New Lung-Box device could save more transplant organs

NCT ID NCT02234128

Completed Disease control Sponsor: Lung Bioengineering Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a device called the Toronto EVLP System that keeps donated lungs warm and breathing outside the body. The goal was to see if it is safe to extend the time doctors can preserve and check the lungs before transplant. 118 adults waiting for a lung transplant took part. Researchers compared their outcomes to standard transplant procedures, focusing on survival and lung function after 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Toronto EVLP System (device that keeps donor lungs warm and breathing outside the body)
What this could lead to: If successful, this could allow more donor lungs to be used for transplant by giving doctors more time to assess them safely.
What could go wrong: This is a safety study, not a test of cure. The device may not improve outcomes, and there are standard risks of lung transplant like organ rejection or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG DISEASE

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke University Health System

Durham, North Carolina, 27705, United States
Inova Fairfax Medical Campus

Falls Church, Virginia, 22042, United States
Loyola University Medical Center

Chicago, Illinois, 60153, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
UPMC

Pittsburgh, Pennsylvania, 15213, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Michigan Health System

Ann Arbor, Michigan, 48109, United States

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