New drug cocktail aims to shrink ovarian tumors before surgery

NCT ID NCT07407452

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial will test a combination of the experimental drug QL1706 with standard chemotherapy or with olaparib and intraperitoneal chemotherapy as a pre-surgery treatment for 50 women with advanced ovarian cancer. The goal is to see if this approach can shrink tumors enough to make surgery more effective. The study is not yet recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

iparomlimab and tuvonralimab (QL1706) combined with chemotherapy drugs (paclitaxel, carboplatin, cisplatin) or olaparib

What this could lead to

If successful, this could lead to a new treatment option before surgery for advanced ovarian cancer, potentially improving tumor shrinkage and surgical outcomes.

What could go wrong

This is an early Phase 2 trial with only 50 patients, so results may not apply to everyone. The combination of multiple drugs may cause significant side effects, and it is not yet known if it will improve long-term survival.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer ovarian cancer ovarian carcinoma peritoneum cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Jiangsu Cancer Hospital

    Nanjing, Jiangsu, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••