Acute disease

Researchers are testing whether adding abatacept to standard immune-suppressing drugs can prevent severe graft-versus-host disease after a double umbilical cord blood transplant. The trial enrolls people with blood cancers such as leukemia, lymphoma, and myelodysplastic syndromes…

This early-stage trial is testing an experimental cell therapy called HY035 in people with CD7-positive blood cancers that have returned or not responded to standard treatment. The goal is to see if the therapy is safe and can help achieve remission. Participants receive a single…

This trial tests whether adding rituximab to the standard drug cladribine can eliminate leftover cancer cells in people with hairy cell leukemia, a rare blood cancer. Half the participants receive both drugs at the start, while the other half get rituximab later only if needed. T…

This early-stage trial is testing an experimental cell therapy for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has returned or not responded to standard treatments. The therapy uses a patient's own immune cells, modified to recognize …

This study tests a new type of immune cell therapy for people with CD19-positive leukemia or lymphoma who have had a stem cell transplant. The cells are specially designed to both recognize and kill cancer cells (through a CD19-targeting antibody) and fight three common viruses (…

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This trial tests a new vaccine called LBVD, which combines protection against six diseases: diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib. The study enrolls healthy infants around 6 to 8 weeks old who receive three doses at 6, 10, and 14 weeks of age. Researche…

This study tests a new vaccine called Shigella4V2 to see if it can protect people from shigellosis, a severe diarrheal disease. About 120 healthy adults will receive either the vaccine or a placebo and then be exposed to the bacteria in a controlled setting. The goal is to see if…

This study tests whether extra COVID-19 vaccine doses are safe and work well for people with weakened immune systems, such as those with HIV, organ transplants, or blood cancers. Around 960 participants will receive different booster schedules to see which one boosts their protec…

This study tests whether a maintenance therapy using a hypomethylating agent (HMA) can help prevent relapse and improve survival in people with favorable risk acute myeloid leukemia (AML). About 77 participants who are already in remission after initial treatment will receive HMA…

This phase 2 trial tests whether giving patients with hard-to-treat acute myeloid leukemia (AML) a special type of immune cell—called a cytokine-induced memory-like natural killer (NK) cell—after a stem cell transplant can improve their chances of staying cancer-free. About 60 ad…

This study tests whether a patient's own modified white blood cells can help kidneys recover faster after acute injury from heart surgery. About 98 adults will receive either the cell therapy or a placebo. The goal is to see if the treatment shortens recovery time and is safe.

This Phase III trial is testing whether adding the immunotherapy drug blinatumomab to standard chemotherapy helps adults with a newly diagnosed type of acute lymphoblastic leukemia (ALL) live longer and stay cancer-free longer. About 488 participants are randomly assigned to rece…

This early-stage trial tests a new antibody drug called Hu8F4 in 72 people with advanced blood cancers like leukemia and myelodysplastic syndrome. The goal is to find the safest dose and see if it can slow or stop cancer growth. Researchers will also track how long patients live …

This study tests a 9-session program called MILAP for young married women (ages 15-24) in Nepal who have experienced intimate partner violence. The program involves the woman, her husband, and her mother-in-law, aiming to reduce depression, violence, and PTSD. 900 participants wi…

This study tests a drug called litifilimab for people with lupus-related skin disease that didn't get better with standard antimalarial pills. About 450 adults with active skin lesions will receive either the drug or a placebo every 4 weeks for 24 weeks, then everyone gets the dr…

This study tests the drug ruxolitinib in 36 Chinese adults and teens (12+) who have severe graft-versus-host disease after a stem cell transplant and did not improve with steroids. Participants take ruxolitinib pills daily for up to 56 days. The main goal is to see how many patie…

This phase 2 trial tests whether a combination of venetoclax and azacitidine can clear measurable residual disease (MRD) in adults with acute myeloid leukemia (AML) who still have or develop leftover cancer cells after initial chemotherapy, and before a stem cell transplant. Abou…

This study offers continued RVU120 treatment to up to 10 patients with advanced solid tumors, acute myeloid leukemia, or high-risk myelodysplastic syndrome who are already benefiting from the drug in an earlier trial. The main goal is to monitor safety and see how long patients c…

This study tests whether using a special camera (OCT) inside the heart's arteries during a heart attack procedure leads to better outcomes than the standard X-ray method. About 3000 people having a heart attack will be randomly assigned to one of the two approaches. The goal is t…

This early-phase study is testing a drug called TAK-243 in people whose acute myeloid leukemia or myelodysplastic syndrome has come back or is not responding to treatment. The goal is to find the best dose and check for side effects. The trial is currently on hold.

Researchers are studying whether the drug chidamide can help keep high-risk acute myeloid leukemia (AML) in remission when used as maintenance therapy. The trial enrolls adults with specific genetic features and measurable residual disease who are not receiving a stem cell transp…

This study tests a new two-drug combination (ASTX727 and venetoclax) in adults with acute myeloid leukemia who are 75 or older, or have health issues that make standard strong chemotherapy too risky. The goal is to see if the drugs work well together and can control the leukemia.…

This study tests a combination of four drugs (ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab) as the first treatment for people with chronic lymphocytic leukemia (CLL) who have a specific genetic marker (mutated IGHV gene). The goal is to see if this combo can achieve…

This early-stage trial is testing a new oral drug called SNDX-5613 alongside standard intensive chemotherapy in people newly diagnosed with acute myeloid leukemia (AML) that has specific genetic changes (KMT2A, NPM1, or NUP98). The study aims to see if the combination is safe and…

This phase 2 trial tests the drug ibrutinib in 44 people with hairy cell leukemia that has come back after treatment. Ibrutinib works by blocking a protein that helps cancer cells grow. The main goal is to see how many patients achieve remission within 32 weeks.

This phase 2 trial is testing whether a combination of chemotherapy drugs typically used in children can be safe and effective for adults aged 18 to 60 with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). The study aims to see if this 'pediatr…

This study tests a new way to treat children and young adults with high-risk blood cancers like leukemia and lymphoma. Doctors take blood cells from a family donor, remove certain T cells that can cause a harmful immune reaction, and then transplant the modified cells. The goal i…

This early-phase trial is testing a new type of immunotherapy called tri-specific CAR T-cells that target three proteins (CD19, CD20, CD22) on cancer cells. It is for adults with B-cell lymphomas that have come back or not responded to standard treatments. The study will enroll 1…

This phase 2 trial tests whether combining venetoclax and azacitidine after a stem cell transplant can prevent leukemia from returning in high-risk patients. About 100 adults aged 18-75 with certain types of acute leukemia who are in remission after transplant will receive the dr…

This Phase 3 trial compares the drug acalabrutinib to a combination of chlorambucil and rituximab in people with previously untreated chronic lymphocytic leukemia (CLL). The study includes 155 participants and measures how long the cancer stays under control (progression-free sur…

This early-phase trial tests a personalized cell therapy called CART123 for people with certain blood cancers (like AML or MDS) that have not responded to standard treatments. Each patient's own immune cells are modified in a lab to recognize and attack cancer cells. The main goa…

This early-phase trial tests a combination of three drugs — bortezomib, sorafenib, and decitabine — in patients with acute myeloid leukemia (AML), especially those who are older or have hard-to-treat forms. The main goal is to find the safest dose and see how well patients tolera…

This study tests a combination of three drugs—gilteritinib, venetoclax, and azacitidine—in people newly diagnosed with a fast-growing form of acute myeloid leukemia (AML) that has a FLT3 gene change. Participants are older or have other health issues that prevent them from receiv…

This early-phase study tests an experimental drug called ABBV-453, given with another cancer drug (obinutuzumab), in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or stopped responding to other treatments. About 60 participa…

This study tests the safety of an antibiotic called Vabomere in children aged 3 months to 12 years who have complicated urinary tract infections, including kidney infections. The children receive the medicine through an IV while in the hospital. Researchers monitor for side effec…

Researchers are testing whether a combination of homoharringtonine, lisaftoclax, and azacitidine can help adults with acute myeloid leukemia (AML) whose disease stopped responding to venetoclax-based treatment. The trial plans to enroll 73 participants and give them the three dru…

This phase 2 trial tests the drug olaparib in 14 adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or not responded to treatment, and whose cancer has a specific change in the IDH gene. Olaparib is a pill that may block enzymes cancer cells need to …

This early-phase study tests a new cell therapy called BSB-2002 in adults with a specific type of acute myeloid leukemia (AML) that has returned or not responded to at least two prior treatments. The main goals are to check safety and see if it can prevent the cancer from coming …

This early study is testing whether bone marrow from deceased donors can be safely used for transplants in people with blood cancers like leukemia and lymphoma. Twelve patients will receive the transplant along with chemotherapy or radiation. The main goal is to see if the new ma…

This trial investigates whether drinking a beverage made from 30 different organic vegetables daily for four weeks can improve gut microbiome diversity, reduce inflammation, and ease PTSD symptoms in adults diagnosed with PTSD. Participants are randomly assigned to receive either…

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This study tests a new monthly injection called ziltivekimab in 10,000 people who recently had a heart attack. The goal is to see if it can lower the risk of having another heart attack, a stroke, or dying from heart disease. Participants will receive either the study drug or a p…

This study tests a combination of drugs (venetoclax plus azacitidine, decitabine, or cytarabine) without traditional anthracycline chemotherapy in 40 adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (CBFβ::MYH11-positive). The goal is to see if thi…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This study tests a pill called venetoclax for people whose hairy cell leukemia has returned after prior treatment. The drug blocks a protein that cancer cells need to survive. About 20 adults will take venetoclax to see if it shrinks tumors and improves blood counts, with the goa…

This study tests an experimental antibody called epcoritamab, which helps the immune system target and kill cancer cells. It is being tested alone or with other drugs in about 194 people with relapsed/refractory chronic lymphocytic leukemia (CLL) or Richter's syndrome. The goal i…

This early-stage trial tests whether adding the immunotherapy drug ipilimumab to the chemotherapy drug decitabine is safe and tolerable for people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) that has come back or stopped responding to treatment. About 54 p…

This study tests whether gently cooling the body (to 34-35°C) combined with muscle-paralyzing drugs can help people with severe lung injury (ARDS) recover. About 340 adults on ventilators will be randomly assigned to cooling plus paralytics or usual care. The main goal is to see …

This trial tests an antibody called epcoritamab in 666 people with B-cell lymphoma that has come back or not responded to treatment. The drug is designed to help the immune system attack cancer cells. The study looks at safety, the right dose, and how well the drug works.

This trial tests a drug called epcoritamab in about 78 Japanese adults with B-cell lymphoma that has returned or not improved after standard treatment. The study has two parts: first, finding a safe dose, and then checking how well the drug works alone or with other chemotherapy.…

This early-phase study tests a new drug called SEA-CD70, alone or with standard drugs azacitidine and venetoclax, in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The main goal is to check safety and find the right dose. About 178 participants will b…

This Phase 3 trial tests whether hydroxychloroquine, given alone or with azithromycin, can improve outcomes for adults hospitalized with moderate to severe COVID-19 lung disease. Participants receive hydroxychloroquine for 10 days, and some also get azithromycin for 5 days. Resea…

This early study tests a new gene therapy called INT2104 in 10 adults with B-cell cancers that have come back or not responded to treatment. The therapy is given as a single IV infusion and works by instructing the body to create its own cancer-fighting T cells and natural killer…

This Phase 2 trial tests two experimental injections, HRS-7249 and SHR-1918, in 108 adults with severely high triglycerides who are at high risk of acute pancreatitis. The study aims to see if these drugs can safely lower fat levels in the blood and reduce the chance of a pancrea…

This early-stage study tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Researchers take a patient's own T cells, modify them in the lab to recognize and attack leukemia cells, and infuse th…

This trial tests whether adding an experimental cell therapy called Amimaitosai to standard steroids can treat severe gut inflammation that sometimes occurs after a stem cell transplant. The study enrolls people with blood cancers who develop this condition, called gastrointestin…

This trial tests an experimental drug called IMGN632 in people with certain blood cancers, including acute myeloid leukemia and blastic plasmacytoid dendritic cell neoplasm. The drug is designed to find and attack cancer cells that carry a protein called CD123 on their surface. R…

This study tests whether combining venetoclax with ASTX727 can help control acute myeloid leukemia (AML) in two groups: patients whose cancer returned or didn't respond to prior treatment, and older adults newly diagnosed who cannot handle strong chemotherapy. The drugs work toge…

This pilot trial tests whether Vyxeos, a liposomal formulation combining two chemotherapy drugs, can effectively treat newly diagnosed low- or intermediate-risk acute myeloid leukemia (AML) in adults aged 18 to 70. Some participants also receive Mylotarg, an antibody-drug conjuga…

This Phase 2 trial is testing a combination of three drugs—zanubrutinib, obinutuzumab, and venetoclax—in people with previously untreated chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma (MCL). The goal is to see if the combo can make …

This study tests whether removing a specific type of immune cell (naive T cells) from donor stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body after a stem cell tr…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This study tests two different drug combinations in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 600 participants will receive either acalabrutinib plus venetoclax or venetoclax plus obinutuzumab. The goal is to see which com…

This study tests a new treatment plan for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot or choose not to have a donor stem cell transplant. The approach uses a 'sandwich' strategy: first, patients receive two types of CAR T-cells (targeting CD22 and CD19), th…

This phase 1 trial tests whether adding the experimental drug calaspargase pegol-mknl to standard chemotherapy can safely help adults with newly diagnosed acute myeloid leukemia (AML). Researchers aim to find the highest tolerable dose and watch for side effects. They will also t…

This study tests whether a personalized 12-week cardiac rehabilitation program, offered in a safety net clinic, helps more heart patients attend rehab compared to the usual referral to an outside program. Researchers will enroll 100 adults who have had a heart attack, surgery, or…

This early-phase trial tests a personalized cell therapy for adults aged 60 and older with B-cell acute lymphoblastic leukemia (ALL) who are in first remission. Researchers take a patient's own immune cells, modify them in the lab to recognize and attack leukemia cells, and infus…

This study tests a new way to deliver radiation before a stem cell transplant for people with leukemia or myelodysplastic syndrome. Instead of radiating the whole body, the new method targets only the bone marrow and lymph nodes, which may reduce damage to healthy organs. The goa…

This trial tests whether L-carnitine, a natural compound, can reduce the damage that occurs when blood flow is restored to the heart after a heart attack. Researchers will give L-carnitine to patients with ST-elevation myocardial infarction (STEMI) who undergo angioplasty, and me…

This trial tests an experimental drug called OBI-3424 in people with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has returned or not responded to treatment. The drug is designed to become active mainly inside cancer cells that produce a specific enzy…

This phase 3 study tests whether a combination of two targeted drugs, ibrutinib and venetoclax, works better than the current standard therapy (chlorambucil plus obinutuzumab) for adults with chronic lymphocytic leukemia (CLL) who have not yet been treated. The main goal is to se…

This phase 3 trial is testing whether adding venetoclax to a standard two-drug regimen (ibrutinib and obinutuzumab) helps younger patients with chronic lymphocytic leukemia (CLL) live longer without their cancer getting worse. The study involves 720 participants who have not yet …

This phase 2 study is testing whether adjusting the dose of ibrutinib—either by starting lower or reducing it when side effects occur—can still effectively control chronic lymphocytic leukemia (CLL) in people who have not yet been treated. Some participants will receive ibrutinib…

This study tested whether a combination of ibrutinib (a targeted drug) and rituximab works better than standard chemotherapy (FCR) for younger patients with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. About 529 people took part. The main goal was t…

This study monitors long-term safety in 120 cancer patients who are already benefiting from treatments like JNJ-75348780, safimaltib, or ibrutinib in earlier trials. Participants have blood cancers, solid tumors, or prostate cancer. The goal is to track serious side effects over …

This phase 3 trial compares the usual two-drug therapy (ibrutinib plus obinutuzumab) against a three-drug combo that adds venetoclax in older adults (65+) with untreated chronic lymphocytic leukemia. The goal is to see if the extra drug keeps the cancer away longer and whether pa…

This early-stage trial tests a new drug called JNJ-89853413 in 64 people whose acute myeloid leukemia (AML) or myelodysplastic neoplasms (MDS) have come back or stopped responding to treatment. The main goal is to check safety and find the right dose, with a second part looking a…

This study is for people aged 65 and older who have chronic lymphocytic leukemia (CLL) that hasn't been treated yet. It compares three treatment plans: a standard chemo-immunotherapy (bendamustine plus rituximab), a targeted therapy plus immunotherapy (ibrutinib plus rituximab), …

This early-stage study tests a new drug called bleximenib combined with other leukemia treatments for people with acute myeloid leukemia (AML) that has specific genetic changes (KMT2A or NPM1). The main goals are to find the best dose and check for side effects. About 196 partici…

This early-phase study tests a new drug called JNJ-80948543 in people with non-Hodgkin lymphoma or chronic lymphocytic leukemia whose cancer has returned or not responded to other treatments. The drug works by redirecting the body's T-cells to attack cancer cells. The main goals …

This early-stage trial tests an investigational drug called ABBV-319 in about 154 adults with certain B-cell cancers (diffuse large B-cell lymphoma, follicular lymphoma, or chronic lymphocytic leukemia) that have returned or not responded to standard treatments. The study has two…

This study tests an experimental drug called IMVT-1402 in people with lupus-related skin rashes (subacute or chronic cutaneous lupus) that haven't gotten better with standard treatments. About 56 participants will receive either the drug or a placebo for 12 weeks, then all get th…

This study tests whether a lower dose of the drug venetoclax can be safely given to adults with acute myeloid leukemia (AML) who are already in remission. The goal is to reduce severe side effects like low white blood cell counts while still preventing the cancer from coming back…

This trial tests a type of engineered immune cell therapy called 19(T2)28z1xx CAR T cells in adults with B-cell cancers that have returned or not responded to treatment. The main goal is to find the highest dose that causes few or mild side effects. Researchers will also check wh…

This trial tests whether a drug called cyclophosphamide (PTCY) can prevent graft-versus-host disease (GVHD) better than the current standard, ATG, in patients receiving stem cell transplants from unrelated donors. GVHD is a serious complication where donor immune cells attack the…

This phase 2 trial tests giving two chemotherapy drugs, clofarabine and melphalan, before a donor stem cell transplant in 72 patients with leukemia or myelodysplastic syndrome in remission. The goal is to prevent the cancer from coming back after the transplant while causing fewe…

This early-phase trial tests a new type of immunotherapy for patients with acute myeloid leukemia (AML) or blastic plasmacytoid dendritic cell neoplasm (BPDCN) that has returned or not responded to treatment. Researchers take a patient's own (or a donor's) T-cells, modify them in…

This phase II trial is studying a combination of chemotherapy (Hyper-CVAD) and the targeted drug dasatinib, with or without a donor stem cell transplant, in 97 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see how well this approa…

This early-phase study tests a new treatment called CLL-1 CAR-T for children aged 3 to 18 with acute myeloid leukemia that has come back or not responded to standard therapy. Ten participants will receive an infusion of their own modified immune cells after chemotherapy. The main…

This phase 3 trial tests whether acalabrutinib is as effective as ibrutinib for people with high-risk chronic lymphocytic leukemia (CLL) who have already tried other treatments. About 533 participants will receive either acalabrutinib or ibrutinib pills. The main goal is to see h…

This early-phase trial tests a new type of immunotherapy called TriCAR19.20.22 T cells for people with certain blood cancers (non-Hodgkin lymphoma, acute lymphoblastic leukemia, and chronic lymphocytic leukemia) that have returned or not responded to standard treatments. The ther…

This study tests a new oral drug (revumenib) combined with standard chemotherapy for infants and young children with a specific type of leukemia (KMT2A-rearranged) that has returned or not responded to treatment. The goal is to see if the combination is safe and works better than…

This early-phase trial tests a new drug called tegavivint, given together with the chemotherapy decitabine, for people whose leukemia has returned or not responded to standard treatments. The main goals are to find the safest dose and to watch for side effects. Only 9 adults with…

This phase 3 trial compares three treatment approaches for people with previously untreated chronic lymphocytic leukemia (CLL): a standard chemo-immunotherapy (obinutuzumab plus chlorambucil), a newer targeted drug (acalabrutinib) combined with obinutuzumab, and acalabrutinib alo…

This early-phase trial is testing whether adding a drug called iadademstat to the standard combination of venetoclax and azacitidine is safe and tolerable for adults with untreated acute myeloid leukemia (AML). About 45 people with intermediate- or high-risk AML will take part. T…

This phase 2 trial tests a combination of two drugs, cladribine and venetoclax, in 20 adults with a specific form of acute myeloid leukemia (monocytic AML) that has stopped responding to or returned after standard treatment. The goal is to see if this new combo can shrink or elim…

This early-phase trial is testing a drug called flotetuzumab in children and young adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. Flotetuzumab is an immunotherapy designed to help the body's immune cells find and attack cancer c…

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This early-phase study tests a new three-drug combination for adults with newly diagnosed acute myeloid leukemia (AML) who cannot receive standard chemotherapy. The treatment includes a targeted radiation antibody (lintuzumab-Ac-225) plus two oral drugs (venetoclax and ASTX-727).…

This early-stage trial is testing whether adding an experimental drug called iadademstat to the approved leukemia drug gilteritinib can help people with a specific type of acute myeloid leukemia (AML) that has returned or not responded to treatment. The study focuses on patients …

This study tests a combination of two drugs, vemurafenib (a pill) and obinutuzumab (an infusion), in 30 people with previously untreated hairy cell leukemia. The goal is to see how many patients achieve a complete response, meaning no signs of cancer after treatment. Participants…

This Phase 3 trial is testing an experimental oral drug called BGB-16673 against standard treatments (bendamustine plus rituximab or high-dose methylprednisolone plus rituximab) in 150 people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymp…

This trial tests whether a structured bundle of supportive care measures—such as careful fluid management, blood pressure control, and medication adjustments—can lower the risk of persistent severe acute kidney injury in patients who develop moderate or severe kidney injury withi…

This early-phase trial is exploring whether combining two drugs, selinexor and azacitidine, can help prevent relapse in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who carry a TP53 mutation and have already undergone a stem cell transplant…

This phase 2 trial is testing whether a sequence of four drugs—bendamustine, obinutuzumab, zanubrutinib, and venetoclax—can eliminate minimal residual disease in people with relapsed or refractory chronic lymphocytic leukemia (CLL). The study enrolls about 42 adults whose CLL has…

This study follows patients who have already been taking ruxolitinib alone or with panobinostat in earlier trials and are still benefiting. Researchers will track side effects over time to see how safe these drugs are for long-term use. About 296 participants with conditions like…

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This study tests whether giving two drugs, decitabine and filgrastim, after a stem cell transplant can help prevent blood cancers like AML and MDS from coming back in children and young adults. About 37 participants will receive the drug combination for up to 6 cycles. The main g…

This phase 3 trial is testing whether adjusting chemotherapy based on a child's early response can improve outcomes for acute myeloid leukemia (AML) or myelodysplastic syndrome in children with Down syndrome. After the first round of treatment, patients are placed into risk group…

This phase II trial tests a personalized cell therapy called tisagenlecleucel (Kymriah) in children and young adults with high-risk B-cell acute lymphoblastic leukemia who still have detectable cancer cells after initial chemotherapy. The treatment involves collecting the patient…

This study tests a new device called enVast that removes blood clots from heart arteries during a severe heart attack (STEMI). About 148 adults with large clots will either get standard care or standard care plus the enVast device. The goal is to see if the device reduces the siz…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is…

This study looks at two different ways to use ventilators for children with acute respiratory distress syndrome (ARDS), a serious lung condition. The goal is to see which method helps children recover faster and breathe better. About 160 children will take part, and the results w…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This trial asks whether giving only ticagrelor (a blood thinner) after a heart attack, instead of the usual ticagrelor plus aspirin, is just as safe and might reduce bleeding and heart muscle damage. About 200 people who had a type of heart attack called STEMI and underwent a ste…

This study tests whether giving the drug anakinra early can prevent severe cytokine release syndrome (CRS) in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) who are receiving CAR-T cell therapy. Participants receive anakinra at the first sign of fever,…

This trial tests whether adding gentle oscillations to standard nasal continuous positive airway pressure (NCPAP) improves breathing support for newborns with respiratory distress syndrome. Premature infants who need NCPAP will be randomly assigned to receive either oscillatory N…

This study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of…

This study tests a new drug called ALXN2030 in 45 adults who have had a kidney transplant and are experiencing antibody-mediated rejection (AMR). The goal is to see if the drug can help resolve signs of rejection seen on a kidney biopsy after one year of treatment. Participants w…

This phase 3 trial is testing whether adding tocilizumab to standard care can slow the decline in kidney function for people who have chronic antibody-mediated rejection after a kidney transplant. Half of the 50 participants will receive tocilizumab plus standard care, while the …

This trial is testing an oral drug called AG-120 (ivosidenib) in adults with myelodysplastic syndrome (MDS) or a related early form of leukemia that carries a specific IDH1 gene mutation. The drug is designed to block the mutated enzyme that drives abnormal blood cell growth. Res…

This trial is testing an oral drug called enasidenib (AG-221) in people with myelodysplastic syndrome (MDS) who have a specific genetic change called an IDH2 mutation. The drug is designed to block the mutated enzyme and help restore normal blood cell production. Participants rec…

This study is for adults with a specific type of acute myeloid leukemia (CD123+ AML) who cannot receive standard strong chemotherapy. It tests a new drug, tagraxofusp, added to two other drugs (venetoclax and azacitidine) to see if it helps more people achieve complete remission.…

This study tests the long-term safety of the drug litifilimab in adults with lupus skin disease (CLE) that didn't improve with standard antimalarial treatment. About 322 participants who completed a prior study will receive injections every 4 weeks for up to 2 years (or 5 years i…

This study follows 192 people with chronic lymphocytic leukemia (CLL) in Spain who started taking acalabrutinib for the first time. Researchers want to see how many patients stay on the drug for at least 24 months and how it works in different groups, like those new to treatment …

This trial is testing whether a catheter that suctions out blood clots can restore blood flow to the intestine in people with acute mesenteric ischemia, a life-threatening blockage of the artery feeding the gut. Participants will undergo thrombus aspiration, and if needed, laparo…

This study looks at whether a telehealth system can help people in rural areas get better heart care. It connects local emergency services and clinics with heart experts at a major medical center. About 215 adults with heart symptoms will take part. The goal is to see if this app…

This study tests a new radioactive drug called [177Lu]Lu-PentixaTher in people with acute leukemia that has come back or not responded to standard treatments. The drug seeks out and delivers radiation directly to leukemia cells that have a specific marker (CXCR4). The main goals …

This study offers continued treatment with the drug ASTX727 to adults with acute myeloid leukemia, chronic myelomonocytic leukemia, or myelodysplastic syndromes who were already benefiting from it in earlier studies. The main goal is to monitor long-term safety. About 332 partici…

This study tests if a drug called inclisiran can reduce fatty plaque buildup in the arteries of people who recently had a heart attack and have high cholesterol. About 318 adults will receive either inclisiran or standard care, and doctors will use special imaging to measure plaq…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This study tests a drug called selatogrel, which people inject themselves at the first sign of a heart attack. The goal is to see if it can prevent death or reduce heart damage. The trial involves 25,000 people who recently had a heart attack and have other risk factors. Particip…

This study tests whether adding a PCSK9 inhibitor (a powerful cholesterol-lowering drug) to high-intensity statin therapy can prevent future cardiovascular events in people who have recently had a heart attack or unstable angina and underwent a stent procedure. About 1,200 partic…

This study tests a new drug, ibrutinib, added to standard chemotherapy (FCR) for younger patients with untreated chronic lymphocytic leukemia (CLL). The goal is to see if this combination can clear all signs of leukemia from the bone marrow (called MRD-negative complete response)…

This study looks at the long-term safety and effectiveness of enpatoran, an experimental drug for lupus. About 379 people who completed a previous 24-week study will take different doses of enpatoran or a placebo for up to 194 weeks. The goal is to see if the drug is safe and hel…

This study tests whether giving patients hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) after an umbilical cord blood stem cell transplant helps the donated stem cells grow faster. The trial enrolls people with blood cancers like leukemia or lymphoma who lack …

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This study tests whether the targeted drug inotuzumab ozogamicin can eliminate minimal residual disease (MRD) in adults with B-cell acute lymphoblastic leukemia (ALL) before they receive a stem cell transplant. Participants have either Philadelphia chromosome-positive or -negativ…

This study looks at 600 people who had a major heart attack and have other narrowings in their heart arteries that are not severe but look unstable. Half will get a stent plus medication, and half will get medication alone. The goal is to see if stenting these unstable plaques re…

This trial tests whether using a special camera inside the arteries (optical coherence tomography, or OCT) is better than standard pressure-wire measurements for deciding which non-blocked arteries need stenting in people who have just had a heart attack. About 1,425 participants…

This study tests a program called TAKE CARE, designed to prevent older adults (75+) from losing their ability to perform daily activities after a hospital stay. The program uses e-health tools, staff training, and environmental changes to address six common causes of hospital-rel…

This study tests whether giving surfactant (a natural substance that helps lungs stay open) through a small airway device placed above the vocal cords, along with standard breathing support (CPAP), is better than CPAP alone for late preterm and early term infants with respiratory…

This Phase 3 trial tests satralizumab, an injected drug, in 120 people with NMDAR or LGI1 encephalitis—rare conditions where the immune system attacks the brain. The goal is to see if the drug improves disability and reduces the need for rescue treatments. Participants receive ei…

This phase 2 trial is testing a combination of two drugs, rituximab and zanubrutinib, in people with hairy cell leukemia or its variant. The goal is to see if this treatment can shrink or eliminate the cancer. Participants take zanubrutinib pills daily and receive rituximab infus…

This study compares a new type of heart stent called Freesolve, which is made of magnesium and dissolves over time, to a standard permanent metal stent. About 1,859 people with coronary artery disease will receive one of the two stents. The goal is to see if the dissolving stent …

This study tests a drug called efgartigimod, given as a shot under the skin, for people who have antibody-mediated rejection after a kidney transplant. The trial includes 30 adults who received a kidney at least 6 months ago and have signs of rejection. Participants will receive …

This Phase 3 trial is testing whether adding the drug quizartinib to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) that lacks a specific genetic mutation (FLT3-ITD). About 700 participants will receive either quizartinib or a placebo alongsi…

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This trial tests whether a home-based tele-rehabilitation program is as effective as traditional center-based cardiac rehabilitation for people who have recently had a heart attack (acute coronary syndrome). Participants will either complete 20 sessions at a rehab center or 20 se…

This Phase 3 trial tests whether adding ivosidenib (a targeted pill) to standard azacitidine helps adults with a specific IDH1-mutated acute myeloid leukemia (AML) who cannot have intensive chemotherapy. About 146 participants receive either the combo or a placebo plus azacitidin…

This trial investigates the best way to treat children with acute myeloid leukaemia (AML) by comparing different chemotherapy drugs and doses. It tests whether adding up to three doses of the targeted drug gemtuzumab ozogamicin to standard chemo is safe and effective. The study a…

This trial was designed to test a milder conditioning regimen using a radioactive antibody (90Y-Epratuzumab) followed by chemotherapy and a stem cell transplant for adults with CD22-positive B-cell acute lymphoblastic leukemia. The goal was to find the safest dose that still cont…

This phase 2 study tests a single infusion of KTE-X19, a CAR T-cell therapy, in 25 Japanese adults whose mantle cell lymphoma or B-cell acute lymphoblastic leukemia has returned or not responded to prior treatments. The goal is to see how well it shrinks tumors and how safe it is…

This phase 3 trial compares a two-drug combination (pevonedistat plus azacitidine) against azacitidine alone in 302 older or unfit adults newly diagnosed with acute myeloid leukemia (AML) who cannot have standard intensive chemotherapy. The main goal is to see if the combination …

This early study tests whether the drug theophylline can prevent kidney injury in newborns who experienced oxygen deprivation at birth (HIE) and are receiving cooling therapy. Thirty infants will receive one or two doses of theophylline within 18 hours of birth. The main goal is …

This phase 3 study tested whether adding venetoclax to azacitidine helps people with untreated acute myeloid leukemia (AML) who cannot receive standard chemotherapy. About 443 adults took part, with two-thirds receiving the drug combo and one-third getting a placebo plus azacitid…

This study tests a drug called felzartamab in people who received a kidney transplant and later developed antibody-mediated rejection (AMR), where the immune system attacks the new kidney. The drug targets immune cells that make harmful antibodies, aiming to reduce kidney damage …

This study tests whether rivastigmine, a drug used for Alzheimer's, can prevent delirium from coming back after initial treatment with physostigmine for anticholinergic poisoning. About 42 people aged 10 and older with controlled delirium will receive either rivastigmine or a pla…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This early-phase study tests a new drug called uproleselan combined with two standard chemotherapy drugs for children and teens with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. The drug works by blocking a protein that helps c…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …

This study tests the drug daratumumab in adults with T-cell acute lymphoblastic leukemia (T-ALL) who still have tiny amounts of cancer cells (called minimal residual disease, or MRD) after standard chemotherapy. The goal is to see if daratumumab can clear these leftover cells and…

This study gives venetoclax to people with certain blood cancers who already benefited from it in earlier studies. The main goal is to track side effects and safety over a longer period. About 165 participants will continue taking the drug to see how well it works and how safe it…

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study offers ongoing treatment with the drug CC-122 (Avadomide) to 12 people with Non-Hodgkin Lymphoma who have already been taking it for over 5 years in earlier trials and are still seeing benefits. The main goal is to monitor long-term safety and serious side effects. Par…

This early-phase study tests a new drug called cusatuzumab alongside usual treatments for adults with acute myeloid leukemia (AML) who cannot have intensive chemotherapy. The main goal is to check the safety and side effects of the combination. About 61 participants will receive …

This study tests an experimental drug called imetelstat in 46 adults with high-risk myelodysplastic syndromes or acute myeloid leukemia that did not improve after standard therapy. The goal is to see if the drug can improve blood cell counts and control the disease. Participants …

This trial compares two different chemotherapy and radiation regimens given before a stem cell transplant for adults aged 40-70 with acute lymphoblastic leukemia (ALL) in remission. The goal is to see if a stronger regimen (using total body irradiation and cyclophosphamide) can r…

This study tests whether a drug called anakinra, which reduces inflammation, can help prevent heart failure in people who have just had a heart attack. About 84 participants will receive daily injections of anakinra or a placebo for up to 14 days. The goal is to see if blocking i…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This clinical trial is testing different treatment strategies to improve outcomes for older adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) who are getting a stem cell transplant. The study compares a new pre-transplant drug (Vyxeos) with stan…

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assi…

This study tests a new way of giving two drugs—venetoclax and azacitidine—to adults with acute myeloid leukemia (AML) who are not healthy enough for standard chemotherapy. Instead of the usual 7 days of azacitidine, this approach uses only 5 days per cycle to try to reduce infect…

This phase 3 trial compares three treatment approaches for people with previously untreated chronic lymphocytic leukemia (CLL): continuous ibrutinib alone, a fixed-duration combination of venetoclax plus obinutuzumab, or a fixed-duration combination of ibrutinib plus venetoclax. …

This study was designed to compare two ways to treat walled-off necrosis (a pocket of dead tissue) caused by severe pancreatitis. One method uses a scope through the mouth to clean out the pocket, the other uses surgery through the stomach. The goal was to see which approach work…

This phase 3 study compares a new oral drug called pirtobrutinib (LOXO-305) against two standard treatment combinations (idelalisib plus rituximab or bendamustine plus rituximab) in 238 adults with chronic lymphocytic leukemia or small lymphocytic lymphoma who have already been t…

This observational study follows 151 Italian adults with chronic lymphocytic leukemia (CLL) who started taking acalabrutinib between May 2021 and April 2022. Researchers want to see how long patients continue the drug and why they might stop, providing real-world insights beyond …

This study tests a new treatment for adults with a type of leukemia (T-ALL) that has come back or not responded to standard therapy. The treatment combines an immunotherapy drug (PD-1 inhibitor) with a targeted drug (venetoclax) and chemotherapy. The goal is to see if this combin…

This study tests a structured nutrition plan for 300 ICU patients who had abdominal surgery and cannot eat normally. The plan includes IV nutrition, oral supplements, and a device to measure calorie needs. Researchers will track infections, ICU stay length, and muscle loss to see…

This study tests a new drug called bexmarilimab, given together with standard treatments, for people with certain blood cancers (MDS, CMML, or AML). The goal is to first find a safe dose and then see if the combination helps shrink or control the cancer. About 181 adults are taki…

This study looks at the long-term safety of the drug pirtobrutinib in people with certain blood cancers, like chronic lymphocytic leukemia or non-Hodgkin lymphoma. It includes 13 participants who already benefited from the drug in an earlier study and will continue treatment ever…

This Phase 3 trial tests whether adding budesonide (an anti-inflammatory) to standard surfactant treatment helps extremely preterm babies avoid chronic lung disease or death. About 642 infants born before 29 weeks or weighing under 1000 grams will receive either the combo or surf…

This study planned to test whether cooling the body before and after opening a blocked artery could help people having a heart attack. It was designed to include 80 patients at up to 15 hospitals. However, the trial was withdrawn before anyone was enrolled, so we have no informat…

This phase 2 trial tests whether empagliflozin (Jardiance), a diabetes drug, can reduce the 'no-reflow' phenomenon—when blood flow fails to fully restore after angioplasty—in 162 heart attack patients. Participants receive a loading dose before the procedure and daily doses for 3…

This study tests a new treatment called MC0518 (made from donor cells) in children who have severe graft-versus-host disease (GvHD) after a stem cell transplant and did not get better with steroids. GvHD happens when the donor's immune cells attack the child's body. The trial com…

This study tests whether adding evolocumab (Repatha) to standard care helps people who recently had a heart attack reach very low LDL cholesterol levels and avoid death or unplanned heart-related hospital stays. About 2,166 participants with STEMI or NSTEMI will be randomly assig…

This study follows 433 people with chronic pancreatitis who undergo a surgery called TPIAT, where the entire pancreas is removed to stop pain and the patient's own insulin-producing islet cells are infused back to lower diabetes risk. Researchers track pain relief, quality of lif…

This study tests a combination of three drugs (homoharringtonine, venetoclax, and azacitidine) in 40 adults newly diagnosed with a rare and aggressive leukemia called mixed-phenotype acute leukemia (MPAL). The goal is to see if this drug combo can safely help more patients achiev…

This study compares using a manual clot-removal catheter (Export) before standard balloon angioplasty versus angioplasty alone in 300 heart attack patients with completely blocked arteries. The goal is to see if removing the clot first improves blood flow and reduces in-hospital …

This early study tests a new freezing treatment for people who recently had a heart attack or unstable chest pain. The treatment uses a special balloon to freeze high-risk plaque in the heart's arteries that could rupture and cause another heart attack. The goal is to stabilize t…

This study tests whether an implantable heart monitor with remote follow-up can help doctors decide when to prescribe blood thinners to patients who have had a heart attack and developed new atrial fibrillation. The goal is to reduce bleeding complications compared to the standar…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This phase 2 trial tests a personalized approach for young adults (18-65) with high-risk chronic lymphocytic leukemia (CLL) who haven't been treated before. Patients first get a combination of venetoclax and obinutuzumab, then their treatment is adjusted based on whether cancer c…

This study tests whether adding four doses of rituximab to an intensified chemotherapy regimen improves outcomes for children and teens with advanced B-cell non-Hodgkin lymphoma or B-cell acute leukemia. About 200 participants in China will receive the new treatment, and research…

This study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to help prevent the donor cells from attacking the patient's body. The goal is to see if th…

This study tests an experimental drug called iopofosine I 131 in people with certain blood cancers (like Waldenstrom macroglobulinemia, multiple myeloma, and lymphomas) that have come back or not responded to standard treatments. The drug delivers radiation directly to cancer cel…

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the h…

This early-phase study is testing whether stem cell therapies and experimental drugs can help repair inner ear damage in people with hearing loss or tinnitus. Researchers will monitor 120 adults over time using hearing tests and symptom surveys. The goal is to see if these regene…

This phase 3 trial tests whether the targeted drug zanubrutinib works better than the standard chemo combination of bendamustine plus rituximab for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 590 participants who cannot tole…

This phase 2 trial tests whether adding daratumumab, an antibody that targets a protein on leukemia cells, to standard chemotherapy can clear all signs of cancer in adults with very high-risk T-cell acute lymphoblastic leukemia (T-ALL). About 31 patients aged 18-65 will receive t…

This phase 3 trial tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. Orca-T is a special mix of stem cells and immune cells from a matched donor, designed to reduce a serious side effect called graft-versus-host disease. The study compares …

This study tests if using a temporary heart pump (Impella CP) for 30 minutes before opening a blocked artery can reduce heart muscle damage in people having a severe heart attack. About 527 adults with a first-time anterior heart attack are enrolled. The goal is to see if this ap…

This study looks at whether giving children with acute lymphoblastic leukemia a daily antibiotic called ciprofloxacin can reduce bacterial infections during the first month of chemotherapy. About 313 children in the UK are taking part. The goal is to see if this approach works be…

This study tests a new type of CAR T cell therapy, called ALLO-501A, made from donor cells (not the patient's own). It is for adults with large B-cell lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma that has come back or not responded to other treatments. The …

This study tests a new care model for people who have had a heart attack. It uses digital tools and specially trained pharmacists to help manage health after leaving the hospital. The goal is to reduce the risk of another heart attack or death. The study involves 1,633 adults in …

This study tests whether painting roofs with a special reflective coating can lower indoor temperatures and improve mental health. About 800 people in Ahmedabad, India, who live in homes with poor insulation will be randomly assigned to get a cool roof or not. Researchers will me…

This phase 2 trial is testing whether adding venetoclax to standard BTK inhibitor therapy can help people with chronic lymphocytic leukemia (CLL) achieve very deep remission. The goal is to see if patients can then safely stop all treatment for a period. The study involves 118 ad…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study compares two ways of giving breathing support (PEEP) to very premature babies right after birth. One method uses a steady pressure, the other starts high then lowers it. The goal is to see which approach reduces the chance of death or chronic lung disease. Over 900 bab…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This phase 2 study tests a combination of three drugs—acalabrutinib, venetoclax, and obinutuzumab—as an initial treatment for chronic lymphocytic leukemia (CLL). The goal is to see if this combo can make the cancer undetectable in the bone marrow after 15 cycles of therapy. The s…

This study tracks over 1,300 heart attack patients who received a procedure called percutaneous coronary intervention (PCI), which opens blocked heart arteries. Researchers want to see if PCI reduces major heart problems like death, another heart attack, or the need for more proc…

This study looks at how well the GENOSS stent works in real-world patients who have had a heart attack or unstable chest pain (acute coronary syndrome). Researchers are tracking heart-related events like death, heart attacks, and the need for repeat procedures. The study involves…

This early-phase study tests a new treatment for people with certain B-cell blood cancers (lymphoma, ALL, or CLL) that have returned or not responded to standard therapy. The treatment uses the patient's own T cells, which are modified in the lab to recognize and attack cancer ce…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study tests whether adding a new targeted drug (pirtobrutinib) to a standard two-drug combination (venetoclax and rituximab) can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma live longer without their cancer getting worse. About 600 adults who h…

This study tests whether a blood test can help doctors safely lower the dose of strong blood thinners (P2Y12 inhibitors) in people who recently had a heart attack or stent. The goal is to reduce bleeding complications without raising the risk of another heart attack or stroke. Ab…

This study offers Erwinase, a different form of chemotherapy, to children and adults with acute lymphoblastic leukemia (ALL) who have had allergic reactions to standard L-asparaginase drugs. The goal is to provide a safe treatment option for those who cannot use the usual medicat…

This phase 3 trial compares a new oral targeted drug, pirtobrutinib, against a standard chemo-immunotherapy combination (bendamustine plus rituximab) in people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. About 309 participants will be randomly assig…

This study follows about 100 adults with acute myeloid leukemia (AML) who are already prescribed venetoclax by their doctors in Israel. Researchers will track how long patients live and how many achieve remission during routine care. The goal is to understand the drug's real-worl…

This early-phase trial is testing whether a new immune cell therapy called CART123, given together with the drug ruxolitinib, is safe for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The study will enroll 12 adults who have no other c…

This early-stage trial tests a new treatment for children aged 6 months to 16 years whose acute myeloid leukemia has returned. The therapy uses donor immune cells that have been gene-edited with a technique called base editing to better target and kill leukemia cells. The main go…

This study gives a small group of adults with acute myeloid leukemia (AML) continued access to an oral form of the chemotherapy drug azacitidine after they finished a previous trial. The main goal is to track any side effects and see how safe the drug is over a longer period. Abo…

This study tests whether people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) can safely increase their dose of the drug venetoclax faster than the usual 5-week schedule. About 40 participants with newly diagnosed or returning disease will be grouped…

This study tests a new combination of two drugs (gemtuzumab ozogamicin and gilteritinib) for adults with a specific genetic form of acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial aims to see if the combination is safe and helps control th…

This early-stage study aimed to test whether infusing donor stem cells could help people recover from acute respiratory distress syndrome (ARDS) caused by COVID-19. The trial was withdrawn before enrolling any participants, so no results are available. The approach was based on e…

This study compares vasopressin to the standard drug noradrenaline for managing blood pressure after heart surgery. The goal is to see if vasopressin reduces the number of patients who develop acute kidney failure or die. About 840 adults having scheduled heart surgery with a hea…

This study looks at whether a combination of four herbs (Phyllanthus urinaria, Adenosma glutinosum, Eclipta prostrata, and ascorbic acid) plus the drug tenofovir can help control hepatitis B over the long term. The treatment aims to strengthen the immune system and reduce virus l…

This study looks at whether older, frail patients with untreated chronic lymphocytic leukemia (CLL) can safely stop taking the targeted drug acalabrutinib after 18 months and then restart it if their disease comes back. The goal is to reduce long-term side effects and the risk of…

This study looks at how well the drug venetoclax works for adults with acute myeloid leukemia (AML) who cannot handle strong chemotherapy. About 210 people across Canada will take venetoclax pills daily as part of their normal care. Researchers will track their overall survival a…

This phase 2 pilot study is testing whether combining two drugs, ibrutinib and daratumumab, can improve outcomes for people with relapsed or refractory chronic lymphocytic leukemia (CLL) that has a p53 gene problem. The 29 participants will take ibrutinib daily and receive daratu…

This early-stage trial is testing a new treatment called CT0991, which uses specially engineered immune cells (CAR-T cells) to fight acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The study involves 24 adults aged 18-75 and aims to check saf…

This phase 2 trial tests a combination of two chemotherapy drugs, fludarabine and treosulfan, given before a stem cell transplant in adults aged 40-65 with acute myeloid leukemia (AML) in remission. The goal is to see if this conditioning regimen improves the chance of being aliv…

This early-phase study tests a new treatment for people with certain blood cancers (lymphoma or leukemia) that have returned after a stem cell transplant. Researchers take immune cells called T cells from the original stem cell donor, modify them to recognize and attack cancer ce…

This study tests a stem cell transplant method that removes certain immune cells (T and B cells) from donated stem cells before giving them to patients with blood cancers like leukemia or lymphoma. The goal is to help the new cells grow (engraft) while reducing the risk of graft-…

This study tests a stem cell transplant method that removes certain immune cells from the donor's blood to lower the chance of graft-versus-host disease (GvHD), a serious complication. It involves 3 patients with blood cancers or non-cancerous blood disorders who lack a perfectly…

This study tests a new type of immune therapy for people with certain blood cancers (CLL, lymphoma, or multiple myeloma) that have come back or not responded to treatment. Researchers take a patient's own T cells, add a special receptor that targets a protein called kappa on canc…

This study tests a single injection of zalunfiban given in the ambulance to people having a severe type of heart attack (STEMI). The goal is to see if the drug improves blood flow and reduces complications like death, stroke, or heart failure within 30 days. About 2,463 participa…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6,000 adults hospitalized for a heart attack are randomly assigned to receive ev…

This early-phase study tests whether adding the steroid dexamethasone to standard low-intensity chemotherapy is safe and tolerable for adults newly diagnosed with acute myeloid leukemia (AML) who cannot have intensive chemo. About 20 participants will receive the combination over…

This study tests an experimental drug called galinpepimut-S (GPS) in adults with acute myeloid leukemia (AML) who are in remission after second-line treatment. The goal is to see if GPS can help keep the cancer from coming back longer than the best available standard treatments. …

This early-stage trial tests a personalized therapy where a patient's own immune cells are genetically modified to recognize and attack cancer cells that carry a protein called CD19. It includes adults with certain types of leukemia, lymphoma, or chronic lymphocytic leukemia that…

This French study looks at 2,044 children and teens with acute lymphoblastic leukemia (ALL) to find the best way to give the drug pegaspargase. Some patients get one large dose, while others get two smaller doses. The goal is to see which schedule works better and causes fewer si…

This study tests whether robot-assisted leg exercises can prevent older patients from losing strength and independence during a hospital stay. 488 patients aged 65 and older will either receive robot-guided training or standard care. The goal is to see if the robot helps them wal…

This trial tests whether a single infusion of stem cells from donated umbilical cords can help people with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in intensive care. The study first finds a safe dose, then randomly gives either stem cells or…

This study tests whether irbesartan, a blood pressure medication, can reduce the risk of major heart problems and kidney disease in people who had acute kidney injury while in the intensive care unit (ICU). About 500 adults aged 18-75 will take either irbesartan or a placebo for …

This study compares two blood thinners (ticagrelor plus aspirin) against aspirin alone after coronary artery bypass grafting (CABG) in people who recently had a heart attack or unstable angina. Over 2,200 participants are being followed for 12 months to see if the dual therapy re…

This phase 2 trial tests whether adding cirmtuzumab to venetoclax can clear remaining leukemia cells in people with chronic lymphocytic leukemia (CLL) who still have detectable disease after standard treatment. Only 5 participants are enrolled, and the main goal is to see if the …

This study compares two blood test schedules for diagnosing heart attacks in the emergency room: the standard 3-hour test and a newer 1-hour test. Over 64,000 adults with chest pain will be enrolled to see if the faster test is just as safe and accurate. If it works, patients cou…

Researchers are testing whether combining data from wearables and remote monitors can predict a sudden health decline within 72 hours. The study will follow 10,000 adults aged 18 to 90 and collect signals such as heart rhythm, oxygen levels, temperature, gait, sleep, voice, and c…

Acute kidney injury is a common and serious complication after heart surgery, affecting up to half of patients and raising the risk of death and chronic kidney disease. Researchers are building a machine-learning model that uses perioperative data from 70,000 adults who had cardi…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This trial tests whether a coronary CT angiography (CCTA) scan can safely identify heart attack patients who do not need invasive angiography. About 300 patients with non-ST-elevation myocardial infarction (NSTEMI) will undergo CCTA before the standard invasive test. The goal is …

This study tests whether a compact 3-lead ECG device can accurately detect acute coronary syndrome (heart attack) in adults arriving at the emergency department with chest pain. Participants receive a HeartBeam ECG recording within 10 minutes of the standard 12-lead ECG. The goal…

This study tests a new rapid blood test that can detect heart damage in about an hour, right in emergency primary care clinics. Researchers will enroll 2,500 adults with chest pain across six Norwegian clinics to see if the test safely rules out heart attacks and reduces hospital…

This study aimed to see if an ultrasound score called VEXUS could help detect acute kidney injury in adults after heart surgery. About 20% of patients develop this complication, which raises the risk of death. However, the study was withdrawn before enrolling any participants, so…

This study is testing a new finger-prick blood test that measures troponin levels in about 10 minutes, compared to the usual 2-hour lab test. Researchers hope it will help diagnose heart attacks faster and reassure patients who are not having one, allowing them to be discharged s…

This study planned to compare a rapid antigen detection test against the standard PCR test for diagnosing COVID-19 in people who were close contacts of infected patients but had no symptoms. The goal was to see if the quick, inexpensive antigen test could reliably identify contag…

This study is testing whether a special heart scan (dynamic SPECT) can accurately detect remaining blockages in heart arteries after a heart attack, compared to the current standard invasive procedure (FFR). Sixty adults with multiple blocked arteries will receive both tests one …

This study enrolls 800 patients having heart attacks to test an artificial intelligence model that reads standard 12-lead ECGs. The AI aims to detect which artery is blocked and how severely blood flow is reduced, at the moment of a heart catheterization. If accurate, this could …

This study is testing whether a device called magnetocardiography (MCG) can quickly and accurately tell if chest pain is caused by a heart attack. Researchers at Mayo Clinic will use the MCG scanner on 1,000 emergency room patients with chest pain and compare its accuracy to stan…

This study involves 800 adults in intensive care who provide urine samples to test a new lab test called ProNephro AKI (NGAL). The goal is to find the right cutoff value that best identifies patients at risk for moderate to severe acute kidney injury within 48-72 hours. The test …

This study looks at whether using a special camera called optical coherence tomography (OCT) during heart artery procedures helps doctors make better decisions and get better results. About 3,200 people with various heart conditions will be included. The goal is to see if OCT gui…

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

This trial tests different vaccination schedules for Japanese encephalitis in healthy children starting at 8 months old. Researchers compare how well each schedule triggers and maintains protective antibodies through age 6, including the effect of booster doses. The study also mo…

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will …

This trial tests whether a structured prevention bundle can reduce delirium in adults aged 70 and older admitted to a cardiac intensive care unit (CICU). Participants are randomly assigned to either usual care or the bundle, which includes daily pain checks, avoiding sedatives wh…

This study tests whether a drug called deferoxamine can prevent acute kidney injury in adults undergoing heart surgery. The drug works by removing excess iron, which is thought to damage the kidneys during surgery. About 320 participants will receive either the drug or a placebo …

This study tests whether a computer program that spots early signs of acute kidney injury can improve patient care. Hospitalized adults at risk are randomly assigned to get an early kidney specialist visit or standard care. The goal is to see if early specialist advice can preven…

This study tests whether a device called RenalGuard can prevent acute kidney injury in 300 adults undergoing heart surgery. The device monitors and manages urine output during and after surgery. Half the patients will get RenalGuard, the other half standard care. Researchers will…

Researchers compare two surgeries for adults with recurrent acute tonsillitis: full tonsil removal (tonsillectomy) and partial tonsil removal (tonsillotomy). The trial enrolls 250 adults who have had at least five tonsillitis episodes in one year or three per year for two years. …

This study looks at whether exercise and weight management can help reduce fatigue in people who have had chronic lymphocytic leukemia (CLL). About 30 adults aged 18-85 with CLL will take part. Participants will be randomly assigned to start the program right away or after a wait…

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

Researchers in Greece are testing a nine-session group program called TRANSFORM for people who have finished treatment for blood cancers such as leukemia, lymphoma, and myeloma. The program combines teaching, reflection, coping exercises, and mindfulness to see whether it can spa…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

This study looks at whether trained service dogs can help reduce PTSD symptoms in military veterans. 150 veterans who already qualified for a service dog are randomly assigned to receive one or to a waitlist. Researchers track their PTSD severity, depression, and overall well-bei…

This phase II trial tests whether ruxolitinib (Jakafi) can reduce fatigue in people with chronic lymphocytic leukemia (CLL) who are not yet ready for standard treatment. Ten participants will take the drug and report their fatigue levels using a simple questionnaire. The goal is …

This trial tests whether people with mild diverticulitis can be safely treated at home with just pain medicines (ibuprofen and acetaminophen) instead of antibiotics. 556 participants will be randomly assigned to receive either pain medicines alone or pain medicines plus an antibi…

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This small study tests whether group drumming sessions can improve emotional well-being for parents of autistic children. Ten parents will take part in drumming groups and report changes in anxiety, depression, and feelings of belonging. The goal is to see if making music togethe…

This study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels in adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 68 critically ill patients on ventilators will either receive the hormone or s…

This study looks at whether having a psychiatric service dog makes prolonged exposure therapy work better for veterans with PTSD. About 216 veterans who already qualify for a service dog will be randomly assigned to get the dog right away or later. The goal is to see if the dog h…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study tests whether a trauma-informed care plan (TICP) placed in the electronic medical record helps healthcare teams better care for patients with trauma and complex needs. About 200 patients and their clinicians will use the plan, and researchers will measure how acceptabl…

This trial compares two types of video laryngoscope blades—hyperangulated and standard geometry—in critically ill adults who need a breathing tube in the emergency department or intensive care unit. About 2,500 participants will be randomly assigned to one blade type. The main go…

This study collects white blood cells from 120 people aged 3 to 65 with leukemia or lymphoma that hasn't been cured by standard treatments. The cells are gathered through a procedure called leukapheresis, then processed and frozen for future use in CAR T-cell therapy. The goal is…

This study follows 500 adults who had COVID-19 to see what health problems they face months later. Researchers will track symptoms like tiredness, breathing trouble, and lung damage. The goal is to learn how common these long-term issues are and who is most likely to have them.

Researchers at the University of Colorado are studying whether anti-nausea drugs given with cisplatin chemotherapy affect the risk of kidney injury. The trial enrolls 45 adults receiving cisplatin. It measures kidney injury biomarkers and cisplatin levels in urine, and examines w…

This long-term study looks at people and families with a higher chance of developing blood or lymph node cancers like leukemia or lymphoma. Researchers collect medical histories, genetic samples, and sometimes perform exams to find inherited genes or environmental triggers. The g…

This study tests whether training ICU staff to keep oxygen levels between 90-96% helps patients on breathing machines recover faster. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to imp…

This study examines how social and genetic factors influence long-term health in 2000 adolescent and young adult survivors of Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information to identify risks for disease recurrence, other illnesses, …

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

This study is testing whether a new genetic test called ChromoSeq can quickly and accurately classify leukemia in children and young adults. Researchers will collect blood or bone marrow samples from 60 participants at diagnosis and compare the test results to standard methods. T…

The KIDCOV study investigates whether mild or asymptomatic COVID-19 that does not require hospitalization increases the risk of kidney injury. Researchers enroll 2,000 adults who tested positive or negative for COVID-19, balanced by race and ethnicity across California, Michigan,…

Researchers at two Beijing hospitals are following more than 800 patients who develop sepsis after surgery. The team collects clinical data and biological samples to map immune patterns linked to acute kidney injury. Using multi-omics and single-cell sequencing, they aim to build…

This study looks at how changes in blood pressure during the start of anesthesia and throughout surgery may affect the risk of kidney injury after non-cardiac surgery. Researchers will review medical records from 5,000 adults to find patterns. The goal is to better understand how…

This study looks at whether using a smaller breathing tube during emergency intubation helps critically ill adults breathe easier and have better voice and swallowing six months later. About 3,180 patients in emergency rooms and intensive care units will be randomly assigned to g…

This observational study tracks about 160 Chinese adults with mantle cell lymphoma (MCL) or chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who take acalabrutinib as part of their normal care. Researchers will record how the drug is used, including doses and com…

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study tests whether a software tool called the Respiratory Knowledge Portal (RKP) can help ICU teams reduce complications in patients on breathing machines. Researchers will collect data from 875 patients to see if the tool improves how alarms are set, helps wean patients of…

This study is testing a new blood test called AlloHeme that measures how much of a patient's own cells remain after a bone marrow transplant. The goal is to see if this test can predict whether the cancer (acute leukemia or myelodysplastic syndrome) will come back. About 307 adul…

This study is not testing a new drug or treatment. Instead, it will observe how doctors in Russia currently treat chronic lymphocytic leukemia (CLL) in everyday practice. About 6000 adults with CLL will be followed for up to 2 years to collect information on their health, treatme…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

This study re-analyzes data from a previous trial of 343 heart surgery patients who received a blood purification device (oXiris) connected to the heart-lung machine. The original trial found a 12% reduction in acute kidney injury within 7 days. Now researchers will examine how t…

This study looks back at dental implant cases to see if bone-related conditions—like vitamin D deficiency, calcium problems, or kidney disease—make implant failure more likely. Researchers will compare 192 failed implants with successful ones from similar patients. The goal is to…

This study looks at whether a computer-based test can reveal how young adult survivors of childhood leukemia feel about exercise. About 125 survivors will take the test before and after a stress test and share their thoughts in an interview. The goal is to see if this approach is…

This study looks at whether breathing slowly (6 breaths per minute) lowers stress more than breathing at a normal pace or just resting. Healthy adults will practice a breathing method, then take a stress test involving cold water and math. Researchers will measure heart rate, str…

This study looks at how well the drug acalabrutinib works for people with chronic lymphocytic leukemia (CLL) when used in regular hospitals, not just in clinical trials. Researchers will track 350 patients in France for about 3 years to see how long they stay on the drug and why …

This study is looking at people hospitalized for a heart attack (STEMI or NSTEMI) who undergo a procedure to open blocked heart arteries, called percutaneous coronary intervention (PCI) or angioplasty. It compares two groups: those having a standard (non-complex) PCI and those ha…

This study looks at how red blood cells break down during prolonged heart-lung bypass in cardiac surgery, releasing free hemoglobin into the blood. Researchers will measure these levels and related proteins in adults undergoing complex heart procedures to see if they can predict …

This observational study will enroll about 8,000 adults across Europe who have coronary heart disease or are at high risk for it, including those with diabetes or chronic kidney disease. Researchers will check whether doctors are following European guidelines for lifestyle advice…

This study is investigating how common muscle loss, known as sarcopenia, is in people with blood cancers like leukemia, lymphoma, and myeloma. Researchers will measure body composition using DXA scans and track hospital stays, disease progression, and survival. The goal is to see…

This study follows about 2,200 mothers and their children in Cox's Bazar, Bangladesh, including Rohingya refugees and local families. Researchers want to understand how growing up in conflict and displacement affects child development and mental health. They are also looking at w…

This study is a registry that will follow 6,000 people who had a heart attack and were treated with emergency angioplasty at Zhongshan Hospital. Researchers will collect information on their health, procedures, and medications, and track their recovery for up to two years. The go…

This study looks at whether a quick, point-of-care blood test for heart damage can give results faster than standard lab tests for people with chest pain in the emergency room. Researchers will compare the time it takes to get test results and how long patients stay in the ER. Th…

This trial tests whether the PulsePoint app — already used to alert trained bystanders to nearby cardiac arrests — can also be used to teach people how to recognize and reverse an opioid overdose using naloxone. Researchers will send either standard or customized push messages to…

This study examines genetic test results from over 600 people who had acute myocarditis (heart muscle inflammation) confirmed by MRI. Researchers want to find out how common certain gene variants are in this group and whether they are linked to worse outcomes like heart failure o…

This study analyzes data from over 1,200 patients with acute hypoxemic respiratory failure who were on breathing machines in Spanish ICUs. Researchers are using a statistical method called mediation analysis to determine whether low oxygen levels directly cause death, or whether …

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study tests a new way to find unstable plaques in the heart arteries of people who come to the emergency room with chest pain but are not having a heart attack. Researchers use a simple calcium scan to group patients by risk, then follow up with special PET scans to see if p…

This study investigates cognitive problems in intensive care patients with acute respiratory distress syndrome (ARDS) who develop delirium (sudden confusion). Researchers use a non-invasive EEG cap and auditory tests to measure brain activity at the bedside. The goal is to identi…

This study follows 200 adults on ECMO (a heart-lung machine) for severe breathing problems. Researchers track how many get hospital-acquired infections and measure antibiotic levels in their blood and lungs. The goal is to learn more about infections and drug dosing in these crit…

This study looks at how patients with advanced blood cancers (like acute myeloid leukemia) who are not eligible for a cure, along with their nurses and doctors, feel about the benefits of blood transfusions. Researchers will give questionnaires before each transfusion to compare …

This study looks at how well the drug acalabrutinib works for people with chronic lymphocytic leukemia (CLL) in real-life settings in Romania. Researchers will collect data from 250 patients over three years to see how long they stay on the drug, why they stop, and how effective …

This study looks at 90 people who recently had a heart attack and have other artery narrowings that may or may not be dangerous. Researchers will use two types of scans—optical coherence tomography (OCT) and magnetic resonance angiography (MRA)—to see if they can tell which narro…

This study looks at women who have had a heart attack or unstable angina but do not have major blockages in their heart arteries. Doctors will use special imaging techniques, like IVUS and MRI, to find hidden causes such as cholesterol plaque in artery walls or problems with tiny…

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study follows up to 90 children and young adults with mitochondrial liver diseases to learn how these conditions progress over time. Researchers will collect medical data and samples to better understand the diseases and find markers that predict outcomes. The goal is to imp…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to und…

This study follows 90 people who survived severe COVID-19 pneumonia and needed intensive care. Researchers will check their physical health, mental health, and quality of life at 3 months, 6 months, 1 year, and 5 years after leaving the ICU. The goal is to better understand the l…

This study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …

This study looks at whether a special heart MRI, done within a week of a heart attack, can help doctors better predict a patient's future health. Researchers will follow 2,000 adults for years to track serious heart events like another attack or heart failure. The goal is to lear…

This study looks back at medical records of 725 older adults (over 65) with acute myeloid leukemia (AML). Researchers want to see if using a special 'fitness' score to choose treatment leads to longer survival. No new treatments are given; the goal is to learn which treatment app…

This study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …

This study looks at whether the immune system mistakenly makes antibodies that attack the body's own nerves and muscles in people with multiple sclerosis, myasthenia gravis, and similar conditions. Researchers will collect blood samples (and sometimes cheek swabs) from 120 adults…

This study planned to test whether giving doctors machine-learning alerts about patient risks after surgery could reduce serious complications like kidney injury or unplanned ICU stays. It was designed for high-risk patients, but the study was withdrawn before enrolling anyone, s…

This study looks at different training methods for ICU staff to improve how they remove breathing tubes from patients. It involves over 13,000 adults on ventilators for more than 24 hours. The goal is to see if better education and care plans can reduce deaths and increase use of…

This study is a large international registry that will collect data from up to 130,000 people who have had a heart attack or unstable chest pain. Researchers will track treatments, outcomes, and safety to understand what works best in real-world care. No new drugs or devices are …

This study watches how people with chronic lymphocytic leukemia (CLL) feel and function while taking standard oral treatments. About 146 adults in Spain will fill out questionnaires about their symptoms, fatigue, and worries during routine doctor visits. No new drugs are given—th…

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study looks at 40 people who recently had a heart attack and had one blockage treated. Researchers will use special pressure wires and optical imaging to examine other blockages that were not treated. The goal is to see how many of these leftover blockages are actually dange…

This study follows about 190,000 Korean radiation workers to see if low-dose radiation exposure over time increases the risk of cancer and other diseases. Researchers will link national health records to track health outcomes. The goal is to better understand the long-term effect…

This study looks at how doctors treat people having a severe heart attack complicated by cardiogenic shock, where the heart can't pump enough blood. Researchers will track 124 patients at 20 U.S. hospitals to see how decisions about using mechanical heart support devices affect s…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study follows 50 athletes who had acute myocarditis (heart muscle inflammation) to see how often they develop dangerous heart rhythms. Participants wear a portable ECG monitor and do a treadmill stress test at 3 months and 1 year after their illness. The goal is to learn mor…

This observational study looks at medical records of 43,000 hospitalized patients to find out how often acute kidney injury (AKI) develops during a hospital stay. Researchers will also compare death rates and readmission rates between patients who develop AKI and those who do not…

This study looks at whether healthcare providers can use skills learned on mannequins when helping real newborns breathe. About 120 respiratory therapists will be observed in both a simulation lab and the delivery room. The goal is to see if their ability to manage a baby's mask …

This study planned to use a biomarker test called NGAL to predict which critically ill children and newborns would develop severe kidney injury. The goal was to help doctors make better decisions about fluids and dialysis. However, the study was withdrawn before enrolling any par…

This study collects information from about 1000 critically ill infants who need a special type of dialysis (blood cleaning) using a new machine called CARPEDIEM. The goal is to learn why doctors start this treatment, how to best use it, and what happens to the babies afterward. T…

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study looks at whether a biomarker test (NGAL) can help doctors better manage fluids and dialysis in children with acute kidney injury in the pediatric ICU. Researchers will follow 420 children at risk for kidney problems to see if the test helps make faster, safer treatment…

This study looks at whether a standard set of guidelines, called the Methodist Acute Pancreatitis Protocol (MAPP), improves care for people with acute pancreatitis. Researchers will compare outcomes like hospital stay length and discharge status before and after the protocol was …

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study is observing brain oxygen levels in two groups of newborns at high risk of brain injury: full-term babies undergoing cooling treatment for oxygen deprivation, and extremely premature babies. Researchers use a non-invasive light sensor (near-infrared spectroscopy) to me…

This study compares a proactive, prescription-based fluid management plan to usual care in 150 critically ill patients who need kidney replacement therapy (dialysis). The goal is to see if a standardized daily prescription can help achieve a neutral or negative fluid balance, pre…

This study follows 178 patients who previously received an AvenCell CAR-T cell therapy for cancers like lymphoma, leukemia, or prostate cancer. Researchers will track delayed side effects, including new cancers or autoimmune issues, for years. No new treatment is given—this is pu…

This study looks at two ways to help people in the ICU who have trouble breathing due to low oxygen levels. It compares using a helmet-like device plus high-flow oxygen through the nose versus high-flow oxygen alone. The goal is to see which approach works better and to gather in…

This study aimed to compare costs and health outcomes for heart surgery patients who developed acute kidney injury versus those who did not. Researchers planned to review medical records from UK hospitals over a 10-year period. The study was withdrawn before enrolling any partici…

This study follows about 150 people who previously received Caribou cell therapy for blood cancers like lymphoma or leukemia. Researchers will check for long-term side effects and overall survival for up to 15 years after treatment. No new treatment is given—this is just observat…

This study looks at babies born to mothers with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes itching and high bile acid levels. Researchers want to see if these bile acids can lead to breathing problems in newborns. They will compare 120 babies—some …

This study tests whether a drug can help red blood cells work better in low-oxygen (hypoxia) and cold (hypothermia) conditions, which are common in high-altitude or military environments. Researchers will measure how the drug affects red blood cell energy and antioxidant defenses…

This study aimed to see if a simple breathing test (Müller maneuver) could predict which patients on ventilators would develop fluid in their lungs during a weaning trial. The test measures changes in heart output to assess fluid status. The study was withdrawn before enrolling a…

This study tracks how doctors in Spain use injectable blood thinners (cangrelor or GPIs) during heart procedures like stent placement. It includes 717 patients and will look at short-term outcomes like death, heart attack, stroke, and bleeding within 48 hours. The goal is to unde…

This study looks at a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. Doctors, patients, and families agree to try treatments for a set time, then check if the patient is recovering. The goal is to see if this approach can reduce ICU…

This study looks at whether vitamin D levels in the blood can help identify kidney injury in people who have had heart surgery. Researchers will compare vitamin D measurements with standard kidney function tests in 46 adults with different levels of kidney health. The goal is to …

This study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …

This study uses a non-invasive breathing test called forced oscillometry to measure lung function in 600 newborn infants, both full-term and premature, with and without lung conditions like respiratory distress or bronchopulmonary dysplasia. The goal is to better understand how t…

This study is testing a new AI-powered decision support system designed to help doctors diagnose and treat acute myocardial infarction (heart attack) more quickly and effectively. The system aims to address common delays in care, such as slow diagnosis in clinics and low complian…

This study follows 200 ICU patients with severe COVID-19 to see how often they develop lung scarring (pulmonary fibrosis). Researchers will use blood tests and CT scans to find early signs of scarring and identify risk factors. The goal is to understand how scarring affects recov…

This study tests whether using rapid, advanced lab tests to identify the exact bacteria causing a severe infection can help doctors choose the right antibiotics faster. About 190 adults with sepsis in Greek ICUs will either get standard care or the new testing strategy. The goal …

This study looks at 500 patients with severe breathing failure due to pneumonia who are using a non-invasive breathing mask. Researchers will measure their energy needs, muscle function, and blood markers to identify different patient types. The goal is to better understand how t…

This pilot study looks at how diet and body fat versus muscle (sarcopenic obesity) affect treatment and recovery in Indian children with acute lymphoblastic leukemia. Researchers will track 115 children's food intake and body composition using DEXA scans. The goal is to understan…

This study looks at gene activity in blood cells from 30 kidney or lung transplant patients who have chronic rejection. Researchers want to find out why some patients improve with a treatment called extracorporeal photoapheresis (ECP) while others do not. The goal is to better un…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This observational study looks at how well antibiotics given through a vein reach infected fluid collections in the pancreas of people with acute pancreatitis. About 40 adults who are already scheduled for drainage of these collections will provide a small fluid sample and a bloo…

This study looks at how often muscle loss (sarcopenia) happens in adults who need a breathing machine in the ICU for more than 48 hours. Researchers will measure muscle health using simple tests and ultrasound. The goal is to understand how common this problem is and how it chang…

This study looks at whether a blood test can help doctors know if treatment for kidney rejection is working in children who have had a kidney transplant. About 27 kids will give blood samples to check for special markers. The goal is to see if the blood test can predict and monit…

This study looks back at over 2,400 people diagnosed with acute mesenteric ischemia (a sudden blockage of blood flow to the intestine) in a region of Sweden between 2000 and 2023. Researchers want to understand how often it occurs, how treatments and survival have changed over ti…

This study tests a computer system that uses patient data to predict complications after surgery. Doctors and the computer will each give risk scores for 200 patients, and researchers will compare which is more accurate. The goal is to see if technology can help improve surgical …

This study follows 1,000 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in France to see how they are actually treated in everyday clinics, not just in controlled trials. Researchers will track which therapies patients receive, in what order, a…

This study watches 137 adults with chronic lymphocytic leukemia (CLL) who are already prescribed acalabrutinib by their doctors. Researchers will track how many patients are still taking the drug after 1 and 2 years. No new treatments or changes are made—just observation of real-…

This observational study will follow over 10,000 adult patients in intensive care units to understand how often acute kidney injury occurs, how severe it gets, and what happens to patients afterward. Researchers will track kidney function, need for dialysis, and survival up to on…

This study looks at whether a common diabetes medicine (SGLT2 inhibitor) can help prevent future heart problems in people with type 2 diabetes who have had a heart attack. Researchers will compare health records of 200,000 adults in Korea who took either an SGLT2 inhibitor or ano…

This study looks at how well medical teams follow safety guidelines when treating people hurt in a chemical, biological, or nuclear attack. Researchers will track 1,000 patients to see if care is given without delay and if contamination is controlled during rescue. The goal is to…

This study planned to create artificial intelligence tools that could diagnose kidney transplant rejection using urine tests instead of invasive biopsies. Researchers wanted to combine urine markers with standard medical data to make diagnosis safer and easier. However, the study…

This study reviews medical records of 200 people hospitalized with unexplained meningitis or meningoencephalitis. Researchers want to see if adding a test for tick-borne encephalitis (TBE) helps find more cases. No new drug or treatment is being tested—only the impact of a change…

This study was designed to test a new catheter that takes two types of pictures inside heart arteries at the same time—using sound and light. The goal was to see if this hybrid approach is safer and better at identifying fatty plaques that could cause heart attacks compared to st…

This study follows 500 adults aged 18-65 who completed chemotherapy for certain cancers and are in remission. Researchers will check for 19 possible late side effects over 5 years, including heart, lung, and hormone problems. The goal is to catch these issues early and connect pa…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…