New hope for tough leukemia? early trial of ABBV-453 begins

NCT ID NCT06291220

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests an experimental drug called ABBV-453, given with another cancer drug (obinutuzumab), in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or stopped responding to other treatments. About 60 participants will receive the drugs and be monitored for side effects, drug levels in the blood, and any changes in their disease. The main goal is to find a safe dose and see how the body handles the drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ABBV-453 (an investigational drug) combined with obinutuzumab (a cancer antibody)

What this could lead to

If it works, this could point toward a new treatment option for people with hard-to-treat CLL or SLL.

What could go wrong

This is a very early Phase 1 trial with only 4 participants so far, focused on safety and dosing. It may not lead to an effective treatment, and side effects are unknown.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA SMALL LYMPHOCYTIC LYMPHOMA

Contacts and locations

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Locations

Atrium Health /ID# 265136

Charlotte, North Carolina, 28204-2963, United States
Austin Health /ID# 256776

Heidelberg, Victoria, 3084, Australia
Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 263062

Perugia, 06156, Italy
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin /ID# 263433

Berlin, 12203, Germany
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 267158

Irvine, California, 92618, United States
City of Hope /ID# 253904

Duarte, California, 91010, United States
Duplicate_Duke Cancer Center /ID# 258707

Durham, North Carolina, 27710-3000, United States
Gold coast University Hospital /ID# 255785

Southport, Queensland, 4215, Australia
Hadassah Medical Center-Hebrew University /ID# 254721

Jerusalem, Jerusalem, 91120, Israel
IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 263065

Bologna, 40138, Italy
IRCCS Ospedale San Raffaele /ID# 263064

Milan, Milano, 20132, Italy
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 264622

Billings, Montana, 59102, United States
MD Anderson Cancer Center /ID# 253713

Houston, Texas, 77030, United States
Royal Perth Hospital /ID# 256464

Perth, Western Australia, 6000, Australia
Royal Prince Alfred Hospital /ID# 263129

Sydney, New South Wales, 2050, Australia
The Chaim Sheba Medical Center /ID# 254383

Ramat Gan, Tel Aviv, 5265601, Israel
Universitaetsklinikum Halle (Saale) /ID# 263299

Halle, Saxony-Anhalt, 06120, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 263730

Hamburg, 20246, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 263150

Kiel, Schleswig-Holstein, 24105, Germany
Universitaetsklinikum Ulm /ID# 263148

Ulm, Baden-Wurttemberg, 89081, Germany
Yitzhak Shamir Medical Center /ID# 257626

Ẕerifin, Central District, 70300, Israel