New lung cancer pill shows promise in Head-to-Head trial

NCT ID NCT02075840

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 study tested alectinib against crizotinib in 303 people with advanced ALK-positive non-small cell lung cancer who had not received prior treatment. Participants took one of the two drugs twice daily until their cancer worsened or side effects became too severe. The main goal was to see which drug better delayed cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Alectinib (drug)
What this could lead to: If alectinib works better than crizotinib, it could become a new first-choice treatment for people with ALK-positive lung cancer, helping them live longer without their cancer growing.
What could go wrong: This is a completed phase 3 trial, so results are more reliable, but alectinib may still have side effects or not work for everyone. It is not a cure, and patients will need to keep taking the drug indefinitely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

A.O. Universitaria Di Parma

Parma, Emilia-Romagna, 43100, Italy
Ankara University Medical Faculty

Ankara, 06100, Turkey (Türkiye)
Asan Medical Center

Seoul, 05505, South Korea
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima

Catania, Sicily, 95122, Italy
Azienda Ospedaliera Di Perugia Ospedale s. Maria Della Misericordia

Perugia, Umbria, 06156, Italy
Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, Piedmont, 10043, Italy
Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital

Adana, 01250, Turkey (Türkiye)
Beth Israel Deaconess Med Ctr

Boston, Massachusetts, 02215, United States
Birmingham Heartlands Hospital

Birmingham, B9 5SS, United Kingdom
CHRU de Lille

Lille, 59037, France
CHUC - Unidade de Pneumologia Oncológica

Coimbra, 3000-075, Portugal
CHUV

Lausanne, 1011, Switzerland
Calvary Mater Newcastle

Waratah, New South Wales, 2298, Australia
Centre Leon Berard

Lyon, 69373, France
Centro Internacional de Estudios Clínicos (CIEC)

Santiago, 8420383, Chile
Centrum Onkologii - Inst.Im. Marii Sklodowskiej-Curie

Warsaw, 02-781, Poland
Chiang Rai Prachanukroh Hospital

Chiang Rai, 57000, Thailand
Chu Grenoble - Hopital Albert Michallon

Grenoble, 38043, France
Clinica CIMCA

San José, DUMMY_VALUE, Costa Rica
Clinical Center of Serbia

Belgrade, 11000, Serbia
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Dana Farber Can Ins

Boston, Massachusetts, 02215, United States
Grupo Angeles

Guatemala City, 01015, Guatemala
Guys & St Thomas Hospital

London, SE1 9RT, United Kingdom
Hopital Haut Leveque

Pessac, 33604, France
Hospital General Univ. de Alicante

Alicante, 3010, Spain
Hospital Universitari Germans Trias i Pujol

Barcelona, 08916, Spain
Hospital Universitario Puerta de Hierro

Madrid, 28222, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
IPO de Lisboa

Lisbon, 1099-023, Portugal
IPO do Porto

Porto, 4200-072, Portugal
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department

Malatya, 44280, Turkey (Türkiye)
Inselspital Bern

Bern, 3010, Switzerland
Institute for pulmonary diseases of Vojvodina

Kamenitz, 21204, Serbia
Instituto Nacional De Enfermedades Respiratorias

Mexico City, Mexico CITY (federal District), 14080, Mexico
Instituto do Cancer do Estado de Sao Paulo - ICESP

São Paulo, São Paulo, 01246-000, Brazil
Irccs Ist. Tumori Giovanni Paolo Ii

Bari, Apulia, 70124, Italy
Irccs Istituto Europeo Di Oncologia (IEO)

Milan, Lombardy, 20141, Italy
Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Lombardy, 20133, Italy
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Kasr Eieny Uni Hospital

Cairo, 11555, Egypt
Khonkaen Hospital

Khonkaen, 40000, Thailand
King Chulalongkorn Memorial Hospital

Patumwan, 10330, Thailand
Kinghorn Cancer Centre

Darlinghurst, New South Wales, 2010, Australia
Kyiv Regional Oncological Dispensary

Kyiv, 04107, Ukraine
Lviv State Oncology Regional Treatment and Diagnostic Centre

Lviv, 79031, Ukraine
Meir Medical Center

Kfar Saba, 44281, Israel
Monash Health Translational Precinct

Victoria, Victoria, 3168, Australia
Moscow City Oncology Hospital #62

Moscovskaya Oblast, Moscow Oblast, 143423, Russia
Mount Sinai Hospital

Toronto, Ontario, M5G 1X5, Canada
Ms Clinsearch Specjalistyczny Niepubliczny Zaklad Opieki Zdrowotnej

Lublin, 20-064, Poland
N.N.Burdenko Main Military Clinical Hospital

Moscow, 105229, Russia
National Cancer Center

Gyeonggi-do, 10408, South Korea
National Cancer Centre

Singapore, 169610, Singapore
National Cancer Inst.

Bangkok, 10400, Thailand
National Cheng Kung Univ Hosp

Tainan, 00704, Taiwan
National Taiwan University Hospital

Taipei, 00100, Taiwan
National University Hospital

Singapore, 119228, Singapore
North Valley Hem Onc Med Grp

Northridge, California, 91325, United States
Ospedale Provinciale Santa Maria Delle Croci

Ravenna, Emilia-Romagna, 48100, Italy
Pamela Youde Nethersole Eastern Hospital

Hong Kong, DUMMY_VALUE, Hong Kong
Policlinico Umberto i di Roma

Rome, Lazio, 00161, Italy
Prince of Wales Hosp

Hong Kong, Hong Kong
Princess Margaret Hospital

Hong Kong, DUMMY_VALUE, Hong Kong
Queen Elizabeth Hospital

Adelaide, South Australia, 5011, Australia
Queen Mary Hospital

Hong Kong, DUMMY_VALUE, Hong Kong
Rambam Medical Center

Haifa, 4959381, Israel
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
SCRI Oncology Partners

Nashville, Tennessee, 37203, United States
SPb City Clin Onc Dsp

Saint Petersburg, Sankt-Peterburg, 197022, Russia
Samsung Medical Center

Seoul, 06351, South Korea
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Scientific Research Oncology Institute named after N.N. Petrov

Saint Petersburg, Sankt-Peterburg, 197758, Russia
Seoul National University Bundang Hospital

Gyeonggi-do, 13620, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Shanghai Pulmonary Hospital

Shanghai, 200433, China
Songklanagarind Hospital

Songkhla, 90110, Thailand
Sun Yet-sen University Cancer Center

Guangzhou, 510060, China
Sunnybrook Odette Cancer Centre

Toronto, Ontario, M4N 3M5, Canada
TMPN/ Cancer Care Associates

Redondo Beach, California, 90277, United States
Taichung Veterans General Hospital

Taichung, 40705, Taiwan
Taipei Veterans General Hospital

Taipei, 00112, Taiwan
Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department

Edirne, 22770, Turkey (Türkiye)
Tuen Mun Hospital

Hong Kong, 852, Hong Kong
Uni of Auckland

Auckland, DUMMY_VALUE, New Zealand
Universitaetsspital Basel

Basel, 4031, Switzerland
University Clinical Center Sarajevo

Sarajevo, 71000, Bosnia and Herzegovina
University College London Hospital

London, NW1 - 2PG, United Kingdom
University of Colorado Cancer Center

Aurora, Colorado, 80045, United States
University of Miami-Deerfield Beach

Deerfield Beach, Florida, 33442, United States
University of Texas M.D. Anderson Cancer Center

Houston, Texas, 77030, United States
UniversitätsSpital Zürich

Zurich, 8091, Switzerland
Uniwersyteckie Centrum Kliniczne

Gda?sk, 80-214, Poland
Vall d'Hebron Institute of Oncology (VHIO), Barcelona

Barcelona, 08035, Spain
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie

Olsztyn, 10-357, Poland
Washington Uni School of Medicine

St Louis, Missouri, 63110, United States

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