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Low oxygen or organ failure? study aims to uncover true driver of ICU deaths

NCT ID NCT07708506

Knowledge-focused Sponsor: Jesus Villar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study analyzes data from over 1,200 patients with acute hypoxemic respiratory failure who were on breathing machines in Spanish ICUs. Researchers are using a statistical method called mediation analysis to determine whether low oxygen levels directly cause death, or whether they are simply a sign of overall organ failure. The goal is to clarify which factor truly drives outcomes in these critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this analysis could help doctors better predict which patients are at highest risk of dying in the ICU, potentially guiding more targeted treatments.
What could go wrong
This is a retrospective analysis of existing data, not a controlled experiment. It can show associations but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,241 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Critically ill patients, intubated and mechanically ventilated, with acute hupoxemic respiratory failure (AHRF)

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * intubation and mechanical ventilation PaO2/FiO2 ratio \< or = 300 mmHg under MV with PEEP \> or = 5 cmH2O, and FiO2 \> 0r = 0.3 Exclusion Criteria: * Brain death patients

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute hypoxemic respiratory failure

Contacts and locations

Locations

  • Anesthesia, Hospital Universitario Río Hortega

    Valladolid, 47012, Spain

  • Cardiff University

    Cardiff, United Kingdom

  • Complejo Asistencial Universitario de León (ICU)

    León, 24001, Spain

  • Complejo Hospitalario Universitario de Albacete (ICU)

    Albacete, 02006, Spain

  • Complejo Hospitalario Universitario de León

    León, Spain

  • Department of Anesthesia, Hospital Clinico Universitario

    Valencia, 46010, Spain

  • Department of Anesthesia, Hospital Clínico Universitario

    Valladolid, 47003, Spain

  • Department of Anesthesia, Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Department of Anesthesia, Hospital Universitario Virgen de Arrixaca

    Murcia, 30120, Spain

  • Department of Anesthesia, Hospital Universitario de Cruces

    Barakaldo, Vizcaya, 48903, Spain

  • Hospital Cinico de Valencia

    Valencia, 46010, Spain

  • Hospital Clinic

    Barcelona, Spain

  • Hospital Clinic de Barcelona (AVI)

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Valencia (Anesthesia)

    Valencia, 46010, Spain

  • Hospital Clinico de Valencia

    Valencia, Spain

  • Hospital Clínic de Barcelona (Anesthesia)

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, Spain

  • Hospital Clínico Universitario de Valladolid

    Valladolid, Spain

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