Waterhouse-Friderichsen syndrome

MONDO:0006015

A serious disorder characterized by massive adrenal gland hemorrhage secondary to a bacterial infection, most often Neisseria meningitidis infection. It is manifested with decreased blood pressure, shock, disseminated intravascular coagulation, and adrenocortical insufficiency.

Also known as: WFS, meningococcal hemorrhagic adrenalitis, Waterhouse–Friderichsen syndrome, fatal pneumococcal Waterhouse-Friderichsen syndrome

2 clinical trials for this condition and its sub-types, 0 tagged with Waterhouse-Friderichsen syndrome itself.

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↑ Syndromic disease (7139) ↑ Acute adrenal insufficiency (0)

Including sub-types (2) Tagged with Waterhouse-Friderichsen syndrome (0)

Trials to join now! 1 Not yet recruiting 1

New imaging tracer could shed light on adrenal cholesterol

Knowledge-focused Recruiting now

This study tests a special radioactive tracer called [18F]FNP-59 to see if it can safely and clearly show cholesterol activity in the adrenal gland using PET scans. About 24 people will take part, including healthy volunteers and those with known adrenal problems. The goal is to …

Early phase 1 • Sponsor: Benjamin Viglianti • Aim: Knowledge-focused

Last updated Jun 27, 2026 08:02 UTC

Waterhouse-Friderichsen syndrome

Where it sits in the disease tree

New imaging tracer could shed light on adrenal cholesterol