New drug alectinib outperforms standard therapy in ALK-Positive lung cancer

NCT ID NCT02075840

First seen May 31, 2026 · Last updated May 31, 2026

Summary

This study tested two oral medications, alectinib and crizotinib, in 303 people with a specific type of advanced lung cancer (ALK-positive non-small cell lung cancer) who had not received prior treatment. Participants took one of the drugs twice daily until their disease worsened or side effects became unacceptable. The main goal was to see which drug delayed cancer growth or death longer. Results showed alectinib was more effective and had fewer severe side effects than crizotinib.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NON-SMALL CELL LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • A.O. Universitaria Di Parma

    Parma, Emilia-Romagna, 43100, Italy

  • Ankara University Medical Faculty

    Ankara, 06100, Turkey (Türkiye)

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Az Ospedaliera Nuovo Garibaldi Quartiere Nesima

    Catania, Sicily, 95122, Italy

  • Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia

    Perugia, Umbria, 06156, Italy

  • Azienda Ospedaliero-Universitaria San Luigi Gonzaga

    Orbassano, Piedmont, 10043, Italy

  • Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital

    Adana, 01250, Turkey (Türkiye)

  • Beth Israel Deaconess Med Ctr

    Boston, Massachusetts, 02215, United States

  • Birmingham Heartlands Hospital

    Birmingham, B9 5SS, United Kingdom

  • CHRU de Lille

    Lille, 59037, France

  • CHUC - Unidade de Pneumologia Oncológica

    Coimbra, 3000-075, Portugal

  • CHUV

    Lausanne, 1011, Switzerland

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Centre Leon Berard

    Lyon, 69373, France

  • Centro Internacional de Estudios Clínicos (CIEC)

    Santiago, 8420383, Chile

  • Centrum Onkologii - Inst.Im. Marii Sklodowskiej-Curie

    Warsaw, 02-781, Poland

  • Chiang Rai Prachanukroh Hospital

    Chiang Rai, 57000, Thailand

  • Chu Grenoble - Hopital Albert Michallon

    Grenoble, 38043, France

  • Clinica CIMCA

    San José, DUMMY_VALUE, Costa Rica

  • Clinical Center of Serbia

    Belgrade, 11000, Serbia

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Dana Farber Can Ins

    Boston, Massachusetts, 02215, United States

  • Grupo Angeles

    Guatemala City, 01015, Guatemala

  • Guys & St Thomas Hospital

    London, SE1 9RT, United Kingdom

  • Hopital Haut Leveque

    Pessac, 33604, France

  • Hospital General Univ. de Alicante

    Alicante, 3010, Spain

  • Hospital Universitari Germans Trias i Pujol

    Barcelona, 08916, Spain

  • Hospital Universitario Puerta de Hierro

    Madrid, 28222, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • IPO de Lisboa

    Lisbon, 1099-023, Portugal

  • IPO do Porto

    Porto, 4200-072, Portugal

  • Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department

    Malatya, 44280, Turkey (Türkiye)

  • Inselspital Bern

    Bern, 3010, Switzerland

  • Institute for pulmonary diseases of Vojvodina

    Kamenitz, 21204, Serbia

  • Instituto Nacional De Enfermedades Respiratorias

    Mexico City, Mexico CITY (federal District), 14080, Mexico

  • Instituto do Cancer do Estado de Sao Paulo - ICESP

    São Paulo, São Paulo, 01246-000, Brazil

  • Irccs Ist. Tumori Giovanni Paolo Ii

    Bari, Apulia, 70124, Italy

  • Irccs Istituto Europeo Di Oncologia (IEO)

    Milan, Lombardy, 20141, Italy

  • Irccs Istituto Nazionale Dei Tumori (Int)

    Milan, Lombardy, 20133, Italy

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Kasr Eieny Uni Hospital

    Cairo, 11555, Egypt

  • Khonkaen Hospital

    Khonkaen, 40000, Thailand

  • King Chulalongkorn Memorial Hospital

    Patumwan, 10330, Thailand

  • Kinghorn Cancer Centre

    Darlinghurst, New South Wales, 2010, Australia

  • Kyiv Regional Oncological Dispensary

    Kyiv, 04107, Ukraine

  • Lviv State Oncology Regional Treatment and Diagnostic Centre

    Lviv, 79031, Ukraine

  • Meir Medical Center

    Kfar Saba, 44281, Israel

  • Monash Health Translational Precinct

    Victoria, Victoria, 3168, Australia

  • Moscow City Oncology Hospital #62

    Moscovskaya Oblast, Moscow Oblast, 143423, Russia

  • Mount Sinai Hospital

    Toronto, Ontario, M5G 1X5, Canada

  • Ms Clinsearch Specjalistyczny Niepubliczny Zaklad Opieki Zdrowotnej

    Lublin, 20-064, Poland

  • N.N.Burdenko Main Military Clinical Hospital

    Moscow, 105229, Russia

  • National Cancer Center

    Gyeonggi-do, 10408, South Korea

  • National Cancer Centre

    Singapore, 169610, Singapore

  • National Cancer Inst.

    Bangkok, 10400, Thailand

  • National Cheng Kung Univ Hosp

    Tainan, 00704, Taiwan

  • National Taiwan University Hospital

    Taipei, 00100, Taiwan

  • National University Hospital

    Singapore, 119228, Singapore

  • North Valley Hem Onc Med Grp

    Northridge, California, 91325, United States

  • Ospedale Provinciale Santa Maria Delle Croci

    Ravenna, Emilia-Romagna, 48100, Italy

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong, DUMMY_VALUE, Hong Kong

  • Policlinico Umberto i di Roma

    Rome, Lazio, 00161, Italy

  • Prince of Wales Hosp

    Hong Kong, Hong Kong

  • Princess Margaret Hospital

    Hong Kong, DUMMY_VALUE, Hong Kong

  • Queen Elizabeth Hospital

    Adelaide, South Australia, 5011, Australia

  • Queen Mary Hospital

    Hong Kong, DUMMY_VALUE, Hong Kong

  • Rambam Medical Center

    Haifa, 4959381, Israel

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • SCRI Oncology Partners

    Nashville, Tennessee, 37203, United States

  • SPb City Clin Onc Dsp

    Saint Petersburg, Sankt-Peterburg, 197022, Russia

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Saskatoon Cancer Centre

    Saskatoon, Saskatchewan, S7N 4H4, Canada

  • Scientific Research Oncology Institute named after N.N. Petrov

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Seoul National University Bundang Hospital

    Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Shanghai Pulmonary Hospital

    Shanghai, 200433, China

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • Sun Yet-sen University Cancer Center

    Guangzhou, 510060, China

  • Sunnybrook Odette Cancer Centre

    Toronto, Ontario, M4N 3M5, Canada

  • TMPN/ Cancer Care Associates

    Redondo Beach, California, 90277, United States

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 00112, Taiwan

  • Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department

    Edirne, 22770, Turkey (Türkiye)

  • Tuen Mun Hospital

    Hong Kong, 852, Hong Kong

  • Uni of Auckland

    Auckland, DUMMY_VALUE, New Zealand

  • Universitaetsspital Basel

    Basel, 4031, Switzerland

  • University Clinical Center Sarajevo

    Sarajevo, 71000, Bosnia and Herzegovina

  • University College London Hospital

    London, NW1 - 2PG, United Kingdom

  • University of Colorado Cancer Center

    Aurora, Colorado, 80045, United States

  • University of Miami-Deerfield Beach

    Deerfield Beach, Florida, 33442, United States

  • University of Texas M.D. Anderson Cancer Center

    Houston, Texas, 77030, United States

  • UniversitätsSpital Zürich

    Zurich, 8091, Switzerland

  • Uniwersyteckie Centrum Kliniczne

    Gda?sk, 80-214, Poland

  • Vall d'Hebron Institute of Oncology (VHIO), Barcelona

    Barcelona, 08035, Spain

  • Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

    Olsztyn, 10-357, Poland

  • Washington Uni School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.