Can a One-Two punch shrink fibroids better?

NCT ID NCT07754877

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether adding a chemical injection to microwave ablation improves treatment for uterine fibroids, common non-cancerous tumors that can cause heavy bleeding and pain. Microwave ablation uses heat to destroy fibroid tissue, but blood flow can cool the area and reduce its effectiveness. The study compares the standard microwave ablation alone versus microwave ablation combined with a chemical agent that may block blood flow and enhance the heat effect. Researchers will measure how much the fibroids shrink, symptom improvement, and safety in 248 women.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Microwave ablation combined with lauromacrogol (chemical ablation) versus microwave ablation alone
What this could lead to
If the combined approach works, it could offer a more effective, less invasive treatment for uterine fibroids, potentially reducing symptoms and preserving fertility better than current options.
What could go wrong
This is a relatively early-stage trial, and the combination may not improve outcomes enough to justify added risks. The heat-sink effect and individual fibroid characteristics could limit the benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Aerospace center hospital

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.