Could extra antibiotics help prolong pregnancy after early water break?

NCT ID NCT07669207

Not yet recruiting Disease control Sponsor: Alexa Henderson Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This pilot study tests whether adding extra doses of the antibiotic azithromycin to standard care can improve outcomes for pregnant people whose water breaks very early (between 22 and 28 weeks). Thirty participants will be randomly assigned to receive either the standard antibiotic regimen or the standard plus seven additional azithromycin doses. The main goal is to see if such a study is feasible, not yet to prove the treatment works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Azithromycin (antibiotic)
What this could lead to: If it works, this could point toward a better antibiotic regimen to prolong pregnancy and improve outcomes after preterm membrane rupture.
What could go wrong: This is a very small pilot study (30 people) focused on feasibility, not effectiveness. It may not show clear benefits, and extra antibiotics could increase side effects or bacterial resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PPROM are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

preterm premature rupture of the membranes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PPROM PRETERM PRELABOR RUPTURE OF MEMBRANES

Contacts and locations

Locations

University of Pittsburgh Magee-Womens Hospital

Pittsburgh, Pennsylvania, 15217, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.