Can a saline flush during labor shield newborn brains?
NCT ID NCT07610642
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. Researchers will randomly assign 80 pregnant women with chorioamnionitis to receive either amnioinfusion or standard care, then measure brain injury markers in the baby's umbilical cord blood after delivery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
amnioinfusion (lactated ringer's solution infused into the uterus during labor)
What this could lead to
If it works, this could point toward a simple, low-cost way to protect babies' brains during labor when the mother has an infection.
What could go wrong
This is a small, early-stage trial with only 80 participants, so results may not be conclusive. The treatment may not reduce brain injury, and there are always risks with any medical procedure during labor.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Froedtert Hospital and Medical College of Wisconsin Birth Center
Milwaukee, Wisconsin, 53045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact