Donor immune cells show promise against returning blood cancers

NCT ID NCT02050347

First seen Nov 16, 2025 · Last updated Jun 13, 2026 · Updated 22 times

Summary

This early-phase study tests a new treatment for people with certain blood cancers (lymphoma or leukemia) that have returned after a stem cell transplant. Researchers take immune cells called T cells from the original stem cell donor, modify them to recognize and attack cancer cells (using a special receptor called CAR), and give them to the patient. The main goals are to find the safest dose and to see if this approach can control the cancer without causing severe side effects.

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Contacts and locations

Locations

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Texas Children's Hospital

    Houston, Texas, 77030, United States

Conditions

The condition(s) this trial relates to.

Burkitt lymphoma Leukemia, B-Cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.