Could a hyperactive immune system fuel PMDD? a new study investigates

NCT ID NCT07771426

NEW Not yet recruiting Knowledge-focused Sponsor: King's College London Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 18, 2026

Summary

This study explores whether inflammation in the body is linked to the mood and psychological symptoms of Premenstrual Dysphoric Disorder (PMDD). Researchers will compare women with PMDD to healthy controls, tracking daily emotions and behaviors over two menstrual cycles and taking blood samples to measure inflammatory markers. The goal is to better understand the biological and psychological factors behind PMDD, which could eventually lead to improved treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If inflammation is linked to PMDD symptoms, it could point toward new anti-inflammatory treatments for the condition.
What could go wrong: This is an observational study, so it cannot prove cause and effect. The findings may not lead to new treatments, and the results may not apply to everyone with PMDD.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation premenstrual dysphoric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PMDD PREMENSTRUAL DYSPHORIC DISORDER PREMENSTRUAL DYSPHORIC DISORDER (PMDD)

Contacts and locations

Locations

Maurice Wohl Clinical Neuroscience Institute

London, 'London, SE5 9RX, United Kingdom

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