Off-the-Shelf CAR t therapy shows promise for Hard-to-Treat lymphoma
NCT ID NCT04416984
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new type of CAR T cell therapy, called ALLO-501A, made from donor cells (not the patient's own). It is for adults with large B-cell lymphoma or chronic lymphocytic leukemia/small lymphocytic lymphoma that has come back or not responded to other treatments. The goal is to see if this therapy is safe and can shrink or control the cancer after a short course of chemotherapy. About 160 people will take part.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advent Health
Orlando, Florida, 06510, United States
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Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Augusta University
Augusta, Georgia, 30912, United States
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Avera Medical
Sioux Falls, South Dakota, 57117, United States
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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CHU de Québec -Université Laval; Hôpital de l'Enfant-Jésus
Québec, Quebec, G1J 1Z4, Canada
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City of Hope
Duarte, California, 91010, United States
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Colorado Blood Cancer Institute
Denver, Colorado, 80218-1234, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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MD Anderson Cancer Center - University of Texas
Houston, Texas, 77030, United States
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Mayo Clinic Hospital
Phoenix, Arizona, 85054, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612-9416, United States
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Monash Medical Centre
Clayton, Victoria, 3168, Australia
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Northside Hospital - Atlanta
Atlanta, Georgia, 30342, United States
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Norton Cancer Institute
Louisville, Kentucky, 40207, United States
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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QEII Health Sciences Centre-VG Site
Halifax, Nova Scotia, B3H 2Y9, Canada
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St. David's South Austin Medical Center
Austin, Texas, 78704, United States
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St. Vincent's Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
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Stanford Cancer Institute
Palo Alto, California, 94035, United States
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Texas Oncology
Dallas, Texas, 75251, United States
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UCLA Medical Center
Los Angeles, California, 90095, United States
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University of Miami
Miami, Florida, 33136, United States
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Vanderbilt Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Yale School of Medicine
New Haven, Connecticut, 06510, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New combo therapy aims to boost remission in Hard-to-Treat lymphoma
- Automated CAR-T therapy shows promise for Tough-to-Treat lymphoma
- New hope for lymphoma patients: glofitamab combo faces standard care in trial
- Double-Barreled attack: CAR-T plus stem cell transplant takes on aggressive lymphoma
- Affordable CAR-T breakthrough: academic therapy offers new hope for blood cancer patients
- Experimental donor CAR-T therapy tested in lymphoma – trial halted early