Could a Light-Activated cream replace surgery for cervical precancer?

NCT ID NCT07669363

Not yet recruiting Disease control Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 6 times

Summary

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is to see if the cream can clear the abnormal cells as effectively as surgery, while possibly being gentler and preserving fertility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hexaminolevulinate hydrochloride (HAL) 5% ointment with light therapy
What this could lead to: If successful, this could offer a non-surgical, outpatient option for treating cervical precancer, potentially preserving fertility and reducing recovery time.
What could go wrong: This is an early Phase II trial with only 230 participants, so results may not apply broadly. The treatment may not be as effective as surgery, and there is a small risk of progression to cancer if it fails.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia cervical intraepithelial neoplasia grade 2/3 dysplasia of cervix human papilloma virus infection squamous cell intraepithelial neoplasia Squamous Intraepithelial Lesions uterine cervix carcinoma in situ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL INTRAEPITHELIAL NEOPLASIA PAPILLOMAVIRUS INFECTIONS

Contacts and locations

Locations

Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

Hangzhou, Zhejiang, 310022, China
Dongguan Maternal and Child Health Care Hosptial

Dongguan, Guangzhou, 523000, China
Foshan Shunde Maternal and Child Health Hospital

Foshan, Guangdong, 528300, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
Guangdong ProvincialHospital of Chinese Medicine

Guangzhou, Guangdong, 510120, China
Guangdong Second Provincial GeneralHospital (Guangdong Provincial Emergency Hospital)

Guangzhou, Guangdong, 510317, China
Guangdong Women and Children Hospital

Guangzhou, Guangdong, 510010, China
Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital

Nanning, Guangxi, 530000, China
Guangzhou First People's Hospital (The Second Affiliated Hospital of South China University of Technology)

Guangzhou, Guangdong, 510180, China
Guangzhou Women and Children's Medical Center (The Affiliated Women and Children's Medical Center of Guangzhou Medical University)

Guangzhou, Guangdong, 510623, China
Panyu Central Hospital Affiliated to Guangzhou Medical University

Guangzhou, Guangdong, 511400, China
Peking University Shenzhen Hospital

Shenzhen, Guangdong, 518036, China
Shanxi Provincial People's Hospital

Taiyuan, Shanxi, 030000, China
Shenzhen Maternity and Child Health Hospital

Shenzhen, Guangdong, 518031, China
The Affiliated Cancer Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510095, China
The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350005, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Provincial People's Hospital)

Nanjing, Jiangsu, 210029, China
The First Affiliated Hospital, Sun Yat-sen University

Zhongshan, Guangdong, 510080, China
The First AffiliatedHospital, Guangzhou University ofTraditional Chinese Medicine

Guangzhou, Guangdong, 510405, China
The First Hospital of Jilin University

Changchun, Jinlin, China
The First People's Hospital of Foshan

Foshan, Guangdong, 528000, China
The General Hospital of Northern Theater Command of the Chinese People's Liberation Army

Shenyang, Liaoning, 110016, China
The West China Second University Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Xiamen Maternity and Child Healthcare Hospital

Xiamen, Fujian, 361001, China
Zhujiang Hospital, Southern Medical University

Guangzhou, Guangdong, 510280, China
he First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361003, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.