New drug combo aims to boost survival in advanced lung cancer

NCT ID NCT02504489

Completed Disease control Sponsor: BeyondSpring Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether adding plinabulin to the chemotherapy drug docetaxel helps people with advanced non-small cell lung cancer live longer. 559 participants who had already tried one or two prior treatments received either the combination or docetaxel alone. The study measured overall survival, tumor response, and side effects like severe neutropenia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: docetaxel and plinabulin
What this could lead to: If successful, this combination could improve survival and reduce severe side effects for people with advanced lung cancer who have already tried other treatments.
What could go wrong: This is a completed phase 3 trial, but results may not show a significant benefit over standard care. The drug combination may also cause side effects like low white blood cell counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

527-Linyi Cancer Hospital

Linyi, Shangdong, 276000, China
Adult Mater Hospital

South Brisbane, Queensland, 4101, Australia
Affiliated Cancer Hospital of Harbin Medical Unive

Harbin, Heilongjiang, 150040, China
Affiliated Tumor Hospital of Xinjiang Medical Univ

Ürümqi, Xinjiang, 830011, China
Allegheny Health Network

Pittsburgh, Pennsylvania, 15212, United States
Anhui Provincial Hospital

Hefei, Anhui, 230000, China
Beijing Cancer Hospital

Beijing, Beijing Municipality, 100142, China
Blacktown Cancer Centre

Blacktown, New South Wales, 2148, Australia
Border Medical Oncology Research Unit

East Albury, New South Wales, 2640, Australia
Cancer Center of Central Connecticut

Plainville, Connecticut, 06062, United States
Cancer Hospital Chinese Academy of Medical Science

Beijing, Beijing Municipality, 100021, China
Carle Cancer Center

Urbana, Illinois, 61801, United States
Central Care Cancer Center

Bolivar, Missouri, 65613, United States
Cookeville Regional Medical Center Cancer Center

Cookeville, Tennessee, 61801, United States
Epworth Hospital

Richmond, Victoria, 3121, Australia
Fiona Stanley Hospital

Murdoch, Western Australia, 6150, Australia
Gosford Hospital

Gosford, New South Wales, 2250, Australia
Guizhou Provincial Hospital

Guiyang, Guizhou, 550002, China
Hattiesburg Clinic Hematology/Oncology

Hattiesburg, Mississippi, 39401, United States
Henan Cancer Hospital

Zhengzhou, Henan, 450008, China
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Innovative Clinical Research Institute

Whittier, California, 90603, United States
Ironwood Cancer & Research Centers

Chandler, Arizona, 85224, United States
Jiangsu Cancer Hospital

Nanjing, Jiangsu, 210009, China
Jiangxi Provincial Tumor Hospital

Nanchang, Jiangxi, 330000, China
Jiangyin People's Hospital

Jiangyin, Jiangsu, 214400, China
Jilin Province Cancer Hospital

Changchun, Jilin, 100013, China
Kansas University Medical Center

Westwood, Kansas, 00913, United States
Liaoning Cancer Hospital & Institute

Shenyang, Liaoning, 110042, China
Memorial Health Care System

Colorado Springs, Colorado, 80909, United States
Michigan Center of Medical Research

Farmington Hills, Michigan, 48334, United States
Nantong Tumor Hospital

Nantong, Jiangsu, 226361, China
Orchard Healthcare Research Inc.

Skokie, Illinois, 60077, United States
Pacific Cancer Medical Center, Inc.

Anaheim, California, 92801, United States
Peachtree Hematoloy-Oncology Consultants, PC

Atlanta, Georgia, 30318, United States
Peninsula and South East Oncology

Melbourne, Victoria, 3199, Australia
Perth Oncology/Mount Hospital

Perth, Western Australia, 6000, Australia
Shandong Cancer Hospital

Jinan, Shangdong, 250117, China
Shanghai Chest Hospital, Shanghai Jiaotong Univers

Shanghai, Shanghai Municipality, 200030, China
Sir Run Run Shaw Hospital, Zhejiang University

Hangzhou, Zhejiang, 310016, China
St John of God Hospital, Subiaco

Subiaco, Western Australia, 6008, Australia
The Fifth People's Hospital of Shanghai

Shanghai, Shanghai Municipality, 200240, China
The First Affiliated Hospital of Xi'an Jiaotong U

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361000, China
The First Affiliated Hospital, Zhejiang University

Hanzhou, Zhejiang, 310003, China
The Fourth Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050011, China
The PLA General Hospital

Beijing, Beijing Municipality, 100853, China
The Second Xiangya Hospital of Central South Unive

Changsha, Hunan, 410011, China
Tianjin People's Hospital

Tianjin, Tianjin Municipality, 300060, China
Toledo Cancer Center

Toledo, Ohio, 43623, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Louisville-Brown Cancer Center

Louisville, Kentucky, 40202, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
West China Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Yantai Yuhuangding Hospital

Yantai, Shangdong, 264000, China
Zhejiang Cancer Hospital

Hangzhou, Zhejiang, 310022, China
Zhongshan Hospital Xiamen University

Xiamen, Fujian, 361000, China

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