New shot could help kidney transplant patients fight rejection
NCT ID NCT06503731
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a drug called efgartigimod, given as a shot under the skin, for people who have antibody-mediated rejection after a kidney transplant. The trial includes 30 adults who received a kidney at least 6 months ago and have signs of rejection. Participants will receive either the drug or a placebo, along with their usual anti-rejection medications, for 48 weeks, followed by 24 weeks of observation. The goal is to see if the drug is safe and can help control rejection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Efgartigimod PH20 SC (a drug given by injection under the skin)
What this could lead to
If it works, this could offer a new way to treat antibody-mediated rejection in kidney transplant patients, potentially helping to preserve kidney function and reduce the need for stronger treatments.
What could go wrong
This is an early Phase 2 trial with only 30 participants, so results may not apply to everyone. The drug is tested alongside standard immunosuppression, and its long-term safety and effectiveness are not yet known.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ANTIBODY-MEDIATED REJECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Allgemeines Krankenhaus der Stadt Wien (AKH Wien) - Medizinischer Universitätscampus
RECRUITINGVienna, 1090, Austria
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Centre Hospitalier Universitaire (CHU) de Bordeaux - Hôpital Pellegrin
RECRUITINGBordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Centre Hospitalier Universitaire (CHU) de Grenoble Alpes - Hôpital Michallon
RECRUITINGLa Tronche, 38700, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Centre Hospitalier Universitaire (CHU) de Toulouse - Hôpital de Rangueil
RECRUITINGToulouse, 31059, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Charité - Universitätsmedizin Berlin
RECRUITINGBerlin, 13353, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Duke University Hospital
RECRUITINGDurham, North Carolina, 27705, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Del Mar
RECRUITINGBarcelona, 08003, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Universitario Miguel Servet
RECRUITINGZaragoza, 50009, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Universitario Vall d'Hebron
RECRUITINGBarcelona, 08035, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hospital Universitario de Bellvitge
RECRUITINGBarcelona, 08907, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Institut klinicke a experimentalni mediciny (IKEM)
RECRUITINGPrague, 140-21, Czechia
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
London Health Sciences Centre
RECRUITINGLondon, N6A 5A5, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITINGDresden, 01307, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Universitair Ziekenhuis (UZ) Gent
RECRUITINGGhent, 9000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Universitair Ziekenhuis Leuven (UZ Leuven) - Campus Gasthuisberg
RECRUITINGLeuven, 3000, Belgium
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Alabama at Birmingham (UAB) Hospital
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60615, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Washington Medical Center
RECRUITINGSeattle, Washington, 98195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Universitätsklinikum Hamburg-Eppendorf
RECRUITINGHamburg, 20246, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Virginia Commonwealth University (VCU) Medical Center Hume-Lee Transplant Center
RECRUITINGRichmond, Virginia, 23298, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••