New antibody therapy targets blood cancers in early trial

NCT ID NCT05424822

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study tests a new drug called JNJ-80948543 in people with non-Hodgkin lymphoma or chronic lymphocytic leukemia whose cancer has returned or not responded to other treatments. The drug works by redirecting the body's T-cells to attack cancer cells. The main goals are to check safety and find the best dose. About 167 participants will take part.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell non-Hodgkin lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Aichi Cancer Center

    Nagoya, 464 8681, Japan

  • Aidport Sp z o o

    Skorzewo, 60-185, Poland

  • CHRU de Lille Hopital Claude Huriez

    Lille, 59037, France

  • Carmel Medical Center

    Haifa, 34362, Israel

  • Chongqing University Cancer Hospital

    Chongqing, 400044, China

  • City of Hope

    Duarte, California, 91010, United States

  • Hadassah Medical Center

    Jerusalem, 9112001, Israel

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Institut Curie

    Paris, 75005, France

  • Institut Universitaire du cancer de Toulouse-Oncopole

    Toulouse, 31059, France

  • Institut de Cancerologie Strasbourg Europe ICANS

    Strasbourg, 67033, France

  • Linear Clinical Research Ltd

    Nedlands, 6009, Australia

  • Macquarie University Hospital

    Macquarie University, 2109, Australia

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • National Cancer Center Hospital East

    Kashiwa, 277 8577, Japan

  • Odense University Hospital

    Odense, 5000, Denmark

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37203, United States

  • Scientia Clinical Research

    Randwick, 2031, Australia

  • Seattle Cancer Care Alliance

    Seattle, Washington, 98109, United States

  • Sun Yat Sen University Cancer Center

    Guangzhou, 510060, China

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • Texas Transplant Institute

    San Antonio, Texas, 78229, United States

  • The Alfred Hospital

    Melbourne, 3004, Australia

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135 8550, Japan

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tianjin cancer hospital

    Tianjin, 300060, China

  • Union Hospital Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, 430030, China

  • Uniwersyteckie Centrum Kliniczne Osrodek Badan Klinicznych Wczesnych Faz

    Gdansk, 80 214, Poland