Targeted drug shows promise for rare vulvar cancer

NCT ID NCT07672782

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This phase 2 trial tests a drug called tisotumab vedotin in people with advanced squamous cell carcinoma of the vulva that has returned or spread. The drug is an antibody-drug conjugate designed to seek out and destroy cancer cells. The study aims to see how many participants' tumors shrink or disappear, and monitors side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

tisotumab vedotin

What this could lead to

If successful, this could offer a new treatment option for people with advanced vulvar cancer that has returned or spread.

What could go wrong

This is a small, early-phase trial with only 28 participants, so results may not apply broadly. The drug can cause side effects like nerve damage or infusion reactions.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Neoplasm Metastasis Recurrence squamous cell carcinoma vulva cancer vulvar carcinoma vulvar squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Atrium Health Levine Cancer Center

    Charlotte, North Carolina, 28204, United States

    Contact