New triple inhaler shows promise for better breathing in COPD

NCT ID NCT03197818

Completed Disease control Sponsor: Chiesi Farmaceutici S.p.A. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether a triple-combination inhaler (CHF 5993) works better than a standard dual inhaler (Symbicort) for people with chronic obstructive pulmonary disease (COPD). Over 700 adults aged 40 and older with a history of smoking took part. The main goal was to see if the triple inhaler improved lung function more than the dual inhaler after 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Beclometasone dipropionate / formoterol fumarate / glycopyrronium bromide (triple-combination inhaler)

What this could lead to

If successful, this triple inhaler could offer better lung function for people with COPD compared to a standard dual inhaler.

What could go wrong

This is a completed phase 3 trial, but results may not apply to all COPD patients. The improvement over the existing treatment may be small and not clinically meaningful for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE)

Contacts and locations

Show contact details

Locations

Chiesi Clinical Trial Site 156001

Guangzhou, 510230, China
Chiesi Clinical Trial Site 156002

Fuzhou, Fujian, 350005, China
Chiesi Clinical Trial Site 156004

Huai'an, Jiangsu, 223300, China
Chiesi Clinical Trial Site 156005

Shanghai, Shanghai Municipality, 200072, China
Chiesi Clinical Trial Site 156006

Shanghai, Shanghai Municipality, 200433, China
Chiesi Clinical Trial Site 156007

Shenyang, Liaoning, 110004, China
Chiesi Clinical Trial Site 156008

Zhanjiang, Guangdong, 524000, China
Chiesi Clinical Trial Site 156010

Chengdu, Sichuan, 610041, China
Chiesi Clinical Trial Site 156011

Shanghai, Shanghai Municipality, 200433, China
Chiesi Clinical Trial Site 156012

Beijing, Beijing Municipality, 100144, China
Chiesi Clinical Trial Site 156013

Guangzhou, Guangdong, 510080, China
Chiesi Clinical Trial Site 156014

Shanghai, Shanghai Municipality, 200025, China
Chiesi Clinical Trial Site 156015

Baotou, Inner Mongolia, 014010, China
Chiesi Clinical Trial Site 156026

Beijing, Beijing Municipality, 100020, China
Chiesi Clinical Trial Site 156036

Changchun, Jilin, 130000, China
Chiesi Clinical Trial Site 156038

Shanghai, Shanghai Municipality, 210009, China
Chiesi Clinical Trial Site 156039

Taiyuan, Shanxi, 030001, China
Chiesi Clinical Trial Site 156040

Changsha, Hunan, 410000, China
Chiesi Clinical Trial Site 156041

Nanchang, Jiangxi, 330000, China
Chiesi Clinical Trial Site 156042

Pingxiang, Jiangxi, 337000, China
Chiesi Clinical Trial Site 156043

Baotou, Inner Mongolia, 014000, China
Chiesi Clinical Trial Site 156044

Shijiangzhuang, Hebei, 050000, China
Chiesi Clinical Trial Site 156045

Chongqing, Chongqing Municipality, 400000, China
Chiesi Clinical Trial Site 156046

Linhai, Zhejiang, 317000, China
Chiesi Clinical Trial Site 156047

Jiujiang, Jiangxi, 332000, China
Chiesi Clinical Trial Site 156048

Guangzhou, Guangdong, 510000, China
Chiesi Clinical Trial Site 158001

Keelung, Keelung Municipality, 204, Taiwan
Chiesi Clinical Trial Site 158003

Douliu, Yunlin, 64041, Taiwan
Chiesi Clinical Trial Site 158004

Kaohsiung City, Penghu, 83301, Taiwan
Chiesi Clinical Trial Site 158005

Taipei, 11217, Taiwan
Chiesi Clinical Trial Site 158006

Kaohsiung City, 824, Taiwan
Chiesi Clinical Trial Site 158008

Taichung, Taiwan
Chiesi Clinical Trial Site 158010

Changhua, 500, Taiwan
Chiesi Clinical Trial Site 158011

Taipei, 220, Taiwan
Chiesi Clinical Trial Site 410001

Bucheon-si, Gyeonggido, 420-717, South Korea
Chiesi Clinical Trial Site 410002

Goyang-si, Gyeonggido, 10380, South Korea
Chiesi Clinical Trial Site 410003

Chuncheon, Gang'weondo, 24289, South Korea
Chiesi Clinical Trial Site 410004

Seoul, Seoul Teugbyeolsi, 100-032, South Korea
Chiesi Clinical Trial Site 410005

Jeonju, Jeonrabugdo, 54907, South Korea
Chiesi Clinical Trial Site 410006

Seoul, Seoul Teugbyeolsi, 136-705, South Korea
Chiesi Clinical Trial Site 410007

Seoul, Seoul Teugbyeolsi, 07985, South Korea
Chiesi Clinical Trial Site 410008

Seoul, Seoul Teugbyeolsi, 07345, South Korea
Chiesi Clinical Trial Site 410009

Gyeonggi-do, Seoul Teugbyeols, 135-720, South Korea
Chiesi Clinical Trial Site 410010

Daegu, Ulsan, 705-703, South Korea
Chiesi Clinical Trial Site 410011

Seoul, 04401, South Korea
Chiesi Clinical Trial Site 410012

Bucheon-si, Gyeonggido, 14584, South Korea
Chiesi Clinical Trial Site 410013

Seoul, 2559, South Korea
Chiesi Clinical Trial Site 410014

Seoul, 5030, South Korea
Chiesi Clinical Trial site 156003

Nanning, Guangxi, 530021, China
Chiesi clinical Trial Site 156017

Beijing, Beijing Municipality, 100029, China
Chiesi clinical Trial Site 156018

Hangzhou, Zhejiang, 310014, China
Chiesi clinical Trial Site 156019

Changchun, Jilin, 130021, China
Chiesi clinical Trial Site 156020

Haikou, Hainan, 570100, China
Chiesi clinical Trial Site 156022

Nanjing, Jiangsu, 210006, China
Chiesi clinical Trial Site 156023

Changchun, Jilin, 130000, China
Chiesi clinical Trial Site 156024

Foshan, Guangdong, 528000, China
Chiesi clinical Trial Site 156025

Yinchuan, Ningxia, 750000, China
Chiesi clinical Trial Site 156028

Nanchang, Jiangxi, 330006, China
Chiesi clinical Trial Site 156031

Beijing, Beijing Municipality, 100000, China
Chiesi clinical Trial Site 156032

Chongqing, Sichuan, 400000, China
Chiesi clinical Trial Site 156033

Jiangyin, Jiangsu, 320281, China
Chiesi clinical Trial Site 156034

Tianjin, Tianjin Municipality, 300052, China
Chiesi clinical Trial Site 156035

Chengdu, Sichuan, 610000, China
Chiesi clinical Trial Site 156037

Shanghai, Shanghai Municipality, 200031, China