Could a common antibiotic prevent early birth in High-Risk pregnancies?

NCT ID NCT07608562

Not yet recruiting Disease control Sponsor: Wake Forest University Health Sciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests whether giving the antibiotic azithromycin before a cervical stitch (cerclage) can help high-risk pregnancies last longer. About 80 pregnant women with a weak cervix will receive either azithromycin or a placebo, plus standard care. The goal is to see if the antibiotic reduces infections and delays delivery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: azithromycin
What this could lead to: If it works, this could help high-risk pregnancies last longer and reduce complications like preterm birth.
What could go wrong: This is a small early-phase trial, so results may not apply widely. Azithromycin can cause side effects like nausea or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical incompetence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL INSUFFICIENCY

Contacts and locations

Locations

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453, United States
Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States

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