BREATHE trial: does tube size affect recovery after emergency breathing support?

NCT ID NCT06939361

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 32 times

Summary

This study looks at whether using a smaller or larger breathing tube during emergency intubation helps critically ill adults breathe better 6 months later. About 3,180 patients in emergency rooms or ICUs will be randomly assigned to get a smaller or larger tube. The main goal is to see if tube size affects shortness of breath, voice, and swallowing after recovery.

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Contacts and locations

Locations

  • Atrium Health Wake Forest Baptist

    Winston-Salem, North Carolina, 27157, United States

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • University of Alabama Hospital

    Birmingham, Alabama, 35233, United States

  • University of Colorado-Denver

    Denver, Colorado, 80045, United States

  • University of Washington Medical Center

    Seattle, Washington, 98104, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.