New lung cancer pill shows promise in Head-to-Head trial

NCT ID NCT04248829

Completed Disease control Sponsor: Yuhan Corporation Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 4 times

Summary

This Phase 3 trial tested a new targeted therapy, lazertinib, against the standard drug gefitinib in 393 people with advanced EGFR-mutated non-small cell lung cancer. The goal was to see if lazertinib could keep cancer from growing longer. Participants took either lazertinib or gefitinib daily, and researchers measured how long until the cancer progressed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lazertinib
What this could lead to: If lazertinib works better than gefitinib, it could become a new standard first-line treatment for people with EGFR-mutated lung cancer, potentially delaying cancer growth longer.
What could go wrong: This trial compares two similar drugs, so the improvement may be modest. As a completed Phase 3 study, results are robust, but individual responses vary and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma of Lung non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Adana Baskent Practice and Research Hospital

Adana, 1120, Turkey (Türkiye)
Ajou University Hospital

Suwon, Gyeonggi-do, 16499, South Korea
Ankara Liv Hospital

Ankara, 06680, Turkey (Türkiye)
Arkhangelsk Regional Clinical Oncological Dispensary

Arkhangelsk, Arkhangelskaya oblast, 163045, Russia
Asan Medical Center

Seoul, 05505, South Korea
Attikon Hospital

Athens, 12462, Greece
Budgetary Healthcare Institution of Omsk Region "Clinical Oncology Dispensary"

Omsk, 644013, Russia
CHA Bundang Medical Center, CHA University

Seongnam-si, Gyeonggi-do, 13496, South Korea
Chiang Mai University - Faculty of Medicine

Chiang Mai, 50200, Thailand
Chungbuk National University Hospital

Cheongju-si, North Chungcheong, 28644, South Korea
Clinical Center Kragujevac

Kragujevac, 34000, Serbia
Clinical Hospital Center "Bezanijska Kosa"

Belgrade, Belgrade, 11080, Serbia
Cukurova University Medical Faculty

Adana, 1330, Turkey (Türkiye)
Debreceni Egyetem

Debrecen, H-4012, Hungary
Eugenideio Therapeutirio - Ongcology Department

Athens, 11528, Greece
First St. Petersburg State Medical University n. a. Pavlov

Saint Petersburg, 197022, Russia
GAUZ Republican clinical oncology dispensary of the Ministry

Kazan', 420029, Russia
GBUZ "Regional clinical oncologic dispensary of Volgograd"

Volgograd, 400138, Russia
GBUZ of Nizhny Novgorod region Clinical diagnostic center

Nizhny Novgorod, Nizhny Novgorod Oblast, 603006, Russia
Gachon University Gil Medical Center

Incheon, 21565, South Korea
Gyeongsang National University Hospital

Jinju, Gyeongsangnam-do, 52727, South Korea
Hacettepe University Medical Faculty - Medical Oncology

Ankara, 6230, Turkey (Türkiye)
Hospital Pulau Pinang

George Town, Pulau Pinang, 10400, Malaysia
Hospital Raja Perempuan Zainab Ii

Kota Bharu, Kelantan, 15586, Malaysia
Hospital Sultan Ismail

Johor Bahru, Johor, 81100, Malaysia
Hospital Tengku Ampuan Afzan

Kuantan, Pahang, 25100, Malaysia
Hospital Umum Sarawak

Kuching, Sarawak, 10450, Malaysia
Inje University Haeundae Paik Hospital

Busan, 48108, South Korea
Inonu University Turgut Ozal Medical Center

Malatya, 44280, Turkey (Türkiye)
Institute for Pulmonary Diseases of Vojvodina

Kamenitz, Vojvodina, 21204, Serbia
Istanbul Medeniyet University Goztepe Training and Research Hospital - Medical Oncology

Istanbul, 34722, Turkey (Türkiye)
Kangbuk Samsung Hospital

Seoul, 03181, South Korea
Keimyung University Dongsan Medical Center

Daegu, 42601, South Korea
Kocaeli University Medical Faculty

Kocaeli, 41380, Turkey (Türkiye)
Komunalne nekomertsiine pidpryiemstvo "Miska klinichna likarnia №4" Dniprvskoi miskoi rady", khimioterapevtychne viddilennia z dennym statsionarom, Derzhavnyi zaklad "Dnipropetrovskyi derzhavnyi medychnyi universitet", kafedra onkolohii i medychnoi radio

Dnipro, 49102, Ukraine
Komunalne nekomertsiine pidpryiemstvo Kharkivskoi oblasnoi rady "Oblasnyi klinichnyi spetsializovanyi dyspanser radiatsiinoho zakhystu naselennia" - khirurhichne viddilennia

Kharkiv, Kharkiv Oblast, 61166, Ukraine
Komunalne nekomertsiine pidpryiemstvo Sumskoi oblasnoi rady "Sumskyi klinichnyi onkolohichnyi tsentr", onkotorakalne viddilennia, Sumskyi derzhavnyi universytet, kafedra onkolohii ta radiolohii, m. Sumy

Sumy, 40022, Ukraine
Korea University Anam Hospital

Seoul, 02841, South Korea
Kyiv City Clinical Oncology Center - Department of Chemotherapy

Kyiv, 3115, Ukraine
LLC "Eurocityclinic"

Saint Petersburg, 197022, Russia
Limited Liability Company "AV Medical Group" - Oncology

Saint Petersburg, 197082, Russia
MBUZ City Clinical Hospital #1

Novosibirsk, Russia
Manila Doctors Hospital - Clinical Trial Office

Manila, Quezon, 1000, Philippines
Medical Point İzmir Hospital

Izmir, 35560, Turkey (Türkiye)
Medincentre (GLAVUPDK)

Moscow, 119034, Russia
Medychnyi tsentr Tovarystva z obmezhenoiu vidpovidalnistiu "Onkolaif"

Zaporizhzhia, 69059, Ukraine
National Cancer Center

Goyang-si, Gyeonggi-do, 10408, South Korea
National Taiwan University Hospital

Taipei, 10002, Taiwan
National University Hospital

Singapore, 119074, Singapore
Oblasne komunalne nekomertsiine pidpryiemstvo "Bukovynskyi klinichnyi onkolohichnyi tsentr", strukturnyi pidrozdil klinichnoi onkolohii, m.Chernivtsi

Chernivtsi, 58013, Ukraine
Perpetual Succour Hospital

Cebu, 6000, Philippines
Philippine General Hospital

Manila, 1000, Philippines
Podilskyi rehionalnyi tsentr onkolohii, viddilennia khimioterapii

Vinnytsia, 21029, Ukraine
Prince of Songkla University

Hat Yai, 90110, Thailand
Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Private medical institution "Euromedservice"

Pushkin, 196603, Russia
Ramathibodi Hospital, Mahidol University

Bangkok, 10400, Thailand
Republic Clinical Oncology Despensary

Kazan', 420029, Russia
SMG-SNU Boramae Medical Center

Seoul, 07061, South Korea
Saint-Petersburg City Clinical Oncology Dispensary

Saint Petersburg, 198255, Russia
Samsung Medical Center

Seoul, 06351, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital

Seoul, 03722, South Korea
Siriraj Hospital

Bangkok, 10700, Thailand
Srinagarind Hospital, Khon Kaen University

Khon Kaen, 40002, Thailand
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
The Catholic University of Korea, Bucheon St. Mary's Hospital

Bucheon-si, Gyeonggi-do, 14647, South Korea
The Catholic University of Korea, Eunpyeong St.Mary's Hospital

Seoul, 03312, South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea
The Catholic University of Korea, St. Vincent's Hospital

Suwon, Gyeonggi-do, 16247, South Korea
Theageneio Anticancer Hospital of Thessaloniki

Thessaloniki, 54007, Greece
Trakya University Medical Faculty

Edirne, 22030, Turkey (Türkiye)
Tsentralna miska klinichna likarnia

Uzhhorod, Zakarpattia Oblast, 88000, Ukraine
Törökbálinti Tüdőgyógyintézet

Törökbálint, 2045, Hungary
Ulsan University Hospital

Ulsan, 44033, South Korea
University Malaya Medical Centre

Kuala Lumpur, Selangor, 59100, Malaysia
VitaMed LLC

Moscow, 121309, Russia
Yaroslavl regional oncology hospital

Yaroslavl, 150054, Russia
Yeungnam University Medical Center

Daegu, 42415, South Korea

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