Experimental CAR-T therapy targets tough leukemia
NCT ID NCT06709131
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing a new treatment called CT0991, which uses specially engineered immune cells (CAR-T cells) to fight acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The study involves 24 adults aged 18-75 and aims to check safety and find the right dose. The trial is currently on hold.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CT0991 CAR-T cells (a type of immune cell therapy)
- What this could lead to
- If successful, this could point toward a new treatment option for patients with hard-to-treat acute myeloid leukemia.
- What could go wrong
- This is a very early Phase 1 trial with only 24 participants, and it is currently suspended. CAR-T therapy can cause severe side effects like cytokine release syndrome, and it may not work for all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The first affiliated hospital of medical college of zhejiang university
Hangzhou, Zhejiang, 310003, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New oral drug targets Tough-to-Treat leukemia
- Off-the-Shelf immune cells take aim at Hard-to-Treat leukemia
- Can lab tests guide better AML treatment choices?
- New hope for tough leukemia: experimental therapy CT1390B enters first human tests
- New drug CLN-049 aims to fight Hard-to-Treat blood cancers
- Experimental CAR-T therapy takes on tough leukemia