BREATHE trial: smaller vs larger breathing tubes in emergency care

NCT ID NCT06939361

First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 26 times

Summary

This study looks at whether using a smaller or larger breathing tube during emergency intubation affects how patients feel months later. About 3,180 critically ill adults in the ER or ICU will be randomly assigned to get either a smaller or larger tube. Researchers will check for breathlessness, voice quality, and swallowing problems 6 months after the procedure.

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Contacts and locations

Locations

  • Atrium Health Wake Forest Baptist

    Winston-Salem, North Carolina, 27157, United States

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • University of Alabama Hospital

    Birmingham, Alabama, 35233, United States

  • University of Colorado-Denver

    Denver, Colorado, 80045, United States

  • University of Washington Medical Center

    Seattle, Washington, 98104, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.