New method aims to help premature babies breathe easier without a breathing tube

NCT ID NCT07176117

ENROLLING_BY_INVITATION Disease control Sponsor: Sharp HealthCare Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study tests whether giving surfactant (a natural substance that helps lungs stay open) through a small airway device placed above the vocal cords, along with standard breathing support (CPAP), is better than CPAP alone for late preterm and early term infants with respiratory distress. About 422 newborns will be enrolled. The goal is to see if this less invasive approach reduces complications and hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surfactant
What this could lead to: If successful, this could provide a safer, less invasive way to treat breathing problems in newborns, potentially reducing complications and hospital stays.
What could go wrong: This is a single-center study, and results may not apply to all hospitals. The procedure still carries risks like any airway device, and the benefit over standard CPAP alone is not yet proven.

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Conditions

The condition(s) this trial relates to.

Pulmonary Atelectasis respiratory distress syndrome in premature infants

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY DISTRESS SYNDROME (NEONATAL) SURFACTANT

Contacts and locations

Locations

Sharp Chula Vista Medical Center

Chula Vista, California, 91911, United States
Sharp Grossmont Hospital

La Mesa, California, 91942, United States
Sharp Mary Birch Hospital for Women & Newborns

San Diego, California, 92123, United States

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