New drug alectinib outperforms standard therapy in ALK-Positive lung cancer
NCT ID NCT02075840
First seen May 31, 2026 · Last updated May 31, 2026
Summary
This study tested two oral medications, alectinib and crizotinib, in 303 people with a specific type of advanced lung cancer (ALK-positive non-small cell lung cancer) who had not received prior treatment. Participants took one of the drugs twice daily until their disease worsened or side effects became unacceptable. The main goal was to see which drug delayed cancer growth or death longer. Results showed alectinib was more effective and had fewer severe side effects than crizotinib.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for NON-SMALL CELL LUNG CANCER are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
A.O. Universitaria Di Parma
Parma, Emilia-Romagna, 43100, Italy
-
Ankara University Medical Faculty
Ankara, 06100, Turkey (Türkiye)
-
Asan Medical Center
Seoul, 05505, South Korea
-
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima
Catania, Sicily, 95122, Italy
-
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia
Perugia, Umbria, 06156, Italy
-
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, 10043, Italy
-
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital
Adana, 01250, Turkey (Türkiye)
-
Beth Israel Deaconess Med Ctr
Boston, Massachusetts, 02215, United States
-
Birmingham Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
-
CHRU de Lille
Lille, 59037, France
-
CHUC - Unidade de Pneumologia Oncológica
Coimbra, 3000-075, Portugal
-
CHUV
Lausanne, 1011, Switzerland
-
Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
-
Centre Leon Berard
Lyon, 69373, France
-
Centro Internacional de Estudios Clínicos (CIEC)
Santiago, 8420383, Chile
-
Centrum Onkologii - Inst.Im. Marii Sklodowskiej-Curie
Warsaw, 02-781, Poland
-
Chiang Rai Prachanukroh Hospital
Chiang Rai, 57000, Thailand
-
Chu Grenoble - Hopital Albert Michallon
Grenoble, 38043, France
-
Clinica CIMCA
San José, DUMMY_VALUE, Costa Rica
-
Clinical Center of Serbia
Belgrade, 11000, Serbia
-
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
-
Dana Farber Can Ins
Boston, Massachusetts, 02215, United States
-
Grupo Angeles
Guatemala City, 01015, Guatemala
-
Guys & St Thomas Hospital
London, SE1 9RT, United Kingdom
-
Hopital Haut Leveque
Pessac, 33604, France
-
Hospital General Univ. de Alicante
Alicante, 3010, Spain
-
Hospital Universitari Germans Trias i Pujol
Barcelona, 08916, Spain
-
Hospital Universitario Puerta de Hierro
Madrid, 28222, Spain
-
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
-
IPO de Lisboa
Lisbon, 1099-023, Portugal
-
IPO do Porto
Porto, 4200-072, Portugal
-
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department
Malatya, 44280, Turkey (Türkiye)
-
Inselspital Bern
Bern, 3010, Switzerland
-
Institute for pulmonary diseases of Vojvodina
Kamenitz, 21204, Serbia
-
Instituto Nacional De Enfermedades Respiratorias
Mexico City, Mexico CITY (federal District), 14080, Mexico
-
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo, 01246-000, Brazil
-
Irccs Ist. Tumori Giovanni Paolo Ii
Bari, Apulia, 70124, Italy
-
Irccs Istituto Europeo Di Oncologia (IEO)
Milan, Lombardy, 20141, Italy
-
Irccs Istituto Nazionale Dei Tumori (Int)
Milan, Lombardy, 20133, Italy
-
Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
-
Kasr Eieny Uni Hospital
Cairo, 11555, Egypt
-
Khonkaen Hospital
Khonkaen, 40000, Thailand
-
King Chulalongkorn Memorial Hospital
Patumwan, 10330, Thailand
-
Kinghorn Cancer Centre
Darlinghurst, New South Wales, 2010, Australia
-
Kyiv Regional Oncological Dispensary
Kyiv, 04107, Ukraine
-
Lviv State Oncology Regional Treatment and Diagnostic Centre
Lviv, 79031, Ukraine
-
Meir Medical Center
Kfar Saba, 44281, Israel
-
Monash Health Translational Precinct
Victoria, Victoria, 3168, Australia
-
Moscow City Oncology Hospital #62
Moscovskaya Oblast, Moscow Oblast, 143423, Russia
-
Mount Sinai Hospital
Toronto, Ontario, M5G 1X5, Canada
-
Ms Clinsearch Specjalistyczny Niepubliczny Zaklad Opieki Zdrowotnej
Lublin, 20-064, Poland
-
N.N.Burdenko Main Military Clinical Hospital
Moscow, 105229, Russia
-
National Cancer Center
Gyeonggi-do, 10408, South Korea
-
National Cancer Centre
Singapore, 169610, Singapore
-
National Cancer Inst.
Bangkok, 10400, Thailand
-
National Cheng Kung Univ Hosp
Tainan, 00704, Taiwan
-
National Taiwan University Hospital
Taipei, 00100, Taiwan
-
National University Hospital
Singapore, 119228, Singapore
-
North Valley Hem Onc Med Grp
Northridge, California, 91325, United States
-
Ospedale Provinciale Santa Maria Delle Croci
Ravenna, Emilia-Romagna, 48100, Italy
-
Pamela Youde Nethersole Eastern Hospital
Hong Kong, DUMMY_VALUE, Hong Kong
-
Policlinico Umberto i di Roma
Rome, Lazio, 00161, Italy
-
Prince of Wales Hosp
Hong Kong, Hong Kong
-
Princess Margaret Hospital
Hong Kong, DUMMY_VALUE, Hong Kong
-
Queen Elizabeth Hospital
Adelaide, South Australia, 5011, Australia
-
Queen Mary Hospital
Hong Kong, DUMMY_VALUE, Hong Kong
-
Rambam Medical Center
Haifa, 4959381, Israel
-
Royal North Shore Hospital
St Leonards, New South Wales, 2065, Australia
-
SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
-
SPb City Clin Onc Dsp
Saint Petersburg, Sankt-Peterburg, 197022, Russia
-
Samsung Medical Center
Seoul, 06351, South Korea
-
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
-
Scientific Research Oncology Institute named after N.N. Petrov
Saint Petersburg, Sankt-Peterburg, 197758, Russia
-
Seoul National University Bundang Hospital
Gyeonggi-do, 13620, South Korea
-
Seoul National University Hospital
Seoul, 03080, South Korea
-
Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
-
Shanghai Pulmonary Hospital
Shanghai, 200433, China
-
Songklanagarind Hospital
Songkhla, 90110, Thailand
-
Sun Yet-sen University Cancer Center
Guangzhou, 510060, China
-
Sunnybrook Odette Cancer Centre
Toronto, Ontario, M4N 3M5, Canada
-
TMPN/ Cancer Care Associates
Redondo Beach, California, 90277, United States
-
Taichung Veterans General Hospital
Taichung, 40705, Taiwan
-
Taipei Veterans General Hospital
Taipei, 00112, Taiwan
-
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department
Edirne, 22770, Turkey (Türkiye)
-
Tuen Mun Hospital
Hong Kong, 852, Hong Kong
-
Uni of Auckland
Auckland, DUMMY_VALUE, New Zealand
-
Universitaetsspital Basel
Basel, 4031, Switzerland
-
University Clinical Center Sarajevo
Sarajevo, 71000, Bosnia and Herzegovina
-
University College London Hospital
London, NW1 - 2PG, United Kingdom
-
University of Colorado Cancer Center
Aurora, Colorado, 80045, United States
-
University of Miami-Deerfield Beach
Deerfield Beach, Florida, 33442, United States
-
University of Texas M.D. Anderson Cancer Center
Houston, Texas, 77030, United States
-
UniversitätsSpital Zürich
Zurich, 8091, Switzerland
-
Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214, Poland
-
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, 08035, Spain
-
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, 10-357, Poland
-
Washington Uni School of Medicine
St Louis, Missouri, 63110, United States
Conditions
Explore the condition pages connected to this study.
Conditions inferred from the trial description
These were inferred from the trial's summary, not listed by the trial registrant.