Double-Barreled attack: CAR-T plus stem cell transplant takes on aggressive lymphoma
NCT ID NCT07538635
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a powerful two-step approach for people with a fast-growing type of lymphoma that has not responded to standard treatments. First, patients receive a CAR-T cell therapy (engineered immune cells) followed by a stem cell transplant with high-dose chemotherapy. The goal is to see if this combination can better control the cancer and improve survival. The trial is currently recruiting 20 adults with high-risk large B-cell lymphoma.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Axicabtagene ciloleucel (a CAR-T cell therapy) combined with a stem cell transplant
- What this could lead to
- If successful, this combination could offer a more effective way to control aggressive lymphoma that has come back or not responded to standard treatments.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply to everyone. The treatment involves intense chemotherapy and carries risks like severe side effects or the cancer not responding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhengjiang, 310022, China
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