Real-World data on acalabrutinib for CLL: what happens outside the lab?

NCT ID NCT06170671

Ongoing Knowledge-focused Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how well the drug acalabrutinib works for people with chronic lymphocytic leukemia (CLL) in real-life settings in Romania. Researchers will collect data from 250 patients over three years to see how long they stay on the drug, why they stop, and how effective it is. The goal is to understand the drug's performance outside of strict clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acalabrutinib
What this could lead to: If successful, this study could provide valuable insights into how acalabrutinib performs outside of clinical trials, helping doctors make better treatment decisions for CLL patients.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may be influenced by patient selection and real-world factors, and the study is limited to Romania.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA

Contacts and locations

Locations

Research Site

Piteşti, Argeş, 110084, Romania
Research Site

Oradea, Bihor County, 410469, Romania
Research Site

Cluj-Napoca, Cluj, 400015, Romania
Research Site

Craiova, Dolj, 200143, Romania
Research Site

Deva, Hunedoara County, 330084, Romania
Research Site

Baia Mare, Maramureş, 430031, Romania
Research Site

Târgu Mureş, Mureș County, 540136, Romania
Research Site

Piatra Neamţ, Neamț County, 610136, Romania
Research Site

Timișoara, Timiș County, 300239, Romania
Research Site

Timișoara, Timiș County, 300254, Romania
Research Site

Focşani, Vrancea, 620034, Romania
Research Site

Brasov, 500052, Romania
Research Site

Bucharest, 20125, Romania
Research Site

Bucharest, 22328, Romania
Research Site

Bucharest, 301710, Romania
Research Site

Bucharest, 30171, Romania
Research Site

Bucharest, 50098, Romania
Research Site

Galati, 800578, Romania
Research Site

Iași, 700483, Romania

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