Lung cancer study matches drug cocktails to tumor markers
NCT ID NCT03516981
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether matching drug combinations to specific biomarkers in advanced non-small cell lung cancer could improve response. 245 patients who had not received prior treatment were grouped by two biomarkers (GEP and TMB) and given pembrolizumab plus another drug. The goal was to see if response rates met pre-set targets for each biomarker group.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AOU San Luigi Gonzaga di Orbassano ( Site 0707)
Orbassano, Torino, 10043, Italy
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AULSS21 Regione Veneto Ospedale Mater Salutis - Legnago ( Site 0701)
Legnago, Verona, 37045, Italy
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Arizona Oncology Associates, PC- HAL ( Site 8001)
Tempe, Arizona, 85284, United States
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Asan Medical Center ( Site 0801)
Songpa-gu, Seoul, 05505, South Korea
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Azienda Ospedaliera Papardo ( Site 0706)
Messina, 98158, Italy
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Azienda Ospedaliera Universitaria Senese ( Site 0705)
Siena, 53100, Italy
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Blacktown Hospital Western Sydney Local Health District ( Site 0200)
Blacktown, New South Wales, 2148, Australia
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Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site
Omsk, Omsk Oblast, 644013, Russia
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CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0310)
Montreal, Quebec, H3T 1M5, Canada
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CIUSSS du Saguenay-Lac-St-Jean ( Site 0305)
Chicoutimi, Quebec, G7H 5H6, Canada
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Cambridge University Hospitals NHS Trust ( Site 1306)
Cambridge, Cambridgeshire, CB2 0QQ, United Kingdom
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Cape Town Oncology Trials Pty Ltd ( Site 2312)
Kraaifontein, Western Cape, 7570, South Africa
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Derriford Hospital ( Site 1301)
Plymouth, PL6 8DH, United Kingdom
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Dolnoslaskie Centrum Onkologii. ( Site 0993)
Wroclaw, Lower Silesian Voivodeship, 53-413, Poland
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Emily Couric Clinical Cancer Center ( Site 0134)
Charlottesville, Virginia, 22903, United States
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Fiona Stanley Hospital ( Site 0201)
Murdoch, Western Australia, 6150, Australia
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Fondazione Policlinico Universitario A. Gemelli ( Site 0703)
Roma, 00168, Italy
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Gallipoli Medical Research Foundation ( Site 0202)
Brisbane, Queensland, 4120, Australia
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Hopitaux Universitaires de Geneve HUG ( Site 2106)
Geneva, Canton of Geneva, 1211, Switzerland
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Hospital General Universitari Vall d Hebron ( Site 1100)
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre ( Site 1102)
Madrid, 28041, Spain
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Hospital Universitario Ramon y Cajal ( Site 1101)
Madrid, 28034, Spain
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Istituto Clinico Humanitas Research Hospital ( Site 0700)
Rozzano, Lombardy, 20089, Italy
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0702)
Meldola, Emilia-Romagna, 47014, Italy
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Jewish General Hospital ( Site 0307)
Montreal, Quebec, H3T 1E2, Canada
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John Theurer Cancer Center at Hackensack University Medical Center ( Site 0112)
Hackensack, New Jersey, 07601, United States
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Kantonsspital Graubuenden ( Site 2103)
Chur, Kanton Graubünden, 7000, Switzerland
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Kantonsspital St. Gallen ( Site 2102)
Saint Gallen, Canton of Aargau, 9007, Switzerland
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Kaohsiung Chang Gung Memorial Hospital ( Site 1203)
Kaohsiung City, 83301, Taiwan
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MED-POLONIA Sp. z o.o. ( Site 0907)
Poznan, Greater Poland Voivodeship, 60-693, Poland
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MPOC ( Site 2310)
Groenkloof Pretoria, Gauteng, 0181, South Africa
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Mayo Clinic Florida ( Site 0115)
Jacksonville, Florida, 32224, United States
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Mayo Clinic Rochester - St. Mary's Hospital ( Site 0117)
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center ( Site 0113)
New York, New York, 10065, United States
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Mid Western Cancer Centre ( Site 2201)
Limerick, V94 YVH0, Ireland
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N.N. Blokhin NMRCO ( Site 1000)
Moscow, Moscow, 115478, Russia
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (
Warsaw, Masovian Voivodeship, 02-781, Poland
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National Cancer Center Hospital ( Site 2001)
Tokyo, 104-0045, Japan
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National Cancer Centre Singapore ( Site 1900)
Singapore, Central Singapore, 169610, Singapore
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National Cheng Kung University Hospital ( Site 1202)
Tainan, 704, Taiwan
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National Taiwan University Hospital ( Site 1200)
Taipei, 10048, Taiwan
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National University Hospital ( Site 1901)
Singapore, South West, 119074, Singapore
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Northwest Cancer Specialists, P.C. ( Site 8000)
Vancouver, Washington, 98684, United States
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Oncology Hematology Care ( Site 8005)
Cincinnati, Ohio, 45242, United States
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Prince of Wales Hospital ( Site 1801)
Hong Kong, 000, Hong Kong
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Princess Margaret Cancer Centre ( Site 0309)
Toronto, Ontario, M5G 2M9, Canada
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Queen Mary Hospital ( Site 1800)
Hong Kong, Hong Kong
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Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1003)
Ufa, Baskortostan, Respublika, 450054, Russia
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Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1005)
Kazan', Tatarstan, Respublika, 420029, Russia
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SBHI Leningrad Regional Clinical Hospital ( Site 1001)
Saint Petersburg, Sankt-Peterburg, 194291, Russia
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Samsung Medical Center ( Site 0805)
Seoul, 06351, South Korea
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Sandton Oncology Medical Group PTY LTD ( Site 2316)
Sandton, Gauteng, 2196, South Africa
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Seconda Universita degli Studi di Napoli ( Site 0704)
Naples, 80131, Italy
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Seoul National University Bundang Hospital ( Site 0803)
Seongnam-si, Kyonggi-do, 13620, South Korea
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Seoul National University Hospital ( Site 0800)
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System ( Site 0802)
Seoul, 03722, South Korea
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St James Hospital ( Site 2200)
Dublin, D08 K0Y5, Ireland
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St Petersburg City Clinical Oncology Dispensary ( Site 1002)
Saint Petersburg, Sankt-Peterburg, 198255, Russia
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Sunnybrook Health Science Centre ( Site 0304)
Toronto, Ontario, M4N 3M5, Canada
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Taipei Veterans General Hospital ( Site 1204)
Taipei, 11217, Taiwan
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Texas Oncology-Memorial City ( Site 8006)
Houston, Texas, 77024, United States
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Texas Oncology-Tyler ( Site 8003)
Tyler, Texas, 75702, United States
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The Cancer Institute Hospital of JFCR ( Site 2000)
Tokyo, 135-8550, Japan
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The Loginov Moscow Clinical Scientific Center ( Site 1008)
Moscow, Moscow, 111123, Russia
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The Ottawa Hospital ( Site 0306)
Ottawa, Ontario, K1H 8L6, Canada
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UCLA Hematology/Oncology -Santa Monica ( Site 0108)
Santa Monica, California, 90404, United States
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UPMC Cancer Center/Hillman Cancer Center ( Site 0104)
Pittsburgh, Pennsylvania, 15232, United States
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Umhlanga Oncolgy Center ( Site 2311)
Umhlanga, KwaZulu-Natal, 4320, South Africa
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Univ. Pretoria and Steve Biko Academic Hospitals ( Site 2315)
Pretoria, Gauteng, 0002, South Africa
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Universitaetsspital Basel ( Site 2104)
Basel, Canton of Basel-City, 4031, Switzerland
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Universitaetsspital Zuerich ( Site 2100)
Zurich, Canton of Zurich, 8091, Switzerland
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University College London Hospital NHS Foundation Trust ( Site 1308)
London, London, City of, NW1 2PG, United Kingdom
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University of California Davis Comprehensive Cancer Center ( Site 0137)
Sacramento, California, 95817, United States
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University of California San Francisco ( Site 0111)
San Francisco, California, 94143, United States
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University of Maryland ( Site 0136)
Baltimore, Maryland, 21201, United States
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University of Pennsylvania ( Site 0132)
Philadelphia, Pennsylvania, 19104, United States
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University of Wisconsin- Madison Carbone Cancer Center ( Site 0130)
Madison, Wisconsin, 53792, United States
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Vaal Triangle Oncology Centre ( Site 2314)
Vereeniging, Gauteng, 1939, South Africa
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Weill Cornell Medical College ( Site 0138)
New York, New York, 10065, United States
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Wits Clinical Research ( Site 2313)
Parktown-Johannesburg, Gauteng, 2193, South Africa
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Yale University School of Medicine ( Site 0100)
New Haven, Connecticut, 06520, United States