Could a Two-Drug combo speed up delivery after pregnancy loss?
NCT ID NCT05322252
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether giving two medications (mifepristone and misoprostol) at the same time helps women deliver faster after a nonviable second-trimester pregnancy, compared to misoprostol alone. Thirty women between 14 and 28 weeks pregnant who needed labor induction took part. The goal was to see if more women delivered within 12 hours with the combo, while keeping safety in mind.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mifepristone and misoprostol
- What this could lead to
- If it works, this could offer a faster, safer way to complete delivery after a nonviable second-trimester pregnancy, reducing infection risk.
- What could go wrong
- This is a very small pilot study (30 people) with no long-term follow-up. Results may not apply to all situations, and the simultaneous regimen might not be faster or could increase side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ABORTION, SECOND TRIMESTER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a simple office procedure replace surgery for early miscarriage care?
- Text messages and personal support may reduce pregnancy risks — a trial puts them to the test
- Ultrasound may predict hidden placental problems before delivery
- Can acupuncture and exercise ease pelvic pain during pregnancy?
- Could a simple massage technique ease a common pregnancy pain?
- Sleep program aims to reduce pregnancy risks in african american women