One-Shot hope: drug may shield fertility in women facing stem cell transplant
NCT ID NCT07552480
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single injection of goserelin, given just before a stem cell transplant, can help preserve ovarian function in women with blood cancers. The trial will enroll 64 women aged 14-50 and measure menstrual recovery six months after transplant. If successful, it could reduce the risk of early menopause and infertility caused by the transplant conditioning regimen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- goserelin
- What this could lead to
- If it works, this could offer a way to protect fertility and ovarian function in women who need a stem cell transplant for blood cancer.
- What could go wrong
- This is a small, early-stage trial with only 64 participants. It may not show a clear benefit, and goserelin could cause side effects like hot flashes or mood changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450000, China
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The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310000, China
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The First People's Hospital of Yunnan Province
Kunming, Yunnan, 650000, China
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430000, China
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simple blood test make a key transplant drug safer?
- Could a shot of your own blood help your ovaries produce more eggs?
- Tailored drug dosing may cut infections after stem cell transplants
- Single shot may shield fertility in women facing stem cell transplant
- Fertility shield: goserelin injection may preserve ovarian function after stem cell transplant
- Can ovarian freezing help girls with turner syndrome have children later?