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Low oxygen or organ failure? study aims to uncover true driver of ICU deaths

NCT ID NCT07708506

Ongoing Knowledge-focused Sponsor: Jesus Villar Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study analyzes data from over 1,200 patients with acute hypoxemic respiratory failure who were on breathing machines in Spanish ICUs. Researchers are using a statistical method called mediation analysis to determine whether low oxygen levels directly cause death, or whether they are simply a sign of overall organ failure. The goal is to clarify which factor truly drives outcomes in these critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this analysis could help doctors better predict which patients are at highest risk of dying in the ICU, potentially guiding more targeted treatments.
What could go wrong
This is a retrospective analysis of existing data, not a controlled experiment. It can show associations but cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HYPOXEMIC RESPIRATORY FAILURE

Contacts and locations

Locations

  • Anesthesia, Hospital Universitario Río Hortega

    Valladolid, 47012, Spain

  • Cardiff University

    Cardiff, United Kingdom

  • Complejo Asistencial Universitario de León (ICU)

    León, 24001, Spain

  • Complejo Hospitalario Universitario de Albacete (ICU)

    Albacete, 02006, Spain

  • Complejo Hospitalario Universitario de León

    León, Spain

  • Department of Anesthesia, Hospital Clinico Universitario

    Valencia, 46010, Spain

  • Department of Anesthesia, Hospital Clínico Universitario

    Valladolid, 47003, Spain

  • Department of Anesthesia, Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Department of Anesthesia, Hospital Universitario Virgen de Arrixaca

    Murcia, 30120, Spain

  • Department of Anesthesia, Hospital Universitario de Cruces

    Barakaldo, Vizcaya, 48903, Spain

  • Hospital Cinico de Valencia

    Valencia, 46010, Spain

  • Hospital Clinic

    Barcelona, Spain

  • Hospital Clinic de Barcelona (AVI)

    Barcelona, 08036, Spain

  • Hospital Clinico Universitario de Valencia (Anesthesia)

    Valencia, 46010, Spain

  • Hospital Clinico de Valencia

    Valencia, Spain

  • Hospital Clínic de Barcelona (Anesthesia)

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, Spain

  • Hospital Clínico Universitario de Valladolid

    Valladolid, Spain

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