a device called the LungVision system, which uses artificial intelligence to help surgeons locate small lung nodules during minimally invasive surgery. The system combines CT scans with live X-ray images to guide a tool to the nodule, then injects a dye to mark i…

This study tests whether a high dose of montelukast (Singulair), given by mouth, can help children aged 4 to 12 who are in the hospital with a moderate or severe asthma attack. The goal is to find the best dose for a future larger study. Children receive either the high-dose mont…

This study tests whether combining two targeted drugs, avutometinib and adagrasib, can shrink tumors in people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants must have already tried a KRAS G12C inhibitor and seen their c…

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study investigates whether following the DASH diet—a heart-healthy eating plan—can improve quality of life for adults whose asthma is not well controlled by medication. Participants are randomly assigned to either a DASH-focused behavioral coaching program or standard asthma…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two-drug inhalers for people aged 12 to 80 with asthma that is not well controlled by their current treatment. Participants receive either the triple inhaler, a two-drug…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This trial tests whether a gentler suction level (-2 cmH2O) on chest tubes after keyhole lung cancer surgery works as well as the standard stronger suction (-10 cmH2O). The goal is to see which setting allows tubes to be removed sooner and causes fewer complications. About 230 ad…

This phase 2 trial investigates the safety and tolerability of EP395, an oral capsule taken once daily for 12 weeks, in people with chronic obstructive pulmonary disease (COPD). The study includes 61 adults aged 45 and older and compares EP395 against a placebo. Researchers monit…

This study tests whether washing the infected chest cavity with povidone-iodine (an antiseptic) helps adults with pleural empyema recover faster than using normal saline alone. Participants receive chest tube drainage plus daily irrigation with either povidone-iodine or saline. T…

This study tests whether adding visual and sound reminders to a standard breathing exercise device (incentive spirometer) helps patients use it more often after surgery. About 231 adults who had surgery under general anesthesia will be split into two groups: one using the device …

This phase II trial tests whether a low-dose, frequent schedule of the chemotherapy drug vinorelbine, taken orally, can boost the effects of the immunotherapy atezolizumab in people with stage IV non-small cell lung cancer. The study enrolls adults whose cancer has progressed aft…

This study tests whether a three-in-one inhaler (budesonide, glycopyrronium, and formoterol) works better than two standard two-drug inhalers for people with asthma that is not well controlled. Adults and adolescents aged 12 to 80 with moderate-to-severe asthma will use the tripl…

This Phase 3 trial tested a new targeted therapy, lazertinib, against the standard drug gefitinib in 393 people with advanced EGFR-mutated non-small cell lung cancer. The goal was to see if lazertinib could keep cancer from growing longer. Participants took either lazertinib or g…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) against a standard two-medicine inhaler in over 1,100 adults with asthma that was not well controlled. The goal was to see if the triple combination improves lung functio…

This study tested a new inhaler that combines three medicines (beclometasone, formoterol, and glycopyrronium) in people whose asthma was not well controlled with standard two-medication inhalers. Over 1,400 adults took part for 52 weeks. The triple inhaler improved lung function …

This phase 2 study tested a combination of two drugs—ivonescimab (AK112) and irinotecan liposome—in 60 people with extensive-stage small-cell lung cancer whose disease had worsened after standard first-line therapy. The goal was to see if the combo could slow cancer growth and sh…

This large phase III trial tested whether adding bevacizumab (Avastin) to standard chemotherapy after complete lung cancer surgery could help patients live longer. Over 1,500 patients with stage IB to IIIA non-small cell lung cancer took part. The study found that adding bevacizu…

This phase II trial studied 168 people with extensive-stage small cell lung cancer. Researchers added either vismodegib or cixutumumab to standard chemotherapy (cisplatin and etoposide) to see if these combinations worked better than chemo alone. The goal was to slow cancer growt…

This study tested whether adding veliparib (a PARP inhibitor) to standard chemotherapy (cisplatin and etoposide) helps people with extensive stage small cell lung cancer or certain other lung cancers that have spread. In the first phase, researchers found the best dose of velipar…

This phase 2 trial tests the drug crizotinib (XALKORI) in people with advanced non-small cell lung cancer that has spread and carries a change in the ROS1 or MET gene. Participants take crizotinib by mouth twice daily. The study aims to see how well the drug shrinks tumors and de…

This phase III trial investigates whether sunitinib, a drug that blocks tumor blood vessel growth, can help patients with advanced non-small cell lung cancer maintain their response after initial chemotherapy. Participants who did not worsen after four cycles of platinum-based ch…

This study looked at whether the Buteyko breathing technique can help control asthma and improve quality of life in children aged 7 to 12. Sixty-five children with asthma participated, learning specific breathing exercises. The goal was to see if this non-drug approach could redu…

This large phase 3 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help people with a specific type of advanced lung cancer live longer than standard chemotherapy. Over 1,200 participants with PD-L1 positive non-small cell lung cancer were randomly assi…

This trial tests a 12-week virtual program called Conmigo, designed to help Latina girls aged 8-11 and their mothers become more physically active together. The program includes weekly 1.5-hour sessions with teaching, skill-building, and at least 30 minutes of exercise. Researche…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested a new drug, JYB1904, in 69 adults with allergic asthma. Participants received either JYB1904 every 8 weeks or the standard drug omalizumab every 2 to 4 weeks for 24 weeks. The goal was to see how the drug behaves in the body, how safe it is, and how well it cont…

This phase 2 study tested three different drug combinations in 151 people with advanced non-small cell lung cancer that had not been treated before. The drugs help the immune system attack cancer cells. Researchers measured how many patients' tumors shrank or stopped growing, and…

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This study looked at adding sunitinib malate (a drug that blocks tumor blood flow) to standard chemotherapy for people with extensive-stage small cell lung cancer. The trial involved 156 participants and aimed to find the best dose and see if maintenance sunitinib after chemo cou…

This study tested whether a natural hormone called DHEA can improve exercise ability in adults with COPD and high blood pressure in the lungs. 51 participants took either a low or high dose of DHEA or a placebo daily for one year. The main goal was to see if DHEA helped them walk…

This study tested whether a smartphone chatbot called Vik-Asthme can teach adults with asthma how to manage their condition as well as the usual in-person training. 73 adults with asthma were split into two groups: one received standard education, the other used the chatbot. Rese…

This phase II trial tested a new drug called AK104 (a bispecific antibody that targets two immune checkpoints) combined with the chemotherapy docetaxel in 44 adults with advanced non-small cell lung cancer whose disease had progressed after platinum-based chemotherapy and an anti…

This study tested the safety and effectiveness of Vizimpro (dacomitinib) in 40 Japanese patients with EGFR-mutated non-small cell lung cancer that could not be surgically removed or had returned. Researchers tracked side effects, especially interstitial lung disease, and measured…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study tested giving immunotherapy drugs (nivolumab alone or with relatlimab) for four weeks before surgery in 90 people with early-stage non-small cell lung cancer. The goal was to see if this approach is feasible and helps shrink tumors before removal. Results help determin…

This study tested whether matching drug combinations to specific biomarkers in advanced non-small cell lung cancer could improve response. 245 patients who had not received prior treatment were grouped by two biomarkers (GEP and TMB) and given pembrolizumab plus another drug. The…

This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers com…

This study tested a new drug called PM8002, which targets two proteins that help cancer grow, combined with standard chemotherapy. It involved 31 adults with a rare cancer called malignant mesothelioma that could not be removed by surgery. The goal was to see if the combination s…

This study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This study tested whether taking high-dose fish oil (n-3 PUFA) for 6 months can improve asthma control in adults with a specific type of asthma called N-ERD, which is triggered by aspirin or NSAIDs. The 18 participants had poorly controlled asthma despite standard treatment. The …

This study followed 105 teenagers with severe uncontrolled asthma who were starting treatment with dupilumab (Dupixent). Researchers tracked their asthma control, flare-ups, and safety over one year. The goal was to see if this medication helps teens manage their condition better…

This early-phase study tested a combination of two drugs, bexarotene and Iressa, in 6 people with advanced non-small cell lung cancer who had already tried standard treatments. The goal was to see if the combination was safe and could help control the disease. The study looked at…

This study tested whether early hemofiltration, a continuous dialysis procedure, could improve survival in children who develop respiratory failure after a bone marrow transplant. Only 6 children took part. The idea was to filter out inflammatory molecules that drive lung damage.…

This Phase 3 trial tested a drug called efzofitimod in 268 adults with pulmonary sarcoidosis, a condition that causes lung inflammation. Participants received either the drug or a placebo every 4 weeks for 48 weeks. The main goal was to see if the drug could help people safely re…

This completed study looked at 80 people with empyema, a serious lung infection. Researchers compared two different antibiotic combinations to see which was safer and more effective. The goal is to help doctors choose the best treatment for this condition.

This study tested a new type of breathing machine that automatically adjusts its settings to match each person's breathing in real time. Fifteen people with severe COPD who already use a ventilator at home tried the device for six weeks. The goal was to see if the smart ventilato…

This study tested an oral drug called PLB1001 in 145 people with advanced non-small cell lung cancer whose tumors have a specific genetic change (c-Met dysregulation). The main goal was to see how many patients' tumors shrank or disappeared. The drug is taken twice daily and aims…

This completed Phase 4 trial tested two different doses of chemotherapy (standard and low-dose) combined with the immunotherapy drug Sintilimab in 20 people with advanced squamous non-small cell lung cancer. The goal was to see if the lower-dose combination could shrink tumors an…

This early-stage trial tested a drug called itolizumab (EQ001) in 18 adults with moderate-to-severe asthma that is not well controlled by standard treatments. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked for early signs that …

This study looked at whether giving immunochemotherapy in the morning or afternoon affects how long people with advanced non-small cell lung cancer live without their disease getting worse. 210 patients were randomly assigned to receive treatment before or after 3 PM. The goal is…

This early-stage trial tested a new drug called PF-07257876 in 29 people with advanced lung, head/neck, or ovarian cancers that had stopped responding to other treatments. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals wer…

This study tested whether a shorter course of radiation (hypofractionated) given with chemotherapy works as well as the standard longer radiation course for people with limited-stage small cell lung cancer. 860 adults aged 18-70 with early-stage disease took part. The main goal w…

This phase 3 study tested alectinib against crizotinib in 303 people with advanced ALK-positive non-small cell lung cancer who had not received prior treatment. Participants took one of the two drugs twice daily until their cancer worsened or side effects became too severe. The m…

This phase II trial tested a drug called huMAb OX40L in 29 adults with mild allergic asthma. The drug is an antibody designed to block a protein that triggers allergic reactions in the airways. Researchers measured whether it could prevent breathing problems caused by allergens, …

This phase 2 study tested a combination of two drugs—KN046 (an immunotherapy) and axitinib (a targeted therapy)—in 95 people with advanced non-small cell lung cancer that had not been treated before. The goal was to see if the combo could shrink tumors and how safe it was. The tr…

This study tested a combination of two drugs, tislelizumab and anlotinib, in 29 people with advanced pulmonary pleomorphic carcinoma, a rare and aggressive lung cancer. The goal was to see if the combo could shrink tumors or slow the disease. Participants had stage III or IV canc…

This study tested a new drug called XTX202 in 95 people with advanced solid tumors that had not responded to standard treatments. The goal was to check safety, find the right dose, and see if the drug could shrink tumors. The trial is now complete.

This study tested the safety and effectiveness of the antifungal drug isavuconazole as a first treatment for Chinese patients with serious invasive fungal infections caused by Aspergillus or other molds. All 70 participants received the drug for up to 84 days (or 180 days for cer…

This study tested whether combining two targeted drugs, savolitinib and osimertinib, works better than standard chemotherapy for people with advanced non-small cell lung cancer that has a specific genetic change (MET amplification) and has stopped responding to initial treatment.…

This early-stage study tested a single shot of depemokimab, a biologic drug for asthma, in 20 healthy Chinese adults. Researchers measured how the drug moves through the body and checked for side effects. The goal was to gather safety and dosing information for future studies in …

This study tested a device called the Toronto EVLP System that keeps donated lungs warm and breathing outside the body. The goal was to see if it is safe to extend the time doctors can preserve and check the lungs before transplant. 118 adults waiting for a lung transplant took p…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study tested whether adding an experimental drug (CCR2/5-inhibitor or anti-IL-8) to the immunotherapy nivolumab before and after surgery could help shrink tumors and improve long-term survival in people with non-small cell lung cancer or liver cancer. 48 participants receive…

This phase 3 trial tested whether adding plinabulin to the chemotherapy drug docetaxel helps people with advanced non-small cell lung cancer live longer. 559 participants who had already tried one or two prior treatments received either the combination or docetaxel alone. The stu…

This study tested whether adding the immunotherapy drug camrelizumab to standard chemotherapy and radiation helps people with advanced lung cancer whose disease has spread to the brain. The trial included 60 patients who had not received chemotherapy before. Researchers measured …

This phase 3 trial tested whether a new inhaler (beclometasone/formoterol) works as well as an existing one (budesonide/formoterol, Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 24 weeks, 750 Chinese adults with moderate-to-severe COPD used one of …

This study tested whether mepolizumab, an asthma drug, can reduce lung inflammation and flare-ups in people with COPD who have high levels of eosinophils (a sign of asthma-like inflammation). Thirty-one participants received mepolizumab every 4 weeks for a year and had MRI scans …

This early-stage study tested a single dose of mesenchymal stromal cells in 7 COVID-19 patients with severe acute respiratory distress syndrome (ARDS) who were on ventilators. The main goal was to check safety, looking for serious side effects like heart problems or blood clots w…

This study tested a 12-week internet-based aftercare program for people with COPD, starting right after they finished inpatient pulmonary rehabilitation. The program included activity tracking, online exercise training, educational modules, and therapist support via phone. Resear…

This study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…

This study looks at children aged 5 to 18 who had an exercise challenge test to see if certain symptoms, like wheezing or coughing during exercise, can predict a positive result. The goal is to find simpler ways to diagnose exercise-induced bronchoconstriction, a condition where …

This trial tests whether an ultra-low-dose CT scan, using a new image reconstruction algorithm, can produce images good enough for diagnosing lung, abdominal-pelvic, and bone lesions, compared to a standard-dose CT scan. About 116 adults will receive both scans as part of their u…

This study investigates whether a liquid biopsy taken from the airways during a bronchoscopy can help diagnose lung cancer and identify genetic mutations. The approach aims to be less invasive and faster than traditional tissue biopsies. Researchers will compare the accuracy of t…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study tests a new, ultra-sensitive blood test (NGS) to detect EGFR gene mutations in patients with advanced lung cancer. Researchers will compare it to the current standard test using stored blood samples from 130 patients. The goal is to see if the new method finds more mut…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This study investigates whether 'showering cells' — a specific type of cell seen under a microscope in fluid from the lungs — can help diagnose aspiration pneumonia, a lung infection caused by inhaling food or stomach contents. Researchers will compare cell samples from 430 hospi…

This study investigates whether patterns in speech and breathing can indicate the presence of obstructive respiratory diseases like COPD. Researchers will collect short voice recordings from patients with and without lung disease and compare them to standard lung function tests. …

This study is testing a new breath test called OWL-EVO1 to see if it can accurately tell the difference between people who have lung cancer and those who do not. The test involves breathing into a device after taking a special probe. Researchers are enrolling adults aged 45-85 wh…

This study tests whether a simple lung ultrasound can accurately detect heart failure in people with chronic obstructive pulmonary disease (COPD) who come to the emergency room with shortness of breath. Heart failure is a common but often missed cause of worsening COPD symptoms. …

This study evaluates an artificial intelligence (AI) software that analyzes chest X-rays to detect signs of interstitial lung disease (ILD), a group of conditions that scar the lungs. Researchers are checking how often the AI's flags for lung abnormalities turn out to be real dis…

This study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…

This completed Phase 1 study tested a new radioactive imaging agent called [123I]I-DARPIN-Ec1 in 10 people with lung or ovarian cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors on SPECT scans. Researchers compared the new scan resu…

This study explores whether ultrasound can identify the reasons some patients fail to come off a mechanical ventilator. Researchers will scan the heart, lungs, and diaphragm of adults who have been on a ventilator for at least 24 hours and have not passed a spontaneous breathing …

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study checked how accurate two rapid tests (LumiraDx SARS-CoV-2 Ag Ultra and LumiraDx SARS-CoV-2 & Flu A/B) are at detecting COVID-19 and flu in people with symptoms. 716 participants provided nasal swabs at clinics. The results were compared to standard lab tests to measure…

This study tested whether an ultra-low dose CT scan, combined with a deep-learning AI reconstruction, can detect lung nodules as accurately as the standard low-dose CT. 70 adults having a chest CT for nodule check-up or follow-up received an extra ultra-low dose scan. The goal wa…

This study tested whether a special MRI technique can measure airway thickness in asthma patients as well as CT scans do, but without radiation. Thirty adults with asthma underwent both scans. The goal is to find a safer way to monitor airway changes over time.

This study investigates whether a machine that analyzes exhaled breath can identify a unique chemical signature for lung cancer. Researchers will compare breath samples from people with lung cancer (before and after surgery) and healthy controls. The goal is to develop a non-inva…

This study looked at whether lung MRI can diagnose bronchiolitis obliterans syndrome (BOS) after allogeneic stem cell transplant as well as chest CT scans. BOS is a serious lung complication that can occur after transplant, and early diagnosis is important. Researchers compared M…

This study tested an AI tool called Carebot AI CXR to see how well it spots lung problems like collapsed lungs, nodules, and fluid buildup on chest X-rays. Researchers compared the AI's performance to that of human radiologists using 956 patient X-rays. The goal was to see if the…

This study looked at a new, non-invasive test to identify asthma patients with high levels of an enzyme called GSNOR, which can cause airway swelling. The test involves inhaling a substance called GSNO and measuring changes in breath and lung function. Researchers hope this offic…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This trial tests whether giving the steroid budesonide directly into the windpipe, together with surfactant, can prevent bronchopulmonary dysplasia — a chronic lung disease — in very preterm infants (born before 32 weeks or weighing under 1500 grams) who have respiratory distress…

This study tests a program called FLARE that teaches families how to protect children from the sun. It includes children ages 8 to 17 who have a parent who survived melanoma and who have had at least one sunburn in the past year. Families are randomly assigned to either the FLARE…

This study tested whether giving breathing support early (non-invasive ventilation and high-flow nasal oxygen) to people with chest injuries and low oxygen levels could prevent them from needing a breathing tube. 144 patients in the ICU took part. The goal was to see if this earl…

This study looked at ways to reduce breathing problems and allergies in over 1,100 Norwegian salmon industry workers. The goal was to find practical changes in the workplace that lower workers' exposure to dust and other particles that can cause asthma. Researchers measured air q…

This study tested a structured physiotherapy program for 60 people who had lung cancer surgery. The program included breathing exercises, early walking, and posture training during their hospital stay. Researchers measured how long people stayed in the hospital and checked vital …

This trial tests a new inflatable cushion called the BathMat, designed to help reposition patients lying on their stomachs (proned) in the ICU. Proning helps patients with severe breathing problems get more oxygen, but repositioning them every few hours currently requires at leas…

This study looked at whether a 10-week supervised aerobic exercise program can help people with pulmonary hypertension (high blood pressure in the lungs) become more active and feel better. About 97 participants, including healthy volunteers and patients, took part. Patients were…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This study tests whether using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the decline in cough strength in 20 people with early ALS. Participants will use a facemask or mouthpiece to help inflate their lungs fully before coughing. Researcher…

This pilot study tests whether a daily herbal supplement made from Lindera obtusiloba can improve quality of life for people with non-small cell lung cancer who are receiving PD-1 or PD-L1 inhibitor immunotherapy. About 20 adults will take the supplement for 8 weeks alongside the…

This trial tests whether adding breathing exercises to standard physiotherapy improves lung function, pain, and quality of life in people with thoracic discopathy, a condition affecting the upper spine. Forty participants will be randomly assigned to receive either 15 sessions of…

This trial investigates whether Su Jok therapy, a complementary technique that stimulates specific points on the hands, can reduce dyspnea (breathlessness) and fatigue in people with chronic obstructive pulmonary disease (COPD). The study will include 30 hospitalized adults with …

This study tests whether teaching family caregivers about lung cancer care—through a handbook and personalized guidance—can reduce stress and improve quality of life for patients undergoing lung cancer surgery. The trial involves 160 patients and their caregivers, with some recei…

This study tests a psychosocial program called Conquer Fear Support (CFS) for people with stage III or IV lung or gynecologic cancer who are experiencing fear of cancer progression. The program includes psychoeducation, attention training, worry management, and detached mindfulne…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This study asks whether Su Jok therapy, a complementary technique that gently stimulates specific points on the hands, can reduce shortness of breath and improve sleep in adults with asthma. Participants will be randomly assigned to receive either Su Jok therapy alongside their u…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This trial tests whether ciprofol, a newer sedative, provides better and safer sedation than the standard drug propofol for people undergoing bronchoscopy, a procedure to examine the airways. Both are given with a low dose of sufentanil for pain relief. The study involves 100 adu…

This early-stage study is testing an extended-release tablet called nalbuphine ER in 10 people with idiopathic pulmonary fibrosis (IPF). The main goal is to see if the drug is safe and whether it affects breathing function. Researchers will monitor oxygen levels, breathing rate, …

This trial tests whether adding nebulized ketamine to lidocaine before a fiberoptic bronchoscopy reduces coughing and discomfort compared to lidocaine alone or standard spray. About 134 adults scheduled for bronchoscopy will receive one of three premedication approaches. The stud…

This trial compares two breathing techniques—Active Cycle of Breathing Technique (ACBT) and Pursed-Lip Breathing (PLB)—to see which better improves lung function, reduces breathlessness, and enhances quality of life in people with moderate to severe COPD. Forty adults aged 40 to …

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

This trial tests whether distraction techniques—like drawing, reading a story, watching a cartoon, or using a toy nebulizer and mask—can lower fear and anxiety in children aged 3 to 6 during inhalation therapy for respiratory infections. Children are randomly assigned to one of t…

This trial tests whether low-intensity body weight exercises combined with blood flow restriction (BFR) are safe and acceptable for people with COPD. Participants perform simple moves like sit-to-stand and knee raises at home, wearing inflatable cuffs on their thighs. The study f…

This study tests whether a device called oscillatory positive expiratory pressure (OPEP) therapy can reduce cough symptoms and improve lung mechanics in people with COPD. Participants use the device at home twice daily for four weeks. Researchers compare lung function and symptom…

This trial tests whether a wearable sensor called the Alio Smart Patch can help catch early signs of febrile neutropenia, a serious infection risk from chemotherapy. Thirty adults with certain cancers will wear the patch and a glucose monitor at home, with a remote care team watc…

This trial tests three methods to prepare children aged 6–12 for a pulmonary function test (spirometry): routine verbal instruction, verbal instruction with a live demonstration, or watching an animation. The goal is to see which approach helps children perform the breathing mane…

This study tested whether a simple balloon-blowing exercise, combined with deep breathing, could increase oxygen levels in people with mild to moderate COPD. 46 adults performed the exercises twice daily for 7 days. The results showed that those who did both balloon blowing and d…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This trial tests whether daily bright light therapy can improve sleep and reduce biological aging in people with lung cancer. Participants wear a light visor for 4 weeks and track sleep, fatigue, and stress. The study compares bright light to usual light exposure to see if it hel…

This trial investigates whether an 8-week systematic symptom management nursing program can improve quality of life, self-management skills, and psychological resilience in people with advanced (stage IIIB–IV) lung cancer. Participants are randomly assigned to receive either rout…

This trial investigates whether adding high-flow nasal oxygen during exercise training can improve endurance and quality of life for people with chronic fibrotic interstitial lung disease (ILD). Participants undergo a 4-week pulmonary rehabilitation program, receiving either high…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This pilot study tests a breathing method called percussive ventilation breathhold (PVB) to help people hold still during lung cancer radiation. The goal is to see if the technique can be used successfully by healthy volunteers and lung cancer patients. If it works, it may allow …

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested two non-invasive breathing machines in 49 newborns (born at 33 weeks or later) with respiratory distress. One machine is the standard nasal CPAP, and the other is a newer device called nasal high frequency percussive ventilation. Researchers measured brain oxyge…

This study tested whether a 4-week home exercise program, guided by a wearable fitness device and supervised remotely, could help lung cancer patients get in better shape before surgery. Thirty people with early-stage non-small cell lung cancer participated. The goal was to see i…

This study looked at 300 infants under 6 months old with severe bronchiolitis in the pediatric ICU. Researchers compared two flow rates of high-flow nasal cannula (2 vs 3 liters per minute per kilogram) to see which one reduced breathing failure within 24 hours. The goal is to fi…

This study looked at whether a specific breathing exercise (forced expiration while lying on the side of the surgery) can shorten the time children need a chest tube after lung surgery. The tube drains fluid that builds up after the operation. The study involved 140 children aged…

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study tested two ways of positioning patients with severe lung injury (ARDS) who are on ventilators and placed face-down (prone) to help breathing. The goal was to see if a 'swimmer' position—where the head is turned and one arm is bent—causes fewer severe pressure sores tha…

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or…

This study tested whether giving extra oxygen through a small tube in the nose during breathing tube placement can prevent dangerous drops in oxygen levels in newborns. About 110 infants in the NICU took part. The approach is simple and could make a common emergency procedure saf…

After surgery, painkillers can slow breathing. This study tested a device that uses a mild electrical pulse on the skin to wake patients when their breathing stops for 10 seconds. Researchers enrolled 60 adults recovering from surgery to see if the system is practical and accepta…

This study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …

This study tested whether a personalized exercise program helps people with early-stage lung cancer or cancer that spread to the lungs recover better after surgery. 182 participants were randomly assigned to either the exercise program or usual care. The main goal was to see if t…

This study looked at whether breathing exercises can improve quality of life for adults with asthma who also have dysfunctional breathing (a pattern of breathing that causes shortness of breath). About 190 adults with poorly controlled asthma took part. Half received usual care, …

This early-stage study tested the safety of a new drug called IBI3002 in 40 healthy volunteers and 20 people with asthma. Participants received either the drug or a placebo, and researchers monitored for side effects. The goal was only to check if the drug is safe enough to study…

This study tested whether personalized motivational messages sent via apps like WhatsApp could improve thinking skills and physical activity in lung cancer survivors who have memory or concentration problems. 124 survivors wore activity trackers and received custom messages for t…

This study looked at 100 adults with COPD who needed a breathing tube and a ventilator. It compared two approaches: giving sedation with daily breaks versus giving no sedation at all. The goal was to see which method leads to more days off the ventilator and fewer complications i…

This study tested an investigational drug called ponsegromab in 187 adults with lung, pancreatic, or colorectal cancer who also had cachexia—a condition causing severe weight loss, loss of appetite, and fatigue. The goal was to see if ponsegromab could help patients gain weight a…

This study tested a procedure called bronchial thermoplasty for people with severe asthma that is not controlled by standard treatments. The treatment uses heat to thin the airway muscles, aiming to reduce breathlessness during exercise. 14 participants were enrolled, and the mai…

This study tested whether wearing an abdominal binder (a supportive wrap around the belly) along with doing special breathing exercises could help people with asthma feel less breathless and improve their quality of life. Thirty-two adults with mild to moderate asthma took part o…

This study tested whether a newer breathing machine method (NAVA) helps patients with respiratory failure come off the ventilator faster than the usual method (PSV). The study included 47 adults who had trouble weaning from the ventilator. Researchers measured how long it took to…

This study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…

This study tested whether a high-flow oxygen system (Optiflow) works better than a standard oxygen mask for patients with breathing failure. About 100 adults in intensive care who needed non-invasive ventilation (NIV) took part. The goal was to see if Optiflow keeps oxygen levels…

This study looked at whether a 4-week program of breathing muscle training, aerobic exercise, or both could improve breathing strength, walking ability, and well-being in women with stable COPD. 68 women aged 48-65 with mild-to-moderate COPD took part. The researchers also checke…

This study looked at whether breathing 60% oxygen during exercise helps people with idiopathic pulmonary fibrosis (IPF) who are taking nintedanib. 78 participants exercised on a bike or walked while getting either high oxygen or standard care. The goal was to see if they could ex…

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. …

This study tested whether giving propofol sedation during a lung exam (bronchoscopy) under noninvasive ventilation helps patients with severe breathing failure stay more comfortable and maintain oxygen levels. Forty-six adults with acute respiratory failure needing a diagnostic l…

This early-phase trial tested a treatment called photodynamic therapy for people with advanced lung cancer that blocks airways. Patients received a light-sensitive drug followed by a laser to activate it inside the tumor. The goal was to see if the treatment is safe and can shrin…

This study tested whether a mobile app with videos and written guides, given before chest surgery, helps patients recover better. 128 adults scheduled for elective chest surgery were split into two groups: one used the app, the other got standard education. Researchers measured q…

This study tested whether sleeping with the head and trunk raised (using an adjustable bed backrest) improves sleep quality in people with chronic obstructive pulmonary disease (COPD). Twenty-four adults with severe COPD and sleep difficulties each tried the raised position and t…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This completed study looked at 83 adults of African, African American, or African Caribbean descent to find genetic and environmental factors linked to asthma. Participants provided blood, skin, and breathing test data. The goal was to build a resource for future research, not to…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This early-stage study tests a new drug called RSS0343 in 48 healthy adults to see if it is safe and how the body handles it. Participants take the drug or a placebo by mouth for a short time. The goal is to check for side effects and measure drug levels in the blood. This study …

This study looked at different ways to collect sputum (phlegm) from people with a lung infection called nontuberculous mycobacterial (NTM) infection. The goal was to see which method gives the best samples for diagnosing and understanding the infection. Participants provided thro…

This trial is testing whether using whole-body PET/CT scans and liquid biopsies (blood tests that detect cancer DNA) can improve the follow-up care of people who have completed treatment for early-stage non-small cell lung cancer. The goal is to see if these advanced tools can fi…

This study examined whether a chemical called TGF-Beta, which is more common in the lungs of people with asthma, makes them more vulnerable to respiratory syncytial virus (RSV). Researchers collected lung cells from 113 healthy adults and mild asthmatics using a bronchoscopy. The…

This international survey asks practicing physicians how they diagnose and treat acute asthma exacerbations—sudden worsening of asthma symptoms. It aims to uncover variations in clinical practice, including medication choices and use of breathing support. The findings could revea…

This study looks at 377 adults with severe lung failure (ARDS) who were treated with prone positioning (lying face down to help breathing). Researchers will use computer models to predict which patients are at highest risk of dying in the ICU. The goal is to help doctors make bet…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study follows over 2,700 people with bladder, lung, or liver cancer who are receiving the drug atezolizumab as part of their normal treatment. Researchers are tracking how long patients live and how well the drug controls their cancer outside of a controlled clinical trial. …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study follows 1,200 people in China newly diagnosed with advanced non-small-cell lung cancer (stage IIIB/IV) that cannot be removed by surgery. Researchers will collect information from medical records and follow patients over time to see what treatments they receive, how lo…

This study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…

This study investigates how the airways respond to two different challenge tests—mannitol inhalation and a controlled hyperventilation exercise—in people with cough variant asthma, those with chronic cough but normal airway sensitivity, and healthy controls. The goal is to see if…

This study investigates how viral infections influence the community of bacteria in the airways of young children with cystic fibrosis. Researchers will collect throat swabs from children under 5 years old over one year, tracking their microbiome, inflammation, and clinical sympt…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This study is testing whether a simple lung ultrasound can tell the difference between a sudden COPD flare-up and stable disease. It will compare ultrasound images, breathing tests, and exercise ability in about 60 people—those with an acute exacerbation, those with stable COPD, …

This trial investigates whether a recruitment maneuver—a brief procedure to open collapsed lung areas—affects blood levels of sRAGE, a marker of lung cell injury, in patients with diffuse acute respiratory distress syndrome (ARDS). The study involves 24 mechanically ventilated IC…

This study collected fluid and cells from the lungs of 574 people with asthma and healthy volunteers using a thin tube called a bronchoscope. The goal was to learn more about airway inflammation and what causes it. The findings may help identify new targets for future asthma trea…

This study looked at whether a lung rehab program done over video calls can help people recover after lung cancer surgery. 36 patients aged 55-75 who had part or all of a lung removed took part. They did exercises and tests like the 6-minute walk and breathing tests, all guided b…

This study tests whether gradually tilting patients with acute respiratory distress syndrome (ARDS) upright—from lying flat to a 90° seated position—improves how their lungs handle mechanical ventilation. Researchers will measure lung pressure, aeration, and oxygen levels at each…

This study looks at whether certain proteins linked to the RAGE receptor—found in lung fluid and blood—are elevated in ICU patients with acute lung injury or ARDS. Researchers will measure these proteins in 60 mechanically ventilated patients within the first day of injury and tr…

This study surveys senior managers at companies in Zambia with silica dust exposure to assess their knowledge, attitudes, and practices regarding tuberculosis. Since these leaders shape workplace policies, their understanding is key to protecting workers. The findings could highl…

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This study looked at whether a special breathing maneuver during gallbladder surgery can reduce lung collapse (atelectasis) after the operation. Researchers used lung ultrasound to check lung aeration in 80 adults before and after surgery. The goal was to gather information, not …

This study tested a special MRI technique using a harmless gas to see how well it can show changes in the lungs of people with interstitial lung disease. Researchers worked with 46 volunteers to find the best way to use this scan. The goal is to create a standard method that doct…

This 100% remote study surveys 250 people diagnosed with non-small cell lung cancer before age 50. Participants answer questions about their environment, lifestyle, and family history, and may donate blood. The goal is to uncover factors linked to genetic changes that drive young…

This study interviews 55 patients with resectable non-small cell lung cancer and their doctors in the US, Germany, and Japan. The goal is to understand what treatment features they value most, such as effectiveness or side effects. Results may help align care with patient priorit…

This study is testing whether a CT-free electromagnetic navigation system can accurately locate small lung nodules before surgery, compared to the standard CT-guided method. The goal is to see if the new approach can mark nodules within 10 millimeters of their center, which is cr…

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

This study observes people in Belgium with non-invasive pneumococcal infections like pneumonia, ear infections, and sinusitis. Researchers will collect bacterial samples to see which strains are circulating and how they compare to invasive infections. The goal is to understand ho…

This study tests a new AI tool called GAPS-Agent that helps doctors plan surgeries for lung cancer. The tool is designed to assist less experienced doctors in making complex decisions. Researchers will compare AI-generated plans to those from a standard AI, and expert surgeons wi…

This study uses ultrasound to measure diaphragm movement and breathing in 15 adults receiving a stellate ganglion block — a nerve injection for certain pain conditions. The goal is to see how often the block temporarily paralyzes one side of the diaphragm. Researchers also check …

This study looks at how anti-tumor T-cell responses change in people with lung or head-and-neck cancer who are receiving radiochemotherapy. Researchers will collect blood and tumor samples to track immune markers. The goal is to understand whether this standard treatment can boos…

This study looks back at medical records of adults who were sent home from the emergency department to receive hospital-level care for common infections like pneumonia, urinary tract infections, or skin infections. The goal is to understand why some of these patients end up needi…

This study looks at whether an artificial intelligence program can detect early signs of idiopathic pulmonary fibrosis (IPF) on chest X-rays earlier than radiologists. IPF is a serious lung disease that causes scarring and is often diagnosed late. Researchers will compare the dat…

This study examines how children under 18 with cancer or a history of a stem cell transplant do when they need a machine called ECMO to help them breathe. Researchers looked at bleeding, infections, and survival rates in children treated at one hospital, and compared survival wit…

This study tests whether alerts in electronic health records help doctors follow best-practice guidelines for bronchiolitis, a common lung infection in young children. About 8,000 children under 2 years old will take part. Doctors will receive either no alert, a gentle reminder, …

This study looks at whether placing patients face-down (prone) to help them breathe can damage nerves in the shoulder area. Researchers will use electrical tests to check for nerve injury in adults with severe lung failure who are sedated and on a ventilator. The goal is to find …

This study explores whether artificial intelligence can predict the stage and survival of non-small cell lung cancer by analyzing CT and PET scans. Researchers will train a deep learning model using existing medical records from 156 patients who had lung cancer surgery. The goal …

This study looks at how children born preterm with chronic lung disease respond to different inhaled bronchodilators. Participants will have their lung function tested before and after using three types of inhalers: salbutamol, ipratropium bromide, and a combination of fenoterol …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study tests whether machine learning can predict death in the intensive care unit for patients with acute hypoxemic respiratory failure (AHRF), a common cause of ICU admission. Researchers will analyze data from over 1,200 patients, using several machine learning algorithms …

This study investigates why COVID-19 causes severe lung injury (ARDS) by looking at tiny blood vessels in the lungs. Researchers will compare 39 patients with COVID-19 ARDS to those with ARDS from other causes. They measure 'alveolar dead space' — lung areas that get air but not …

This study tests whether machine learning can predict if a patient with acute hypoxemic respiratory failure will need a breathing machine for a week or longer. Researchers analyzed data from over 1,200 ICU patients in Spain, using information from the first 48 hours to build a pr…

This study investigates whether electrical impedance tomography (EIT) — a non-invasive imaging technique — can help doctors choose the best ventilator settings for each patient with acute respiratory distress syndrome (ARDS). Researchers will compare different methods of setting …

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This trial tests whether presenting a cancer screening appointment as a pre-selected default option (opt-out) makes people at high risk for lung or stomach cancer more likely to accept it, compared to a standard opt-in approach. Participants complete an online questionnaire and d…

This study develops and tests a tool designed to help lung cancer nurses talk to patients about clinical trials. The tool provides information on available trials, communication tips, and practical guidance. Researchers will test it in four UK hospitals to see if it improves nurs…

This study aims to develop and test a tool that helps lung cancer nurses talk to patients about clinical trials. Only about 8% of lung cancer patients in the UK join trials, and nurses often lack the time or confidence to discuss them. The tool will be tested in four UK hospitals…

This study investigates whether a simple blood test (liquid biopsy) can track how advanced non-small cell lung cancer changes during immunotherapy or targeted therapy. Researchers will analyze tumor DNA circulating in the blood to see if it can predict treatment response and dete…

This study tested a new breathing test to decide when to remove breathing tubes in patients with acute hypoxic respiratory failure. The test uses noninvasive ventilation to see if patients can breathe on their own earlier. Researchers hope this approach reduces time on invasive v…

This pilot study tracks changes in a specific inflammatory marker (IL-1β) in the nasal passages of adolescents during an asthma attack. Researchers collect nasal fluid samples daily for five days during an attack and compare them to baseline samples taken when the participant is …

This study investigates how a specific strain of pneumococcus bacteria (serotype 3) colonizes the nose of healthy adults. Researchers will give volunteers nose drops containing the bacteria to see what dose leads to colonization and how long the bacteria stay before the immune sy…

This study looks at whether chronic lung inflammation from bronchiectasis raises the risk of heart disease and accelerates aging. Researchers will measure heart function, artery stiffness, bone density, muscle mass, and blood markers in 110 adults aged 40 to 80 with confirmed bro…

This observational study looks at why some people with severe asthma continue to have flare-ups even while taking tezepelumab, an approved treatment. Researchers will track 150 patients over a year, measuring changes in inflammatory cells and markers in blood and airways during a…

This study follows 1500 adults with interstitial lung disease to understand how the condition changes over time. Researchers will track symptoms, lung function, and treatments used. The goal is to build a detailed picture of the disease's course and improve future care.

This study looked at 30 people with early-stage non-small cell lung cancer who had surgery. Researchers collected blood from a vein near the tumor and from a regular arm vein to study tiny particles called exosomes. The goal was to see if these particles could help predict whethe…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looks at how breathing machines (mechanical ventilators) might injure the diaphragm, the main muscle used for breathing. Researchers will monitor 50 ICU patients over their first 7 days on the ventilator, measuring diaphragm activity and function. The goal is to unders…

This study tracked 60 children aged 5 to 15 who survived a near fatal asthma attack in the UK and Ireland. Researchers collected data on risk factors, medical care, and social and environmental influences. The goal is to create better care guidelines and reduce future risks.

This study tested a non-invasive imaging method called electrical impedance tomography (EIT) to measure airway opening pressure in 6 adults with acute lung injury or ARDS. The goal was to see if EIT could detect where and when small airways open during a slow breath, which might …

This completed study in Greece enrolled 200 people with stage 4 non-small cell lung cancer. Researchers used genetic testing to map each tumor's unique features and gave half the patients access to a digital platform to report side effects. The goal was to see if combining person…

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study looks at how the community of bacteria, fungi, and viruses in the lungs changes when a person with COPD has a severe flare-up that requires intensive care. Researchers collect sputum samples from patients to analyze the genetic material of these microbes. The goal is t…

This study followed 39 lung cancer patients who received radiation therapy to see how it affected their breathing. Researchers measured lung volume and gas exchange capacity before and after treatment, looking for a 20% or greater drop in diffusion capacity at 3 months. The goal …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This study looks at how common pneumococcus bacteria are in the noses and throats of healthy Vietnamese children aged 6 months to 5 years. Researchers will take a simple swab and interview parents about factors like vaccination history, antibiotic use, and living environment. The…

This study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…

This study tests an artificial intelligence program designed to predict the best time to remove a breathing tube (extubation) from patients in intensive care. Researchers will use data from 1500 adults who were on a ventilator for at least 72 hours across four hospitals. The AI a…

This study uses lung ultrasound to measure how the lungs change after surgery to remove part of a lung due to cancer. Researchers will check lung aeration before surgery, right after, and 24 hours later in about 32 adults. They aim to see if ultrasound findings relate to oxygen l…

This completed study enrolled 336 people with non-small cell lung cancer to collect detailed family cancer histories using a questionnaire. Researchers want to see if certain patterns of cancer in relatives, along with smoking and other risk factors, can help identify patients wh…

This study looked at whether a blood test called ISET can find circulating tumor cells in people with early-stage non-small cell lung cancer. Researchers checked blood samples from 256 patients before surgery to see if these cells were linked to cancer stage, type, and survival. …

This study tested whether a protein called GLUT1 could help doctors better classify lung neuroendocrine tumors. Researchers analyzed tumor samples from 36 patients to see if GLUT1 staining patterns matched tumor type. The goal was to find a more reliable diagnostic tool than curr…

This observational study at Hospital H+ Querétaro looked at 150 patients with suspected or confirmed invasive aspergillosis, a serious fungal infection. Researchers measured a substance called galactomannan in lung fluid samples to see if higher levels were linked to worse outcom…

This study tested whether a CT scan of the lungs could predict which patients with severe eosinophilic asthma would respond well to the drug benralizumab. 59 adults received benralizumab for 48 weeks and had CT scans at the start, middle, and end of treatment. The goal was to see…

This study tested two different injection devices (a safety syringe and an autoinjector) to see how the body absorbs depemokimab, a potential asthma treatment. 140 healthy adults received a single dose. The goal was to compare the drug levels in the blood, not to treat asthma.

This study looked at whether a narrower oxygen saturation target range helps an automated oxygen control system work better for very low birth weight infants on breathing support. Eleven babies were randomly assigned to either a 3% or a shifted 3% target range. The goal was to se…

This completed study looked at whether a breathing treatment called Intrapulmonary Percussive Ventilation (IPV) can improve lung stiffness (compliance) in critically ill children who are on breathing machines. Researchers measured lung function before and after one IPV session in…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looks at why some people develop pneumonia after accidentally inhaling food, drink, or stomach contents. Researchers will track patients in intensive care and general medicine who have had a known or suspected inhalation event. The goal is to identify risk factors and …

This study observed 61 adults having shoulder surgery to see how a specific combination of nerve blocks affects the diaphragm, the main muscle for breathing. Researchers used ultrasound to measure diaphragm movement before and after the block. The goal was to find out if this tec…

This study looked at whether a quick stomach ultrasound before emergency surgery can help doctors choose the safest way to place a breathing tube. In 43 adult emergency patients, doctors used ultrasound to measure stomach contents and then decided on the airway method. The goal w…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study looked at whether measuring procalcitonin (PCT) levels in the blood could help detect infections earlier in people with stage IV non-small cell lung cancer starting chemotherapy. Researchers enrolled 45 patients and took a PCT blood sample before their first chemo sess…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This study looked at whether using a bedside ultrasound device to measure blood clotting can reduce the amount of blood products given during double-lung transplantation. The trial involved 128 adult patients. The goal was to see if this quick test helps doctors make better decis…

This study examined 41 patients treated for non-tuberculous mycobacteria (NTM) infections, comparing those with and without cancer. The goal was to count side effects from NTM treatment in each group to understand why cancer patients often stop therapy. Researchers hope this will…

This study analyzed health records from over 229,000 people with newly diagnosed lung cancer in Korea to see if getting a brain MRI every year helps find cancer that has spread to the brain. The goal was to learn whether these scans catch brain metastases earlier, when they might…

This study explored sleep disorders in 37 adults with non-small cell lung cancer. Participants filled out questionnaires about their sleep, symptoms, mood, and quality of life. The goal was to create a guide to help doctors diagnose and treat sleep issues in this group, ultimatel…

This study looks at how exercise training affects the growth and maturation of tiny blood vessels in the leg muscles of people with COPD. Researchers will compare healthy volunteers and COPD patients doing different exercise intensities for 5 to 10 weeks. The goal is to understan…

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study explores whether certain blood cells called fibrocytes play a role in the airway remodeling seen in chronic obstructive pulmonary disease (COPD). Researchers will compare blood samples and lung function between people with COPD and healthy volunteers, including smokers…

This study looked at whether offering smoking cessation support to people undergoing tests for lung cancer helps them try to quit. 86 patients from several hospitals took part. Some hospitals offered extra support, while others continued their usual care. The researchers measured…

This completed study tested different ways to use a nebulizer for asthma medication. 36 people with mild to moderate asthma received the drug salbutamol through various nebulization modes. The goal was to see which mode delivers more medication to the lungs and reduces waste. Res…

This study looks at fibrocytes—cells involved in scarring—in the lungs and blood of 50 people with COPD compared to healthy controls. Researchers want to understand how these cells contribute to airway remodelling, the abnormal tissue repair that makes COPD worse. The goal is to …

This study looked at the medical records of one person from a sleep clinic to see if their breathing problems were due to a condition called dysanapsis (where airways are smaller than normal) rather than true asthma. The goal was to better understand why some people with sleep ap…

This study looked at two breathing treatments—high-flow oxygen and non-invasive ventilation—in 16 adults with sudden breathing failure from pneumonia. The goal was to see which one better opens up the lungs. The results showed no major difference in lung opening, though non-invas…

This study reviewed the medical records of 569 adults who had surgery for lung or esophageal cancer. Researchers wanted to see if taking statins (cholesterol-lowering drugs) around the time of surgery was linked to fewer complications and better long-term outcomes. The goal is to…

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study measured the peak tidal inspiratory flow (PTIF)—how fast infants breathe in—in 50 babies under 6 months old with moderate to severe viral bronchiolitis. Researchers used a spirometer to record 20 breaths per infant within 24 hours of hospital admission. The goal was to…

This study tested whether a special 4D PET-CT scan can help doctors better target radiation for lung cancer. Seven patients with non-small cell lung cancer received both a standard CT scan and a 4D PET-CT scan before radiotherapy. Researchers compared the tumor volumes identified…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at 302 patients with advanced non-small cell lung cancer in Greece who were treated with a combination of nivolumab, ipilimumab, and chemotherapy as their first therapy. Researchers tracked patient characteristics, treatment patterns, and survival rates over tim…

This study collected tissue and blood samples from 143 people with malignant pleural effusion (cancer that has spread to the lining of the chest). The goal was to create a biobank for future research into why cancer cells in the chest may differ from the original tumor. No treatm…

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This study looked at 13 adults who had been on a breathing tube for at least 2 days and were at risk for breathing trouble after the tube was removed. Researchers compared two types of noninvasive breathing support: one that senses the patient's own breathing signals (NAVA) and o…

This study looked at whether neck muscle activity during sleep affects breathing recovery in 17 COVID-19 patients who were on ventilators in the ICU. Researchers used sleep tests and activity monitors to track sleep quality and breathing patterns. The goal was to understand why s…

This study tested whether a mobile health app called LIVEBORN can help nurse midwives improve how they support newborns who have trouble breathing right after birth. Over 14,000 newborns and their nurses took part. The app gave either real-time guidance or a summary after the eve…

This study looked at how a low dose of ketamine, a medicine often used for anesthesia, affects breathing and brain activity in 15 critically ill patients who were on breathing machines (ventilators) in the ICU. The goal was to see if ketamine could help stimulate breathing and im…

This study looked at 56 patients in a French hospital who had infections from a rare type of Klebsiella pneumoniae bacteria that can be treated with the common antibiotic amoxicillin. Researchers used genetic sequencing to understand why these bacteria are sensitive to amoxicilli…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study tested a new way to monitor breathing at home in 120 adults with severe asthma. The goal was to see if a special analysis of resting breath patterns could predict when an asthma attack might occur. The approach is observational and aims to improve early warning, not to…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study looked at how people with COPD experience physical activity. Researchers interviewed 54 participants and had them wear activity monitors to compare standard activity levels with personalized intensity measures. The goal was to better understand how to tailor activity r…

This study looked at 50 ICU patients with acute respiratory failure to see if a heart ultrasound test (measuring how the main vein collapses) could predict who would die or need a breathing tube. The goal is to help doctors give fluids more safely. It was an observational study, …

This completed observational study included 123 adults with COPD or asthma. Researchers measured breathing muscle strength using a special device and then tried to predict those results from simpler tests like spirometry and body composition. The goal was to see if doctors could …

This completed study looked at 150 people with advanced non-small cell lung cancer to see if proteins and metabolites in blood and urine could help monitor how well immunotherapy is working. Researchers used mass spectrometry to measure these markers before, during, and after tre…

This completed study tested whether an AI system could improve how ventilators are set for children (ages 1 month to 18 years) in the pediatric ICU with breathing problems like pneumonia or respiratory failure. Researchers compared AI-generated recommendations to the actual adjus…

This study looked at how to best set a breathing machine during lung surgery when only one lung is being used. The goal was to see if using smaller breaths with higher pressure could keep oxygen levels stable. 88 adults having lung surgery took part. The study measured oxygen in …

This study analyzed blood samples from 50 adults with advanced ALK-positive lung cancer whose disease had stopped responding to one or two ALK inhibitors. The goal was to identify genetic changes in the cancer that cause drug resistance. By matching these changes to the right nex…

This study looked at how a new drug called HEC585 interacts with two existing medicines for idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Thirty-three healthy adults took part to measure drug levels and safety. The goal was to see if combining these drugs cause…

This study looked at whether a lung specialist (pulmonologist) can quickly check biopsy samples during a lung cancer procedure, a job usually done by a pathologist. Researchers compared the pulmonologist's on-the-spot assessment with the pathologist's final report in 189 patients…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study tested a smartphone app that reminds people to walk several times a day. It was designed to help lung cancer patients stay active during radiotherapy. Thirty healthy volunteers downloaded the app and rated how easy it was to use. The goal was to see if the app is user-…

This study tested a virtual navigation system that helps doctors guide a bronchoscope to lung nodules for sampling. Researchers compared results from 110 patients who used the system to historical data from standard procedures. The goal was to see if the system improves biopsy su…

This study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …

This study looked at 10 adults with moderate-to-severe ARDS who were on breathing machines. Researchers used a non-invasive imaging method (EIT) to adjust ventilator pressure settings and then checked how the heart's right side responded using ultrasound. The goal was to find the…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…