Gene-Edited super cells take on childhood leukemia
NCT ID NCT05942599
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests a new treatment for children aged 6 months to 16 years whose acute myeloid leukemia has returned. The therapy uses donor immune cells that have been gene-edited with a technique called base editing to better target and kill leukemia cells. The main goal is to check safety and see if the cells can clear the cancer before a bone marrow transplant.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Base-edited CAR T cells (BE CAR-33) made from donor white blood cells
What this could lead to
If it works, this could offer a way to clear leukemia before a bone marrow transplant, potentially preventing the cancer from coming back.
What could go wrong
This is a very early, small phase 1 trial with only 10 children. The therapy may cause severe side effects like cytokine release syndrome or graft-versus-host disease, and it may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Great Ormond Street Hospital for Children
London, WC1N3JH, United Kingdom