Could a Two-Antibiotic cocktail prevent infections after water breaks?
NCT ID NCT07563504
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether giving two antibiotics (ampicillin and gentamicin) instead of one (ampicillin alone) can better prevent infections in pregnant women whose water breaks before labor starts. About 320 women at term will be randomly assigned to one of the two treatments. The goal is to reduce chorioamnionitis (a serious infection of the amniotic sac) and other complications for both mother and baby.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Ampicillin and gentamicin (antibiotics)
- What this could lead to
- If successful, this could show that adding gentamicin to standard care reduces serious infections in mothers and newborns after membrane rupture.
- What could go wrong
- This is a single-center trial with 320 participants, so results may not apply broadly. Gentamicin carries risks of kidney and hearing issues, though these are monitored.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Miri Hospital
Miri, Sarawak, 98000, Malaysia
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Sarawak General Hospital
Kuching, Sarawak, 93586, Malaysia
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Sarikei Hospital
Sarikei, Sarawak, 96100, Malaysia
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