Female reproductive system disorder

This trial tests whether combining an immune-boosting cream (imiquimod) with a low dose of an immunotherapy drug (nivolumab) can shrink vulvar squamous cell carcinoma tumors before surgery. About 50 women with resectable, early-to-moderate stage vulvar cancer will receive the dru…

This trial explores whether a new type of radiotherapy called CT online-adaptive radiotherapy can safely deliver treatment for endometrial cancer in just 5 sessions over a week and a half, instead of the usual 25 sessions over 5 weeks. The study includes 30 adults who have had su…

This trial tests a drug called sacituzumab govitecan in people with advanced or recurrent ovarian, fallopian tube, or primary peritoneal cancer that has high levels of a protein called TROP-2. Participants must have already tried standard treatments without success. The drug is g…

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This trial tests a personalized mRNA vaccine called NeoOVIV in people with stage II or III ovarian cancer who have had surgery. The vaccine is designed to teach the immune system to recognize and attack cancer cells. Participants receive the vaccine alongside standard chemotherap…

This phase 2 trial tests a drug called tisotumab vedotin in people with advanced squamous cell carcinoma of the vulva that has returned or spread. The drug is an antibody-drug conjugate designed to seek out and destroy cancer cells. The study aims to see how many participants' tu…

This Phase 3 trial compares a new drug called BL-M07D1 against standard chemotherapy in 404 people with HER2-expressing ovarian, fallopian tube, or peritoneal cancer that has become resistant to platinum-based treatment. Participants will receive either BL-M07D1 or one of several…

This phase 2 trial tests whether combining two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemotherapy before surgery can improve outcomes for people with advanced ovarian cancer. Participants receive 3-4 cycles of the combination, followed by surgery to rem…

This study tests a new biologic drug called XYA02 in 190 adults with advanced solid tumors (including lung, ovarian, and pancreatic cancers) that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can shrink tumo…

This early-stage trial tests an injection called BBM-C101 in 60 women with high-grade cervical precancer linked to HPV16 or HPV18. The goal is to see if the drug is safe and can shrink or eliminate abnormal cells, potentially offering a non-surgical alternative. Participants rece…

This study tests whether a combination of two immunotherapy drugs (QL1706), a targeted therapy (bevacizumab), and standard chemotherapy can shrink advanced ovarian cancer before surgery. About 36 women with stage III-IV ovarian cancer will receive the treatment every 3 weeks, the…

This study tests a new oral drug called DAT-2645 in up to 30 people with advanced or metastatic ovarian cancer that has a BRCA1/2 mutation or is HRD-positive. Participants take the drug daily in 21-day cycles. The main goal is to see if the drug shrinks tumors, and researchers wi…

This study compares two surgical techniques for ovarian endometrioma—standard cyst removal (cystectomy) versus a newer method using argon plasma coagulation (APC) to vaporize the cyst lining. The goal is to see which better preserves ovarian reserve, measured by antral follicle c…

This pilot study tests whether adding extra doses of the antibiotic azithromycin to standard care can improve outcomes for pregnant people whose water breaks very early (between 22 and 28 weeks). Thirty participants will be randomly assigned to receive either the standard antibio…

This study tests whether a silicone cervical pessary can reduce vaginal bleeding and help women with placenta previa carry their pregnancy longer. About 190 pregnant women with this condition will either receive the pessary or standard care. The goal is to see if this simple devi…

This study tests whether giving the antibiotic azithromycin before a cervical stitch (cerclage) can help high-risk pregnancies last longer. About 80 pregnant women with a weak cervix will receive either azithromycin or a placebo, plus standard care. The goal is to see if the anti…

This early-phase trial tests a one-time treatment called OPB-201, where a patient's own immune cells are modified in a lab to better recognize and attack cancer cells that carry a protein called PRAME. The study will enroll 30 adults with recurrent endometrial cancer or platinum-…

This study tests a new drug called GenSci142, given as a vaginal capsule, for treating bacterial vaginosis (BV). About 30 women with BV will receive either GenSci142 or a standard antibiotic cream to compare safety and how well each works. The goal is to see if the new capsule is…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This phase 2 trial tests whether adding tirzepatide (a weight-loss injection) to a levonorgestrel intrauterine device (LNG-IUD) can eliminate precancerous or early-stage endometrial cancer in overweight or obese women. About 55 women who want to avoid hysterectomy will receive bo…

This early-phase trial tests a new cell therapy called NK521 for people with advanced liver cancer (hepatocellular carcinoma) or ovarian cancer that has not responded to standard treatments. NK521 are natural killer (NK) cells that have been gene-edited to remove three proteins t…

This study looks at how well a combination of two drugs, iparomlimab and tuvonralimab (called QL1706), works for people with recurrent or metastatic cervical cancer that has worsened after platinum-based chemotherapy. Researchers will compare outcomes of those receiving QL1706 to…

This study tests the safety of the immunotherapy drug dostarlimab when given together with standard chemotherapy (carboplatin and paclitaxel) as a first treatment for adults in India with advanced or recurrent endometrial cancer. Participants receive the drug combination initiall…

This trial tests whether fluzoparib plus bevacizumab works as well as the standard olaparib plus bevacizumab for maintenance therapy in women with HRD-positive advanced ovarian cancer after initial chemotherapy. The study enrolls about 120 participants and tracks how long they st…

This Phase II trial tests whether adding the immunotherapy drug cadonilimab to chemotherapy before surgery helps people with locally advanced cervical cancer live longer without the disease coming back. About 134 participants will be randomly assigned to receive either the drug c…

This study looks at whether giving a GnRH agonist hormone treatment before a frozen embryo transfer can improve pregnancy and live birth rates in women with persistent chronic endometritis (a uterine infection that doesn't clear with antibiotics). About 150 women aged 20-40 will …

This Phase 3 trial tests a new biologic drug (PF-08634404) plus chemotherapy against the approved drug Keytruda plus chemotherapy in 600 women with advanced or recurrent pMMR endometrial cancer. The goal is to see if the new combination helps patients live longer without their ca…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This study tests a new drug, ubamatamab, combined with standard chemotherapy drugs (carboplatin, paclitaxel, and bevacizumab) in 43 people with advanced ovarian cancer that did not respond well to initial treatment. The goal is to see if the combination is safe and can shrink tum…

This study tests a radiation treatment called Cesium-131 brachytherapy for women whose cervical or endometrial cancer has returned in the vagina after prior pelvic radiation. Tiny radioactive seeds are placed directly into the tumor to kill cancer cells while sparing healthy orga…

This phase 2 trial is testing a new, intensive treatment plan for 28 people with advanced ovarian cancer. The approach combines chemotherapy given into the abdomen and vein, a special vaccine made from the patient's own immune cells, and the immunotherapy drug Keytruda. The goal …

This phase II trial tests whether combining elacestrant, a drug that lowers estrogen, with everolimus, which stops cancer cells from growing and cuts their blood supply, can control advanced or recurrent ER+ endometrial cancer. About 50 adults whose cancer has returned or spread …

This study tests a new drug (GV20-0251) combined with an immunotherapy (anti-PD-1) in people with advanced solid tumors that have not responded to or cannot tolerate standard treatments. About 227 adults with various cancers, including lung, breast, and colorectal, will participa…

This early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…

This study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will receive either tirzepatide or no additional treatment for 4 weeks be…

This Phase 2 trial tests a combination of three drugs—camrelizumab, famitinib, and standard chemotherapy—in 54 women with recurrent or metastatic cervical cancer that cannot be treated with surgery or radiation. The goal is to see if the combo shrinks tumors and controls the dise…

This study tests whether injecting poly-L-lactic acid (PLLA), a substance already used in cosmetic treatments, into the vaginal wall can safely and effectively treat cystocele (a type of pelvic organ prolapse). Twenty women with stage 2 cystocele will receive either PLLA or a pla…

This early-stage trial tests a new drug called ONC-783 in 20 people with advanced solid tumors, including colorectal, ovarian, pancreatic, or breast cancer. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal is to find a safe d…

This trial investigates whether giving a thyroid hormone (levothyroxine) to very small preterm infants with mildly low thyroid function can improve their physical growth and brain development by age two. The study includes infants born weighing under 1500 grams who are small for …

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The …

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This phase II trial is testing whether adding an immunotherapy drug (QL1706) to standard chemotherapy before surgery can help shrink tumors in women with early-stage cervical cancer (stages IB1-IB3). About 50 participants will receive the combination, then undergo conservative su…

This large Phase 3 trial will test a new drug called Rina-S, alone or with bevacizumab, against standard platinum-based chemotherapy for women with ovarian cancer that has returned after initial treatment. About 688 participants will be randomly assigned to receive either the new…

This phase II trial compares a new two-drug combination (sacituzumab govitecan plus bevacizumab) against standard chemotherapy (carboplatin, liposomal doxorubicin, and bevacizumab) in 87 women with platinum-sensitive ovarian cancer that has progressed after PARP inhibitor mainten…

This phase 3 trial compares a new drug called Rina-S to standard chemotherapy in 82 people with platinum-resistant ovarian cancer. Participants are randomly assigned to receive either Rina-S or one of four approved chemotherapies. The goal is to see if Rina-S can delay cancer gro…

This study tests whether letrozole, a drug that lowers estrogen, can treat early ectopic pregnancy as effectively as the standard drug methotrexate. The trial will enroll 70 women with confirmed ectopic pregnancy and low hormone levels. Participants will receive one of the two dr…

This phase 3 study tests a new weekly growth hormone injection (inpegsomatropin) against an existing one (givopegsomatropin) in 84 girls with Turner syndrome who have short stature. The goal is to see which works better for increasing growth over 52 weeks. Participants are prepub…

This early-stage study tests a new drug called HH160 in about 56 adults with advanced solid tumors (cancers that have spread). The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will receive HH160 alone or with other cancer tr…

This study tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to chemotherapy before standard chemoradiation can help people with locally advanced cervical cancer live longer without the disease getting worse. About 486 adults aged 18-75 with stage III-IV…

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This phase II trial tests whether an IGFBP-2 vaccine, given after one dose of carboplatin, can stop ovarian cancer from growing in patients whose recurrence is detected only through a blood test. The vaccine helps the immune system target cancer cells, while carboplatin primes th…

This study tests a new drug called mocertatug rezetecan (Mo-Rez) in 450 people with ovarian cancer that has stopped responding to platinum chemotherapy. The goal is to see if Mo-Rez helps people live longer without their cancer growing compared to standard treatments. Researchers…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy can better treat early-stage uterine cancer or pre-cancer in overweight women. About 30 participants will either get the standard progesterone IUD alone or the IUD plus tirzepatide. The g…

This early-stage trial tests whether tocilizumab, an anti-inflammatory drug, can help women with a rare breast condition called granulomatous lobular mastitis that hasn't improved with steroids. About 31 women aged 20-50 will receive two doses of the drug intravenously. The main …

This study tests a combination of two drugs, liposomal irinotecan and enlonstobart, in 30 women with ovarian cancer that no longer responds to platinum chemotherapy. The goal is to see if the combo can shrink tumors and delay cancer growth. Participants receive treatment every tw…

This early-stage trial tests two experimental drugs, XmAb541 and XmAb808, in people with advanced ovarian cancer that has come back or spread. The main goal is to see if the combination is safe and find the best dose. About 90 adults with a specific tumor marker (CLDN6) will take…

This phase 2 trial tests whether transferring vaginal fluid from healthy donors can help women aged 18-25 with recurrent bacterial vaginosis (BV). Participants first receive standard antibiotics, then the transplant. The goal is to see if this restores a healthy vaginal microbiom…

This study will observe 500 women with ovarian, fallopian tube, or primary peritoneal cancer who are taking the drug senaparib. Researchers will track side effects and how well the drug controls the cancer in real-world conditions, outside of a strict clinical trial. The goal is …

This study tests whether infusing a woman's own platelet-rich plasma (PRP) into the uterus can improve the uterine lining in women with a thin or unresponsive endometrium and a history of failed embryo transfers. About 80 women will receive either standard hormone therapy alone o…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers…

This phase 2 trial tests whether curcumin, the active compound in turmeric, can clear HPV and prevent precancerous cervical lesions from returning. About 200 women with low-grade or recently treated high-grade cervical precancer will insert curcumin or placebo capsules vaginally …

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This study looks at whether making small punctures in the ovary during egg retrieval can help women with low ovarian reserve (DOR) produce more eggs in a later cycle. About 214 women undergoing IVF will be randomly assigned to get the puncture procedure or standard care. The main…

This study tests whether adding losartan, a blood pressure medication, to weekly paclitaxel chemotherapy can shrink tumors in people with ovarian cancer that no longer responds to platinum-based drugs. About 27 adults with advanced ovarian, fallopian tube, or primary peritoneal c…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This study looks at whether giving two antibiotics (ampicillin and gentamicin) instead of one (ampicillin alone) can better prevent infections in pregnant women whose water breaks before labor starts. About 320 women at term will be randomly assigned to one of the two treatments.…

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14-50 and measure menstrual recovery six months after transplant. If successful,…

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. Instead of removing the whole cyst, doctors drain it and inject a solution to shrink it, which may better preserve a woman's egg supply. The study…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with severe aplastic anemia. The trial will enroll 132 women aged 14–50 and compare menstrual recovery rates six months after transplant…

This early-stage trial tests a single injection of stem cells from donated umbilical cords in 21 women with primary ovarian insufficiency (early menopause). The goal is to see if the treatment is safe and if it can improve hormone levels. Participants will be monitored for 24 wee…

This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14 to 50 and measure if their menstrual cycles return naturally within six month…

This study tests whether a traditional Chinese herbal formula (Tiaoshen Anti-cancer granules) combined with cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and possibly extend survival in 360 women with advanced ovarian cancer. Participants will receive either…

This study tests whether a special high-energy formula called InfaCore can help undernourished infants (1-12 months old) gain weight and tolerate feeding better. About 35 babies who are not growing well or are at risk will receive the formula. The main goal is to see if their wei…

This study tests a traditional Chinese medicine called Yulinzhu in 60 women aged 18-40 with diminished ovarian reserve (low egg supply). Participants take the herbal therapy for 12 weeks, and researchers measure changes in hormone levels and egg count. The goal is to see if the t…

This early-phase study tests an experimental oral drug called KQB368 in 48 adults with advanced solid tumors (like lung, colorectal, or uterine cancer) that have a specific KRAS mutation (G12C or G12S). The main goals are to find a safe dose and see if the drug can shrink tumors.…

This study tests two experimental drugs, MRG003 and QL1706, together in people with cervical cancer that has returned or spread and no longer responds to standard chemotherapy. About 41 adults will receive the combination to see if it shrinks tumors. The goal is to control the di…

This study tests whether a natural blood product called i-PRF can help heal the womb lining after surgery for moderate to severe uterine adhesions (scarring). The trial will involve 200 women aged 20-40 who want to have children. After surgery, some will receive i-PRF and others …

This study tests whether a probiotic called Lactobacillus gasseri KABP®064 can prevent bacterial vaginosis (BV) from returning after standard antibiotic treatment. BV is a common vaginal infection that often comes back within a year. The trial will involve 160 women with a histor…

This study compares vaginal estradiol tablets (Vagifem) to a vaginal moisturizer (Replens) for treating menopause-related vaginal and urinary symptoms in women living with HIV. Researchers will also check how these treatments affect the vaginal microbiome. The study includes 62 p…

This early-stage study tests two drugs, CKD-215 and D215, in 24 adults aged 19-75 with advanced BRCA-mutated ovarian, fallopian tube, or primary peritoneal cancer. The goal is to compare how the body processes each drug and check for side effects. Participants will receive both d…

This phase 2 trial is testing a daily pill called Inavolisib in about 48 people with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The drug targets that mutation to try to shrink tumors or stop them from growing. Researchers will measure how ma…

This study compares two methods to control bleeding during laparoscopic myomectomy (surgery to remove fibroids from the uterus). One method uses a temporary tourniquet to block blood flow, and the other injects a medicine called epinephrine into the uterus to narrow blood vessels…

This study looks at whether adding a special stitch (Hayman suture) to a standard surgery (Kasr Al-Ainy technique) can reduce blood loss during delivery for women with placenta accreta, a condition where the placenta grows too deeply into the uterus. About 48 women aged 18-40 wit…

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This study tests a new way to deliver radiotherapy for endometrial cancer after surgery. Using real-time MRI guidance, doctors can target radiation more accurately and reduce damage to nearby organs like the bowel and bladder. About 61 women will receive five high-dose sessions o…

This study compares two surgical approaches for early-stage endometrial cancer: laparoscopic staging (minimally invasive) and open staging laparotomy (traditional open surgery). Researchers will enroll 30 patients to see if laparoscopy is as safe and effective as open surgery, wi…

This study tests whether a Chinese herbal medicine called Sanyong Jiedu Granules can safely shrink breast lumps caused by non-lactational mastitis (inflammation not related to breastfeeding). About 210 women aged 20–50 with lump-type mastitis will receive the granules or a placeb…

This study tests whether adding the experimental drug JSKN033 to standard chemotherapy (with or without bevacizumab) is safe and effective for people with advanced cervical cancer that has spread or come back. About 78 adults will take part. The goal is to control the disease and…

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and low-dose Cyclophosphamide) in 40 women whose ovarian, fallopian tube, or peritoneal cancer has come back. The goal is to see if this mix can keep the cancer from growing for longer. Participants must be …

This study tests whether regular ultrasound checks of the groin can safely replace the standard surgery to remove lymph nodes in women with early-stage vulvar cancer. The goal is to reduce side effects and improve recovery while still keeping the cancer under control. About 640 w…

This study looks at whether a special program called Primary Care Connect (PC2) helps cancer survivors who also have conditions like high blood pressure, diabetes, or high cholesterol keep their heart risks under control during cancer treatment. About 266 adults with early-stage …

This study tests whether adding FuKe Qianjin capsules, a Chinese herbal remedy, to standard antibiotics works better than antibiotics alone for chronic endometritis, a womb infection that can cause infertility and miscarriage. About 300 women aged 20-40 will take either the herba…

This study tests a new treatment called FB301 in 120 women aged 18-45 with bacterial vaginosis (BV). Before FB301, some women will receive an antibiotic or a vaginal wash to see if that helps restore healthy bacteria. The goal is to improve the balance of good bacteria in the vag…

This phase 2 trial tests whether a peptide vaccine (NY-ESO-1) combined with an immunotherapy drug (toripalimab-tpzi) can prevent resistance to treatment in 24 women with stage III/IV ovarian cancer that no longer responds to platinum chemotherapy. The vaccine primes the immune sy…

This early study tests a personalized vaccine (YS247) made from a patient's own immune cells to fight a specific type of ovarian cancer (HRD-negative). Only 9 women who haven't been cured by standard therapy will take part. The main goal is to check safety, not yet to prove it wo…

This study tests whether giving a dye called Cytalux a few days before surgery works as well as giving it closer to the operation. The dye makes tumors glow under a special light, helping surgeons remove them more completely. About 106 adults with suspected lung cancer or confirm…

This study tests whether adding a glutaminase inhibitor (telaglenastat) to standard chemoradiation helps people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III–IVA cervical cancer will receive the drug alongside standard…

This study tests whether a combination of two drugs (camrelizumab and famitinib) can help prevent cervical cancer from returning after surgery. It involves 30 women with specific cancer types and PD-L1 positive tumors. The main goal is to see how many patients remain cancer-free …

This early-phase trial is testing an experimental drug called WSK-IM02 in 36 women with platinum-resistant recurrent ovarian cancer, a type that no longer responds to standard platinum chemotherapy. The drug is given as an injection into the abdomen. The main goal is to check saf…

This study compares a non-invasive ultrasound treatment (HIFU) to standard observation for low-grade cervical lesions (LSIL/CIN1) in 180 pre-menopausal women. Most of these lesions go away on their own, but the trial aims to see if HIFU can speed up clearance of the lesion and th…

This trial tests whether enoxaparin, a blood thinner, can improve outcomes for babies with poor growth and low amniotic fluid. 108 pregnant women will receive either enoxaparin plus standard care or standard care alone until delivery. The study will measure live birth rates, low …

This study tests whether transplanting ovarian tissue from a sister can restore fertility and hormone production in women with premature ovarian failure (early menopause). Ten women will receive tissue from their non-identical sister, along with immunosuppressive drugs to prevent…

This study tests whether antibiotics or steroids work better for granulomatous lobular mastitis, a rare inflammatory breast condition that mostly affects young women after childbirth. Seventy-two participants will receive either an 8-week course of antibiotics or tapering doses o…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This study tests a new drug combination for women with recurrent ovarian cancer that still responds to platinum chemotherapy. The treatment includes an immunotherapy (iparomlimab/tuvonralimab) plus standard chemo, followed by a maintenance drug (olaparib). The goal is to see if t…

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This phase II trial tests a drug called cadonilimab combined with radiation therapy for women with advanced cervical cancer who cannot receive standard chemotherapy due to age or health issues. The study will enroll 45 participants and measure how many have a complete response (n…

This study tests a new two-drug combination (Alpibectir and Ethionamide) added to standard treatment for tuberculosis meningitis, a serious brain infection. About 64 adults newly diagnosed with the condition will receive the drugs to see how well they reach the brain and how safe…

This study tests a combination of two drugs—CVL237 tablets and serplulimab injection—in people with advanced solid tumors that have lost or have low levels of a protein called PTEN. The trial aims to find the safest dose and see if the combo can shrink tumors or delay their growt…

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This study tests a new, custom-made 3D-printed applicator for delivering high-dose radiation (brachytherapy) to treat locally advanced cervical cancer. About 25 participants will receive the treatment to see if the device works safely and as planned. The goal is to improve how ra…

This study tests whether adding an experimental immunotherapy (Aitua Combination Antibody) to standard chemotherapy can help shrink advanced ovarian cancer more effectively before surgery. About 82 women with stage IIIC-IV high-grade serous ovarian cancer who cannot have optimal …

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study compares two drugs—tranexamic acid and vasopressin—to see which works better at reducing blood loss during planned C-sections in women with placenta previa, a condition where the placenta covers the cervix. 58 women will be randomly assigned to receive one of the drugs…

This study compares two surgical approaches for women with early-stage, high-risk endometrial cancer that has a p53 gene mutation. One group will get the standard extensive lymph node removal, while the other gets a less invasive sentinel node biopsy. The goal is to see if the si…

This early-phase study tests a new cell therapy called KT032 in 24 adults with advanced solid tumors (ovarian, mesothelioma, colon cancer) that have spread to the abdomen and haven't responded to standard treatments. The main goal is to check safety and find the best dose, while …

This study tests a daily pill called hetrombopag to see if it can safely raise low platelet counts in women with gynecological cancers (like ovarian or cervical cancer) after chemotherapy. About 244 women whose platelets dropped too low will take the drug to help them complete th…

This phase 2 trial tests whether a single dose of the HPV vaccine (Gardasil-9) can reduce the infectivity of high-risk HPV in women aged 18-29 who already have the virus. Researchers will compare cervical samples from vaccinated and unvaccinated women at 6 months to see if vaccin…

This Phase 2 trial will test a combination of the experimental drug QL1706 with standard chemotherapy or with olaparib and intraperitoneal chemotherapy as a pre-surgery treatment for 50 women with advanced ovarian cancer. The goal is to see if this approach can shrink tumors enou…

This study compares a single chemotherapy drug (paclitaxel) to the standard two-drug combo (paclitaxel plus carboplatin) as initial treatment before surgery for advanced ovarian cancer. It is for patients whose tumors have high levels of a protein called PARK2, which may make the…

This study looks at whether a blood test score (KELIM) can help doctors decide the best time for surgery in people with advanced ovarian cancer. After three rounds of chemotherapy, those with a good score will have surgery right away, while those with a poor score will get more c…

This Phase 3 trial tests whether a combination of two drugs, WX390 and toripalimab, can help people with recurrent or metastatic cervical cancer that has not responded to platinum-based chemotherapy. About 440 participants will be randomly assigned to receive either the new combi…

This study tests whether a combination of two drugs (fluzoparib and famitinib) can help keep advanced ovarian cancer from returning after successful initial chemotherapy. About 43 women with stage III-IV ovarian cancer who responded to platinum-based chemo will take these pills d…

This study tests whether a 10-week psychoeducational health and lifestyle program can help women with Functional Hypothalamic Amenorrhea (FHA) restart their menstrual cycles and improve hormone levels. Seventy women will either take part in the program or receive standard care. R…

This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compa…

This study tests two immunotherapy drugs (iparomlimab and tuvonralimab) in 30 women with a specific type of endometrial cancer that is mismatch repair-deficient. The goal is to see if the treatment can make the cancer disappear or shrink enough to avoid surgery. Participants must…

This Phase 2 trial tests a new drug called JPI-547 combined with bevacizumab in 81 women with relapsed ovarian cancer who have already been treated with PARP inhibitors and responded to platinum chemotherapy. The study aims to find the best dose and see if the combination helps k…

This phase II trial tests whether adding pembrolizumab and lenvatinib to standard chemoradiation and brachytherapy can improve outcomes for adults with high-risk locally advanced cervical cancer. About 87 participants will receive the drug combination and be followed for two year…

This study tests whether adding letrozole to standard GnRH agonist therapy improves pregnancy rates in women with adenomyosis undergoing frozen embryo transfer. About 700 participants will be randomly assigned to one of two groups. The main goal is to see if more women have a hea…

This phase II trial tests a combination of two drugs—Utidelone and Toripalimab—in people with recurrent or metastatic cervical cancer that has stopped responding to standard treatments. All 32 participants will receive the same treatment, and doctors will monitor tumor shrinkage …

This phase 2 trial tests two oral drugs, zeprumetostat and fuzuloparib, in 30 people with advanced or recurrent ovarian cancer who do not have BRCA gene mutations. The goal is to see if the combination can shrink tumors and delay progression. Participants first take fuzuloparib a…

This study tests a drug called enfortumab vedotin in up to 12 people with advanced endometrial (uterine) cancer that has worsened after standard treatments like immunotherapy. The drug works by targeting a protein on cancer cells to kill them. Researchers will measure how many pa…

This study tests two drug combinations (fluzoparib plus famitinib or fluzoparib plus SHR-1701) given before surgery to shrink advanced ovarian cancer in 104 women whose tumors cannot be fully removed right away. The goal is to see how well these treatments work and how safe they …

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study tests whether using platelet-rich fibrin (PRF) – a concentrate made from a patient's own blood – can reduce pain and improve healing after endodontic microsurgery (root-end surgery). Twenty adults with failed root canals and persistent infection in front teeth or premo…

This study tests a combination of three drugs (sacituzumab tirumotecan, iparomlimab, and tuvonralimab) given before surgery to people with locally advanced cervical cancer. The goal is to see if the treatment can completely eliminate the tumor before the operation. About 25 parti…

This study tests whether a lower daily dose (150 IU) of follicle-stimulating hormone (FSH) is as effective as a higher dose (225 IU) for women with normal ovarian reserve undergoing IVF. The main goal is to see if the lower dose leads to similar live birth rates while possibly re…

This study tests an experimental pill called ZL-85FA in people with advanced solid tumors (breast, ovarian, fallopian tube, primary peritoneal, or prostate cancer) that have not responded to standard treatments. The trial has two phases: first, finding a safe dose, then checking …

This study tests whether adding a vaginal tablet containing good bacteria and a low-dose hormone (Gynoflor®) to standard preterm labor treatment can help women stay pregnant longer. About 80 pregnant women between 24 and 33 weeks will receive either the tablet or a placebo for 6 …

This clinical trial tests whether a traditional Chinese herbal formula, Bushen Tongzhi, can improve pregnancy rates in women with diminished ovarian reserve who are undergoing IVF. About 348 women aged 22-39 will take either the herbal granules or a placebo three times daily for …

This study tests a combination of two drugs (sacituzumab tirumotecan and bevacizumab) in 30 women with platinum-resistant recurrent ovarian cancer, a type that is very hard to treat. The goal is to see if the combo can shrink tumors better than current options. Participants must …

This study tests a new drug called BRY812 in people with advanced ovarian, endometrial, or ovarian clear cell cancers that have a specific marker (LIV-1). The goal is to see if the drug can shrink tumors and how safe it is. About 56 participants will receive the drug, and researc…

This study tests a treatment called photodynamic therapy (PDT) for women with low-grade cervical precancer caused by HPV types 16 or 18. A photosensitizing cream is applied to the cervix, then activated with light to destroy abnormal cells. The trial will compare 225 women who re…

This study compares a light-activated gel treatment (ALA-PDT) to standard surgery (LEEP) for women with high-grade cervical precancer (HSIL/CIN2). About 560 women will receive either the gel plus red light therapy or surgery. The goal is to see if the gel treatment works as well …

This early-stage trial tests a new drug called GenSci142 in 30 healthy Chinese women to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo, and are monitored for side effects for 15 days. The goal is to gather safety infor…

This early-stage study tests a new drug called YB-1113 for women with premature ovarian insufficiency (early menopause). The goal is to see if it is safe and can help restart ovarian function, potentially allowing women under 40 to become pregnant. Only 6 participants will receiv…

This Phase 3 trial will test whether adding a traditional Chinese herbal formula to the standard fertility drug letrozole can improve natural pregnancy rates in women aged 22–39 with diminished ovarian reserve (low egg supply). The study plans to enroll 320 women who will receive…

This study looks at whether a second surgery to remove visible tumors (secondary cytoreductive surgery) after chemotherapy helps women with platinum-sensitive recurrent ovarian cancer. About 160 participants will be randomly assigned to get surgery plus chemo or chemo alone. The …

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can help improve egg production and IVF success. It includes 142 women with poor ovarian response or premature ovarian insufficiency. The treatment is given via ultrasound-guided injectio…

This study tests a new treatment for women whose ovaries don't respond well to fertility drugs, making it hard to get eggs for IVF. Doctors will take cells from the patient's own fat or blood and inject them into the ovaries. The goal is to see if this improves egg count and preg…

This study tests whether a gel placed inside the uterus after robotic fibroid removal can reduce scarring (adhesions) that may harm fertility. About 62 women having fibroid surgery will be randomly assigned to receive the gel or standard care. Researchers will check for adhesions…

This study tests a method called PIPAC, where the chemotherapy drug paclitaxel is turned into a pressurized spray and delivered directly into the abdomen. It is for women with ovarian cancer that has come back and no longer responds to platinum-based chemotherapy. The trial has t…

This Phase 3 trial tests whether adding the drug EG-007 to a standard combination of lenvatinib and pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without their cancer growing. About 450 participants will be randomly assigned to receive eithe…

This phase 2 trial tests whether adding a repurposed drug called EG-007 to the standard combination of lenvatinib and pembrolizumab is safe for people with advanced or recurrent endometrial cancer. The study will enroll 28 adults whose cancer has progressed after platinum chemoth…

This study will observe 1,300 patients with advanced or recurrent cervical cancer who are treated with camrelizumab, famitinib, or combinations of these drugs. The goal is to see how safe and effective these treatments are in real-world settings. Patients are placed into one of s…

This study compares two surgical methods for early-stage cervical cancer (IB2-IIA1). One is traditional open surgery, and the other is a minimally invasive approach using a stapler to prevent cancer cells from spreading. About 494 participants will be followed for 4.5 years to se…

This phase 2 trial tests whether adding the immunotherapy drug ivonescimab to chemotherapy before standard chemoradiation can improve outcomes for women with high-risk, locally advanced cervical cancer. About 42 participants will receive two cycles of the combination, then procee…

This study tests whether shrinking the radiation target area after chemotherapy can safely control stage IIb cervical cancer. Sixty participants will receive induction chemo followed by radiation that covers only the uterus, nearby tissues, and a small margin below the tumor. The…

This study compares three treatments for vulvar lichen sclerosus, a chronic skin condition causing itching and pain. 45 women aged 30-80 will receive either a steroid cream, an immune-modulating cream, or platelet-rich plasma (PRP) injections. The goal is to see which approach be…

This phase 2 trial tests a combination of three drugs—liposomal irinotecan, sintilimab, and anlotinib—in 36 people with recurrent or persistent ovarian clear cell carcinoma. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have alre…

This study tests a minimally invasive treatment called microwave ablation for uterine fibroids. It uses heat to shrink fibroids and reduce symptoms like heavy bleeding and pelvic pressure, while preserving the uterus. The study will enroll 20 premenopausal women with fewer than f…

This phase 3 trial tests whether the experimental drug SYS6002 works better than standard chemotherapy for people with recurrent or metastatic cervical cancer that has not responded to platinum chemo and immunotherapy. About 412 adults aged 18-75 will be randomly assigned to rece…

This study tests three different doses of the drug famitinib combined with camrelizumab in 120 people with recurrent or metastatic cervical cancer that cannot be cured by standard treatments. The goal is to find a dose that keeps the cancer under control while causing fewer sever…

This study looks at whether a single, image-guided radiation implant can control advanced cervical cancer as well as the usual multiple implants. About 400 women from six French hospitals who had this single-implant treatment between 2014 and 2024 will have their medical records …

This study tests a minimally invasive procedure that uses heat (radiofrequency or microwave) to destroy abnormal growths in the abdominal wall, such as cancer spread, desmoid tumors, or endometriosis. It involves 30 people who cannot have surgery or choose not to. The goal is to …

This study tests penfluridol, a drug originally used for mental health, in 33 adults with small cell lung or cervical cancer that has returned after at least two prior treatments. The goal is to see if the drug can shrink tumors or slow disease progression. Participants take the …

This study tests an immunotherapy called PDS0101 in 27 adults with both HIV and HPV 16. The goal is to see if it is safe and can strengthen the immune system's response against HPV, which can cause cancers like anal and cervical cancer. All participants will receive three doses o…

This Phase 2 trial compares two approaches for locally advanced cervical cancer: standard chemoradiotherapy versus a newer strategy of chemotherapy plus immunotherapy (sintilimab) before surgery. The study will enroll 180 people and track how long they live without the cancer get…

This study looks at whether a specialized blood test can detect tiny bits of cancer DNA in the blood of women with advanced ovarian cancer after they finish initial treatment. Researchers will follow 300 women for up to 3 years, taking blood samples at key times. The goal is to s…

This study tests whether community health workers can help women in rural North Carolina use at-home HPV self-collection kits to screen for cervical cancer. About 112 women aged 30-64 who haven't been screened recently will receive kits through local organizations. The goal is to…

This study tests a new radioactive tracer called 68Ga-FAPI-PSMA for PET/CT scans to see if it can find and stage solid tumors (like prostate, liver, and ovarian cancers) better than current tracers. About 20 adults with suspected or confirmed tumors will receive the tracer and ha…

This study aims to develop a blood test that can accurately detect serious cervical lesions in women infected with HPV16 or HPV18, the high-risk types linked to cervical cancer. Researchers will collect blood samples and medical data from about 1,465 women across three hospitals …

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study will test a new blood test that looks for DNA changes to detect ovarian cancer, especially in early stages. Researchers will compare test results from 1,000 women with and without ovarian cancer to see how accurate it is. If it works well, it could lead to a simple scr…

The PRIORITY study is testing a new approach to diagnose cervical cancer earlier by combining self-sampling at home with digital colposcopy and telemedicine. Researchers will enroll 700 women aged 30 to 65 to see if this method is more accurate and faster than current care. The g…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This study looks at whether a simple vaginal swab test, called ROM-Plus, can quickly tell if a pregnancy of unknown location (PUL) with vaginal bleeding is high or low risk for ectopic pregnancy. About 122 English-speaking, stable patients will provide a swab during their first v…

This study will test if a new type of high-definition endoscopy with special imaging is more accurate than the standard colposcopy for finding abnormal areas on the cervix and vagina. About 270 women who need a colposcopy will get both exams, and doctors will compare how well eac…

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue right where the patient is being seen. The goal is to see if it can give doctors the same quality images as a standard lab test, but much faster. About 400 women in Mozambique and Br…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can accurately detect these cancers compared to standard tests. About 300 women, some with c…

This study will test whether a special type of MRI called diffusion-weighted imaging can accurately tell the difference between benign (non-cancerous) and malignant (cancerous) growths in the lining of the uterus. Researchers will compare the MRI results with the standard method—…

This observational study will test a new molecular test called CISENDO, which looks at DNA methylation in cells from a routine cervical smear. The goal is to see if it can accurately detect endometrial cancer or precancerous lesions in women at medium-to-high risk. Researchers wi…

This study will check if an artificial intelligence (AI) model can accurately tell the difference between common, non-cancerous uterine fibroids and a rare but serious cancer called uterine sarcoma using MRI scans. Researchers will enroll 500 women who are scheduled for surgery o…

This study tests a new, less invasive biopsy method for uterine masses. The procedure uses a thin needle guided by ultrasound through the cervix to take a tissue sample. Researchers want to see if it can accurately tell benign from malignant growths, potentially helping women avo…

This study tests whether artificial intelligence (AI) can predict the type of ovarian cancer and how well surgery might work by analyzing videos from a diagnostic laparoscopy. Researchers will collect videos from 100 women with advanced ovarian cancer and train an AI to recognize…

This study will test whether detailed 2D and 3D ultrasound scans can accurately tell the difference between two serious pregnancy complications: placenta accreta spectrum and uterine scar dehiscence. Researchers will scan 50 women in their third trimester who have a low-lying pla…

This pilot study will test whether a fluorescent dye called indocyanine green (ICG), used with a special handheld camera, can find sentinel lymph nodes as well as the standard blue dye in early-stage vulvar cancer. Ten patients will receive both dyes during surgery, and doctors w…

This study tests a personalized support program called PTBCARE+ for pregnant individuals at high risk of delivering early. The program includes a stress reduction toolkit, a website/app, care coordination, and optional massage. Researchers will compare stress levels and birth out…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This study tests whether removing the fallopian tubes at the same time as gallbladder surgery is safe and practical. Ovarian cancer often starts in the fallopian tubes, so removing them may prevent it. The trial will enroll 240 women aged 35 and older to see if the extra procedur…

This study aims to make cervical cancer screening easier for people who are unhoused or unstably housed. Researchers will bring a mobile health unit to community locations in Tucson, Arizona, where participants can learn about cervical cancer, collect their own sample for HPV tes…

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePr…

This study tests whether a simple, low-cost oral health program for pregnant women in rural Nepal can reduce the number of babies born too early, too small, or underweight. About 2,280 women will either receive daily antiseptic mouthwash and intensive oral hygiene education, or j…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study checks if testing for high-risk HPV before a subtotal hysterectomy can help prevent cervical cancer. About 300 women scheduled for this surgery will get an HPV test; if positive, they will have a cone biopsy to remove any precancerous cells during the same operation. T…

This study will test if giving a 9-valent HPV vaccine to women who previously received the bivalent HPV vaccine is safe and boosts their immune response. Researchers will enroll 360 healthy women aged 18-45 and compare two different dosing schedules (two doses vs. three doses) ag…

This study tests whether a cream called triethanolamine (Trolamine) can prevent or reduce vaginal inflammation caused by radiation therapy in cervical cancer patients. About 238 women will either use the cream daily during radiotherapy plus routine care, or receive routine care a…

This study tests whether a single dose of the CERVAVAC HPV vaccine works as well as a single dose of Gardasil in preventing HPV infection. About 1,266 girls, boys, and young women in Zambia will receive one shot of either vaccine. Researchers will check their immune response at 6…

This study tests whether BPR-101 capsules, taken with the antibiotic metronidazole, can prevent bacterial vaginosis (BV) from coming back. Eighty women with BV will receive either the active treatment or a placebo. The main goal is to see if the combination lowers the rate of BV …

This study tests a new two-step preventive surgery for women with gene mutations (like BRCA1) that raise their risk of ovarian cancer. Instead of removing both ovaries and fallopian tubes at once, the first step removes only the fimbria (the end of the fallopian tube), and the ov…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study tests whether the HPV vaccine can prevent the return of high-grade squamous intraepithelial lesions (HSIL) in people who have already been treated for them. About 984 adults aged 18–55 with HPV-related HSIL of the cervix, vulva, vagina, penis, or anus will receive eith…

This pilot study aims to see if offering self-collection kits for cervical cancer screening and HPV vaccination in emergency departments can reach women who have limited healthcare access. Researchers will enroll 100 women aged 18-65 and track how many participate and complete th…

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have non-atrophic endometrial changes and pain. Participants will be randomly assigned to take aspirin or not, a…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study continues a community project in rural Kenya to prevent cervical cancer. It offers the 9-valent HPV vaccine to 2000 adolescent girls and tests self-collected swabs for high-risk HPV in adult women. Researchers will also study why some families do not participate and wh…

This study tests whether alendronate, a drug used for osteoporosis, can prevent pelvic fractures in cervical cancer patients who have had chemotherapy and radiation. About 65 adults with non-metastatic cervical cancer will receive alendronate to see if it strengthens bones and re…

This study tests a program that helps doctors improve cervical cancer screening and follow-up for patients who are overdue. The program combines education with quality improvement methods and allows clinicians to earn board certification credits. Researchers will enroll 80,000 pa…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This study tests a web-based mind-body awareness program for women undergoing infertility treatment. The program includes education and relaxation practices over 3 sessions in 2 weeks. Researchers will measure if it improves fertility awareness and feelings of preparedness in 78 …

This study tests whether adding core muscle exercises to standard pelvic floor training can better reduce urinary incontinence. Fifty adults with stress or mixed incontinence will do 12 weeks of exercises, either standard or with core co-activation. Researchers will measure sympt…

This study tests whether Pilates or gym exercises better relieve pain from primary dysmenorrhea (period pain) in young women aged 17-25. Fifty-two participants will do either Pilates or gym workouts three times a week for three months. Researchers will measure pain intensity, sym…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This study tests whether taking high doses of vitamin E and CoQ10 daily for 90 days can reduce chronic side effects from pelvic radiation in people treated for prostate, uterine, cervical, or anal cancer. Researchers will monitor safety, side effects, and quality of life in 200 a…

This study tests whether Emotional Freedom Techniques (EFT), a therapy that combines tapping on acupressure points with focused thoughts, can reduce pain intensity, pain-related worrying, and emotional distress in nursing students who suffer from painful periods. Participants are…

This study tests a wearable sleeve with semiconductors that claim to boost blood flow and reduce pain. One hundred women with painful periods will wear either the active sleeve or a placebo version. The goal is to see if the sleeve can ease cramping and improve quality of life wi…

This study tests whether gentle belly massage can reduce period pain and improve quality of life in women with painful periods, with or without endometriosis. About 80 women will be randomly assigned to receive either real massage or a light touch (sham) over three menstrual cycl…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This study looks at whether an 8-week supervised weightlifting program can help active women with functional hypothalamic amenorrhea (a condition where periods stop due to stress and low calorie intake) safely regain their menstrual cycles. Researchers will compare 28 women—some …

This trial tests if leaving out vaginal gauze packing after prolapse surgery helps women recover faster. 360 women having surgery for pelvic organ prolapse will be randomly assigned to either receive standard packing for two hours or no packing at all. The goal is to see if skipp…

This pilot trial will test whether a prehabilitation program (exercise, protein drinks, breathing exercises, and coaching) is feasible for women awaiting ovarian cancer surgery. It compares in-person delivery, remote delivery via a web app, and standard education-only care. The s…

This pilot study tests whether a physiatry-led prehabilitation program—including exercise, nutrition, and mind-body practices—can help women with advanced gynecologic cancer stay stronger before surgery. Twenty-five participants will follow the program during their neoadjuvant tr…

This study tests whether cauterizing the uterine artery at its origin before removing the uterus via laparoscopy reduces blood loss and surgery time compared to the standard technique. It will involve 44 women over 35 with non-cancerous conditions like fibroids or abnormal bleedi…

This study tests a psychological program for teens aged 15-19 with painful periods. The program uses cognitive restructuring and psychoeducation to help them change negative thoughts and improve emotional control. Researchers will measure pain and coping skills before and after t…

This study tests whether an 8-week home exercise program can reduce pain and improve walking and brain function in young women with painful periods. Eighty-six single women aged 18-25 with moderate to severe period pain will do 30-minute sessions three times a week, including rel…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

This study tests whether a special care plan called Enhanced Recovery After Surgery (ERAS) helps women recover faster after a hysterectomy. About 78 women will be randomly assigned to either ERAS or standard care. The goal is to see if ERAS shortens hospital stays and reduces pai…

This study will test whether Emotional Freedom Technique (a type of tapping) and music therapy can reduce stress, anxiety, and depression in women with a high-risk pregnancy due to early rupture of membranes. About 177 women will be randomly assigned to receive these therapies or…

This pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…

This study tests a brief sleep-focused workshop for people with PMDD who have trouble sleeping. The workshop teaches about sleep and simple strategies to improve it. Researchers want to see if it's practical and helpful, using sleep diaries and activity watches. 72 participants w…

This study tests whether N-Acetyl-Cysteine (NAC), a supplement, can reduce chemotherapy-related cognitive impairment (often called 'chemo brain') in ovarian cancer patients. About 102 postmenopausal women with advanced ovarian cancer receiving platinum-based chemotherapy will tak…

This study tests whether acupuncture, with or without daily self-acupressure, can reduce hot flashes in women with BRCA gene mutations who had their ovaries removed. About 200 participants will receive 8 weekly acupuncture sessions, then half will also practice acupressure at hom…

This study will test whether a 21-day spa program can improve hormone levels and well-being in 55 women aged 20-40 with infertility. Participants will receive comprehensive spa care including treatments and rehabilitation. The goal is to see if this approach can help reduce stres…

This study tests whether a dietary supplement called CL25216 can help women with painful periods (primary dysmenorrhea). Eighty healthy women aged 25-40 will take either CL25216 or a placebo daily for 84 days. Researchers will measure changes in menstrual pain, pain duration, and…

This study tests a medical device called Rephegyn vaginal ovules to help treat fungal (candidiasis) and bacterial infections. The device is designed to help heal the vaginal lining and reduce symptoms like discharge, pain, and itching. About 34 adults with recurrent infections wi…

This study tests whether a whole food, plant-based diet combined with behavioral education can improve quality of life and diet adherence in 60 women with metastatic breast or endometrial cancer. Participants are randomly assigned to either the plant-based diet with support or a …

This study tests if breathing nitrous oxide (laughing gas) can reduce pain and anxiety when removing a cervical stitch (cerclage) in late pregnancy. About 60 pregnant women will be randomly assigned to receive either nitrous oxide or standard care (no pain medicine) during the qu…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study will test whether a structured yoga program can reduce pain and improve quality of life in 30 young women aged 18-25 with primary dysmenorrhea (painful periods). Participants will do breathing exercises, relaxation, and pelvic-focused yoga poses. Researchers will measu…

This early-stage study tests whether LCFA-01, a natural gel containing oleic acid, is safe and comfortable when placed in the vagina. Thirty healthy women aged 18-40 will use the gel and be monitored for side effects, discomfort, and how much of the product enters the bloodstream…

This trial tests a new single-channel bag used during keyhole surgery to remove uterine fibroids. The bag holds the fibroid while it is cut into smaller pieces, and the goal is to see if it makes the surgery faster and simpler than the current two-channel bag. About 78 women aged…

This study compares two types of prehabilitation (exercise, nutrition, and psychological support) for 225 women with advanced ovarian cancer. One group starts prehab early during chemotherapy, while the other starts just before surgery. The goal is to see if early prehab reduces …

This early-stage trial tests whether a single vaginal dose of sildenafil (100 mg) can reduce painful uterine contractions during menstruation. About 50 adults with moderate-to-severe period pain will receive the drug or a placebo in two separate cycles. The study uses MRI to meas…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study tests whether an 8-week online mindfulness program can improve hope, emotional coping, quality of life, and psychological well-being in women with gynecological cancer. About 96 women currently receiving treatment will be randomly assigned to either the mindfulness pro…

This study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…

This study tests a procedure that blocks abnormal veins in the pelvis to relieve chronic pelvic pain caused by Pelvic Congestion Syndrome. It involves 100 women aged 18-60 who have had pain for over 6 months. The goal is to see if the procedure significantly reduces pain and othe…

This study looks at whether a gamified healthy lifestyle training program can help women going through fertility treatments (like IVF) adopt healthier habits and feel more in control. About 105 women will be split into three groups: one gets the game-like program plus a booklet, …

This study tests whether a new way of planning radiation—sparing the pelvic and lower spine bones—can lower the risk of severe blood-related side effects in women with advanced cervical cancer. About 72 participants will receive standard chemoradiotherapy, but half will have thei…

This study tests whether a mobile app that tracks periods and teaches about menstrual health can improve quality of life for teens with painful or heavy periods. About 874 adolescents who have started their periods and speak Dutch, English, Turkish, or Moroccan-Arabic will use th…

This study tests whether an oral collagen supplement (Collagendep) can reduce vulvar dryness in 40 women with genital lichen sclerosus who are also receiving fat grafting. Participants take the supplement daily for 4 months. The main goal is to see if dryness improves, with secon…

This study tests whether shatavari (Asparagus racemosus) root extract can help relieve premenstrual syndrome (PMS) symptoms like mood swings, irritability, and fatigue. Sixty women with mild to moderate PMS will take either the herb or a placebo daily for 12 weeks. Researchers wi…

This observational study will follow 33 women with endometriosis who are taking relugolix combination therapy for pelvic pain. Researchers will track pain changes over 24 weeks using a standard pain scale, along with other symptoms and safety. The goal is to see how well this tre…

This study tests whether preparing the uterus for frozen embryo transfer with a completely natural cycle or a modified cycle (with ovulation-triggering medication) works better. It also looks at adding letrozole tablets early in the cycle. About 120 women undergoing IVF will be r…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study compares two standard radiation methods—proton therapy and photon therapy—for women with newly diagnosed cervical or endometrial cancer. The goal is to see which approach causes fewer stomach and bowel side effects. About 116 participants will be randomly assigned to o…

This study will test a program that combines sexual health support and lifestyle changes for women treated for cervical cancer. The goal is to see if it improves their sexual function and quality of life compared to standard care. 120 women from hospitals in Spain will take part.

This study tests whether a non-surgical radiofrequency device can improve vaginal health and sexual function in postmenopausal women. Forty women aged 40-65 will receive either active treatment or a sham procedure over six weekly sessions. The goal is to see if this approach safe…

This study tests whether a personalized diet can improve quality of life in 100 women with advanced gynecologic or breast cancer who are receiving antibody-drug conjugate therapy. Participants will either follow a diet tailored to their needs or receive general Mediterranean diet…

This study looks at whether exercise can lessen nerve damage caused by certain chemotherapy drugs. About 140 people with colorectal or gynecologic cancer will either exercise or receive usual care. Researchers will measure nerve function, blood markers, and quality of life to see…

This pilot study tests if a gentle massage technique called manual lymphatic drainage (MLD) can reduce period pain in young women aged 18-25 with primary dysmenorrhea. Twenty participants will receive three monthly MLD sessions before their period. Researchers will measure pain, …

This study tests whether an 8-session mindfulness-based compassionate living program can help university students with painful periods feel less stress, less pain, and more in control. About 68 students will either take the training or receive no intervention. Researchers will me…

This phase 3 trial tests whether a daily dose of sodium-copper-chlorophyllin, a chlorophyll derivative, can reduce long-term bladder and bowel side effects from radiation therapy in 316 women with locally advanced cervical cancer. Participants take the supplement for 3 months aft…

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This phase III trial tests a therapy called CALM-TF for women with advanced ovarian cancer who experience traumatic stress. 300 participants will either receive 3-6 sessions of this trauma-focused therapy or standard care. Researchers will measure stress, depression, and quality …

This study tests whether a comfort theory-based education program can help university students with primary dysmenorrhea (painful periods) feel better. The program involves three face-to-face sessions over three months, each lasting 40 minutes. Researchers will compare pain level…

This study looks at whether hand and foot exercises can reduce nerve pain (numbness, tingling) and improve quality of life in adults aged 65+ with gynecological cancer who are on chemotherapy. About 74 participants will do these exercises to see if they help with chemotherapy sid…

This study tests whether intravenous lidocaine or magnesium sulfate can better stabilize blood pressure and heart rate as women wake up from general anesthesia during infertility-related laparoscopic surgery. Sixty-nine women will be randomly assigned to receive one of the two dr…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This Phase 3 trial tests HMI-115, a monoclonal antibody, in 540 women with moderate to severe endometriosis pain. Participants receive either the drug or a placebo for 24 weeks, with a 28-week extension. The goal is to see if HMI-115 reduces menstrual and pelvic pain better than …

This study tests whether a device that sends mild electrical pulses to a nerve in the ankle (TTNS) can reduce pain and distress from period cramps. Thirty-six women with primary dysmenorrhea will receive either standard care (heat packs and stretches) or standard care plus TTNS f…

This study tests whether up to 9 sessions of electroacupuncture can reduce pelvic pain in women with suspected endometriosis who are scheduled for diagnostic surgery. 38 women aged 18-45 with moderate to severe pain will be enrolled. The goal is to see if this treatment can impro…

This study looks at whether following a Mediterranean diet can reduce inflammation and improve quality of life for women with endometriosis. Researchers will track pain, bloating, and fatigue in 104 women aged 18-45. The goal is to see if this anti-inflammatory diet helps manage …

This study looks at whether magnetic stimulation using a device called the 'Tesla chair' can help reduce pain in women with endometriosis. Many women still have pain even after surgery or medication, and painkillers may stop working. The study will include 30 women and measure pa…

This study tests whether a cream containing both testosterone and estrogen works better than estrogen alone to reduce pain during sex for women with vulvodynia. About 44 adult women with moderate to severe pain will use one of the two creams daily. The goal is to find a more effe…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help women who have trouble urinating after surgery for cervical cancer. About 208 participants will receive either real or fake electroacupuncture alongside standard care. The ma…

This study tests a behavioral program to help women who have had pelvic radiation use vaginal dilators more regularly. Dilators can prevent or treat vaginal narrowing that makes exams or sex painful. 88 women will be randomly assigned to either the program (with coping strategies…

This study tests a Traditional Chinese Medicine (TCM) regimen to help ovarian cancer patients with common symptoms like trouble sleeping, fatigue, sadness, and distress. About 316 participants will receive either the TCM regimen or a placebo to see if it improves these symptoms. …

This study looks at whether pregnant women at high risk of preterm birth can safely express breastmilk from week 28 to 34 of pregnancy. Researchers will check if it affects how soon the baby is born, how much milk is available at birth, and whether it helps with breastfeeding. Th…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at blood flow in a part of the fetal heart called the aortic isthmus in pregnancies where the baby is not growing well (fetal growth restriction). Researchers will compare Doppler measurements between affected fetuses and healthy ones to see if these patterns can…

This study looks at whether pieces of tumor DNA and HPV DNA circulating in the blood can predict if cervical cancer will return after successful first-line treatment. Researchers will collect blood samples over time from 60 patients whose cancer has gone into complete remission. …

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study looks at whether an educational video can help people with certain cancers make informed choices about genetic testing. Participants will take a survey, watch a short video, and then take another survey to see if their knowledge and attitudes changed. The goal is to se…

This study looks at how common stigma is for breast and cervical cancer patients, caregivers, and community health workers in Rwanda. It also tests a program called RISE that includes resilience training, support groups, and videos of cancer survivors to see if it can reduce stig…

This study looks at women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs, making IVF harder. Researchers are examining specific RNA molecules in the fluid around eggs to see how they relate to egg quality and embryo development. The goal is …

This study will test whether regularly checking pregnant women for hidden genital infections can reduce problems like preterm birth and low birth weight. 250 pregnant women will be split into two groups: one gets the extra screening and treatment, the other gets standard care. Th…

This study compares immune cells, specifically natural killer cells, in women with deep endometriosis and those without the condition. Researchers will collect blood, tissue, and vaginal samples from 50 participants to look for differences that might explain the disease. The goal…

This study will send different types of WhatsApp messages to 235,000 people in Chile who are due for cancer or chronic disease screenings. Researchers want to see if the way a message is worded (basic, risk-focused, or peace-of-mind) and whether it mentions one test or both tests…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 women will be followed for two years. Those with a negative blood test may safely skip radiation, while others re…

This study will develop and test a free, cloud-based platform to educate women aged 18-45 with early-stage gynecologic cancer about fertility preservation options. Researchers will compare awareness, knowledge, and attitudes between a group using the platform and a group receivin…

This study looks at how doctors in tumor board meetings work together when discussing ovarian and uterine cancer cases. About 400 physicians will fill out surveys after each meeting to measure things like communication, teamwork, and decision-making. The goal is to understand wha…

This pilot study investigates how well a dual-wavelength diode laser can destroy endometriotic tissue inside ovarian cysts (endometriomas). Researchers will apply the laser to cyst walls removed during surgery and examine the tissue under a microscope to see if all abnormal cells…

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 100 people with advanced cervical cancer who are getting radiation and chemo. Researchers want to see if checking for HPV and other markers in the blood and cervix can better predict if the cancer will come back. The goal is to find recurrences earlier and …

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study looks at whether a web-based education program can improve women's attitudes and beliefs about HPV testing, which is key for preventing cervical cancer. About 120 women aged 18-60 will take part, with half receiving the online education and the other half getting stand…

This study looks at how a special program, called the Geriatric Surgery Verification Program, works at the James Cancer Hospital. The program helps doctors and nurses better care for patients aged 65 and older who need cancer surgery. It includes checking for age-related issues l…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study aims to better understand and treat myofascial pelvic pain, a common cause of long-term pelvic pain in women. Researchers will use a noninvasive imaging technique to measure pelvic floor muscle function before and after three different treatments: education with relaxa…

This study looks at whether digital tools like chatbots, games, and videos can help parents in Nigeria decide to vaccinate their daughters against HPV, a virus that can cause cervical cancer. About 3,340 parents of unvaccinated girls aged 9-14 will be randomly assigned to try one…

This study compares two minimally invasive surgical methods for early-stage endometrial cancer: standard laparoscopy (small abdominal cuts) and vNOTES (surgery through the vagina with no visible scars). Researchers will enroll 160 women to see how well each method finds sentinel …

This study aims to find genetic reasons why some women lose ovarian function before age 40, a condition called premature ovarian insufficiency. Researchers will compare DNA from 100 women with the condition and 100 healthy women using whole exome sequencing. No drugs or treatment…

This study follows 250 gynecologic cancer patients and their informal caregivers over 6 months. Researchers will use surveys to track caregiver distress and unmet needs. The goal is to understand what caregivers go through and find ways to better support them.

This study tests whether a dye called indocyanine green can help surgeons find cancer spread in early ovarian cancer. About 30 women will receive the dye during surgery to see if it can identify affected lymph nodes. If it works, it may reduce the need for removing many lymph nod…

This study tests a program called HOLA that teaches oncologists special communication skills to build better relationships with their Latino patients who have advanced cancer. Researchers will compare how strong the bond is between doctors who take the training and those who don'…

This study looks at a new way to classify ovarian cysts found in unborn babies using detailed ultrasound features. Researchers will follow 100 pregnant women whose fetuses have an ovarian cyst, tracking the cyst's size and appearance over time. The goal is to see if this classifi…

This early-stage study looks at whether taking oral paclitaxel with encequidar on an empty stomach or after a meal changes how much drug gets into the body. About 46 adults with advanced solid tumors (like breast, lung, or stomach cancer) will take the drugs in different sequence…

This study will ask 50 people aged 35 and older with abnormal uterine bleeding to collect daily urine samples and track their bleeding at home for several months. Researchers will use a home monitor to measure hormone levels and see if certain patterns are linked to uterine cance…

This study looks at whether recommending bed rest to pregnant women with a short cervix actually helps prevent preterm birth. Researchers will compare women who are told to rest with those who continue normal daily activities. The goal is to see if avoiding bed rest is just as sa…

This study looks at whether the LASMAR scoring system can predict how well hysteroscopic myomectomy works for women with submucous fibroids. Researchers will check if the score matches surgery time, number of sessions, fluid use, and complications. The goal is to help doctors pla…

This study tests a new way to estimate a baby's weight before birth using ultrasound. Instead of only measuring bones, it also measures soft tissue thickness in the belly and thigh. Researchers hope this will give more accurate weight predictions, especially for very large or ver…

This study tests a plastic scintillation detector that can monitor radiation dose and source position in real time during brachytherapy for prostate and gynecologic cancers. The goal is to see if the device can be used without disrupting the treatment workflow. If it works, it co…

This study looks at how emotional regulation varies across the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any diagnosed condition. The goal is to better underst…

This study looks at better ways to screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that identifies specific HPV types and viral load. The goal is to see if this approach is practical for a larger future study. About 750 wome…

This study looks at whether a blood test can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, ovarian, or pancreatic cancer. Researchers will collect blood and tumor samples from 300 adults to analyze cancer cells and their DN…

This study tests whether a special education program can increase breast and cervical cancer screening among visually impaired women. About 74 women over age 40 will receive training on cancer risks and how to schedule screenings. Researchers will check if screening rates and kno…

This study looks at how well different labs agree when testing for a protein called FRa in stored tumor samples from women with ovarian cancer. About 1,000 women's archived tissue will be tested, but no new treatments or visits are needed. The goal is to improve consistency of FR…

This study looks at whether transferring an embryo on day 2 or day 3 after fertilization leads to more live births in women aged 35 or older with low ovarian reserve. About 470 women will be randomly assigned to one of the two transfer times. The goal is to find out which timing …

This study will follow 75 women aged 18-42 with early-stage triple-negative breast cancer who are receiving chemotherapy plus immunotherapy before surgery. Researchers will measure hormone levels, track menstrual patterns, and use questionnaires to see how treatment affects ovari…

This study tests whether a structured face-to-face education program can improve women's knowledge about cervical cancer and their attitudes toward the HPV vaccine. One hundred women aged 18-49 in Turkey will be split into two groups: one receives the education, the other gets ro…

This study asks Black women aged 45 and older how they feel about using a vaginal fluid sample to test for DNA markers of endometrial cancer. The goal is to understand if women would accept this as a screening method. No treatment is given—just a 30-minute virtual interview to ga…

This study follows 42 women with HPV-positive pelvic cancer (cervix, vagina, vulva, or anus) to understand how radiotherapy, with or without surgery, affects their sexual quality of life. Participants complete questionnaires about sexual function and emotional distress over time.…

This study looks at two ways to measure endometriosis growths in the bowel before and during surgery. About 98 women will get both a standard vaginal ultrasound before surgery and a special ultrasound during their operation. The goal is to see if the during-surgery ultrasound giv…

This study looks at whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women with bowel endometriosis will have their surgery guided by ultrasound. The goal is to see if this approach r…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study tests whether real-time AI feedback helps healthcare professionals measure fetal size more accurately during ultrasound. 75 participants (novices, intermediates, and experts) will be randomly assigned to use AI assistance or standard methods. The main goal is to see if…

This study compares laparoscopic (keyhole) hysterectomy to traditional open abdominal hysterectomy in women aged 35-65 with benign gynecologic conditions. The main goal is to see which approach leads to a shorter hospital stay. The trial takes place in a low-resource setting, whe…

This study uses an anonymous online survey to ask 200 women with gynecologic cancers whether they would be interested in receiving long chemotherapy infusions at night instead of during the day. The goal is to understand patient preferences and potential barriers. No treatment is…

This study is testing a new questionnaire (called the QLQ-OV39) to see how well it measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to make sure the questio…

This study aims to see if a special device called a U-Cup bioreactor can predict how well standard chemotherapy will work in women with high-grade ovarian cancer. Researchers will take tumor samples from 120 patients before treatment and test them in the lab. The goal is to find …

This study looks at how levels of follicle-stimulating hormone (FSH) change during ovarian stimulation for IVF. Researchers will measure FSH, LH, and estradiol at several points during treatment in 500 women. They want to see if these hormone levels are linked to the number of eg…

This observational study will follow 200 pregnant women with placenta accreta spectrum (PAS) at Sohag University Hospital in Egypt. Researchers will use ultrasound to measure how deeply the placenta invades the cervix and the length of the cervix. The goal is to understand how co…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study is creating a European registry for people with idiopathic granulomatous mastitis (IGM), a rare inflammatory breast condition that causes pain, redness, and abscesses. Researchers will collect information from 1,000 participants to better understand symptoms, treatment…

This study looks at whether giving women reproductive health education after an ectopic pregnancy helps them plan to use contraception and improves their sexual quality of life. Researchers will survey 102 women in Turkey about their intentions and well-being, and provide an educ…

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study follows 2100 women under 55 who had a hysterectomy, some with fallopian tube removal and some without. Researchers want to see if removing the tubes leads to earlier menopause. Participants will collect a few drops of blood at home and answer online questionnaires twic…

This study looks at how well different methods—imaging, a small camera surgery (laparoscopy), and open surgery (laparotomy)—agree on whether an ovarian mass can be completely removed. It will involve 28 women with primary ovarian cancer. The goal is to see if less invasive method…

This study looks at tissue samples from 200 people with relapsed ovarian, fallopian tube, or primary peritoneal cancer to see how often a protein called folate receptor alpha (FRα) is present at high levels. The goal is to understand how common this protein is, which may help doc…

This study looks at how the size and number of ovarian follicles (fluid-filled sacs containing eggs) on the day of the trigger shot affect how many eggs are retrieved during an IVF cycle. Researchers will measure follicles using ultrasound in 60 women aged 18-35 undergoing ICSI. …

Placenta accreta is a serious pregnancy problem where the placenta grows too deeply into the womb, raising risks of heavy bleeding and other complications during C-section. This study looks back at the records of 50 women to compare spinal anesthesia versus general anesthesia, fo…

This study looks at how doctors trust artificial intelligence (AI) when it estimates a baby's weight during pregnancy. Over 300 clinicians will review ultrasound cases and choose between AI-based or traditional weight estimates. Some doctors will also see how reliable the AI is. …

This study reviews past research and hospital data to compare three types of fertility-sparing surgeries for cervical adenocarcinoma: conization, simple trachelectomy, and radical trachelectomy. The goal is to see which offers the best balance between controlling cancer and allow…

This study will examine tissue samples from 30 women having surgery for bowel endometriosis to see if genetic changes in the affected bowel might increase the risk of colorectal cancer. The goal is to better understand any hidden connection and improve how doctors assess cancer r…

This study looks at 100 women undergoing fertility treatment to understand why some experience repeated implantation failure or pregnancy loss. Researchers will compare immune cells and microbes in the uterus of affected women versus those without such history. The goal is to fin…

This study looks at whether women with endometriosis who use AI tools like ChatGPT to prepare for their doctor visit have better or worse experiences. Researchers will compare satisfaction, treatment plan adherence, and communication quality between AI users and non-users. About …

This study uses a special 3D ultrasound to look at blood flow inside cervical and ovarian tumors. Researchers want to see if blood flow patterns can help tell the difference between cancer and pre-cancer, and if they can predict how well patients will do over time. About 100 adul…

This study is testing a new blood test that looks for tiny bits of cancer DNA (called minimal residual disease or MRD) in patients with endometrial or cervical cancer. The goal is to see if this test can find cancer coming back earlier than standard scans or exams. About 600 part…

This study aims to create a new lab model of human diaphragm muscle cells using tissue from women undergoing surgery for diaphragmatic endometriosis. Researchers will compare these cells to arm muscle cells to understand what makes the diaphragm unique. The goal is to provide a t…

This study will analyze tumor samples from 50 women with advanced or recurrent endometrial cancer to find biological markers that predict whether immunotherapy will work. Researchers will examine the tumor's DNA, epigenetics, and surrounding environment. The goal is to better und…

This study looks at a protein called DHODH in tissue from 72 women with a type of ovarian cancer. Researchers want to see if the amount of this protein can help predict how well chemotherapy works and how long patients live. The goal is to better understand the disease, not to te…

This study will survey 402 female medical students at Sohag University to understand how period pain (primary dysmenorrhea) impacts their academic performance and quality of life. Participants will fill out two questionnaires about their pain and its effects. The goal is to gathe…

This study will test 20 people with endometrial cancer who also have a BRCA mutation in their tumor. Researchers will look for inherited (germline) gene changes using a blood test. The goal is to better understand genetic risks in this type of cancer. No treatment is given; it is…

This study will compare 70 women with and without primary dysmenorrhea (painful periods) to see how the condition affects pain sensitivity, joint flexibility, physical activity, breathing strength, attitudes about menstruation, and mood. Researchers hope to identify key areas aff…

This study will use Doppler ultrasound to measure blood flow in the uterine artery before and after removing a molar pregnancy. The goal is to see if these measurements can predict which patients will develop persistent gestational trophoblastic neoplasia, a type of cancer. Resea…

This study checks if surgeons can tell key details about ovarian cancer by looking at images from a camera inside the belly. About 70-80 surgeons will review pictures from 19 patients and guess the cancer type and growth pattern. The goal is to see if visual clues can help plan t…

This study will test whether an AI system can help doctors make better treatment decisions for pregnant women with cervical cancer. Researchers will compare the AI's recommendations to those from a real team of experts and from junior doctors. The goal is to see if the AI can pro…

This observational study will follow 45 women with primary ovarian insufficiency (POI)—a condition that causes early menopause—who are starting estrogen replacement therapy. Researchers will measure heart health markers before and after 6 months of treatment and compare them to h…

This observational study looks at women with MRKH syndrome, a rare condition where the uterus and vagina are underdeveloped. Researchers will use ultrasound and other imaging to describe the anatomy and create a new classification system. The goal is to improve diagnosis and unde…

This study explores whether a text-message education program and a mail-in HPV self-sampling kit can help women living with HIV who are overdue for cervical cancer screening get tested. Researchers will enroll 130 women and healthcare providers to see if the approach is practical…

This study looks at 100 women aged 18-45 with early-stage endometrial cancer who want to preserve their fertility. Researchers will analyze the tumor's molecular subtype (based on gene testing) to see how it affects response to hormone therapy and recurrence rates. The goal is to…

This study looks at 38 women who had pelvic side effects (like pain in the rectum, bladder, or vagina) after radiation or chemotherapy for gynecological cancers. Researchers will compare their gut bacteria to healthy controls and see if rectal ozone therapy changes the microbiome…

This study tests whether point-of-care STI tests, which give results in about 10 minutes, can speed up treatment for pregnant women compared to standard lab tests. About 756 pregnant women at Grady Memorial Hospital will either get the rapid tests or standard testing. The goal is…

This study follows 100 women with deep endometriosis for 2 years to see if their lesions grow, shrink, or stay the same, and how this relates to symptoms and quality of life. Researchers will use regular ultrasounds and questionnaires to track changes. The goal is to learn whethe…

This study will test a new way to screen and treat cervical cancer in women with HIV in Mozambique. About 8,445 women aged 25-49 who are already receiving HIV care will be offered HPV testing and same-day treatment if needed. The goal is to see if this approach can screen more wo…

This study will check if an ultrasound scoring system called O-RADS can accurately tell benign from cancerous ovarian masses. About 80 women aged 18 to 70 with ovarian cysts or masses will get standard care, including detailed ultrasound and, if needed, surgery. Researchers will …

This study tests whether removing a larger piece of the pelvic lining during surgery can find tiny cancer deposits that standard biopsies might miss. About 390 adults with early-stage ovarian or fallopian tube cancer will undergo this procedure. The goal is to improve staging acc…

This study examines if different eating patterns, especially low-carbohydrate diets, are linked to better outcomes in women with high-grade serous ovarian cancer who are on maintenance therapy with PARP inhibitors. Researchers will review medical records and survey 600 patients f…

This pilot study will test whether it is safe and effective to remove uterine fibroids and retrieve eggs in a single surgical step for infertile women aged 18–45. The researchers will track pregnancy, miscarriage, and live birth rates after frozen embryo transfer. Only 20 women w…

This study looks at whether a blood test for circulating tumor DNA (ctDNA) can detect leftover cancer after surgery in people with breast, lung, prostate, ovarian, or stomach cancer. About 840 participants will give blood samples before and after standard treatments. No new treat…

This study looks at how well patients do after surgery that removes both advanced gynecologic cancers and the major blood vessels they have grown into. Researchers will track 130 participants for up to 5 years to see survival rates and how long it takes for the cancer to return. …

This study looks at whether using CT scans instead of MRI for planning brachytherapy (internal radiation) can work just as well for locally advanced cervical cancer. About 1,200 participants will receive standard treatment, and researchers will track tumor control and side effect…

This study focuses on a rare and aggressive type of cervical cancer called large cell neuroendocrine carcinoma (LCNEC). Researchers will look back at medical records and follow 200 patients over time to understand the disease's behavior and what factors affect survival. The goal …

This study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …

This study looks back at the medical records of 200 people treated for gynecological cancers (like ovarian, cervical, or uterine cancer) at Assiut University Hospital between 2022 and 2025. The goal is to measure how long patients survive after diagnosis and compare those numbers…

This study reviews 300 cases of placenta accreta spectrum (PAS) over 10 years at an Egyptian hospital. PAS is a pregnancy complication where the placenta grows too deeply into the uterine wall, risking severe bleeding. Researchers will compare traditional surgery (removing the ut…

This study tests whether a new device called a pelotte can measure vaginal temperature more accurately during deep hyperthermia (heat therapy) for gynecologic cancer. Twenty-seven women receiving radiation plus heat therapy will have their temperature measured with both the pelot…

This study tests a new AI-powered software that helps doctors see, in real time, how well a minimally invasive fibroid treatment (uterine artery embolization) is working. The goal is to make the procedure more accurate and consistent. The study will involve 250 women with symptom…

This study looks at whether measuring IL-6 and lactate in cord blood can detect early signs of infection or inflammation in full-term newborns. Researchers will compare 160 women whose fetal heart rate patterns suggest possible inflammation with those whose patterns are normal. I…

This study looks at how often pregnant women who have their water break early carry antibiotic-resistant bacteria. Researchers will collect samples from 250 women across French hospitals to track these bacteria and identify risk factors. The goal is to help doctors choose better …

This study looks at whether blood flow in a small fetal vein, measured by ultrasound, can predict pregnancy outcomes. Researchers will compare 160 pregnant women with and without intrauterine growth restriction (IUGR) between 24 and 37 weeks. The goal is to improve early detectio…

This study will examine tissue samples from 50 people with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to how aggressive the cancer is and how long patients live without th…