Can a drug break improve CLL treatment for frail patients?
NCT ID NCT04963946
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether older, frail patients with untreated chronic lymphocytic leukemia (CLL) can safely stop taking the targeted drug acalabrutinib after 18 months and then restart it if their disease comes back. The goal is to reduce long-term side effects and the risk of drug resistance. About 160 patients aged 70 and older with other health issues will be followed for one year after stopping treatment to see how well they do without the drug.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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ARGENTEUIL - Centre hospitalier Victor Dupouy
Argenteuil, France
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BOBIGNY - Hôpital Avicenne
Bobigny, France
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Bordeaux Pessac
Pessac, 33604, France
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CENTRE HOSPITALIER SAINTJEAN - Hématologie Clinique
Perpignan, 66000, France
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CERGY-PONTOISE - Centre Hospitalier René Dubos
Pontoise, France
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CHR ORLEANS - Hématologie
Orléans, 44100, France
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CHU Estaing - Hématologie Clinique Adulte
Clermont-Ferrand, 63000, France
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CHU Grenoble - Hématologie
Grenoble, 388043, France
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CHU Nancy Brabois
Vandœuvre-lès-Nancy, 54500, France
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CHU Pontchaillou - Hématologie Clinique BMT-HC
Rennes, 35033, France
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Centre Henri Becquerel - Service Hématologie Clinique
Rouen, 76038, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, 69495, France
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Centre Hospitalier Regional Metz Thionville
Metz, 57085, France
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Centre Hospitalier du Mans
Le Mans, 72000, France
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Centre Léon Bérard - Hématologie
Lyon, 69373, France
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Ch Avignon
Avignon, 84000, France
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Ch Cote Basque
Bayonne, 64109, France
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Chu Angers
Angers, 49933, France
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Chu Reims
Reims, 51092, France
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Corbeil-Essonnes -
Corbeil-Essonnes, France
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Hopital E.Muller
Mulhouse, 68100, France
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Hopital Pitie Salpetriere Service Hematologie Clinique - Pavillon de L'Enfant Et Adolescent
Paris, 75651, France
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Hôpital Bretonneau - Hématologie et Thérapie Cellulaire
Tours, 37044, France
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Hôpital Privé Sévigné
Cesson-Sévigné, 35510, France
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Hôpital Saint Vincent de Paul
Lille, 59000, France
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Hôpital Saint-Eloi - Hématologie Clinique
Montpellier, 34295, France
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Hôpital de la Milétrie - Hématologie et Thérapie Cellulaire
Poitiers, 86021, France
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IUCT ONCOPOLE - Hématologie
Toulouse, 31059, France
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Institut Paoli-Calmettes - Hématologie Clinique
Marseille, 13273, France
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Institut de Cancérologie Lucien Neuwirth
Saint-Priest-en-Jarez, 42271, France
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VERSAILLES - Hôpital André Mignot
Versailles, France
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Vannes - Chba
Vannes, France