Two probes better than one? new study aims to cut cervical cancer in women with HIV

NCT ID NCT07390916

Not yet recruiting Prevention Sponsor: Fred Hutchinson Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is to improve cervical cancer prevention in high-risk groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: thermal ablation (heat treatment to remove precancerous cells)
What this could lead to: If successful, this could improve cervical cancer prevention for women with HIV, potentially reducing cancer rates in high-risk populations.
What could go wrong: This is a small feasibility study, not yet recruiting. The two-probe technique may not work better than the standard one-probe approach, and results may not apply to other groups.

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Conditions

The condition(s) this trial relates to.

AIDS cervical intraepithelial neoplasia dysplasia of cervix HIV infectious disease human papilloma virus infection cervical cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL PRECANCER HIV (HUMAN IMMUNODEFICIENCY VIRUS) HPV

Contacts and locations

Locations

Research for Development (RD) Rwanda

Kigali, Rwanda

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