New study to reveal hidden toll of breast cancer drugs on fertility

NCT ID NCT07527819

Not yet recruiting Knowledge-focused Sponsor: Peter MacCallum Cancer Centre, Australia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will follow 75 women aged 18-42 with early-stage triple-negative breast cancer who are receiving chemotherapy plus immunotherapy before surgery. Researchers will measure hormone levels, track menstrual patterns, and use questionnaires to see how treatment affects ovarian function and fertility. No extra drugs are given—participants receive standard care. Results may help doctors better counsel patients about fertility risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help doctors understand the impact of these treatments on ovarian health and fertility, guiding future care and counseling for young women with breast cancer.
What could go wrong: This is an observational study, not a treatment trial. It only collects data and does not test any new therapy, so it cannot directly improve outcomes. Results may take years to influence practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation primary ovarian failure triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRIPLE-NEGATIVE BREAST CANCER (TNBC)

Contacts and locations

Locations

Chris O'Brien Lifehouse

Camperdown, New South Wales, 2050, Australia
Eastern Health

Box Hill, Victoria, 3128, Australia
Icon Cancer Centre

Hobart, Tasmania, 7000, Australia
Lyell McEwin Hospital

Adelaide, South Australia, 5112, Australia
Mater Hospital Sydney

Sydney, New South Wales, 2060, Australia
Monash Health

Clayton, Victoria, 3168, Australia
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Royal Melbourne Hospital

Melbourne, Victoria, 3052, Australia
Sir Charles Gairdner Hospital

Nedlands, Washington, 6009, Australia

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